European Psychiatry最新文献

{"title":"Sleep-administered ketamine/psychedelics: A streamlined strategy to address two challenges in research on ketamine and psychedelics.","authors":"Shokouh Arjmand, Mats B Lindström, Carl M Sellgren, Gregers Wegener","doi":"10.1192/j.eurpsy.2025.14","DOIUrl":"10.1192/j.eurpsy.2025.14","url":null,"abstract":"<p><p>The dissociative effects of ketamine and psychedelics might be associated with their rapid antidepressant properties, raising questions about whether these effects are necessary for their therapeutic action. Additionally, the distinct dissociative experiences often reported by patients in clinical trials may reveal whether they receive an active treatment or a placebo, potentially introducing bias into the results. In this viewpoint, we propose administering ketamine/psychedelics to patients during sleep, offering a novel approach to address and explore these challenges.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e29"},"PeriodicalIF":7.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory disease in people with major depressive disorder: A systematic review and Meta-analysis.","authors":"Ana Jiménez-Peinado, David Laguna-Muñoz, María José Jaén-Moreno, Cristina Camacho-Rodríguez, Gloria Isabel Del Pozo, Eduard Vieta, Javier Caballero-Villarraso, Fernando Rico-Villademoros, Fernando Sarramea","doi":"10.1192/j.eurpsy.2025.13","DOIUrl":"10.1192/j.eurpsy.2025.13","url":null,"abstract":"<p><strong>Background: </strong>Living with major depressive disorder (MDD) reduces life expectancy, with respiratory disease being a significant threat. However, evidence on respiratory disease in this population has not yet been meta-analyzed.</p><p><strong>Methods: </strong>This meta-analysis examines respiratory disease prevalence and odds ratio (OR) in patients with MDD and treatment resistant depression (TRD). A systematic literature search was conducted, with a snowball search of reference and citation lists. Inclusion criteria covered studies in MDD and TRD patients with confirmed diagnoses of respiratory diseases (asthma, chronic obstructive pulmonary disease [COPD], pneumonia, lung cancer, and tuberculosis), comparing with a control group when possible.</p><p><strong>Results: </strong>From 4,138 retrieved articles, 15 (including 476,927 individuals with MDD, 50,680 with TRD, and 1,108,979 control group) met the inclusion criteria. In MDD patients, COPD prevalence was 9.0% (95% CI: 3.8-19.6%), asthma 8.6% (95% CI: 5.7-12.8%), and pneumonia 2.5% (95% CI: 2.2-2.9%). In TRD patients, COPD prevalence was 9.9% (95% CI: 4.2-21.9%) and asthma 10.9% (95% CI: 10.7-11.2%), but meta-analysis limited to those diseases showed no significant relative risk differences. Compared to the general population, individuals with MDD had significantly higher rates of COPD (OR 1.79, 95% CI: 1.49-2.16), even higher in younger populations (1.85 [95% CI: 1.74-1.97]) and more prevalent in women.</p><p><strong>Conclusions: </strong>This first meta-analysis on this topic shows that MDD is associated with an increased risk of respiratory illness compared to the general population. The prevalence of asthma doubles the mean described in the general population worldwide, and in COPD, women and younger people are at particular risk. Prevention policies are urgently needed.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e34"},"PeriodicalIF":7.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychiatric adverse events associated with Glucagon-like peptide-1 receptor agonists: a pharmacovigilance analysis of the FDA Adverse Event Reporting System database.","authors":"Wenchao Lu, Shihan Wang, Huilin Tang, Tao Yuan, Wei Zuo, Yuling Liu","doi":"10.1192/j.eurpsy.2024.1803","DOIUrl":"10.1192/j.eurpsy.2024.1803","url":null,"abstract":"<p><strong>Background: </strong>Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used due to their profound efficacy in glycemic control and weight management. Real-world observations have revealed potential neuropsychiatric adverse events (AEs) associated with GLP-1RAs. This study aimed to comprehensively investigate and characterize these neuropsychiatric AEs with GLP-1RAs.</p><p><strong>Methods: </strong>We analyzed GLP-1RA adverse reaction reports using the FDA Adverse Event Reporting System database. Disproportionality analysis using reporting odds ratio (ROR) identified eight categories of neuropsychiatric AEs associated with GLP-1RAs. We conducted descriptive and time-to-onset (TTO) analyses and explored neuropsychiatric AE signals among individual GLP-1RAs for weight loss and diabetes mellitus (DM) indications.