Journal of neonatal-perinatal medicine最新文献

Understanding and addressing bias in neonatal drug screening practices. 理解和解决新生儿药物筛选实践中的偏见。

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Journal of neonatal-perinatal medicine Pub Date : 2026-09-02 DOI: 10.1177/19345798261483253

Megan Kalata, Alexandra Van Cleave, Lillian Eason, Mary Kate Eiden, Amrita Purkayastha, Sun Young Guwn, Meghan Fries, Lauren Seger, Emily Callahan

{"title":"Understanding and addressing bias in neonatal drug screening practices.","authors":"Megan Kalata, Alexandra Van Cleave, Lillian Eason, Mary Kate Eiden, Amrita Purkayastha, Sun Young Guwn, Meghan Fries, Lauren Seger, Emily Callahan","doi":"10.1177/19345798261483253","DOIUrl":"https://doi.org/10.1177/19345798261483253","url":null,"abstract":"BackgroundUrine drug screening (UDS) is commonly utilized to identify substance use during pregnancy and facilitate timely interventions aimed at mitigating adverse parental and neonatal outcomes. Current literature has demonstrated that UDS among pregnant patients is not uniformly applied across populations but less is known about screening practices among neonates. This study aimed to evaluate the demographics, clinical indications, documentation and disclosure practices, and outcomes associated with neonatal drug screening.MethodsA retrospective chart review was completed for neonates at one academic institution whose birthing parent had undergone UDS. Statistical methods to analyze this data included t-tests, calculated percentages, and chi square analysis to compare whether the independent variables evaluated affected screening decisions.ResultsOf 651 neonates of parents who completed a UDS during their pregnancy, 273 (42.5%) screens were positive. Amphetamine (36.8%) and cannabinoid (38.6%) accounted for the majority of positive substances. Neonatal race and ethnicity data showed that the overall racial distribution of neonatal drug screens obtained was proportional to the racial representation in the study's population. However, the proportion of patients screened in the study does not reflect the proportion of patients within each race and ethnicity found among the birthing population. The majority (97.8%) of drug screens obtained did not include documentation of parental consent.ConclusionsSystemic changes need to be made to ensure equitable screening protocols exist for neonatal drug screens as well as ensure parental consent and knowledge of screening results is documented.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261483253"},"PeriodicalIF":1.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of extracorporeal membrane oxygenation in neonates with severe bronchiolitis: Our experience over the last 10 years. 使用体外膜氧合新生儿重症细支气管炎：我们在过去10年的经验。

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Journal of neonatal-perinatal medicine Pub Date : 2026-09-01 Epub Date: 2026-01-19 DOI: 10.1177/19345798261416360

Amaia Merino-Hernández, Agustín Muñoz-Cutillas, Susana Zeballos-Sarrato, Belén Bernardo-Atienza, Manuel Sánchez-Luna

{"title":"Use of extracorporeal membrane oxygenation in neonates with severe bronchiolitis: Our experience over the last 10 years.","authors":"Amaia Merino-Hernández, Agustín Muñoz-Cutillas, Susana Zeballos-Sarrato, Belén Bernardo-Atienza, Manuel Sánchez-Luna","doi":"10.1177/19345798261416360","DOIUrl":"10.1177/19345798261416360","url":null,"abstract":"BackgroundBronchiolitis is the most common lower respiratory tract infection in infants under 1 year of age. Although outcomes are generally good in neonates, preterm infants may experience rapid clinical deterioration and require extracorporeal membrane oxygenation (ECMO) as a rescue therapy.ObjectiveTo describe the characteristics and clinical outcomes of neonates requiring ECMO for acute bronchiolitis over the past decade.MethodsAn observational, retrospective, single-center study conducted in a level IIIC neonatal unit. All neonates admitted between 2013 and 2022 who required ECMO for bronchiolitis-related respiratory failure were included. Demographic, clinical, and outcome variables were analyzed.ResultsSix patients were included: five (83%) were preterm, with a median gestational age of 28.6 weeks (IQR 27.1-29.6). Respiratory syncytial virus was isolated in four patients, rhinovirus in one and influenza A in one. At ECMO initiation, median age was 48.5 days (IQR 34-120), median postmenstrual age was 38 weeks (IQR 35-41.8), and median weight was 2490 g (IQR 1800-2900). The median duration of ECMO was 14 days (IQR 9-24). Two patients (33%) died, both preterm with RSV infection. All survivors were followed up by pediatric pulmonologists and neurologists. Two required home oxygen, and three showed neurodevelopmental disorders.ConclusionIn our cohort, the two non-survivors were preterm, RSV positive, and required prolonged ECMO support. Among survivors, respiratory and neurodevelopmental complications were common, underscoring the need for structured long-term follow-up. Neurodevelopmental impairment was the most frequent sequela observed.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"547-554"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time is brain: Impact of early intervention on neurodevelopment after Fetomaternal hemorrhage. 时间就是大脑：早期干预对胎儿出血后神经发育的影响。

