European Psychiatry最新文献

{"title":"Impaired health-related quality of life, and depressive symptoms in a cohort of healthy adults with symptoms of attention deficit/hyperactivity disorder.","authors":"Annemette Hald, Ole Birger Pedersen, Kristoffer Sølvsten Burgdorf, Lise W Thørner, Christina Mikkelsen, Lea A N Christoffersen, Henrik Ullum, Henrik Hjalgrim, Christian Erikstrup, Mie T Bruun, Bitten Aagaard, Susan Mikkelsen, Thomas F Hansen, Thomas Werge, Andrew J Schork, Sisse Rye Ostrowski, Maria Didriksen","doi":"10.1192/j.eurpsy.2025.30","DOIUrl":"10.1192/j.eurpsy.2025.30","url":null,"abstract":"<p><strong>Background: </strong>Attention deficit/hyperactivity disorder (ADHD) prevalence has increased in the last 10 years, most likely due to increased recognition by clinicians. Even so, an issue with under-diagnostics may persist. Historically ADHD has been described as a male-dominant disorder. However, recent evidence shows that ADHD prevalence is similar between the sexes, but that the related impairment or symptomatology might vary. This study estimated the prevalence of undiagnosed ADHD symptoms (pADHD) and explored the sex-stratified symptomatology and associations with self-perceived health-related quality of life (HRQL) and experience of depressive symptoms.</p><p><strong>Methods: </strong>This was done in a unique cohort of 50,937 healthy blood donors - individuals who successfully maintain regular commitments despite potential ADHD symptoms. ADHD symptoms were estimated using the Adult ADHD Self-Report Scale (ASRS), health-related quality of life (HRQL) measured using mental and physical component scores (MCS/PCS) estimated based on a 12-item Short-Form Health Survey (SF-12) with a higher score indicating better HRQL, and depressive symptoms were measured using Major Depression Inventory (MDI) with higher score indicating more depressive symptoms.</p><p><strong>Results: </strong>In total, 3% were classified with pADHD (sex ratio 1:1). pADHD was associated with reduced MCS and PCS, and increased MDI score. Males scored on average higher on inattentive symptoms compared to females, whereas females scored on average higher on hyperactive-impulsive symptoms. Individuals scoring high on the combined inattentive and hyperactive-impulsive ADHD symptom presentation were most likely to be impaired in terms of higher MDI scores and lower PCS when compared to non-ADHD controls.</p><p><strong>Conclusions: </strong>In conclusion, ADHD symptoms are common in this seemingly healthy and undiagnosed population. Symptom presentations differ between sexes and the type of presentation seems to impact the association with depressive symptoms and level of reduced HRQL.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e44"},"PeriodicalIF":7.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal risk among adolescent psychiatric inpatients: the role of insomnia, depression, and social-personal factors.","authors":"Valentina Baldini, Martina Gnazzo, Martina Maragno, Rebecca Biagetti, Camilla Stefanini, Francesco Canulli, Giorgia Varallo, Cristina Donati, Giovanni Neri, Andrea Fiorillo, Giuseppe Plazzi","doi":"10.1192/j.eurpsy.2025.29","DOIUrl":"10.1192/j.eurpsy.2025.29","url":null,"abstract":"<p><strong>Background: </strong>Adolescents with psychiatric disorders are at increased risk of suicide, with insomnia, depression, and social-personal factors playing pivotal roles. This study investigates the interplay between these factors in a sample of adolescent psychiatric inpatients in Italy, with a particular focus on their association with suicide attempts.</p><p><strong>Methods: </strong>We conducted a cross-sectional study on 95 adolescent inpatients (54 suicide attempters, 41 non-attempters) to explore their sociodemographic and clinical variables, including insomnia, depression, and social-personal factors as history of bullying. Logistic regression analyses and Pearson's correlations were used to identify significant predictors of suicide attempts and their interrelations.