Journal of neonatal-perinatal medicine最新文献

{"title":"Applications of lung ultrasound as an emerging tool in neonates.","authors":"Aimann Surak, Huma Shaireen, Yasser Elsayed","doi":"10.1177/19345798251325492","DOIUrl":"https://doi.org/10.1177/19345798251325492","url":null,"abstract":"<p><p>Lung ultrasound is increasingly used in neonatal intensive care units. We summarized the ultrasonographic patterns, features of most neonatal respiratory morbidities, and clinical application in neonates. Lung ultrasound is a non-invasive, radiation-free, and reproducible adjunct tool that can guide the clinical management of neonates presenting with respiratory distress.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"187-196"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study between nebulized and intravenous magnesium sulfate for treatment of persistent pulmonary hypertension in neonates.","authors":"Nashwa Farouk Mohamed, Osama Abu El Fetouh Zaki El Feky, Heba Morsy Saad El Din El Ganady, Walid Abd Elatif Abd El Halim","doi":"10.1177/19345798251325510","DOIUrl":"https://doi.org/10.1177/19345798251325510","url":null,"abstract":"<p><p>BackgroundPersistent pulmonary hypertension of the newborn (PPHN) is a life-threatening condition resulting from elevated pulmonary vascular resistance, causing severe hypoxemia. Magnesium sulfate (MgSO₄) is a potent vasodilator used in PPHN treatment, but its intravenous administration can cause systemic side effects. This study aims to compare the effects of nebulized and intravenous MgSO₄ on oxygenation and hemodynamic parameters in neonates with severe PPHN.MethodsThis non-randomized controlled study was conducted on 40 mechanically ventilated neonates with severe PPHN at Benha University Hospitals. Neonates were divided into two groups: one received nebulized MgSO₄ (NebMag, <i>n</i> = 20) and the other intravenous MgSO₄ (IVMag, <i>n</i> = 20). Primary outcome was the change in Oxygenation Index (OI) at 12 and 24 hours. Secondary outcomes included changes in mean arterial pressure (MABP), serum magnesium levels, and vasoactive inotropic score (VIS).ResultsBoth groups showed improvements in oxygenation and ventilatory parameters. However, after 24 hours, the NebMag group had significantly lower OI (19.75 ± 2.9 vs 22.1 ± 2.19, <i>p</i> = 0.032) and higher PaO₂ (69.45 ± 7.56 mmHg vs 60.75 ± 5.9 mmHg, <i>p</i> = 0.008). MABP was significantly higher and VIS was lower in the NebMag group at all time points. Serum magnesium levels were significantly lower in the NebMag group at 12 hours (3.6 ± 0.18 vs 1.2 ± 0.17 mmol/L, <i>p</i> < 0.001).ConclusionNebulized MgSO₄ may offer a safer alternative to intravenous administration, providing effective pulmonary vasodilation with fewer systemic side effects in neonates with PPHN.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"246-254"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Story-Telling Attention-Refocusing (STAR) intervention to alleviate acute stress in parents of infants in the NICU.","authors":"Anisia Wong, Sandra Fucile","doi":"10.1177/19345798251324449","DOIUrl":"10.1177/19345798251324449","url":null,"abstract":"<p><p>IntroductionAdmission of an infant to the neonatal intensive care unit (NICU) is a stressful event for parents. The physical separation and inability to hold their child due to minimal handling protocols or infection control such as in the recent COVID-19 pandemic is a major contributor to parental stress. Knowledge on a contact-free parent administered intervention to reduce the stress of parents whose infant necessitates neonatal intensive care is lacking.ObjectiveTo assess the effect of a contact-free, Story-Telling Attention-Refocusing (STAR) intervention on the acute stress of parents whose infant is in the NICU.MethodsA block-randomized controlled single-blind trial was conducted in a level II-III NICU. Parents in the experimental group provided the STAR intervention which consisted of designated prompts to share stories with their infants over a ten-minute period, three times per week, for 1 week. Parent acute stress was measured using the PSS:NICU questionnaire before and after the STAR intervention period, and differences in acute stress between mothers and fathers were assessed as well as parent satisfaction.ResultsTwenty-one parents completed the study. Results revealed that overall PSS:NICU stress scores lowered significantly within the intervention group (<i>p</i> = 0.04), and the intervention mediated acute stress of mothers and fathers differently (<i>p</i> = 0.01). Parents reported feeling overall satisfied with the STAR program and they felt less stressed in the hospital and more connected to their infants.ConclusionThe STAR program provides parents a unique opportunity to interact with their infant in a positive meaningful manner and may reduce acute stress in parents during their infants NICU stay.