</p><p><strong>Results: </strong>We identified 25,110 cases of GLP-1RA-related neuropsychiatric AEs. GLP-1RAs showed an association with headache (ROR 1.74, 95% confidence interval [CI] 1.65-1.84), migraine (ROR 1.28, 95%CI 1.06-1.55), and olfactory and sensory nerve abnormalities (ROR 2.44, 95%CI 1.83-3.25; ROR 1.69, 95%CI 1.54-1.85). Semaglutide showed a moderate suicide-related AEs signal in the weight loss population (ROR 2.55, 95%CI 1.97-3.31). The median TTO was 16 days (interquartile range: 3-66 days).</p><p><strong>Conclusions: </strong>In this study, we identified eight potential neuropsychiatric adverse events (AEs) associated with GLP-1RAs and, for the first time, detected positive signals for migraine, olfactory abnormalities, and sensory abnormalities. We also observed positive suicide-related signals of semaglutide, in weight loss population. This study provides a reliable basis for further investigation of GLP-1RA-related neuropsychiatric AEs. However, as an exploratory study, our findings require confirmation through large-scale prospective studies.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"68 1","pages":"e20"},"PeriodicalIF":7.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11823005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between antidepressants and risk of suicidal behavior and violent crimes in personality disorder.","authors":"Kimmo Herttua, Giulio Scola, Tapio Paljarvi, Seena Fazel","doi":"10.1192/j.eurpsy.2025.16","DOIUrl":"10.1192/j.eurpsy.2025.16","url":null,"abstract":"<p><strong>Background: </strong>Despite uncertain benefits, antidepressants are used in the management of personality disorders (PDs). We investigated the association between antidepressants and two adverse outcomes - suicidal behaviour and violent crimes - in individuals with PDs.</p><p><strong>Methods: </strong>We used nationwide Danish healthcare registries to identify all individuals with a diagnosed PD aged 18-64 years from 2007 to 2016. Antidepressant use was identified using dispensed prescriptions. Individuals were followed up for healthcare presentations of suicidal behaviour and separately for police-recorded charges of violent crimes. We applied a within-individual design comparing rates of suicidal behaviour and violent crimes during time periods of antidepressant treatment with periods without treatment. Subgroup analyses were performed according to PD clusters, individual antidepressants, specific PDs, psychiatric comorbidities, and history of suicidal behaviour and violent crime.</p><p><strong>Results: </strong>The cohort included 167,319 individuals with a diagnosed PD, 19,519 (12%) of whom were prescribed antidepressants and presented at least one outcome event during follow-up, making them eligible for within-individual analyses. Overall, we found an association with lower rates of suicidal behavior during periods of antidepressant treatment, compared with periods when individuals were not on antidepressants (incidence rate ratio 0.86, 95% CI 0.84-0.89). However, this association was modified by specific PDs, individual antidepressants, comorbidities, and past history. For violent crimes, we did not observe consistent associations in any direction.</p><p><strong>Conclusions: </strong>Antidepressants were associated with lower rates of suicidal behaviour, but less clearly in violent crimes. Types of PDs, individual antidepressants, and comorbidities modified these associations.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e28"},"PeriodicalIF":7.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing the EPA guidance of pharmacological treatment of schizophrenia - results of a Delphi process.","authors":"Peter Falkai, Elias Wagner, Miriam John, Vladislav Yakimov, Silvana Galderisi, Istvan Bitter, Geert Dom, Andrea Schmitt, Wolfgang Gaebel, Bernardo Carpiniello, Alkomiet Hasan","doi":"10.1192/j.eurpsy.2024.1794","DOIUrl":"10.1192/j.eurpsy.2024.1794","url":null,"abstract":"<p><strong>Background: </strong>The development of guidelines is time-consuming and cost-intensive. The heterogeneity of clinical practice, evidence, and patients' needs is an issue across Europe. An European core guidance for a specific psychiatric disorder may help to overcome this issue. Here, we present a progress report on the European Psychiatric Association (EPA) proof-of-concept approach to develop a European consensus guidance on the pharmacological treatment of schizophrenia.</p><p><strong>Methods: </strong>All national psychiatric associations in Europe were contacted to provide their schizophrenia guidelines. Six guidelines were rated by three experts, experienced in the development of national and international guidelines, from three different countries (Italy, Hungary, and Germany), and the German schizophrenia guideline published in 2019 was found to have the highest quality. For this proof-of-concept approach, 45 recommendations on the pharmacological treatment of schizophrenia from the German guideline were evaluated in a two-step Delphi process to determine their acceptability throughout the European continent.