{"title":"Comparing neonatal outcomes of positive- versus negative-pressure extubation: A randomized trial.","authors":"S Nourolahi, P Solimani, A Direkvand-Moghadam","doi":"10.1177/19345798251330807","DOIUrl":"https://doi.org/10.1177/19345798251330807","url":null,"abstract":"<p><p>BackgroundNeonatal respiratory distress is a major issue for many infants. When non-invasive ventilation fails, endotracheal intubation is often used to secure the airway. However, extubation moving from mechanical ventilation to spontaneous breathing also has its challenges and risks.ObjectiveThis randomized controlled trial aimed to compare neonatal outcomes between positive- and negative-pressure extubation methods in a cohort of neonates ready for extubation.MethodsThis randomized controlled trial was conducted at Ayatollah Taleghani Hospital in Ilam, Iran, from May 2021 to March 2023; the study enrolled 101 neonates, who were divided into three groups: positive pressure, negative pressure, and self-extubation. Neonates with congenital respiratory defects, meconium aspiration, and bacterial pneumonia were excluded from the study. The primary outcomes assessed included the duration of intubation, need for oxygen post-extubation, and length of hospitalization. Statistical analysis was performed using the independent-samples Kruskal-Wallis test, with a significance level set at <i>p</i> < 0.05.ResultsNo statistically significant differences were found in the duration of intubation (<i>p</i> = 0.436), need for oxygen after extubation (<i>p</i> = 0.785), and length of hospitalization (<i>p</i> = 0.357) among the groups. There was a significant difference in the duration of intubation, need for oxygen after extubation, and length of hospital stay based on gestational age at birth (<i>p</i> = 0.000). However, there was no significant correlation between age at birth and re-intubation (<i>p</i> = 0.297).ConclusionThere are no significant differences in key outcomes like intubation duration, post-extubation oxygen needs, and hospitalization length, suggesting that the choice of extubation method may not greatly affect these factors.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251330807"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdessamad Lalaoui, Ghizlane Kassal, Chaima Haidar, Khalid Abi El Aala, Fatiha Bennaoui, Nadia El Idrissi Slitine, Asma Hanchi, Nabila Soraa, Fadl Mrabih Rabou Maoulainine
{"title":"Neonatal malignant pertussis and exchange transfusion: A case report.","authors":"Abdessamad Lalaoui, Ghizlane Kassal, Chaima Haidar, Khalid Abi El Aala, Fatiha Bennaoui, Nadia El Idrissi Slitine, Asma Hanchi, Nabila Soraa, Fadl Mrabih Rabou Maoulainine","doi":"10.1177/19345798251330800","DOIUrl":"https://doi.org/10.1177/19345798251330800","url":null,"abstract":"<p><p>Whooping cough (pertussis) is a bacterial infection caused by Bordetella pertussis. It poses a significant risk, especially in neonates. This contagious respiratory infection is transmitted via the aerosol route from human reservoirs. The severe form can lead to mortality in approximately 70% of cases. The aim of our study is to report the severity of malignant whooping cough in neonates and the potential contribution of exchange transfusion to improving prognosis. In this case, a 26-day-old infant presented with malignant whooping cough, confirmed by PCR testing. Initial clinical findings included tachycardia, fever, dyspnea, and right apical lesion with pulmonary arterial hypertension. Despite initial treatment with josamycin and supportive measures, the patient's condition deteriorated, requiring an exchange transfusion, which led to clinical improvement. The patient was successfully discharged after a 12-day hospitalization. Exchange transfusion should be considered for malignant whooping cough with leukocytosis and acute respiratory failure, but enhancing vaccination coverage remains the most effective prevention strategy.