Journal of neonatal-perinatal medicine最新文献

Comparing Heated Humidified High Flow Nasal Cannula to Nasal Continuous Positive Airway Pressure as post-extubation respiratory support in preterm infants: A comprehensive systematic review and meta-analysis. 比较热湿高流量鼻插管与鼻持续气道正压通气作为早产儿拔管后呼吸支持：一项全面的系统综述和荟萃分析。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-30 DOI: 10.1177/19345798251348160

Amir Mohammad Armanian, Behzad Barekatain, Negin Ghasemi Kahrizsangi, Payam Naseh Ghafoori, Maryam Yazdi, Elaheh Mazaheri, Mina Nekuei

{"title":"Comparing Heated Humidified High Flow Nasal Cannula to Nasal Continuous Positive Airway Pressure as post-extubation respiratory support in preterm infants: A comprehensive systematic review and meta-analysis.","authors":"Amir Mohammad Armanian, Behzad Barekatain, Negin Ghasemi Kahrizsangi, Payam Naseh Ghafoori, Maryam Yazdi, Elaheh Mazaheri, Mina Nekuei","doi":"10.1177/19345798251348160","DOIUrl":"https://doi.org/10.1177/19345798251348160","url":null,"abstract":"BackgroundThis study aims to compare the efficacy and complications of CPAP with HHHFNC, as post-extubation modalities for respiratory support in neonates.MethodsA comprehensive search was conducted in five electronic databases: MEDLINE (via PUBMED), Scopus, Web of Science, Google Scholar, and Embase in September 2022; screening observational and clinical trial studies for eligibility. Primary outcomes of the study included extubation failure at 72 hours and at 7 days.ResultsNine clinical trials were included, encompassing 1471 infants. Extubation failure at 72 days was more common with HHHFNC although insignificantly (OR = 3.40, 95% CI: 0.87, 13.23), but it was found to be significantly higher at 7 days when opting for HHHFNC (OR = 1.65, 95% CI: 1.02, 2.67). In an overall analysis, extubation failure was significantly higher in infants treated with HHHFNC (OR = 1.61, 95% CI: 1.14, 2.26). Among secondary outcomes, nasal trauma was significantly higher when CPAP was utilized (OR = 0.20 95% CI: 0.10, 0.42). Meta-analysis suggests that there are no differences in the risks for BPD (OR = 1.27, 95% CI: 0.79, 2.06), ROP (OR = 0.88, 95% CI: 0.51, 1.52), NEC (OR = 0.63, 95% CI: 0.41, 0.97), PVL (OR = 0.71, 95% CI: 0.29, 2.96), IVH (OR = 1.04, 95% CI: 0.53, 2.04), and mortality (OR = 0.96, 95% CI: 0.56, 1.66).ConclusionAccording to our review, CPAP remains the choice of non-invasive respiratory support modality regarding its lower risk for extubation failure. Although nasal trauma continues to be a challenging side effect for neonates treated with CPAP, other neonatal complications are equally prevalent when comparing CPAP and HHHFCN.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251348160"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of sequential functional echocardiography in predicting clinically apparent patent ductus arteriosus in preterm very low birth weight newborns: An observational study. 序贯功能超声心动图在预测早产儿极低出生体重新生儿临床明显动脉导管未闭中的作用：一项观察性研究。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-15 DOI: 10.1177/19345798251343494

