European Psychiatry最新文献

{"title":"Relationships between cognition, functioning, and quality of life of euthymic patients with bipolar disorder: Structural equation modeling with the FACE-BD cohort.","authors":"P Roux, S Frileux, N Vidal, V Aubin, R Belzeaux, P Courtet, C Dubertret, B Etain, E Haffen, M Leboyer, A Lefrere, P M Llorca, K M'Bailara, E Marlinge, E Olié, M Polosan, R Schwan, E Brunet-Gouet, C Passerieux","doi":"10.1192/j.eurpsy.2024.1789","DOIUrl":"10.1192/j.eurpsy.2024.1789","url":null,"abstract":"<p><strong>Background: </strong>Quality of life is decreased in bipolar disorders (BD) and contributes to poor prognosis. However, little is known about the causal pathways that may affect it. This study aimed to explore health-related QoL (HRQoL) in BD and investigate its relationship with cognition and psychosocial functioning.</p><p><strong>Methods: </strong>This multicenter cross-sectional study used a neuropsychological battery to assess five cognition domains. Functioning was evaluated using global and domain-based tools, and health-related HRQoL was assessed using the EQ-5D-3L. Structural equation modeling was used to test whether the association between cognition and HRQoL would be mediated by functioning in BD while controlling for covariates such as residual depression, anxiety, antipsychotic medication, and psychotic features.</p><p><strong>Results: </strong>We included 1 190 adults with euthymic BD. The model provided a good fit for the data. In this model, the direct effect of cognition on HRQoL was not significant (β = - 0.03, <i>z =</i> -0.78, <i>p =</i> 0.433). The total effect of cognition on HRQoL was weak, albeit significant (β = 0.05, <i>z =</i> 3.6, <i>p <</i> 0.001), thus suggesting that cognition affected HRQoL only indirectly through functioning. Anxiety was associated with decreased functioning (β = -0.27, <i>z =</i> -7.4, <i>p <</i> 0.001) and QoL (β = -0.39, <i>z =</i> -11.8, <i>p <</i> 0.001).</p><p><strong>Conclusions: </strong>These findings suggest that improving cognition may not directly lead to a higher HRQoL. Cognitive remediation is expected to improve HRQoL only through functioning enhancement. They also reveal the potential importance of functional remediation and reduction of comorbid anxiety symptoms in improving HRQoL in BD.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"67 1","pages":"e78"},"PeriodicalIF":7.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A never-ending story: The COVID-19 pandemic and the increase of hospital admissions for typical and atypical anorexia nervosa in children, adolescents and young adults in the post-pandemic era in Germany.","authors":"Beate Herpertz-Dahlmann, Stefan Eckardt, Astrid Dempfle","doi":"10.1192/j.eurpsy.2024.1788","DOIUrl":"10.1192/j.eurpsy.2024.1788","url":null,"abstract":"<p><strong>Background: </strong>A large increase in the rate of hospitalizations for adolescents and children with anorexia nervosa (AN) was observed during the coronavirus disease (COVID-19) pandemic. It is still not clear whether this was a temporary effect or whether the increased admission rates persist.</p><p><strong>Methods: </strong>Data were retrieved from the largest health insurance in Germany comprising 2.5 million children between 9 and 19 y. All patients of this age group with a discharge diagnosis of typical (AN) and atypical AN (AAN) according to the International Classification of Diseases, Tenth Revision (ICD-10), were included. Admission rates per 10,000 person-years were computed separately by sex, age and type of AN for entire years from 2019 to 2022 and the first half of 2023 in relation to the entire number of insured persons of the same sex and age per year.</p><p><strong>Results: </strong>Two years after the final lockdown admission rates were still significantly higher in adolescent and childhood AN than in the pre-COVID-19 time. While admission rates declined for adolescents in 2023, those for children remained high, with an increase for girls of more than 40% compared with the rate before the pandemic (1.42 (CI 1.26, 1.60); <i>p</i> < 0.0001). The highest admission risk for AAN relative to the pre-COVID-19 period was observed in adolescents in the first half of 2023 (1.6; CI 1.34; 1.90; <i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>Children appear to be especially vulnerable to the pandemic-associated disruptions. Clinicians should try to determine the ongoing effects of the pandemic and support early detection and treatment of AN to prevent its often lifelong consequences.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"67 1","pages":"e77"},"PeriodicalIF":7.