</p><p><strong>Results: </strong>44 experts participated in the first round and 40 experts in the second round of the Delphi process. Agreement among the involved experts was reached for 75% of the presented recommendations from the German schizophrenia guidelines. 11 out of 45 recommendations (24.4%) did not reach this level of agreement.</p><p><strong>Conclusions: </strong>This progress report highlights the possibility of developing a pan-European core guidance on the pharmacological treatment of schizophrenia by adapting national guidelines and reconciling their recommendations. However, several barriers in this adaptation process, such as non-agreement in recommendations with strong scientific evidence in the reconciling process, were identified and must be considered when developing the final guidance.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e26"},"PeriodicalIF":7.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of social distancing on mental health during the COVID-19 pandemic: a nationwide study of 4.6 million Danish adults.","authors":"Andreas Geest, Barbara Bonnesen, Alexander Jordan, Louise Tønnesen, Valdemar Rømer, Charlotte S Ulrik, Zitta Harboe, Josefin Eklöf, Pradeesh Sivapalan, Jens-Ulrik Stæhr Jensen","doi":"10.1192/j.eurpsy.2025.5","DOIUrl":"10.1192/j.eurpsy.2025.5","url":null,"abstract":"<p><strong>Background: </strong>Current knowledge on psychiatric illness following periods of social distancing during the COVID-19 pandemic is mostly limited to smaller studies in selected populations. This nationwide study of all 4.6 million Danish adults examined if periods of social distancing were associated with changes in surrogate measures of mental health.</p><p><strong>Methods: </strong>All Danish adults (≥18 years) were included and rates of collection of antidepressant prescriptions, psychiatric hospital admissions, and suicide or suicide attempts for the periods March 12, 2020-May 20, 2020 (lockdown period 1), and December 21, 2020-March 1, 2021 (lockdown period 2), were compared to corresponding periods 1 year prior. Individuals were censored due to death or SARS-CoV-2 infection.</p><p><strong>Results: </strong>Antidepressant consumption increased for both period 1 and period 2, with an incidence rate ratio (IRR) of 1.02 (95% CI: 1.01-1.02, <i>p</i> < 0.001) and IRR 1.08 (95% CI: 1.08-1.09<i>, p</i> < 0.001) respectively, compared to the control periods. Psychiatric hospitalization rates decreased significantly, with an IRR of 0.65 (95% CI: 0.63-0.66, <i>p</i> < 0.001) for period 1, and IRR 0.86 (95% CI: 0.84-0.88, <i>p</i> < 0.001) for period 2. The risk of suicide did not increase in period 1, IRR 0.96 (95% CI: 0.82-1.13, <i>p</i> = 0.64), but seemed increased during period 2, IRR 1.19 (95% CI: 1.02-1.38, <i>p</i> = 0.03).</p><p><strong>Conclusion: </strong>Periods of social distancing during the COVID-19 pandemic were associated with an increase of antidepressant consumption, but decreased rates of psychiatric hospitalization. Suicide risk seemed increased during the second lockdown period.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e30"},"PeriodicalIF":7.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European Psychiatry: 2024 in review.","authors":"Sophia Frangou, Andrea Fiorillo","doi":"10.1192/j.eurpsy.2025.4","DOIUrl":"10.1192/j.eurpsy.2025.4","url":null,"abstract":"","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"1-7"},"PeriodicalIF":7.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts.","authors":"Amelia J Edmondson-Stait, Ella Davyson, Xueyi Shen, Mark James Adams, Golam M Khandaker, Veronique E Miron, Andrew M McIntosh, Stephen M Lawrie, Alex S F Kwong, Heather C Whalley","doi":"10.1192/j.eurpsy.2025.7","DOIUrl":"10.1192/j.eurpsy.2025.7","url":null,"abstract":"<p><strong>Background: </strong>Peripheral inflammatory markers, including serum interleukin 6 (IL-6), are associated with depression, but less is known about how these markers associate with depression at different stages of the life course.</p><p><strong>Methods: </strong>We examined the associations between serum IL-6 levels at baseline and subsequent depression symptom trajectories in two longitudinal cohorts: ALSPAC (age 10-28 years; <i>N</i> = 4,835) and UK Biobank (39-86 years; <i>N</i> = 39,613) using multilevel growth curve modeling. Models were adjusted for sex, BMI, and socioeconomic factors. Depressive symptoms were measured using the Short Moods and Feelings Questionnaire in ALSPAC (max time points = 11) and the Patient Health Questionnaire-2 in UK Biobank (max time points = 8).