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251330800"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Colonization of extended-spectrum beta-lactamase-producing bacteria in healthy pregnant women and its impact on perinatal care: A cross-sectional study.","authors":"Shigekatsu Hatanaka, Yukiko Ohashi, Tamae Mitsuhashi, Rie Imada, Misato Kawamura, Shigemi Okusa, Yuriko Takenaka, Yoko Ichikawa, Michiya Kobayashi","doi":"10.1177/19345798251318610","DOIUrl":"https://doi.org/10.1177/19345798251318610","url":null,"abstract":"<p><p>BackgroundColonization of extended-spectrum beta-lactamase (ESBL)-producing organisms is increasing becoming more frequent not only in hospitalized patients but also in healthy individuals. Although these bacteria are thought to be transmitted to newborns on their way through the birth canal, molecular evidence for this is scarce. In this study, we aimed to survey the current prevalence of resistant bacterial colonization in this area by examining the colonization carriage of this organism before and after delivery.MethodsWe examined the colonization rate of ESBL-producing bacteria in healthy pregnant women, the colonization rate in newborns, and the transmission rate from pregnant women who are carriers of the bacteria to their newborns. We also performed resistance gene and similarity analyses for each strain in pairs of mother-child carriers.ResultsOf 494 pregnant women, 33 carried ESBL-producing bacteria, all of whom were identified as Escherichia coli. The colonization carriage rate among pregnant women was 6.7%. Among newborns, the rate rose from 1.0% immediately after birth to 6.9% at the one-month checkup. Furthermore, of the 13 strains detected among mothers and children, 10 pairs had matching resistance genes.ConclusionsSome ESBL-producing bacterial carriers exist even among healthy pregnant women, and about half of them go on to infect their newborns. However, routes of transmission beyond vertical transmission cannot be ruled out. Therefore, it is important to promote infection control in the healthcare environment and in the families of newborns, as well as antimicrobial stewardship among pregnant women.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251318610"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cutaneous aspergillosis in a premature infant.","authors":"Prateek Sharma, Tazuddin Mohammed","doi":"10.1177/19345798251330833","DOIUrl":"https://doi.org/10.1177/19345798251330833","url":null,"abstract":"<p><p>Fungal infections in preterm infants are uncommon, but serious infections that carry a high mortality rate. Preterm infants who are extremely low birth weight are at high risk for fungal infections due to immaturity of their immune system and skin barrier. Factors which further reduce host immunity in premature infants include prolonged use of broad-spectrum antibiotics and corticosteroids. Our case presentation involves an extremely low-weight 23-week preterm infant diagnosed with primary invasive cutaneous aspergillosis (PCA) confirmed by skin biopsy and cultures obtained from skin debridement. His inoculation was thought to be secondary to either a thermal burn or from macerated skin from prolonged incubation. This case highlights the importance of keeping fungal infections at the forefront of one's differential diagnosis when an extremely low-weight infant presents with cutaneous lesions as disseminated fungal infections carry a high mortality rate.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251330833"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gordon Y Chang, Cynthia A Cox, Ellen A Kane, Giovanna Palermo Tye, Paul Fawcett, Thomas H Shaffer
{"title":"Comparison of stress-induced hemolysis in neonatal intravenous catheters: Theoretical and experimental analysis of shear stress, exposure time, and index of hemolysis.","authors":"Gordon Y Chang, Cynthia A Cox, Ellen A Kane, Giovanna Palermo Tye, Paul Fawcett, Thomas H Shaffer","doi":"10.1177/19345798251326071","DOIUrl":"https://doi.org/10.1177/19345798251326071","url":null,"abstract":"<p><p>BackgroundSeveral studies report hemolysis when packed red blood cells (PRBCs) are transfused through small-inner-diameter (ID) catheters using presence of biomarkers but do not address cause and amount of hemolysis. This study aims to determine the cause and index of hemolysis percent (IH%) when PRBCs are infused through small-ID catheters.MethodsThe IH% was calculated using Giersiepen's empirical power law, which describes a relationship between hemolysis and magnitude of shear stress and exposure time. Six- and 27-day-old PRBCs were infused through five catheters with IDs of 0.20 mm to 0.70 mm at infusion rates of 3 mL and 10 mL/hour. Shear