</p><p><strong>Results: </strong>Suicide attempters were predominantly female (90% vs. 75%, <i>p</i> = 0.04) and more likely to have a family psychiatric history (83% vs. 63%, <i>p</i> = 0.04), a history of bullying (26% vs. 9%, <i>p</i> = 0.01), and insomnia (79% vs. 53%, <i>p</i> = 0.01). Depression was strongly associated with suicide attempts (96% vs. 70%, <i>p</i> = 0.01), while physically active adolescents were significantly less likely to attempt suicide (27% vs. 53%, <i>p</i> = 0.01). Insomnia and depression were highly correlated (<i>r</i> = 0.94, <i>p</i> = 0.02), emphasizing the critical role of the former in emotional dysregulation. Behavioral factors, such as physical inactivity and bullying, emerged as additional key contributors to suicidal behavior.</p><p><strong>Conclusion: </strong>This study highlights the multifaceted nature of suicide risk in adolescent psychiatric inpatients, with sleep disturbances, depression, and behavioral factors playing central roles. These findings underscore the need for integrated interventions targeting sleep, emotional regulation, and behavioral vulnerabilities to mitigate suicide risk.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e42"},"PeriodicalIF":7.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could the mood disorder symptoms can be predict by metabolic disturbances? - CORRIGENDUM.","authors":"J Rog, M Futyma-Jędrzejewska, D Juchnowicz, R Karpiński, H Karakula-Juchnowicz","doi":"10.1192/j.eurpsy.2025.17","DOIUrl":"10.1192/j.eurpsy.2025.17","url":null,"abstract":"","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"68 1","pages":"e31"},"PeriodicalIF":7.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADHD symptom trajectories across childhood and early adolescence and risk for hypomanic symptoms in young adulthood.","authors":"Buse Beril Durdurak, Isabel Morales-Muñoz, Georgina Mayling Hosang, Steven Marwaha","doi":"10.1192/j.eurpsy.2025.24","DOIUrl":"10.1192/j.eurpsy.2025.24","url":null,"abstract":"<p><strong>Background: </strong>There is increasing evidence that childhood Attention-Deficit Hyperactivity Disorder (ADHD) elevates the risk of later Bipolar Spectrum Disorder (BD). However, it remains unclear whether different trajectories of ADHD symptoms confer differential risk for BD.</p><p><strong>Methods: </strong>Data from the Avon Longitudinal Study of Parents and Children were available from 7811 children at age 8 years, 7435 at 10, 6798 at 13, and 1217 at 21-23 years. ADHD symptoms were assessed at 8, 10, and 13 years with the Development and Well-Being Assessment. Clinically significant hypomanic symptoms (CSHS) at 21-23 years were assessed using the Hypomania Symptom Checklist (HCL-32). Group trajectories of ADHD and its subtypes were estimated using latent class growth analysis. The prospective associations between different ADHD trajectories and CSHS were tested using logistic regression analysis.</p><p><strong>Results: </strong>Persistently high, increasing, remitting, and persistently low ADHD symptom trajectories were identified for the three ADHD-related categories. Individuals with persistently high and increasing levels of ADHD symptoms had increased odds of CSHS compared to persistently low class. Sensitivity analyses validated these results. In separate analyses, persistently high levels of hyperactivity and inattentive, and increasing levels of inattentive symptoms were also independently associated with CSHS.</p><p><strong>Conclusions: </strong>Young people with a longitudinal pattern of high and increasing ADHD symptoms are at higher risk for developing CSHS in young adulthood compared to individuals with low symptom patterns. These two trajectories in childhood and adolescence may represent distinct phenotypic risk profiles for subsequently developing BD and be clinically significant targets for prevention and treatment of BD.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e37"},"PeriodicalIF":7.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic links between symptoms of eating disorders and suicidal ideation.","authors":"Agnieszka Musial, Una Foye, Saakshi Kakar, Tom Jewell, Janet Treasure, Gursharan Kalsi, Iona Smith, Laura Meldrum, Shannon Bristow, Ian Marsh, Chelsea Mika Malouf, Jahnavi Arora, Helena Davies, Rina Dutta, Ulrike Schmidt, Gerome Breen, Moritz Herle","doi":"10.1192/j.eurpsy.2025.25","DOIUrl":"10.1192/j.eurpsy.2025.25","url":null,"abstract":"","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"1-31"},"PeriodicalIF":7.