Journal of neonatal-perinatal medicine最新文献

Utility of doppler ultrasound in early-onset neonatal sepsis: A case-control study. 多普勒超声在早期新生儿败血症中的应用：病例对照研究

Journal of neonatal-perinatal medicine Pub Date : 2024-10-01 DOI: 10.3233/NPM-240028

A H Kasim, S A Mohammad, L A Habib, G A Saleh, S H Salah

{"title":"Utility of doppler ultrasound in early-onset neonatal sepsis: A case-control study.","authors":"A H Kasim, S A Mohammad, L A Habib, G A Saleh, S H Salah","doi":"10.3233/NPM-240028","DOIUrl":"https://doi.org/10.3233/NPM-240028","url":null,"abstract":"Background: Early-onset sepsis is one of the leading causes of neonatal morbidity and mortality worldwide and timely diagnosis is, therefore, of paramount importance. As there is a lack of literature regarding early alteration of the cerebral blood flow (CBF) in neonatal sepsis, our study aimed to appraise changes in the CBF velocities and Doppler indices in neonates with early-onset neonatal sepsis (EONS) and to assess its diagnostic accuracy.Methods: A total of 99 neonates were recruited in the study; 56 neonates with EONS, and the age-matched 43 neonates without any manifestations of sepsis. A Transcranial Doppler examination and cerebral hemodynamics were assessed in neonates during the first seventy-two hours of life. Doppler indices and CBFV were measured in the anterior cerebral artery (ACA), and middle cerebral artery (MCA), of either side. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were calculated.Results: A significantly lower resistance in Resistivity (RI) and Pulsatility (PI) indices, a significant high end-diastolic velocity (EDV), and relatively higher peak systolic velocity (PSV) in both ACA and MCA have been documented within 72 hours of birth in neonates with EONS compared to the control group of neonates without sepsis.Conclusion: Our Study revealed that assessment of CBF at early hours of birth by Transcranial Doppler examination showed alteration in cerebral hemodynamics in neonates with EONS with an increase in the CBF and a decrease in the resistance. It can be adopted as a bedside, noninvasive tool with immediate diagnostic value.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of serum interleukin-6 for neonatal encephalopathy outcomes. 血清白细胞介素-6对新生儿脑病预后的预测价值。

Journal of neonatal-perinatal medicine Pub Date : 2024-09-28 DOI: 10.3233/NPM-230224

J Saito, J Shibasaki, K Yamamoto, M Fujita, K Toyoshima

{"title":"Predictive value of serum interleukin-6 for neonatal encephalopathy outcomes.","authors":"J Saito, J Shibasaki, K Yamamoto, M Fujita, K Toyoshima","doi":"10.3233/NPM-230224","DOIUrl":"https://doi.org/10.3233/NPM-230224","url":null,"abstract":"Background: Serum interleukin-6 (IL-6) may predict adverse outcomes of neonatal encephalopathy (NE); however, limited data regarding the predictive utility of IL-6 during neurodevelopmental follow-up are available. We aimed to determine the utility of IL-6 for predicting adverse outcomes at 18 to 22 months of age.Methods: Eighty-seven patients with NE who received therapeutic hypothermia were enrolled in this study. Serial serum IL-6 levels during the first 3 postnatal days were collected. Patients were classified into three groups: 1) death, 2) survival with moderate to severe neurodevelopmental disability (NDD) at 18-22 months of age, and 3) survival without NDD (favorable outcome). The predictive ability of IL-6 was determined by the area under the receiver-operating characteristic curve (AUC).Results: Serial IL-6 data of 80 patients with NE were available and showed peak levels on postnatal day 1; these levels gradually decreased toward day 3. By 18-22 months of age, 13 and 17 patients died and experienced moderate to severe NDD without death, respectively. Fifty patients experienced favorable outcomes. Higher IL-6 levels on day 1 predicted the composite adverse outcome (including death and survival with NDD; n = 30; AUC, 0.648). Higher IL-6 levels on day 1 predicted death (n = 13; AUC, 0.799), whereas higher IL-6 levels on day 1 predicted survival with NDD (n = 17; AUC, 0.536).Conclusions: The AUC of IL-6 that predicted survival with NDD was lower than the AUC of IL-6 that predicted death; therefore, IL-6 may have insufficient utility for predicting NDD without death.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of methemoglobinemia in a preterm newborn with unclear etiology. 一例病因不明的早产新生儿高铁血红蛋白症罕见病例。