Anchala Bhardwaj, Arvind Saili, Dinesh Kumar Yadav, Ajay Kumar

{"title":"Role of sequential functional echocardiography in predicting clinically apparent patent ductus arteriosus in preterm very low birth weight newborns: An observational study.","authors":"Anchala Bhardwaj, Arvind Saili, Dinesh Kumar Yadav, Ajay Kumar","doi":"10.1177/19345798251343494","DOIUrl":"https://doi.org/10.1177/19345798251343494","url":null,"abstract":"BackgroundThe prolonged ductal patency in preterm newborns despite being associated with short- and long-term morbidities has failed to show significant improvement in the long-term outcome with routine ductal treatment. Echocardiography has been shown to have a predictive and diagnostic role in identifying the significant patent ductus arteriosus (PDA) before its clinical detection and providing selective treatment for PDA to avoid unnecessary therapy or delay of necessary therapy. Several echocardiographic ductal markers have been evaluated for their predictive utility with a wide range of sensitivity (26%-100%) and specificity (6%-100%). Ductal diameter, left pulmonary artery (LPA) velocity, and left atrial to aortic width (La/Ao) ratio are the common markers being used routinely for PDA. This research was planned to assess the predictive utility of additional ductal echocardiographic markers in preterm newborns.MethodsIt was a prospective observational cohort study conducted in the tertiary care neonatal intensive care unit (NICU) at Lady Hardinge Medical College, Delhi. 50 very low birth weight newborns underwent four sequential Echo scans within the first 72 hrs; the first within 12 hours, and the next three scans at completed 24 hrs, 48 hrs, and 72 hrs of age. These newborns were then monitored for clinical signs of PDA up to 2 weeks of life.ResultsThe left atrial volume index (LAVI), left ventricle to aortic width (Lv/Ao ratio), left ventricular output/superior vena cava (LVO/SVC) flow ratio with different cut-off values at different hours of life, shunt pattern and altered blood flow in the anterior cerebral, and superior mesenteric vessels predicted persistence of ductus arteriosus.ConclusionThis study provides insights into the predictive utility of additional ductal echo markers apart from the routinely measured ones.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251343494"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of individuals born with orofacial clefts in the United States and Brazil. 美国与巴西先天性唇腭裂之比较研究。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-15 DOI: 10.1177/19345798251343829

Adriana M da Silva, V S Freitas, A R Vieira

{"title":"Comparative study of individuals born with orofacial clefts in the United States and Brazil.","authors":"Adriana M da Silva, V S Freitas, A R Vieira","doi":"10.1177/19345798251343829","DOIUrl":"https://doi.org/10.1177/19345798251343829","url":null,"abstract":"BackgroundIn Brazil, little attention has been focused on gestational complications related to orofacial cleft. The objective was to characterize the burden of orofacial clefts in Brazil by comparing the prevalence, risk factors, and birth health conditions of children born with clefts in Brazil and the United States.MethodsThis was a population-based cross-sectional study conducted using national data from 13,297 to 8853 individuals born with orofacial cleft in Brazil and the United States, respectively, between 2017 and 2021. Risk factors (maternal ethnicity, maternal age, infant sex, and plurality) and birth health conditions (number of prenatal care appointments, delivery method, Apgar score at 5 minutes, gestational age, and birthweight) were gathered from national data in both countries. The prevalence of clefts in both countries and prevalence ratios were calculated.ResultsThe prevalence of clefts was 7.1/10,000 in the United States and 6.2/10,000 in Brazil. Newborns with clefts in Brazil were significantly more likely to have a cleft palate (PR = 1.32, p = 0.000), be premature (PR = 1.37, p = 0.000), be born by cesarean section (PR = 1.00, p = 0.000), and have low birth weight (PR = 1.49, p = 0.000). Their mothers tended to be older (PR = 1.09, p = 0.001), non-white (PR = 0.48, p = 0.000), and had fewer than 10 prenatal care appointments (PR = 2.14, p = 0.000), compared to the United States cohort.ConclusionThe frequency of risk factors and adverse outcomes associated with being born with clefts was higher in the Brazilian cohort, suggesting that social determinants of health play a significant role in increasing individuals' susceptibility to risk factors for clefts and poor birth health conditions.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251343829"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of newborn individualized developmental care and assessment program (NIDCAP) on pain caused by eye examination for ROP screening. 新生儿个体化发展护理与评估计划（NIDCAP）对ROP筛查眼科检查引起的疼痛的影响。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-15 DOI: 10.1177/19345798251330827

Naimeh Abbasi, Monir Ramezani, Mohammad Heidarzadeh, Naser Shoeibi

{"title":"The effect of newborn individualized developmental care and assessment program (NIDCAP) on pain caused by eye examination for ROP screening.","authors":"Naimeh Abbasi, Monir Ramezani, Mohammad Heidarzadeh, Naser Shoeibi","doi":"10.1177/19345798251330827","DOIUrl":"https://doi.org/10.1177/19345798251330827","url":null,"abstract":"BackgroundEye examination is one of the painful procedures for infants. Eye screening of retinopathy of prematurity (ROP) is essential intervention to prevent visual impairment in preterm infants. However, Newborn Individualized Developmental Care and Assessment Program (NIDCAP) is a well-established framework for all of the interventions on premature infants and pain management is the main subject of this program.PurposeThe aim of this study is to determine the effect of NIDCAP on the pain caused by eye examination for ROP screening.MethodsIn this non-randomized controlled clinical trial, 60 infants were classified in two groups (30 infants in the intervention group and 30 infants in the control group). The infants of the intervention group underwent NIDCAP protocols before, during, and after the examination and the infants of the control group received routine cares. Then, according to PIPP tool, level of pain in the two groups was evaluated.ResultsThe two groups were homogeneous in terms of demographic variables. The results showed that the interventions group experienced significantly lower increases in heart rate during exams (p = 0.001). The reduction of oxygen saturation during the examination in the intervention group was less than the control group, which was not statistically significant (p = 0.577). The two groups have no difference in behavioral status score during examination. While, facial scores during the examination in the intervention group were significantly lower than the control group (p = 0.011). In terms of the total score of pain during examination, the newborns of the intervention group have a significantly lower pain score than the control group (p = 0.033).","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251330827"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination therapy for patent ductus arteriosus in preterm infants: Narrative review. 早产儿动脉导管未闭的综合治疗：叙述性回顾。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-07 DOI: 10.1177/19345798251337433