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"226-234"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between isolated oligohydramnios at term and risk of small for gestational age: A meta-analysis.","authors":"Amir Mohammad Salehi, Ensiyeh Jenabi","doi":"10.1177/19345798251324453","DOIUrl":"10.1177/19345798251324453","url":null,"abstract":"<p><p>BackgroundDue to the scarcity of available data on the association between isolated oligohydramnios and the risk of small for gestational age (SGA), we undertook a meta-analysis to investigate this relationship.MethodsPubMed (Medline), Web of Science, Scopus, and Science Direct were systematically queried up to February 26, 2024. Analysis was conducted using the random-effects model. Heterogeneity was evaluated among studies utilizing the chi-square test (χ²) and the I² statistic. Additionally, we conducted regression tests including Egger's and Begg's tests to assess publication bias. We employed the modified Newcastle-Ottawa Scale (NOS) to assess the quality of observational articles. Statistical significance was set at a <i>p</i>-value less than 0.05 using Stata software, version 13.ResultsIn the present meta-analysis, seven studies met the inclusion criteria and were included in the present systematic review and meta-analysis. The association between isolated oligohydramnios at term and the risk of SGA in crude studies was 2.22 (95% CI: 1.49, 2.94; I² = 82.5%). Conversely, in adjusted studies, the association was 2.18 (95% CI: 1.78, 2.57; I² = 0.0%).ConclusionThe present meta-analysis indicates that isolated oligohydramnios is a significant risk factor for the SGA. Therefore, monitoring to diagnose SGA should be done in mothers with isolated oligohydramnios.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"197-202"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of newborns' characteristics between neonates with proper and improper breastfeeding positions.","authors":"Maryam Zakerihamidi, Gholamali Maamouri, Abbas Boskabadi, Forough Rakhshanizadeh, Zahra Parvini, Asal Ramazani, Fatemeh Bagheri, Hassan Boskabadi","doi":"10.1177/19345798251327382","DOIUrl":"10.1177/19345798251327382","url":null,"abstract":"<p><p>IntroductionProper positioning for successful breastfeeding is important. The current study aimed to compare newborns' characteristics with proper and improper breastfeeding positions.MethodsThe current cross-sectional study was conducted on 591 neonates referred to the Neonatal Clinic, Ward, and Emergency Department of Ghaem Hospital in Mashhad, Iran, within 2019-2023. The subjects were selected through the availability sampling method. Neonates referred for the routine physical examination, jaundiced cases not requiring hospitalization, and newborns with hyperthermia and weight loss were included in the study. Neonates with less than 34 weeks of gestation, jaundiced cases requiring hospitalization, newborns with congenital anomalies, or those with confirmed infectious diseases were excluded from the study. Proper breastfeeding position was considered due to the status of attachment of the neonate to the mother's breast. The data collection tool was a researcher-made checklist, including laboratory data and maternal and neonatal characteristics. The data were analyzed using the t-test and chi-square test.ResultsAmong the 591 neonates, 466 (78.8%) and 125 (21.2%) subjects were nursed with proper and improper positioning, respectively. There were significant differences between the two groups in terms of admission weight (<i>p</i> = .000), daily weight loss (<i>p</i> = .000), daily weight loss percentage (<i>p</i> = .000), first breastfeeding time after delivery (<i>p</i> = .000), breastfeeding frequency (<i>p</i> = .000), breastfeeding duration (<i>p</i> = .002), urination frequency (<i>p</i> = .000), defecation frequency (<i>p</i> = .000), and serum levels of sodium (<i>p</i> = .000), urea (<i>p</i> = .000), creatinine (<i>p</i> = .000), hematocrit (<i>p</i> = .002), platelet count (<i>p</i> = .001), and blood glucose (<i>p</i> = .010). Moreover, lethargy, irritability, seizure, mucosal dryness, inverted fontanelle, hyperthermia, unsoftened breast after breastfeeding, nipple fissure, and pregnancy problems were higher in the group nursed with improper positioning than the other group.ConclusionIn our study, breast problems, feeding problems, hypernatremia, hyperuremia, and weight loss were more common in infants of mothers with improper positioning of breastfeeding. Therefore, it is recommended to provide mothers with appropriate training and strategies for proper breastfeeding position.