stress and exposure time were calculated. Data were analyzed as a function of catheter ID, infusion rates, and blood age.ResultsThe study demonstrated that shear stress was supraphysiologic during laminar flow in catheters with IDs of 0.20 mm and 0.28 mm. These catheters' IH% were ∼117 times higher at 3 mL/hour and ∼75 times higher at 10 mL/hour than catheters with larger IDs of 0.48 mm, 0.51 mm, and 0.70 mm. For blood age, in catheters with IDs of 0.20 mm and 0.28 mm, IH% was ∼155 times higher at 6 days and ∼76 times higher at 27 days than in catheters with IDs of 0.48 mm, 0.51 mm, and 0.70 mm.ConclusionsThis study demonstrated that when RBCs are subjected to supraphysiologic shear stress in catheters with IDs of ≤0.28 mm, index of hemolysis is greater than in catheters with IDs ≥0.48 mm.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251326071"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hani Ajrina Zulkeflee, Nur Atiqah Zulkefli, Aliyyah Mohammad Khuzaini
{"title":"Observed hepatic dysfunction following diazoxide administration in a neonate with liver impairment: A case report.","authors":"Hani Ajrina Zulkeflee, Nur Atiqah Zulkefli, Aliyyah Mohammad Khuzaini","doi":"10.1177/19345798251327371","DOIUrl":"https://doi.org/10.1177/19345798251327371","url":null,"abstract":"<p><p>Diazoxide is commonly used to treat neonatal hypoglycaemia when first-line treatment fails by inhibiting insulin secretion. We present a case of a full-term female infant with refractory hypoglycaemia who developed elevated liver enzymes and worsening jaundice following diazoxide administration. After discontinuation of diazoxide, her liver enzyme levels rapidly improved. Although liver impairment has not been commonly reported as a side effect of diazoxide, previous reports, such as one by Tas et al. in 2015, have documented similar findings in patients with hypoalbuminemia, where altered drug metabolism may play a role. Diazoxide undergoes metabolism in the liver, raising the possibility that preexisting liver impairment could affect its clearance and potentially exacerbate hepatic dysfunction. These observations suggest that careful consideration is required when using diazoxide in neonates with compromised liver function. Further studies are needed to explore the mechanisms that may contribute to this association and to establish guidelines for its use in this vulnerable population. This case challenges the conventional understanding of diazoxide as a safe intervention for neonatal hypoglycaemia. Additional research is required to elucidate the mechanisms leading to hepatotoxicity and to establish clear guidelines for the use of diazoxide in this vulnerable population.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251327371"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maryam Zakerihamidi, Gholamali Maamouri, Abbas Boskabadi, Forough Rakhshanizadeh, Zahra Parvini, Asal Ramazani, Fatemeh Bagheri, Hassan Boskabadi
{"title":"Comparison of newborns' characteristics between neonates with proper and improper breastfeeding positions.","authors":"Maryam Zakerihamidi, Gholamali Maamouri, Abbas Boskabadi, Forough Rakhshanizadeh, Zahra Parvini, Asal Ramazani, Fatemeh Bagheri, Hassan Boskabadi","doi":"10.1177/19345798251327382","DOIUrl":"https://doi.org/10.1177/19345798251327382","url":null,"abstract":"<p><p>IntroductionProper positioning for successful breastfeeding is important. The current study aimed to compare newborns' characteristics with proper and improper breastfeeding positions.MethodsThe current cross-sectional study was conducted on 591 neonates referred to the Neonatal Clinic, Ward, and Emergency Department of Ghaem Hospital in Mashhad, Iran, within 2019-2023. The subjects were selected through the availability sampling method. Neonates referred for the routine physical examination, jaundiced cases not requiring hospitalization, and newborns with hyperthermia and weight loss were included in the study. Neonates with less than 34 weeks of gestation, jaundiced cases requiring hospitalization, newborns with congenital anomalies, or those with confirmed infectious diseases were excluded from the study. Proper breastfeeding position was considered due to the status of attachment of the neonate to the mother's breast. The data collection tool was a researcher-made checklist, including