Journal of neonatal-perinatal medicine Pub Date : 2024-04-16 DOI: 10.3233/npm-230163

M. Abu Zahra, Dunia Z. Jaber, Eman F. Badran

引用次数: 0

Morphological and clinical findings in placentas and newborns with a history of tobacco, alcohol, and other substance abuse during pregnancy. 妊娠期间有烟草、酒精和其他药物滥用史的胎盘和新生儿的形态学和临床发现。

Journal of neonatal-perinatal medicine Pub Date : 2024-04-13 DOI: 10.3233/npm-230104

H. F. Mendez-Reyes, M. Franco-Olaya, O. Cañón-Cubillos, J. M. Uribe-Lopez, M. C. Delgado-Alvarez, M. Velasquez-Portilla, M. Olaya-C

{"title":"Morphological and clinical findings in placentas and newborns with a history of tobacco, alcohol, and other substance abuse during pregnancy.","authors":"H. F. Mendez-Reyes, M. Franco-Olaya, O. Cañón-Cubillos, J. M. Uribe-Lopez, M. C. Delgado-Alvarez, M. Velasquez-Portilla, M. Olaya-C","doi":"10.3233/npm-230104","DOIUrl":"https://doi.org/10.3233/npm-230104","url":null,"abstract":"BACKGROUND\u0000Exposure to toxins during pregnancy is the main modifiable behavior that affects the placenta and, consequently, the fetus. In particular, smoking is a recognized risk factor for negative outcomes. Our study pretended to examine gross and microscopic placental features in women who reported exposure to tobacco, alcohol, or other psychoactive substances.\u0000\u0000\u0000METHODS\u0000In this observational case-control study, we collected 706 placentas to assess precise substance exposure histological-interaction features of in the placenta. We examined gross and microscopic placental features, and then recorded maternal and newborn clinical conditions.\u0000\u0000\u0000RESULTS\u0000We found that 4.8% of mothers admitted to consumption of some type of (harmful) substance. The most common pre-existing maternal condition was obesity (20.3%); predominant complications included amniotic infection (32.3%), urinary tract infection (14.5%) and hypertensive disorders of pregnancy (14.5%). In newborns, we discovered positive associations as respiratory distress syndrome. Macroscopically, exposed mothers had heavier placentas, more true knots, and single umbilical artery; microscopically, they were more likely to exhibit fetal vascular malperfusion (FVM).\u0000\u0000\u0000CONCLUSIONS\u0000Until our present study, no research linked umbilical cord defects to toxic substance exposure; our study results do confirm association with adverse outcomes in neonates and alterations in the neuro-cardio-placental circuit through FVM.\u0000\u0000\u0000IMPLICATIONS\u0000The results are confirming the importance of this modifiable risk factor and how its presence may potentially affect the course of pregnancy, as well as the health of both mother and child.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of early total enteral feeding vs incremental feeding in small for gestational age very low birth weight infants: A randomized controlled trial. 小胎龄极低出生体重儿早期全肠喂养与渐进式喂养的效果：随机对照试验。

Journal of neonatal-perinatal medicine Pub Date : 2024-04-13 DOI: 10.3233/npm-230195

T. K. Sahu, S. Manerkar, J. Mondkar, P. Kalamdani, S. Patra, T. Kalathingal, S. Kaur

引用次数: 0

Severe pulmonary hypertension and circulatory failure associated with Congenital syphilis. Case report. 与先天性梅毒有关的严重肺动脉高压和循环衰竭。病例报告。

Journal of neonatal-perinatal medicine Pub Date : 2024-04-13 DOI: 10.3233/npm-230133