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Journal of neonatal-perinatal medicine Pub Date : 2026-09-01 Epub Date: 2026-03-02 DOI: 10.1177/19345798261431205

Tatiana Moreira, Madalena von Hafe, Susana Guimarães, Américo Gonçalves, Henrique Soares, Ana Vilan

{"title":"Time is brain: Impact of early intervention on neurodevelopment after Fetomaternal hemorrhage.","authors":"Tatiana Moreira, Madalena von Hafe, Susana Guimarães, Américo Gonçalves, Henrique Soares, Ana Vilan","doi":"10.1177/19345798261431205","DOIUrl":"10.1177/19345798261431205","url":null,"abstract":"BackgroundFetomaternal hemorrhage (FMH) is a rare but serious condition. Early recognition and intervention are critical to reduce morbidity and mortality. This study aimed to evaluate the clinical presentations, management strategies and outcomes associated with FMH.MethodsA retrospective case series (2009-2025) was conducted in a tertiary care hospital.ResultsTen mother-infant dyads were analyzed. All neonates presented with pallor and/or hypotonia and required intensive care. Hemoglobin ranged from 2.1-9.5 g/dL (median 4.2 g/dL). Four neonates received red blood cell transfusion within the first hour of life. One neonate underwent therapeutic hypothermia. Favorable neurological outcomes were observed in three of the four neonates transfused within the first hour; the most severe long-term sequelae occurred among those who received later transfusions. Placental pathology (five cases) revealed features suggestive of fetal anemia/hypoxic stress.ConclusionFMH should be considered in any pale and/or hypotonic neonate. In this case series, earlier transfusion was more frequently observed among infants with favorable outcomes, but causality cannot be established. Placental pathology did not clarify the underlying pathogenesis of FMH. Brain MRI remains essential for prognosis. When feasible, therapeutic hypothermia should be considered when standard criteria are met and no contraindications are present.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"508-514"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital malformations-related mortality trends in under-five U.S. children: A 24-year analysis from CDC-WONDER database (1999-2023). 美国5岁以下儿童先天性畸形相关死亡率趋势：来自CDC-WONDER数据库的24年分析（1999-2023）

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Journal of neonatal-perinatal medicine Pub Date : 2026-09-01 Epub Date: 2026-02-07 DOI: 10.1177/19345798261424787

Shree Rath, Ahmed Hasan, Muhammad Ali, Soha Waseem, Kumail Mustafa Ali, Arham Khalid Farooq, Umama Alam, Amar Lal

{"title":"Congenital malformations-related mortality trends in under-five U.S. children: A 24-year analysis from CDC-WONDER database (1999-2023).","authors":"Shree Rath, Ahmed Hasan, Muhammad Ali, Soha Waseem, Kumail Mustafa Ali, Arham Khalid Farooq, Umama Alam, Amar Lal","doi":"10.1177/19345798261424787","DOIUrl":"10.1177/19345798261424787","url":null,"abstract":"BackgroundCongenital malformations remain a major cause of under-five mortality in the United States, yet contemporary long-term trends and demographic disparities have not been comprehensively evaluated. This study examined national patterns in congenital malformation-related mortality among U.S. children under 5 years from 1999 to 2023.MethodsMortality data were obtained from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC-WONDER) Database, focusing on congenital malformations-related deaths among children aged under 5 years between 1999 and 2023 in the U.S. Cases were identified using ICD-10 codes from Q00 to Q89.9.ResultsThis comprehensive analysis included a total of 143,931 deaths, demonstrating significant trends and disparities. The overall age-adjusted mortality rate (AAMR) declined from 34.70 (95% CI: 33.86-35.54) in 1999 to 25.95 (95% CI: 25.21-26.68) in 2023, showing an average annual percentage change (AAPC) of -1.21 (95% CI: -1.50 to -1.02). Mortality was higher in males than in females. Across all races, the least decline was noted among NH American Indian or Alaska Natives. Non-metropolitan areas exhibited higher overall AAMR (34.80 [95% CI: 34.33-35.27]) compared to metropolitan areas (29.02 [95% CI: 28.85-29.19]).ConclusionThe overall AAMR decreased from 1999 to 2023, with significantly higher deaths among males, rural regions and Alaskan Natives. These findings demonstrate an overall decline in mortality but persistent demographic and geographic inequities, highlighting the need for targeted public health and policy interventions to improve outcomes for vulnerable pediatric populations.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"484-494"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nephrotoxic versus nephroprotective: What is the role of antenatal steroids in preterm neonates. 肾毒性与肾保护：产前类固醇在早产儿中的作用是什么？