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors for improvement in personality functioning during outpatient psychotherapy: A machine learning approach within a psychodynamic psychotherapy sample.","authors":"I Dönnhoff, D Kindermann, S Stahl-Toyota, J Nowak, M Orth, H-C Friederich, C Nikendei","doi":"10.1192/j.eurpsy.2024.1780","DOIUrl":"10.1192/j.eurpsy.2024.1780","url":null,"abstract":"<p><strong>Background: </strong>Since its introduction in the diagnostic manuals DSM-5 and ICD-11, the construct of personality functioning has gained increasing attention. However, it remains unclear which factors might predict improvement in personality functioning.</p><p><strong>Methods: </strong>We examined a sample of 648 completed psychodynamic psychotherapies conducted by 172 therapists at the Heidelberg Institute for Psychotherapy. A machine learning approach was used to filter for variables that are relevant for the prediction of the improvement of personality functioning from a broad data set of variables collected at the beginning of each psychodynamic psychotherapy.</p><p><strong>Results: </strong>On average, we found an improvement of 0.24 (SD = 0.48) in the OPD-SQ. This corresponds to a medium effect in the improvement of personality functioning. Patients with initially high impairment experienced particularly large improvements. Overall, we found a large number of variables that proved to be predictive for the improvement of personality functioning. Limitations in social activity due to physical and emotional problems proved to be one of the most important predictors of improvement. Most of the effect sizes were small.</p><p><strong>Conclusions: </strong>Overall, the improvement in personality functioning during psychotherapy is determined more by the sum of a large number of small effects than by individual variables. In particular, variables that capture social areas of life proved to be robust predictors.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"67 1","pages":"e79"},"PeriodicalIF":7.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let's focus on the insula in addiction: A refined anatomical exploration of insula in severe alcohol and cocaine use disorders.","authors":"Pauline Billaux, Shailendra Segobin, Angeline Maillard, Vanessa Bloch, Christine Delmaire, Nicolas Cabé, Alice Laniepce, Pierre Maurage, Margaux Poireau, Emmanuelle Volle, Florence Vorspan, Anne-Lise Pitel","doi":"10.1192/j.eurpsy.2024.1784","DOIUrl":"10.1192/j.eurpsy.2024.1784","url":null,"abstract":"<p><strong>Background: </strong>Theoretical and empirical contributions have identified insula as key in addiction. However, anatomical modifications of the insula in addictive states, and their variations across substance use disorders (SUDs), remain to be specifically explored. We therefore explored the specificities and commonalities of insula gray matter (GM) alterations in severe alcohol use disorder (sAUD) and severe cocaine use disorder (sCUD).</p><p><strong>Methods: </strong>We explored insula GM volume through a refined parcellation in 12 subregions (six bilateral): anterior inferior cortex (AIC), anterior short gyrus, middle short gyrus, posterior short gyrus, anterior long gyrus (ALG), and posterior long gyrus (PLG). Using a linear mixed model analysis, we explored the insula volume profiles of 50 patients with sAUD, 61 patients with sCUD, and 36 healthy controls (HCs).</p><p><strong>Results: </strong>In both sAUD and sCUD, we showed overall insular lower volume with a right-sided lateralization effect, and a major volume deficit in bilateral ALG. Moreover, differences emerged across groups, with higher left AIC and PLG volume deficits in sCUD compared to sAUD and HC.</p><p><strong>Conclusions: </strong>We offered the first joint exploration of GM insular volumes in two SUD through refined parcellation, thus unveiling the similarities and dissimilarities in volume deficit profiles. Our results bring evidence complementing prior ones suggesting the core role of the right and posterior insula in craving and interoception, two crucial processes in addiction. Left AIC and PLG group differences also show that, while insula is a region of interest in SUD, sCUD and sAUD generate distinct insular profiles, which might parallel clinical differences across SUD.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"67 1","pages":"e75"},"PeriodicalIF":7.