M. Sanchez-Holgado, M. Bravo, P. Alvarez-Garcia, P. López-Ortego, S. Criado Camargo, A. Pellicer

{"title":"Severe pulmonary hypertension and circulatory failure associated with Congenital syphilis. Case report.","authors":"M. Sanchez-Holgado, M. Bravo, P. Alvarez-Garcia, P. López-Ortego, S. Criado Camargo, A. Pellicer","doi":"10.3233/npm-230133","DOIUrl":"https://doi.org/10.3233/npm-230133","url":null,"abstract":"BACKGROUND\u0000Congenital syphilis is a vertical infection caused by Treponema pallidum. Despite the implementation of preventive strategies during pregnancy, its incidence is increasing, and it constitutes an important public health problem. Most patients with congenital syphilis are asymptomatic; however, a small group may develop severe disease at birth with the need of advanced resuscitation in the delivery room, acute hypoxemic respiratory failure, and hemodynamic instability. Therefore, awareness is needed.\u0000\u0000\u0000METHODS AND RESULTS\u0000This series describes the clinical course of two late preterm infants with congenital syphilis who developed acute hypoxemic respiratory failure, pulmonary hypertension, and circulatory collapse early after birth. Integrated hemodynamic evaluation with neonatologist-performed echocardiography (NPE) and therapeutic management is provided.\u0000\u0000\u0000CONCLUSIONS\u0000A comprehensive hemodynamic evaluation including early and serial functional echocardiography in these patients is needed to address the underlying complex pathophysiology and to help to establish accurate treatment.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"66 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140708455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indocyanine green lymphography in the congenital chylothorax and chylous ascites. 先天性乳糜胸和乳糜腹水的吲哚菁绿淋巴造影。

Journal of neonatal-perinatal medicine Pub Date : 2024-04-13 DOI: 10.3233/npm-230171

T. Lin, J. Shibasaki, K. Yamamoto, T. Shimokaze, K. Toyoshima

{"title":"Indocyanine green lymphography in the congenital chylothorax and chylous ascites.","authors":"T. Lin, J. Shibasaki, K. Yamamoto, T. Shimokaze, K. Toyoshima","doi":"10.3233/npm-230171","DOIUrl":"https://doi.org/10.3233/npm-230171","url":null,"abstract":"BACKGROUND\u0000The prognosis of congenital chylothorax and ascites ranges from spontaneous resolution to death, but no established examination exists to predict the prognosis. We aimed to develop a clinically useful method to evaluate lymphatic abnormalities using indocyanine green (ICG) lymphography in infants with congenital chylothorax and ascites.\u0000\u0000\u0000METHODS\u0000We retrospectively evaluated infants with congenital chylothorax and chylous ascites who underwent ICG lymphography in our hospital between 2012 and 2022. The ICG lymphography findings was evaluated. We defined the dermal backflow in the trunk as the lymphatic flow from the end of the limb back through the lymphatic vessels on the surface of the trunk. The association between the dermal backflow in the trunk and clinical outcomes, as follows, are investigated: the duration of the drainage period, the duration of endotracheal intubation, and the length of hospital stay.\u0000\u0000\u0000RESULTS\u0000Twenty infants had a dermal backflow in the trunk, and ten did not. Clinical outcomes in infants with and without dermal backflow in the trunk were as follows (median): the duration of the drainage period (20 vs. 0 days, p = 0.001), the duration of endotracheal intubation (12 vs. 2 days, p = 0.04), and the length of hospital stay (62 vs. 41 days, p = 0.04), respectively. In multivariate linear regression analysis adjusted for gestational age, the duration of the drainage period was correlated with the dermal backflow in the trunk [exp(B) = 2.62; p = 0.003].\u0000\u0000\u0000CONCLUSIONS\u0000The dermal backflow in the trunk in ICG lymphography was useful in predicting the clinical course of congenital chylothorax and ascites.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"98 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital fibrous fusion of the jaws (synechiae) with cleft palate: A case report. 先天性纤维性颌骨融合（synechiae）伴腭裂：病例报告。

Journal of neonatal-perinatal medicine Pub Date : 2024-04-08 DOI: 10.3233/npm-230184

W. Alhussin, S. Susnerwala

引用次数: 0

Association of hypermagnesemia at birth and admission hypothermia in pre-term infants: A secondary analysis of a prospective cohort study. 早产儿出生时的高镁血症与入院时体温过低的关系：一项前瞻性队列研究的二次分析。

Journal of neonatal-perinatal medicine Pub Date : 2024-04-08 DOI: 10.3233/npm-230130