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Journal of neonatal-perinatal medicine Pub Date : 2026-09-01 Epub Date: 2026-03-07 DOI: 10.1177/19345798261431232

Rafia Gul, Attiqua Muzamil, Samer Fatima, Sidra Niamat

{"title":"Nephrotoxic versus nephroprotective: What is the role of antenatal steroids in preterm neonates.","authors":"Rafia Gul, Attiqua Muzamil, Samer Fatima, Sidra Niamat","doi":"10.1177/19345798261431232","DOIUrl":"10.1177/19345798261431232","url":null,"abstract":"BackgroundAntenatal corticosteroids (ANS) enhance pulmonary maturation in preterm neonates, but their renal effects remain incompletely understood. This study evaluated the association ANS exposure with the prevalence and severity of acute kidney injury (AKI) in preterm neonates.MethodologyThis prospective cross-sectional study was conducted in NICU, Fatima Memorial Hospital, Shadman, Lahore, Pakistan from March 2023 to January 2025. It included 399 preterm neonates of 28-36 + 6 weeks gestation. Neonates were categorized based on antenatal steroids exposure as complete, incomplete, or no ANS groups. AKI was defined and staged according to KDIGO criteria during the first 14 days of life. All variables in descriptive statistics with p < 0.05 incorporated into multivariate logistic regression. The model fit was assessed using Hosmer-Lemeshow test.ResultsOf 399 neonates, 64 (16%) of neonates received a complete ANS course, 51.4% incomplete, and 32.6% none. The incidence of AKI was significantly lower in the complete ANS group compared with the incomplete and no-ANS groups (23.4% vs 47.3% and 45.4%, respectively (p = 0.003). On multivariate analysis, complete ANS remained an independent protective factor (p = 0.006, AOR 0.33, 95% CI 0.15-0.73) reducing the odds of renal failure by approximately 63%.ConclusionComplete antenatal steroid (ANS) exposure in preterm neonates was associated with lower incidence and severity of acute kidney injury, with multivariate analysis confirming reduced odds of AKI.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"534-541"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the prognostic nutritional index in preterm infants: A retrospective study examining its relationship with retinopathy of prematurity and clinical risk factors. 评估早产儿预后营养指数：一项回顾性研究，探讨其与早产儿视网膜病变和临床危险因素的关系。

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Journal of neonatal-perinatal medicine Pub Date : 2026-09-01 Epub Date: 2026-03-04 DOI: 10.1177/19345798261431199