Eyad Bitar, Aimann Surak, Kumar Kumaran, Abbas Hyderi

引用次数: 0

To retrospectively study the use of antibiotics among neonates with a gestational age of ≥ 35 weeks experiencing respiratory distress, and to identify the risk factors associated with antibiotic use. 回顾性研究胎龄≥35周出现呼吸窘迫的新生儿抗生素使用情况，并确定与抗生素使用相关的危险因素。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-06 DOI: 10.1177/19345798251339652

Sarfrazul Abedin, Khalil Mohd Khalil Salameh, Lina Hussain M Habboub, Sajid Thyvilayil Salim, Samer Mahmoud Alhoyed, Brijroy Viswanathan, Rajai Rofail Raja Al-Bedaywi, Hoda Eljelani Rahoma, Esam Mohamed Elhadi Elhaji, Anvar Paraparambil Vellamgot

{"title":"To retrospectively study the use of antibiotics among neonates with a gestational age of ≥ 35 weeks experiencing respiratory distress, and to identify the risk factors associated with antibiotic use.","authors":"Sarfrazul Abedin, Khalil Mohd Khalil Salameh, Lina Hussain M Habboub, Sajid Thyvilayil Salim, Samer Mahmoud Alhoyed, Brijroy Viswanathan, Rajai Rofail Raja Al-Bedaywi, Hoda Eljelani Rahoma, Esam Mohamed Elhadi Elhaji, Anvar Paraparambil Vellamgot","doi":"10.1177/19345798251339652","DOIUrl":"https://doi.org/10.1177/19345798251339652","url":null,"abstract":"BackgroundRespiratory distress is a common reason for NICU admission among late preterm and term neonates. Antibiotic use is prevalent among these neonates requiring respiratory support. This study investigates antibiotic use and its associated risk factors.MethodsA retrospective study was conducted at Al Wakra Hospital, Qatar, from January to December 2022. Neonates born at 35 weeks gestation or more, admitted to the NICU with respiratory distress, and requiring respiratory support were included based on specific criteria.ResultsOf the 1194 neonates admitted to the NICU, 1062 were 35 weeks or more gestational age. Among these, 485 neonates developed respiratory distress requiring respiratory support, with 442 included in the final analysis. Antibiotics were used in 56.1% (248/442) of cases. Factors such as maternal age, parity, rupture of membranes, chorioamnionitis, group B streptococci, antenatal prophylactic antibiotics, mode of delivery, sex, fetal distress, meconium-stained amniotic fluid, need for resuscitation, Apgar score ≤7 at 5 minutes, age at NICU admission, duration of NICU admission, maximum respiratory support, and duration of respiratory support were significantly associated with antibiotic use. Regression analysis identified parity, gestational age, sex, meconium-stained amniotic fluid, and duration of respiratory support as significant predictors of antibiotic use.ConclusionsRespiratory distress leads to frequent NICU admissions among late preterm and term neonates, with 56.1% receiving antibiotics. To mitigate potential harm from antibiotic exposure, strategies to reduce use without increasing neonatal sepsis risk are essential.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251339652"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal level of care and length of stay of moderate and late preterm infants. 中度和晚期早产儿的新生儿护理水平和住院时间。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-05 DOI: 10.1177/19345798251339648

Prashanth Murthy, Amuchou Soraisham, Sarfaraz Momin, Ayman Abou Mehrem, Sumesh Thomas, Nalini Signal, Belal Alshaikh