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How should professional psychiatric associations respond to a large-scale disaster?","authors":"Emre Mutlu, Alper Bülbül, Emre Cem Esen, İrem Ekmekçi Ertek, H Rengin Güvenç, Koray Başar, M Hamid Boztaş, M İrem Yıldız, Münevver Hacıoğlu Yıldırım, Rümeysa Taşdelen, Ejder Akgün Yıldırım","doi":"10.1192/j.eurpsy.2025.23","DOIUrl":"10.1192/j.eurpsy.2025.23","url":null,"abstract":"<p><p>Disasters pose unique challenges, triggering significant psychological and social crises with both short- and long-term impacts. In this article, we address the critical role of professional psychiatric associations (PPAs) in responding to large-scale disasters, emphasizing the operational model connected with the Psychiatric Association of Türkiye's (PAT) response to the 2023 earthquakes in Türkiye and Northern Syria. We propose the SOLIDARITE model, a structured response framework, which incorporates sustained preparedness, organized networks, resource libraries, on-site and remote interventions, and comprehensive disaster planning across early, middle, and long-term phases. The model emphasizes a multidimensional approach integrating pre-disaster preparedness through training, various psychosocial support options, the establishment of networks, and the formulation of a master disaster response plan. The implementation of this model by PAT during the 2023 earthquakes facilitated an effective and prompt response, underlining the importance of PPAs' role in disaster preparedness and action. The SOLIDARITE model supports the need for deeper integration of disaster psychiatry into psychiatric training and calls for national and international collaboration to enhance the preparedness and response capacity of PPAs.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e40"},"PeriodicalIF":7.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression.","authors":"Jacob J Crouse, Shin Ho Park, Brittany L Mitchell, Enda M Byrne, Sarah E Medland, Tian Lin, Jan Scott, Zsofi de Haan, Emiliana Tonini, Frank Iorfino, Naomi R Wray, Nicholas G Martin, Ian B Hickie","doi":"10.1192/j.eurpsy.2025.20","DOIUrl":"10.1192/j.eurpsy.2025.20","url":null,"abstract":"<p><strong>Background: </strong>Increasing daylight exposure might be a simple way to improve mental health. However, little is known about daylight-symptom associations in depressive disorders.</p><p><strong>Methods: </strong>In a subset of the Australian Genetics of Depression Study (<i>N</i> = 13,480; 75% female), we explored associations between self-reported number of hours spent in daylight on a typical workday and free day and seven symptom dimensions: depressive (overall, somatic, psychological); hypo-manic-like; psychotic-like; insomnia; and daytime sleepiness. Polygenic scores for major depressive disorder (MDD); bipolar disorder (BD); and schizophrenia (SCZ) were calculated. Models were adjusted for age, sex, shift work status, employment status, season, and educational attainment. Exploratory analyses examined age-stratified associations (18-24 years; 25-34 years; 35-64 years; 65 and older). Bonferroni-corrected associations (<i>p</i> < 0.004) are discussed.</p><p><strong>Results: </strong>Adults with depression reported spending a median of one hour in daylight on workdays and three hours on free days. More daylight exposure on workdays and free days was associated with lower depressive (overall, psychological, somatic) and insomnia symptoms (<i>p</i>'s<0.001), but higher hypo-manic-like symptoms (<i>p</i>'s<0.002). Genetic loading for MDD and SCZ were associated with less daylight exposure in unadjusted correlational analyses (effect sizes were not meaningful). Exploratory analyses revealed age-related heterogeneity. Among 18-24-year-olds, no symptom dimensions were associated with daylight. By contrast, for the older age groups, there was a pattern of more daylight exposure and lower insomnia symptoms (<i>p</i> < 0.003) (except for 25-34-year-olds on free days, <i>p</i> = 0.019); and lower depressive symptoms with more daylight on free days, and to some extent workdays (depending on the age-group).</p><p><strong>Conclusions: </strong>Exploration of the causal status of daylight in depression is warranted.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e41"},"PeriodicalIF":7.