laboratory data and maternal and neonatal characteristics. The data were analyzed using the t-test and chi-square test.ResultsAmong the 591 neonates, 466 (78.8%) and 125 (21.2%) subjects were nursed with proper and improper positioning, respectively. There were significant differences between the two groups in terms of admission weight (<i>p</i> = .000), daily weight loss (<i>p</i> = .000), daily weight loss percentage (<i>p</i> = .000), first breastfeeding time after delivery (<i>p</i> = .000), breastfeeding frequency (<i>p</i> = .000), breastfeeding duration (<i>p</i> = .002), urination frequency (<i>p</i> = .000), defecation frequency (<i>p</i> = .000), and serum levels of sodium (<i>p</i> = .000), urea (<i>p</i> = .000), creatinine (<i>p</i> = .000), hematocrit (<i>p</i> = .002), platelet count (<i>p</i> = .001), and blood glucose (<i>p</i> = .010). Moreover, lethargy, irritability, seizure, mucosal dryness, inverted fontanelle, hyperthermia, unsoftened breast after breastfeeding, nipple fissure, and pregnancy problems were higher in the group nursed with improper positioning than the other group.ConclusionIn our study, breast problems, feeding problems, hypernatremia, hyperuremia, and weight loss were more common in infants of mothers with improper positioning of breastfeeding. Therefore, it is recommended to provide mothers with appropriate training and strategies for proper breastfeeding position.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251327382"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hareshan Suntharalingam, Daniel Briatico, Nathalie Carey, Ali McBryde, Erik Skarsgard, Esther Huisman, Michael H Livingston
{"title":"Feeding practices for infants with gastroschisis: A survey of neonatal intensive care units in Canada.","authors":"Hareshan Suntharalingam, Daniel Briatico, Nathalie Carey, Ali McBryde, Erik Skarsgard, Esther Huisman, Michael H Livingston","doi":"10.1177/19345798251327370","DOIUrl":"https://doi.org/10.1177/19345798251327370","url":null,"abstract":"<p><p>BackgroundFeeding practices for infants with gastroschisis are often based on institutional protocols, clinician judgement, and usual practice. The purpose of this study was to describe the range of feeding practices used in neonatal intensive care units across Canada.MethodsWe developed an 18-item survey with open-ended questions focused on feeding and nutrition among infants with gastroschisis. Clinicians from neonatal intensive care units that manage infants with gastroschisis were invited to participate. Interviews were completed via virtual meeting or email. Data were analyzed using descriptive statistics.ResultsSemi-structured interviews were conducted with 14 of 17 centers (82% response rate). Participants included neonatologists (12/14 centers) and dieticians (10/14 centers). Pediatric surgeons from 3/14 centers participated at the request of neonatologists. None of the centers reported using a gastroschisis feeding protocol routinely, although two centers noted occasional use of a protocol from another hospital, and another indicated that a gastroschisis feeding protocol is in development. All centers reported that patients with gastroschisis qualify for donor human milk if maternal breast milk is unavailable. Routine use of sham feeding, contrast studies, rectal irrigations, or motility agents was not reported. There was variation between centers regarding feeding advancement, type of formula used if breast milk is unavailable, use of probiotics, and strategies to introduce breastfeeding.ConclusionThere is variation in some but not all aspects of enteral feeding among infants with gastroschisis at neonatal intensive care units in Canada. The development of institutional feeding protocols and clinical practice guidelines may help standardize practice.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251327370"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implications of maternal health status on term and close to term neonates in a socioeconomically high-risk population.","authors":"Rita P Verma, Neeti Luke, Joshua Fogel","doi":"10.1177/19345798251324450","DOIUrl":"https://doi.org/10.1177/19345798251324450","url":null,"abstract":"<p><strong>Objective: </strong>To investigate maternal morbidities and their implications on term neonates in a socioeconomically underprivileged population.