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal transition rates and their predictors in the adult general population: a repeated survey over 21 years in France.","authors":"Fabrice Jollant, Christophe Leon","doi":"10.1192/j.eurpsy.2024.1782","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2024.1782","url":null,"abstract":"<p><strong>Background: </strong>The \"suicidal transition\" from ideation to an act has become a specific topic of research. However, rates in the general population, variations across time and risk factors are unclear.</p><p><strong>Methods: </strong>Data were collected from the phone survey <i>Baromètre Santé</i> among 18-75-year-olds in France. Seven independent samples interviewed between 2000 and 2021 (total N = 133,827 people; 51.3% females) were questioned about suicidal ideation and attempts over the previous 12 months. Transition was calculated as the weighted ratio of attempt on ideation 12-month rates.</p><p><strong>Results: </strong>Mean 12-month rates of suicidal ideation, attempts and transition were 4.7% (95% Confidence Interval (CI) (4.6-4.8)), 0.5% (95% CI (0.4-0.5)) and 7.7% (95% CI (6.8-8.6)), respectively. Transition rates varied between 4.5 and 11.9% across surveys. In multivariable analyses, higher transitions rates were associated with a previous suicide attempt (adjusted Odds Ratio (aOR) = 11.1 95% CI (7.9-15.6)); 18-25 vs 26-55-year-olds (1.8 95% CI (1.2-2.8)); lower vs higher income (1.7 95% CI (1.0-2.7); and lower vs higher professional categories (aOR around 1.9). No significant association was found with gender, education level, employment status, living alone, urbanicity, current major depression, daily smoking, weekly heavy drinking, cannabis use, and body mass index.</p><p><strong>Conclusions: </strong>Most people with suicidal ideation do not attempt suicide. These findings emphasize the need to avoid generic terms such as \"suicidality\", and to increase research on suicidal transition to improve prevention and prediction. They may also inform the organization of suicide prevention in the general population.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"67 1","pages":"e74"},"PeriodicalIF":7.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient trust in the use of machine learning-based clinical decision support systems in psychiatric services: A randomized survey experiment.","authors":"Erik Perfalk, Martin Bernstorff, Andreas Aalkjær Danielsen, Søren Dinesen Østergaard","doi":"10.1192/j.eurpsy.2024.1790","DOIUrl":"10.1192/j.eurpsy.2024.1790","url":null,"abstract":"<p><strong>Background: </strong>Clinical decision support systems (CDSS) based on machine-learning (ML) models are emerging within psychiatry. If patients do not trust this technology, its implementation may disrupt the patient-clinician relationship. Therefore, the aim was to examine whether receiving basic information about ML-based CDSS increased trust in them.</p><p><strong>Methods: </strong>We conducted an online randomized survey experiment in the Psychiatric Services of the Central Denmark Region. The participating patients were randomized into one of three arms: Intervention = information on clinical decision-making supported by an ML model; Active control = information on a standard clinical decision process, and Blank control = no information. The participants were unaware of the experiment. Subsequently, participants were asked about different aspects of trust and distrust regarding ML-based CDSS. The effect of the intervention was assessed by comparing scores of trust and distrust between the allocation arms.</p><p><strong>Results: </strong>Out of 5800 invitees, 992 completed the survey experiment. The intervention increased trust in ML-based CDSS when compared to the active control (mean increase in trust: 5% [95% CI: 1%; 9%], <i>p</i> = 0.0096) and the blank control arm (mean increase in trust: 4% [1%; 8%], <i>p</i> = 0.015). Similarly, the intervention reduced distrust in ML-based CDSS when compared to the active control (mean decrease in distrust: -3%[-1%; -5%], <i>p</i> = 0.021) and the blank control arm (mean decrease in distrust: -4% [-1%; -8%], <i>p</i> = 0.022). No statistically significant differences were observed between the active and the blank control arms.</p><p><strong>Conclusions: </strong>Receiving basic information on ML-based CDSS in hospital psychiatry may increase patient trust in such systems.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"67 1","pages":"e72"},"PeriodicalIF":7.