J.P.de Siqueira Caldas, Elibene Orro Junqueira, J. F. de Camargo, S.T.M. Marba

{"title":"Association of hypermagnesemia at birth and admission hypothermia in pre-term infants: A secondary analysis of a prospective cohort study.","authors":"J.P.de Siqueira Caldas, Elibene Orro Junqueira, J. F. de Camargo, S.T.M. Marba","doi":"10.3233/npm-230130","DOIUrl":"https://doi.org/10.3233/npm-230130","url":null,"abstract":"BACKGROUND\u0000Hypothermia on admission is associated with increased mortality in preterm infants. Drugs administered to pregnant women is implicated in its occurrence. Since magnesium sulfate has a myorelaxant effect, we aimed evaluating the association of hypermagnesemia at birth and admission hypothermia (axillary temperature <36.5°C) in preterm infants.\u0000\u0000\u0000METHODS\u0000We performed a secondary analysis of a prospective cohort study database including inborn infants <34 weeks, without congenital malformations. Hypermagnesemia was considered if the umbilical magnesium level > 2.5 mEq/L. Maternal and neonatal variables were used to adjust the model, submitted to the multivariate hierarchical modelling process.\u0000\u0000\u0000RESULTS\u0000We evaluated 249 newborns with median birth weight and gestational age of 1375 (IQR 1020-1375) g and 31 (IQR 28-32) weeks, respectively. Hypermagnesemia occurred in 28.5% and admission hypothermia occurred in 28.9% . In the univariate analysis, the following variables were identified as being associated with admission hypothermia: hypermagnesemia (OR 3.71; CI 2.06-6.68), resuscitation (OR 2.39; CI 1.37-4.19), small to gestational age (OR 1.91; CI1.03-3.53), general anesthesia (OR 3.34; CI 1.37-8.13), birth weight (OR 0.998; CI 0.998-0.999) and gestational age (OR 0.806; CI 0.725-0.895). In the hierarchical regression model, hypermagnesemia remained independent associated with admission hypothermia (OR 3.20; CI 1.66-6.15), as well as birth weight (OR 0.999; CI 0.998-0.999) and tracheal intubation (3.83; CI 1.88-7.80).\u0000\u0000\u0000CONCLUSION\u0000Hypermagnesemia was associated with an increased risk of admission hypothermia, as did tracheal intubation and lower birth weight.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"223 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of umbilical cord clamping time on cerebral oxygenation and early cardiac function in term infants. 脐带闭合时间对足月儿脑氧合和早期心脏功能的影响

Journal of neonatal-perinatal medicine Pub Date : 2024-04-06 DOI: 10.3233/npm-230223

M. Satar, A. H. Erol, M. Özdemir, N. Özbarlas, A. Atmış, F. Özlü, S. Büyükkurt

{"title":"Influence of umbilical cord clamping time on cerebral oxygenation and early cardiac function in term infants.","authors":"M. Satar, A. H. Erol, M. Özdemir, N. Özbarlas, A. Atmış, F. Özlü, S. Büyükkurt","doi":"10.3233/npm-230223","DOIUrl":"https://doi.org/10.3233/npm-230223","url":null,"abstract":"BACKGROUND\u0000Delayed cord clamping is the standard of care for both term and preterm infants worldwide. The aim of this study was to evaluate the effect of 60-second or 180-second delayed cord clamping during labor on cerebral oxygenation and cardiac function.\u0000\u0000\u0000METHODS\u0000Healthy newborns were divided into two groups: a 60-second delay in cord clamping (60-s DCC) and a 180-second delay in cord clamping (180-s DCC) at birth. Pulse oximetry and cerebral near-infrared spectroscopy (cNIRS) probes were placed during postnatal care. A total of 84 healthy newborns were included in this study. Preductal oxygen saturation (SpO2), heart rate, and cNIRS values were recorded at 5 and 10 minutes after delivery. The cardiac function of the infants was assessed by echocardiography at 3-7 days postnatally.\u0000\u0000\u0000RESULTS\u0000There was no significant difference between the groups in SpO2 and cNIRS values at 5 and 10 min. While there was no significant difference in the number of neonates with targeted SpO2 at the 5th and 10th min and targeted cNIRS values at the 10th min, there was a significant difference in the number of neonates with target cNIRS values at the 5th min between groups (p < 0.001). Echocardiographic findings showed that pulmonary flow velocity was increased in the 180-s DCC group; the difference was statistically significant (p = 0.04).\u0000\u0000\u0000CONCLUSION\u0000Our results showed that the number of infants with normal cNIRS values regarding cerebral oxygenation was higher in the 180-s DCC group. The pulmonary flow velocity was significantly increased in the 180-s DCC group in terms of echocardiographic findings.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"44 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0