{"title":"美国与巴西先天性唇腭裂之比较研究。","authors":"Adriana M da Silva, V S Freitas, A R Vieira","doi":"10.1177/19345798251343829","DOIUrl":null,"url":null,"abstract":"<p><p>BackgroundIn Brazil, little attention has been focused on gestational complications related to orofacial cleft. The objective was to characterize the burden of orofacial clefts in Brazil by comparing the prevalence, risk factors, and birth health conditions of children born with clefts in Brazil and the United States.MethodsThis was a population-based cross-sectional study conducted using national data from 13,297 to 8853 individuals born with orofacial cleft in Brazil and the United States, respectively, between 2017 and 2021. Risk factors (maternal ethnicity, maternal age, infant sex, and plurality) and birth health conditions (number of prenatal care appointments, delivery method, Apgar score at 5 minutes, gestational age, and birthweight) were gathered from national data in both countries. The prevalence of clefts in both countries and prevalence ratios were calculated.ResultsThe prevalence of clefts was 7.1/10,000 in the United States and 6.2/10,000 in Brazil. Newborns with clefts in Brazil were significantly more likely to have a cleft palate (PR = 1.32, <i>p</i> = 0.000), be premature (PR = 1.37, <i>p</i> = 0.000), be born by cesarean section (PR = 1.00, <i>p</i> = 0.000), and have low birth weight (PR = 1.49, <i>p</i> = 0.000). Their mothers tended to be older (PR = 1.09, <i>p</i> = 0.001), non-white (PR = 0.48, <i>p</i> = 0.000), and had fewer than 10 prenatal care appointments (PR = 2.14, <i>p</i> = 0.000), compared to the United States cohort.ConclusionThe frequency of risk factors and adverse outcomes associated with being born with clefts was higher in the Brazilian cohort, suggesting that social determinants of health play a significant role in increasing individuals' susceptibility to risk factors for clefts and poor birth health conditions.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251343829"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative study of individuals born with orofacial clefts in the United States and Brazil.\",\"authors\":\"Adriana M da Silva, V S Freitas, A R Vieira\",\"doi\":\"10.1177/19345798251343829\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>BackgroundIn Brazil, little attention has been focused on gestational complications related to orofacial cleft. The objective was to characterize the burden of orofacial clefts in Brazil by comparing the prevalence, risk factors, and birth health conditions of children born with clefts in Brazil and the United States.MethodsThis was a population-based cross-sectional study conducted using national data from 13,297 to 8853 individuals born with orofacial cleft in Brazil and the United States, respectively, between 2017 and 2021. Risk factors (maternal ethnicity, maternal age, infant sex, and plurality) and birth health conditions (number of prenatal care appointments, delivery method, Apgar score at 5 minutes, gestational age, and birthweight) were gathered from national data in both countries. The prevalence of clefts in both countries and prevalence ratios were calculated.ResultsThe prevalence of clefts was 7.1/10,000 in the United States and 6.2/10,000 in Brazil. Newborns with clefts in Brazil were significantly more likely to have a cleft palate (PR = 1.32, <i>p</i> = 0.000), be premature (PR = 1.37, <i>p</i> = 0.000), be born by cesarean section (PR = 1.00, <i>p</i> = 0.000), and have low birth weight (PR = 1.49, <i>p</i> = 0.000). Their mothers tended to be older (PR = 1.09, <i>p</i> = 0.001), non-white (PR = 0.48, <i>p</i> = 0.000), and had fewer than 10 prenatal care appointments (PR = 2.14, <i>p</i> = 0.000), compared to the United States cohort.ConclusionThe frequency of risk factors and adverse outcomes associated with being born with clefts was higher in the Brazilian cohort, suggesting that social determinants of health play a significant role in increasing individuals' susceptibility to risk factors for clefts and poor birth health conditions.</p>\",\"PeriodicalId\":16537,\"journal\":{\"name\":\"Journal of neonatal-perinatal medicine\",\"volume\":\" \",\"pages\":\"19345798251343829\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of neonatal-perinatal medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/19345798251343829\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of neonatal-perinatal medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/19345798251343829","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
在巴西,很少有人关注与口面裂相关的妊娠并发症。目的是通过比较巴西和美国出生时患有唇腭裂的儿童的患病率、危险因素和出生健康状况来确定巴西唇腭裂负担的特征。方法:这是一项基于人群的横断面研究,使用了2017年至2021年间分别在巴西和美国出生的13297至8853名唇腭裂患者的国家数据。从两国的国家数据中收集了风险因素(产妇种族、产妇年龄、婴儿性别和多胞胎)和出生健康状况(产前护理预约次数、分娩方法、5分钟时的Apgar评分、胎龄和出生体重)。计算了两国唇裂的患病率和患病率比率。结果美国唇裂患病率为7.1/ 10000,巴西唇裂患病率为6.2/ 10000。在巴西,唇裂新生儿患腭裂(PR = 1.32, p = 0.000)、早产(PR = 1.37, p = 0.000)、剖宫产(PR = 1.00, p = 0.000)和低出生体重(PR = 1.49, p = 0.000)的可能性明显更高。与美国队列相比,他们的母亲往往年龄较大(PR = 1.09, p = 0.001),非白人(PR = 0.48, p = 0.000),产前护理预约少于10次(PR = 2.14, p = 0.000)。结论在巴西队列中,与先天性唇裂相关的危险因素和不良后果出现的频率更高,这表明健康的社会决定因素在增加个体对唇裂危险因素和不良出生健康状况的易感性方面发挥了重要作用。
Comparative study of individuals born with orofacial clefts in the United States and Brazil.
BackgroundIn Brazil, little attention has been focused on gestational complications related to orofacial cleft. The objective was to characterize the burden of orofacial clefts in Brazil by comparing the prevalence, risk factors, and birth health conditions of children born with clefts in Brazil and the United States.MethodsThis was a population-based cross-sectional study conducted using national data from 13,297 to 8853 individuals born with orofacial cleft in Brazil and the United States, respectively, between 2017 and 2021. Risk factors (maternal ethnicity, maternal age, infant sex, and plurality) and birth health conditions (number of prenatal care appointments, delivery method, Apgar score at 5 minutes, gestational age, and birthweight) were gathered from national data in both countries. The prevalence of clefts in both countries and prevalence ratios were calculated.ResultsThe prevalence of clefts was 7.1/10,000 in the United States and 6.2/10,000 in Brazil. Newborns with clefts in Brazil were significantly more likely to have a cleft palate (PR = 1.32, p = 0.000), be premature (PR = 1.37, p = 0.000), be born by cesarean section (PR = 1.00, p = 0.000), and have low birth weight (PR = 1.49, p = 0.000). Their mothers tended to be older (PR = 1.09, p = 0.001), non-white (PR = 0.48, p = 0.000), and had fewer than 10 prenatal care appointments (PR = 2.14, p = 0.000), compared to the United States cohort.ConclusionThe frequency of risk factors and adverse outcomes associated with being born with clefts was higher in the Brazilian cohort, suggesting that social determinants of health play a significant role in increasing individuals' susceptibility to risk factors for clefts and poor birth health conditions.