{"title":"Neonatal level of care and length of stay of moderate and late preterm infants.","authors":"Prashanth Murthy, Amuchou Soraisham, Sarfaraz Momin, Ayman Abou Mehrem, Sumesh Thomas, Nalini Signal, Belal Alshaikh","doi":"10.1177/19345798251339648","DOIUrl":"https://doi.org/10.1177/19345798251339648","url":null,"abstract":"ObjectiveTo compare the length of hospitalization for moderate and late preterm infants (MLPIs; 320/7-366/7 weeks gestation) born at tertiary care (level III) perinatal centers versus secondary care perinatal centers (level II).MethodsThis was a retrospective cohort study of all MLPIs born at one of four perinatal centers (one tertiary and three secondary) in Calgary, Canada. All preterm infants born before 360/7 were routinely admitted to neonatal intensive care units (NICUs). We excluded infants with major congenital anomalies and those receiving planned palliative care. Multivariable logistic, propensity score-matched, and quantile regression analyses were used to adjust for potential confounding factors.ResultsOf the 1958 infants who met inclusion criteria, 676 (34.5%) infants were born at a tertiary care perinatal center with a level III NICU, and 1284 (65.5%) were born in secondary care perinatal centers with a level II NICU. The average gestational age was 34.8 weeks. Infants born at level II centers had shorter durations of hospital stay (adjusted mean difference [aMD] -1.0 day; 95% CI -1.7, -0.4) and tube feeding (aMD -2.2 day; 95% CI -2.9, -1.4), a lower need for peripheral intravenous access (adjusted odds ratio (aOR) 0.66; 95% CI 0.53, 0.83), reduced use of infant formula during hospitalization (aOR 0.58; 95% CI 0.43, 0.78), and a higher rate of breastmilk feeding at discharge (aOR 1.34; 95% CI 1.01, 1.77).ConclusionDelivery of MLPIs in secondary care perinatal centers is associated with shorter hospital stays and higher breastmilk feeding rates at discharge.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251339648"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A neonate with upper cervical spinal cord injury as a previously unrecognized complication of vacuum-assisted delivery and uterine fundal pressure. 新生儿上颈脊髓损伤是先前未被认识到的真空辅助分娩和子宫底压并发症。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-02 DOI: 10.1177/19345798251339661

S Watanabe, N Ohama, S Suga, E Kondo, T Hoshina, K Yoshino

引用次数: 0

Observed hepatic dysfunction following diazoxide administration in a neonate with liver impairment: A case report. 观察到二氮氧化合物给药后肝功能障碍新生儿肝损害：1例报告。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-18 DOI: 10.1177/19345798251327371

Hani Ajrina Zulkeflee, Nur Atiqah Zulkefli, Aliyyah Mohammad Khuzaini

{"title":"Observed hepatic dysfunction following diazoxide administration in a neonate with liver impairment: A case report.","authors":"Hani Ajrina Zulkeflee, Nur Atiqah Zulkefli, Aliyyah Mohammad Khuzaini","doi":"10.1177/19345798251327371","DOIUrl":"10.1177/19345798251327371","url":null,"abstract":"Diazoxide is commonly used to treat neonatal hypoglycaemia when first-line treatment fails by inhibiting insulin secretion. We present a case of a full-term female infant with refractory hypoglycaemia who developed elevated liver enzymes and worsening jaundice following diazoxide administration. After discontinuation of diazoxide, her liver enzyme levels rapidly improved. Although liver impairment has not been commonly reported as a side effect of diazoxide, previous reports, such as one by Tas et al. in 2015, have documented similar findings in patients with hypoalbuminemia, where altered drug metabolism may play a role. Diazoxide undergoes metabolism in the liver, raising the possibility that preexisting liver impairment could affect its clearance and potentially exacerbate hepatic dysfunction. These observations suggest that careful consideration is required when using diazoxide in neonates with compromised liver function. Further studies are needed to explore the mechanisms that may contribute to this association and to establish guidelines for its use in this vulnerable population. This case challenges the conventional understanding of diazoxide as a safe intervention for neonatal hypoglycaemia. Additional research is required to elucidate the mechanisms leading to hepatotoxicity and to establish clear guidelines for the use of diazoxide in this vulnerable population.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"274-278"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare yet preventable complication of lower extremity PICC malposition in an extreme preterm: Implications for enhanced procedural imaging standards. 一种罕见但可预防的极端早产下肢PICC错位并发症：提高程序成像标准的意义。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1177/19345798251327379

Manal Mouhssine, Aimen Ben Ayad, Aiman Rahmani

引用次数: 0