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"218-225"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of neonatal near miss among neonates admitted at Bahir Dar public hospitals, North West Ethiopia: A case-control study.","authors":"Daniel Mekete Alemu, Eleni Admasu, Mekonnen Melkie, Asnake Gashaw Belayneh","doi":"10.1177/19345798251324513","DOIUrl":"https://doi.org/10.1177/19345798251324513","url":null,"abstract":"<p><p>BackgroundNeonatal near miss is a significant public health issue in Ethiopia. Previous studies have often overlooked health system-related and behavioral factors of neonatal near miss. This study aimed to identify determinants of neonatal near misses in Bahir Dar public hospitals to fill those gaps in the aforementioned studies.MethodsAn unmatched case-control study was conducted in Bahir Dar public hospitals from October to December 2022, involving 443 neonates (147 cases, 296 controls). Cases were recruited consecutively, while controls were selected using systematic sampling. Data were collected using a pre-tested structured interviewer-administered questionnaire at discharge and from patients' cards using Epicollect5. Data were analyzed with SPSS version 26 for bivariable and multivariable binary logistic regression at a 95% confidence interval (CI). The Hosmer and Lemeshow test checked the model fit, with <i>p</i>-value <0.05 considered significant.ResultsDeterminants of neonatal near misses included not receiving exclusive breastfeeding within an hour of delivery [AOR = 3.13, 95% CI: 1.25, 7.83], a history of pregnancy-induced hypertension [AOR = 5.55, 95% CI: 2.34, 12.85], fewer than four antenatal care visits [AOR = 8.38, 95% CI: 3.62, 19.44], and travel time over an hour to reach health facilities [AOR = 6.55, 95% CI: 2.56, 16.78].Conclusion and recommendationDelayed initiation of exclusive breastfeeding, pregnancy-induced hypertension, travel time to health facilities, and the number of antenatal care visits were key determinants of neonatal near miss. Enhancing maternal health services, such as exclusive breastfeeding practices, increasing antenatal visits, improving ambulance accessibility, and prioritizing mothers with pregnancy-induced hypertension, is essential.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"235-245"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malposition of a nasogastric tube into the middle ear of a premature one week old infant.","authors":"Abeer Alali, Sharon Cushing, Adrian James, Krista Marcotte, Noah Ditkofsky","doi":"10.1177/19345798251327369","DOIUrl":"10.1177/19345798251327369","url":null,"abstract":"<p><p>A significant number of pediatric patients require a nasogastric tube (NGT) during their hospital stay for indications including nutrition support, medication delivery and decompression of the gastrointestinal tract. As such NGT placement is commonly performed; however, misplacement can occur into other anatomic sites within proximity.Primary DiagnosisWe report a first in the literature case of NGT misplacement into the middle ear via the eustachian tube in a one-week-old premature infant that required an NGT for feeding support.Clinical FindingsThere was no reported resistance or concerns during NGT insertion; however, blood was noted in the syringe during aspiration performed to confirm tube position. A plain film radiograph and thereafter high-resolution computed tomography (HRCT) imagining confirmed the malposition of the tube within the middle ear.Interventions and OutcomesAfter transfer to a tertiary center, the NGT was removed without event in the neonatal intensive care unit (NICU) under direct vision with a flexible nasal endoscopy and successful replacement occurred thereafter. No injury to the middle ear structures or hearing occurred.Practice RecommendationsWhile not a common site of misplacement, nasogastric tubes can be misdirected via the eustachian tube into the middle ear. Imaging modalities such as plain film radiographs and computed tomography can be helpful when misplacement is suspected based on bedside assessment. Protocols for routine replacement of functional nasogastric tubes after specific time periods in an effort to prevent nasal alar or nasal cavity complications from pressure should consider the risk of misplacement and consequences thereof.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"282-284"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of stress-induced hemolysis in neonatal intravenous catheters: Theoretical and experimental analysis of shear stress, exposure time, and index of hemolysis.","authors":"Gordon Y Chang, Cynthia A Cox, Ellen A Kane, Giovanna Palermo Tye, Paul Fawcett, Thomas H Shaffer","doi":"10.1177/19345798251326071","DOIUrl":"10.1177/19345798251326071","url":null,"abstract":"<p><p>BackgroundSeveral studies report hemolysis when packed red blood cells (PRBCs) are transfused through small-inner-diameter (ID) catheters using presence of biomarkers but do not address cause and amount of hemolysis. This study aims to determine the cause and index of hemolysis percent (IH%) when