Büşra Çalışkan, Dilara Korkut, Kadir Şerafettin Tekgündüz, Mustafa Kara

{"title":"Evaluation of the prognostic nutritional index in preterm infants: A retrospective study examining its relationship with retinopathy of prematurity and clinical risk factors.","authors":"Büşra Çalışkan, Dilara Korkut, Kadir Şerafettin Tekgündüz, Mustafa Kara","doi":"10.1177/19345798261431199","DOIUrl":"10.1177/19345798261431199","url":null,"abstract":"Background/AimThis study evaluated the development and stage of retinopathy of prematurity (ROP), clinical risk factors and prognosis, as well as the nutritional index (PNI) values obtained in the early and late periods.Materials and MethodsA retrospective analysis was conducted on 189 premature infants screened in the neonatal intensive care unit. Two critical time points were determined in the study: the first 24 h postnatally, reflecting the antenatal period (early period), and PMA 34-36 weeks (late period), which is a critical transitional phase both pathophysiologically and clinically, were used to determine lymphocyte and albumin results for PNI values. Statistical analyses were employed.ResultsPNI values in the ROP group were significantly lower than those in the non-ROP group in both the early and late periods (p < 0.001). In subgroup analyses, PNI levels were lowest in cases requiring treatment. Furthermore, PNI values were significantly lower in cases requiring transfusion, surfactant therapy, necrotizing enterocolitis, patent ductus arteriosus, intraventricular hemorrhage, postnatal steroids, and mechanical ventilation. In the multivariate analyses, birth weight and early albumin levels were identified as independent predictors, while PNI values were not an independent predictor. In the ROC analysis, PNI showed moderate discriminatory ability, whereas gestational age and birth weight demonstrated higher discriminatory ability.ConclusionThe development and severity of ROP in preterm newborns were found to be substantially correlated with PNI values. Based on multivariate analyses, PNI can be considered as a complementary indicator reflecting clinical fragility rather than an independent predictor for ROP.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"515-524"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal trends in heart rate characteristic index preceding necrotizing enterocolitis in preterm infants. 早产儿坏死性小肠结肠炎前心率特征指数的时间趋势。

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Journal of neonatal-perinatal medicine Pub Date : 2026-09-01 Epub Date: 2026-02-11 DOI: 10.1177/19345798261424720

Haley J McCalpin, William King, Alistair S Mukondiwa, Lacie Fallin, Peter J Porcelli, Parvesh M Garg

{"title":"Temporal trends in heart rate characteristic index preceding necrotizing enterocolitis in preterm infants.","authors":"Haley J McCalpin, William King, Alistair S Mukondiwa, Lacie Fallin, Peter J Porcelli, Parvesh M Garg","doi":"10.1177/19345798261424720","DOIUrl":"10.1177/19345798261424720","url":null,"abstract":"ObjectiveTo evaluate temporal trends in heart rate variability as defined by the Heart Rate Characteristic index (HRCi) preceding necrotizing enterocolitis (NEC) in preterm infants.Study DesignRetrospective cohort study of neonates with NEC (Bell Stage II/III) at a tertiary NICU from 2020 to 2024. Continuous HRCi data were extracted for 15 days before and 4 days after NEC diagnosis. HRCi trajectories were analyzed using generalized additive models, Wilcoxon signed-rank tests, and linear regression. Logistic regression models were fit to daily HRCi with NEC diagnosis day (Day 0) as the binary outcome, adjusting for gestational age, small for gestational age (SGA) status, and birth weight Z-scores. Model discrimination was assessed using receiver operating characteristic curves and area under the curve (AUC).ResultsAmong 51 infants with NEC, median birth weight was 900 g and gestational age 27.7 weeks. HRCi rose progressively 2 weeks before onset of NEC, with a significant increase 3 days before diagnosis (median difference 0.31; p = 0.031). Logistic regression showed HRCi remained independently associated with NEC diagnosis day (OR = 1.28; 95% CI: 1.12-1.45; p < 0.001), while gestational age and birth weight Z-score were not. Within-patient AUCs were modest (0.65-0.66); exploratory comparison to the broader NICU population yielded higher discrimination (AUC = 0.84).ConclusionRising HRCi preceded NEC diagnosis, with significant elevation 3 days before onset. HRCi demonstrated independent temporal association with NEC, though modest discrimination reflects the exploratory design. Prospective validation with matched controls and confounder adjustment is required to establish clinical utility.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"473-483"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital double lower lip in a newborn with feeding difficulties. 新生儿先天性双下唇，喂养困难。

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Journal of neonatal-perinatal medicine Pub Date : 2026-09-01 Epub Date: 2026-02-06 DOI: 10.1177/19345798261424790

Irene Fernández-Bueno, Mireya Fernández-Pérez, Irene Saura-Pérez, Sara Guzmán-Quirós, Teresa Pérez-Oliver, José María Lloreda-García, José Ramón Férnandez-Fructuoso

引用次数: 0

Impact of feeding strategies during red blood cell transfusion on cerebral and splanchnic oxygenation in preterm infants: Randomized pilot study. 红细胞输注过程中喂养策略对早产儿脑和内脏氧合的影响：随机先导研究。