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom profile in suicide attempters during the COVID-19 pandemic: Relationships with suicide outcomes.","authors":"Patricia Díaz-Carracedo, Carolina Marín, Marina Diaz-Marsa, Guilherme Borges, Alejandro de la Torre-Luque, Matilde Elices, Alba Toll, Iria Grande, Natalia Roberto, Mireia Vázquez, Ana González-Pinto, Miguel Ruiz-Veguilla, Manuel Canal-Rivero, Ana I Cebria, Diego Palao, Teresa Bobes-Bascaran, Luis Jimenez-Treviño, Pilar Saiz, Jorge Andreo-Jover, Katya March, Angela Palao-Tarrero, Víctor Perez","doi":"10.1192/j.eurpsy.2024.1759","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2024.1759","url":null,"abstract":"<p><strong>Background: </strong>Suicidal behavior constitutes a multi-cause phenomenon that may also be present in people without a mental disorder. This study aims to analyze suicidal behavior outcomes in a sample of attempters, from a symptom-based approach.</p><p><strong>Methods: </strong>The sample comprised 673 patients (72% female; <i>M</i> = 40.9 years) who attended a hospital emergency department due to a suicide attempt. A wide range of clinical factors (e.g., psychopathology symptoms, psychiatric diagnoses, impulsivity, acquired capability), was administered within 15 days after the index attempt. Nine psychopathology domains were explored to identify the profile of symptoms, using latent profile analysis. The relationship between the profile membership and suicide outcome (i.e., intensity of suicidal ideation, number of suicide behaviors, and medical injury derived from index attempt) was also studied, using linear and logistic regression.</p><p><strong>Results: </strong>Three psychopathology profiles were identified: high-symptom profile (45.02% of participants), moderate-symptom profile (42.50%), and low-symptom profile (12.48%). High-symptom profile members were more likely to show higher risk of non-suicidal self-injury, acquired capability for suicide, and more severe suicide behavior and ideation. On the other hand, a more severe physical injury was associated with low-symptom profile membership in comparison to membership from the other profiles (<i>OR</i> < 0.45, <i>p</i> < .05).</p><p><strong>Conclusions: </strong>A symptom-based approach may be useful to monitor patients and determine the risk of attempt repetition in the future and potential medical injury, and to optimize prevention and intervention strategies.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"67 1","pages":"e73"},"PeriodicalIF":7.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of autistic traits and their relationships with other psychopathological domains in young adults seeking psychiatric attention: a cluster analysis.","authors":"Benedetta Demartini, Gianmarco Ingrosso, Francesca Serio, Veronica Nisticò, Giovanni Broglia, Angelo Bertani, Raffaella Faggioli, Orsola Gambini, Gabriele Massimetti, Liliana Dell'Osso, Barbara Carpita","doi":"10.1192/j.eurpsy.2024.1791","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2024.1791","url":null,"abstract":"<p><strong>Background: </strong>Nearly two-thirds of individuals with a mental disorder start experiencing symptoms during adolescence or early adulthood, and the onset of a mental disorder during this critical life stage strongly predicts adverse socioeconomic and health outcomes. Subthreshold manifestations of autism spectrum disorders (ASDs), also called autistic traits (ATs), are known to be associated with a higher vulnerability to the development of other psychiatric disorders. This study aimed to assess the presence of ATs in a population of young adults seeking specialist assistance and to evaluate the study population across various psychopathological domains in order to determine their links with ATs.</p><p><strong>Methods: </strong>We recruited a sample of 263 adolescents and young adults referring to a specialized outpatient clinic, and we administered them several self-report questionnaires for the evaluation of various psychopathological domains. We conducted a cluster analysis based on the prevalence of ATs, empathy, and sensory sensitivity scores.</p><p><strong>Results: </strong>The cluster analysis identified three distinct groups in the sample: an AT cluster (22.43%), an intermediate cluster (45.25%), and a no-AT cluster (32.32%). Moreover, subjects with higher ATs exhibited greater symptomatology across multiple domains, including mood, anxiety, eating disorder severity, psychotic symptoms, and personality traits such as detachment and vulnerable narcissism.</p><p><strong>Conclusions: </strong>This study highlights the importance of identifying ATs in young individuals struggling with mental health concerns. Additionally, our findings underscore the necessity of adopting a dimensional approach to psychopathology to better understand the complex interplay of symptoms and facilitate tailored interventions.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"67 1","pages":"e71"},"PeriodicalIF":7.