PRBCs are infused through small-ID catheters.MethodsThe IH% was calculated using Giersiepen's empirical power law, which describes a relationship between hemolysis and magnitude of shear stress and exposure time. Six- and 27-day-old PRBCs were infused through five catheters with IDs of 0.20 mm to 0.70 mm at infusion rates of 3 mL and 10 mL/hour. Shear stress and exposure time were calculated. Data were analyzed as a function of catheter ID, infusion rates, and blood age.ResultsThe study demonstrated that shear stress was supraphysiologic during laminar flow in catheters with IDs of 0.20 mm and 0.28 mm. These catheters' IH% were ∼117 times higher at 3 mL/hour and ∼75 times higher at 10 mL/hour than catheters with larger IDs of 0.48 mm, 0.51 mm, and 0.70 mm. For blood age, in catheters with IDs of 0.20 mm and 0.28 mm, IH% was ∼155 times higher at 6 days and ∼76 times higher at 27 days than in catheters with IDs of 0.48 mm, 0.51 mm, and 0.70 mm.ConclusionsThis study demonstrated that when RBCs are subjected to supraphysiologic shear stress in catheters with IDs of ≤0.28 mm, index of hemolysis is greater than in catheters with IDs ≥0.48 mm.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"255-269"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal malignant pertussis and exchange transfusion: A case report.","authors":"Abdessamad Lalaoui, Ghizlane Kassal, Chaima Haidar, Khalid Abi El Aala, Fatiha Bennaoui, Nadia El Idrissi Slitine, Asma Hanchi, Nabila Soraa, Fadl Mrabih Rabou Maoulainine","doi":"10.1177/19345798251330800","DOIUrl":"https://doi.org/10.1177/19345798251330800","url":null,"abstract":"<p><p>Whooping cough (pertussis) is a bacterial infection caused by Bordetella pertussis. It poses a significant risk, especially in neonates. This contagious respiratory infection is transmitted via the aerosol route from human reservoirs. The severe form can lead to mortality in approximately 70% of cases. The aim of our study is to report the severity of malignant whooping cough in neonates and the potential contribution of exchange transfusion to improving prognosis. In this case, a 26-day-old infant presented with malignant whooping cough, confirmed by PCR testing. Initial clinical findings included tachycardia, fever, dyspnea, and right apical lesion with pulmonary arterial hypertension. Despite initial treatment with josamycin and supportive measures, the patient's condition deteriorated, requiring an exchange transfusion, which led to clinical improvement. The patient was successfully discharged after a 12-day hospitalization. Exchange transfusion should be considered for malignant whooping cough with leukocytosis and acute respiratory failure, but enhancing vaccination coverage remains the most effective prevention strategy.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251330800"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal inpatient stays longer than one year: Who was admitted, what happened, and how much did it cost?","authors":"Nihaal Shah, Angel Sunny, Fredrick Dapaah-Siakwan","doi":"10.1177/19345798251315153","DOIUrl":"10.1177/19345798251315153","url":null,"abstract":"<p><p>BackgroundAnecdotal evidence suggests that some preterm infants remain hospitalized for more than a year, but little is known about this population. We aimed to describe the characteristics, the hospital course, and the hospital costs for preterm hospitalizations with length of stay (LOS) ≥365 days.MethodsThis was a retrospective, descriptive cohort study of the 2016 and 2019 Kids Inpatient Database. ICD-10 codes were used to identify preterm infants, their comorbidities, and surgical interventions. The study population was dichotomized into LOS ≤364 days (PT364) and LOS ≥365 days (PT365) and compared using Chi-square or Mann-Whitney U test as appropriate. The exposure was PT365, and the outcomes were the characteristics, comorbidities, discharge disposition, and inflation-adjusted hospital costs.ResultsAmong 688,995 preterm infants, 111 had LOS ≥365 days (0.016%). Compared to PT364, PT365 were more likely to be males (74.6% vs 53.2%), of gestational age ≤27 weeks (71.5% vs 4.7%), and <1000 gm birthweight (64.2% vs 4.0%). PT365 were more likely to have a higher prevalence of comorbidities in each organ system, surgical and procedural interventions, and neonatal chronic complex conditions (872% vs 13.3%). PT365 were less likely to be discharged home (45.7% vs 93.4%) and more likely to be discharged to home healthcare (28.0% vs 5.7%) or to a skilled nursing facility (16.0% vs 0.8). The median hospital cost per surviving PT365 was $1,616,336.ConclusionPT365 was rare but was associated with complex chronic conditions, increased morbidity and surgical burden, and high inflation-adjusted hospital costs.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"173-178"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}