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Journal of neonatal-perinatal medicine Pub Date : 2026-09-01 Epub Date: 2026-03-02 DOI: 10.1177/19345798261431200

Sevgi Aslan Tuncay, Hulya Ozdemir, Abdullah Sarioz, Hulya Selva Bilgen

{"title":"Impact of feeding strategies during red blood cell transfusion on cerebral and splanchnic oxygenation in preterm infants: Randomized pilot study.","authors":"Sevgi Aslan Tuncay, Hulya Ozdemir, Abdullah Sarioz, Hulya Selva Bilgen","doi":"10.1177/19345798261431200","DOIUrl":"10.1177/19345798261431200","url":null,"abstract":"BackgroundRed blood cell (RBC) transfusion in very preterm infants has been linked to transfusion-related necrotizing enterocolitis (TR-NEC), and peri-transfusion feeding practices vary. We examined whether three different feeding strategies affect cerebral and splanchnic oxygenation.MethodsIn this single-center randomized pilot trial, infants <32 weeks' gestation requiring RBC transfusion were allocated to feeds withheld, feeds reduced by 50%, or feeds continued during transfusion. Near-infrared spectroscopy measured cerebral and splanchnic rSO2 from 2 h before transfusion start through 42 h after completion (covering the remainder of the 48-h post-initiation window used to define TR-NEC). FTOE and SCOR were calculated. Prespecified primary endpoints were between-group differences in changes in CrSO2, SrSO2, and corresponding FTOE across pre-specified epochs; secondary endpoints were feeding intolerance and TR-NEC (Bell stage ≥II within 48 h).ResultsForty-five infants were enrolled (14, 14, and 17 per group). Splanchnic rSO2 increased and splanchnic FTOE decreased during and after transfusion; cerebral rSO2 increased after transfusion with decreased cerebral FTOE. No statistically significant differences in, FTOE, or SCOR were detected between feeding groups. TR-NEC occurred in eight infants (2, 1, and 5 per group). In exploratory analyses, infants who developed TR-NEC had lower splanchnic rSO2 and higher splanchnic FTOE before and during transfusion.ConclusionsNo statistically significant differences were demonstrated in cerebral or splanchnic oxygenation among three feeding strategies during RBC transfusion. As a pilot, hypothesis-generating study, these findings should not be interpreted as equivalence between strategies and require confirmation in larger trials.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"525-533"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lamellar body count in gastric aspirates of healthy term newborns: A prospective evaluation. 健康足月新生儿胃吸出物的片层体计数：一项前瞻性评价。

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Journal of neonatal-perinatal medicine Pub Date : 2026-09-01 Epub Date: 2026-02-11 DOI: 10.1177/19345798261424785

Sema Arayici, Gulsum Kadioglu Simsek, Birgul Livaoglu Say, Nurdan Uras, Mehmet Yekta Oncel, Umran Buyukkagnici, Sevilay Karahan

{"title":"Lamellar body count in gastric aspirates of healthy term newborns: A prospective evaluation.","authors":"Sema Arayici, Gulsum Kadioglu Simsek, Birgul Livaoglu Say, Nurdan Uras, Mehmet Yekta Oncel, Umran Buyukkagnici, Sevilay Karahan","doi":"10.1177/19345798261424785","DOIUrl":"10.1177/19345798261424785","url":null,"abstract":"BackgroundLamellar body count serves as a crucial indicator of pulmonary surfactant production, with deficiencies implicated in various pulmonary conditions causing respiratory distress in term infants. This study aimed to assess lamellar body count in gastric aspirates of healthy term newborns using an automated hematology analyzer.MethodsA prospective study was conducted, obtaining gastric aspirates from healthy infants within 30 min of birth, with dithiothreitol utilized as a liquefying agent. Lamellar body count analysis was conducted using the platelet channel of the cell counter.ResultsA total of 262 gastric aspirate samples were analyzed. The median lamellar body count was found to be 441,000/μL (49,000-3,493,000). Gestational age-specific lamellar body count values were described using percentile distributions.ConclusionThis pioneering study presents the first evaluation of lamellar body count in gastric aspirates of healthy term newborns. The findings suggest that lamellar body count measurement in gastric aspirates may provide supportive information on pulmonary surfactant status in term newborns and offer baseline physiological data in healthy term infants, serving as a foundation for future studies evaluating its potential role in the management of respiratory disorders.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"542-546"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0