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring potential working mechanisms of accelerated HF-rTMS in refractory major depression with a focus on locus coeruleus connectivity.","authors":"Guo-Rong Wu, Chris Baeken","doi":"10.1192/j.eurpsy.2024.1769","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2024.1769","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the effects of accelerated high-frequency repetitive transcranial magnetic stimulation (aHF-rTMS), applied to the left dorsolateral prefrontal cortex (DLPFC), on locus coeruleus (LC) functional connectivity in the treatment of refractory medication-resistant major depression (MRD).</p><p><strong>Methods: </strong>We studied 12 antidepressant-free refractory MRD patients, focusing on how aHF-rTMS affects the LC, a central component of the brain's noradrenergic system and key to mood regulation and stress response.</p><p><strong>Results: </strong>A stronger decrease in LC functional connectivity following aHF-rTMS treatment resulted in better clinical improvement. We observed such LC functional connectivity decreases with several brain regions, including the superior frontal gyrus, precentral gyrus, middle occipital gyrus, and cerebellum. Moreover, our exploratory analyses hint at a possible role for E-field modeling in forecasting clinical outcomes. Additional analyses suggest potential genetic and dopaminergic factors influencing changes in LC functional connectivity in relation to clinical response.</p><p><strong>Conclusions: </strong>The findings of this study underscore the pivotal role of the LC in orchestrating higher cognitive functions through its extensive connections with the prefrontal cortices, facilitating decision-making, influencing attention, and addressing depressive rumination. Additionally, the observed enhancement in LC-(posterior) cerebellar connectivity not only highlights the cerebellum's role in moderating clinical outcomes through noradrenergic system modulation but also suggests its potential as a predictive marker for aHF-rTMS efficacy. These results reveal new insights into the neural mechanisms of refractory depression and suggest therapeutic targets for enhancing noradrenergic activity, thereby addressing both cognitive and psychomotor symptoms associated with the disorder.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"67 1","pages":"e70"},"PeriodicalIF":7.2,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specificity in the commonalities of inhibition control: using meta-analysis and regression analysis to identify the key brain regions in psychiatric disorders.","authors":"Li Wan, Pingting Pei, Qinghui Zhang, Wenxiang Gao","doi":"10.1192/j.eurpsy.2024.1785","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2024.1785","url":null,"abstract":"<p><strong>Background: </strong>The differential diagnosis of psychiatric disorders is relatively challenging for several reasons. In this context, we believe that task-based magnetic resonance imaging (MRI) can serve as a tool for differential diagnosis. The aim of this study was to explore the commonalities in brain activities among individuals with psychiatric disorders and to identify the key brain regions that can distinguish between these disorders.</p><p><strong>Methods: </strong>The PubMed, MEDLINE, EMBASE, Web of Science, Scopus, PsycINFO, and Google Scholar databases were searched for whole-brain functional MRI studies that compared psychiatric patients and normal controls. The psychiatric disorders included schizophrenia (SCZ), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder, attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). Studies using go-nogo paradigms were selected, we then conducted activation likelihood estimation (ALE) meta-analysis, factor analysis, and regression analysis on these studies subsequently.</p><p><strong>Results: </strong>A total of 152 studies (108 with patients) were selected and a consistent pattern was found, that is, decreased activities in the same brain regions across six disorders. Factor analysis clustered six disorders into three pairs: SCZ and ASD, MDD and BD, and ADHD and BD. Furthermore, the heterogeneity of SCZ and ASD was located in the left and right thalamus; and the heterogeneity of MDD and BD was located in the thalamus, insula, and superior frontal gyrus.</p><p><strong>Conclusion: </strong>The results can lead to a new classification method for psychiatric disorders, benefit the differential diagnosis at an early stage, and help to understand the biobasis of psychiatric disorders.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"67 1","pages":"e69"},"PeriodicalIF":7.2,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}