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating plasticity into precision psychiatry.","authors":"Igor Branchi","doi":"10.1192/j.eurpsy.2025.19","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2025.19","url":null,"abstract":"","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"1-12"},"PeriodicalIF":7.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The epidemiology and phenomenology of non-antipsychotic-induced dystonia: a hybrid systematic-narrative review.","authors":"Kirsten Catthoor, Johan Detraux, Marc De Hert","doi":"10.1192/j.eurpsy.2025.18","DOIUrl":"10.1192/j.eurpsy.2025.18","url":null,"abstract":"<p><strong>Background: </strong>Medication-induced dystonia (MID) is a movement disorder (MD), characterized by involuntary sustained or intermittent muscle contractions, causing abnormal, often repetitive, movements, postures, or both. Although MID is commonly associated with the use of antipsychotics, it also occurs with many other medications widely used in clinical practice.</p><p><strong>Methods: </strong>A systematic literature search (from inception to November 2023), using the PubMed and Embase databases, was conducted without language restriction for articles reporting on MID in people without pre-existing MDs, and this for all potentially relevant non-antipsychotic medications. A narrative synthesis of the available evidence was undertaken.</p><p><strong>Results: </strong>MID is common (1 to 10%) with certain antiemetics. Selective serotonin reuptake inhibitors and the antiepileptics valproate, carbamazepine, and lamotrigine are rarely (0.01 to 0.1%) or very rarely (<0.01%) associated with MID. All other medications are very rarely (<0.01%) associated with MID or have a risk that cannot be precisely estimated. The actual rate of dystonic reactions with most non-antipsychotic agents remains unknown, owing to misdiagnosis and underreporting in the scientific literature. In general, MID seems to occur more often in children and adolescents, even with a single low dose, and with polymedication. In most cases, MID is acute in onset (occurring within hours to days) and involves the head and neck.</p><p><strong>Conclusions: </strong>Although MID is most common with dopamine receptor-blocking antiemetics, many other medications may also produce dystonic reactions, particularly in children and adolescents. Although such incidents remain rare, there are indications that MID is underreported for many classes of medications.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e36"},"PeriodicalIF":7.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of diagnosis in mental health: Promises and challenges of biomarkers to identify reliable and highly predictive biosignatures of affective disorders.","authors":"Alessandra Berry, Mario Luciano, Francesca Cirulli, Andrea Fiorillo","doi":"10.1192/j.eurpsy.2025.15","DOIUrl":"10.1192/j.eurpsy.2025.15","url":null,"abstract":"<p><p>Current evidence points to a research-practice gap in mental health. There is a specific unmet need to identify novel strategies to improve diagnostic criteria, especially when clinical manifestations overlap as in the case of bipolar (BD) and major depressive disorder (MDD). Based on the rapidly evolving notion that affective disorders are characterized by disrupted brain-body communication, current efforts of neuropsychiatric research are converging towards the identification of specific clusters of peripheral interconnected biomarkers. We argue that these can capture the complexity of the disease as they are linked to the fundamental pathophysiological mechanisms underlying BD or MDD, and can thus deliver an unbiased biosignature. Here we provide a critical viewpoint on the promises and challenges of biomarkers to identify reliable biosignatures of affective disorders. Novel methodological insight and relevant biomarkers are discussed with a main focus on immunometabolic derangements and disrupted redox balance. Major advancements are reviewed taking into consideration that an unbiased diagnosis can only derive from a deep understanding of how biological, psychological, and social factors interact ultimately affecting the clinical manifestation of affective disorders.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e32"},"PeriodicalIF":7.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}