</p><p><strong>Results: </strong>Higher baseline IL-6 was associated with worse depression symptom trajectories in both cohorts (largest effect size: 0.046 [ALSPAC, age 16 years]). These associations were stronger in the younger ALSPAC cohort, where additionally higher IL-6 levels at age 9 years was associated with worse depression symptoms trajectories in females compared to males. Weaker sex differences were observed in the older cohort, UK Biobank. However, statistically significant associations (pFDR <0.05) were of smaller effect sizes, typical of large cohort studies.</p><p><strong>Conclusions: </strong>These findings suggest that systemic inflammation may influence the severity and course of depressive symptoms across the life course, which is apparent regardless of age and differences in measures and number of time points between these large, population-based cohorts.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e27"},"PeriodicalIF":7.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to improve psychiatric nosography in the XXI century: a phenomenologist\"s viewpoint.","authors":"Giovanni Stanghellini","doi":"10.1192/j.eurpsy.2025.11","DOIUrl":"10.1192/j.eurpsy.2025.11","url":null,"abstract":"<p><p>Classifications of mental disorders reflect much more the minds of psychiatrists than the patients' minds since these classifications are more focused on the interests of stakeholders (including governmental agencies, advocacy groups, medical insurance, and pharmaceutical companies) than on the experiences of patients. We live in times of rapid socio-cultural changes, and respective changes in the forms of mental suffering are increasingly characterized by fragmentariness and episodicity. These new forms of suffering may escape nosographic framing based on the identification of symptoms and syndromes. A paradigm shift in the psychiatric nosography is necessary. The way forward could be to enhance the ability of clinicians to grasp the \"fragments\" provided by patients rather than aggregations of symptoms. \"Existential knots\" can manifest themselves in these fragments to be used as \"floating buoys\" for clinical navigation, in the absence of exhaustive and detailed \"maps\" of the symptoms and syndromes that afflict patients. A tentative collection of these existential knots is provided, building on and extending the legacy of existential philosophy and phenomenological psychopathology.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e25"},"PeriodicalIF":7.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excess costs of post-traumatic stress disorder related to child maltreatment in Germany.","authors":"Thomas Grochtdreis, Hans-Helmut König, Falk Leichsenring, Manfred E Beutel, Lila Feix, Harald Gündel, Andrea Hermann, Melissa Hitzler, Christine Knaevelsrud, Iris-Tatjana Kolassa, Johannes Kruse, Helen Niemeyer, Fatima Nöske, Simone Salzer, Karoline Sophie Sauer, Patrick Schuster, Christiane Steinert, Kerstin Weidner, Jörn von Wietersheim, Jürgen Hoyer, Judith Dams","doi":"10.1192/j.eurpsy.2025.6","DOIUrl":"10.1192/j.eurpsy.2025.6","url":null,"abstract":"<p><strong>Background: </strong>Childhood maltreatment (CM) significantly increases the risk of developing post-traumatic stress disorder (PTSD) for which the prevalence in Europe is higher than initially assumed. While the high economic burden of PTSD is well-documented, little is known about the health care cost differences between individuals with PTSD-CM and those without PTSD in Germany. This study aimed to determine the excess health care and absenteeism costs associated with PTSD-CM in Germany.</p><p><strong>Methods: </strong>Baseline data from a multi-center randomized controlled trial on individuals with PTSD-CM (n = 361) were combined with data from individuals without PTSD (n = 4760). Entropy balancing was used to balance the data sets with regard to sociodemographic characteristics. Six-month excess health care costs from a societal perspective were calculated for 2022, using two-part models with logit specification for the first part and a generalized linear model for the second part.</p><p><strong>Results: </strong>The total six-month excess costs associated with PTSD-CM were €8864 (95% CI: €6855 to €10,873) per person. Of this, the excess health care costs accounted for €4647 (95% CI €3296 to €5997) and the excess costs of absenteeism for €4217 (95% CI: €3121 to €5314). Individuals with mild to moderate PTSD symptoms incurred total excess costs of €6038 (95% CI: €3879 to €8197), while those with severe to extreme symptoms faced €11,433 (95% CI: €8220 to €14,646).</p><p><strong>Conclusions: </strong>Excess health care and absenteeism costs associated with PTSD-CM were substantial, with absenteeism accounting for roughly half of the total excess costs.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":" ","pages":"e24"},"PeriodicalIF":7.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}