</p><p><strong>Methods: </strong>In a retrospective population-based study, maternal morbidities were associated with neonatal birth weight (BW), gestational age (GA), Apgar scores, respiratory distress (RD), admission to Neonatal intensive care nursery (NICU), feeding difficulties, and the length of hospital stay (LOS) in infants admitted to the level 1 nursery via multivariate regression analyses.</p><p><strong>Results: </strong>In the 508 mother-infant pairs, 61.4% were Hispanic, 18.4% were African American, 9.6% were non-Hispanic white, and 10.6 % were Asian/Pacific islanders. 8.7% of the neonates [GA 38.63 (1.3) weeks and BW 3196.3 (574.6) g] had Apgar scores <7 at 1 and 2.2% at 5 minutes of life. The prevalence of maternal hypertension (8.5%), Preeclampsia-eclampsia (10.1%), Apgar scores <7 (8.7, 2.2 % at 1 and 5 minutes), NICU admission (20.4%), and feeding difficulty (7.5%) were higher than reported. Mean LOS at 4.29 days was higher than documented in term infants. Apgar scores were associated with eclampsia/preeclampsia, C-section, and antepartum hemorrhage; NICU admission with chorioamnionitis, C-section, and substance abuse; feeding difficulties with maternal alcohol consumption; and longer LOS with preeclampsia/eclampsia, chorioamnionitis, C-section, and tobacco abuse. Maternal hematocrit had positive associations with BW and GA and negative associations with LOS, feeding difficulties, and NICU admission rates.</p><p><strong>Conclusions: </strong>In the underprivileged multiethnic maternal-neonatal population, term neonates exhibited low-intensity complications attributable to adverse maternal conditions. Optimizing maternal hematocrit may improve neonatal birth weight and maturational status and decrease adverse outcomes.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251324450"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Ostroff, J Abu-Ali, V DeBari, F Kiblawi, A Zauk, S Datta-Bhutada, Z Pua
{"title":"POCUS using the neo-ECHOTIP protocol plus the retract, advance, and position (RAP) technique to improve lower extremity catheter positioning in neonates.","authors":"M Ostroff, J Abu-Ali, V DeBari, F Kiblawi, A Zauk, S Datta-Bhutada, Z Pua","doi":"10.1177/19345798251318585","DOIUrl":"https://doi.org/10.1177/19345798251318585","url":null,"abstract":"<p><strong>Background: </strong>International guidelines recommend point-of-care ultrasonography (POCUS) in neonatology for diagnostic, therapeutic, and procedural purposes. However, there are few standard protocols for using POCUS to confirm lower extremity catheter tip positioning.</p><p><strong>Methods: </strong>In this prospective study, subcutaneously tunneled femorally inserted central catheters (ST-FICCs) were placed in eligible neonates according to physician orders. In line with the Neo-ECHOTIP (NE) protocol, a subcostal longitudinal view was used to identify the catheter, and saline flush test (SFT) was performed to confirm catheter tip placement below the right atrium. During the study, a novel \"retract, advance, and position (RAP)\" technique was added to the existing NE-SFT protocol to improve catheter positioning. Two-view radiographs of the chest and abdomen were obtained to verify catheter tip position for all subjects. The agreement rate with post-procedural radiographs and the total number of radiographs needed to achieve proper catheter positioning were assessed.</p><p><strong>Results: </strong>The agreement rate of POCUS with radiographs for catheter terminal tip position was 75% (39/52) for the NE-SFT group compared to 100% (48/48) for the NE-SFT + RAP group (<i>p</i> < 0.001). Catheters in the NE-SFT group required repositioning (25%); no malpositioned catheters were observed in the NE-SFT + RAP group. Repositioning of the catheter in the NE-SFT group resulted in 22 repeat radiographs in the NE-SFT group; none were required in the NE-SFT + RAP group (<i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>This single-center study demonstrated that applying the RAP technique to the Neo-ECHOTIP protocol improved the ease and accuracy of lower extremity catheter tip position localization in neonates, thus eliminating the use of radiography.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251318585"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}