Journal of neonatal-perinatal medicine最新文献

{"title":"Early postoperative morbidity and mortality in neonatal intestinal obstruction: Predictors and challenges in a low-income country.","authors":"Saloua Ammar, Emna Krichen, Imen Sellami, Nadia Kolsi, Chiraz Rgaieg, Manel Kammoun, Anouar Jarraya, Amira Bouraoui, Nedia Hmida, Hayet Zitouni, Riadh Mhiri","doi":"10.1177/19345798251394353","DOIUrl":"10.1177/19345798251394353","url":null,"abstract":"<p><p>ObjectivesPreventable complicated outcomes and death from neonatal intestinal obstruction (NIO) need to be identified with insights into how to improve survival. This study aimed to evaluate the incidence and predictors of early postoperative morbidity and mortality (EPMM) in NIO.Material and methodsCharts of neonates with NIO operated between 2013 and 2023 were reviewed. The primary outcomes were the incidence of EPMM within 30 days. The secondary outcomes were the evaluation of the relationship between explanatory variables and EPMM using univariate and multivariate logistic regression.ResultsA total of 130 newborns were enrolled in the study. The most common etiology of NIO was anorectal malformations. Forty two patients (32.3%) presented associated congenital anomalies. The mean age at surgery was 4 days. The mean duration of the intervention was 105 min. The 30-day morbidity and mortality rates were, respectively, 36.5% and 23.1%. Sepsis was the most important postoperative complication. The independent risk factors of postoperative morbidity were the presence of associated malformations (<i>p</i> = 0.011, OR = 2.728, CI [1.255-5.931]) and prolonged duration of surgery (<i>p</i> = 0.039, OR = 2.361, CI [1.044-5.340]). The independent risk factors of early mortality were the low birth weight (<i>p</i> < 10-3, OR = 5,907, CI [2241-15,574]) and the prolonged duration of surgery (<i>p</i> = 0.009, OR = 3,643, CI [1381-9608]).ConclusionThis study underscores the high burden of EPMM in NIO from LICs. Sepsis, associated malformations, low birth weight, prematurity, and prolonged surgery were major contributors. Addressing these challenges through improved perioperative care, infection control, and healthcare infrastructure may improve outcomes in such settings.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"396-403"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of base excess in neonatal sepsis: A systematic review and meta-analysis.","authors":"Ghea Mangkuliguna, Muhammad Ifan Romli, Nicholas Adrianto","doi":"10.1177/19345798251394355","DOIUrl":"10.1177/19345798251394355","url":null,"abstract":"<p><p><b>Background:</b> Sepsis remains a significant cause of neonatal mortality and morbidity. Early diagnosis remains challenging due to nonspecific clinical presentation and limitations of current diagnostic approaches. Base excess (BE), derived from routine blood gas analysis, has emerged as a potential rapid biomarker reflecting metabolic disturbances associated with sepsis. We aim to evaluate the diagnostic and prognostic utility of BE in neonatal sepsis.<b>Methods:</b> A literature search was conducted across PubMed/MedLine, Scopus, Cochrane Library, EBSCOHost, and gray literature repositories from inception to July 2025. We included studies reporting BE measurement in neonatal sepsis. Two-by-two data were pooled using bivariate random-effects models to estimate sensitivity, specificity, and area under the curve (AUC). Mortality risk was assessed using odds ratios. This study followed the PRISMA guideline, and evidence certainty was evaluated using the GRADE methodology. The protocol has been registered in the PROSPERO (CRD42024601108).<b>Results:</b> Six studies were included in this meta-analysis. BE threshold ≤-5 mEq/L from arterial/capillary blood demonstrated a pooled sensitivity of 85.8% (95% CI: 59.9%-96.1%), a specificity of 82.9% (95% CI: 46.2%-96.5%), and an AUC of 0.909. Cord blood BE ≤ -10 mEq/L showed high specificity (96.7%, 95% CI: 91.5%-98.8%) but low sensitivity (10.3%, 95% CI: 6.5%-15.7%). Decreased BE levels were associated with increased mortality risk (OR 3.14; 95% CI: 1.34-7.36). The certainty of evidence was low.<b>Conclusion:</b> BE shows potential as a biomarker for neonatal sepsis. However, the low-certainty evidence underscores the need for further prospective validation and exploration of BE's role within combined biomarker algorithms before widespread clinical implementation.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"363-372"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-organ biomarkers for the identification of neonatal encephalopathy in the absence of traditional fetal acidemia: A three-year clinical cohort study.","authors":"M M Farag, M H Gouda, A S M El-Hadidi, E W Abd-El-Aziz","doi":"10.1177/19345798261460891","DOIUrl":"https://doi.org/10.1177/19345798261460891","url":null,"abstract":"<p><p>BackgroundTraditional diagnostic criteria for hypoxic-ischemic encephalopathy (HIE) rely heavily on documented fetal acidemia, which may be missing or unavailable in resource-limited settings. This study evaluated the diagnostic utility of multi-organ biomarkers in identifying neonates with HIE who do not meet classic acidemic criteria (\"non-classic HIE\").MethodsThis clinical population study analyzed 416 full-term and late-preterm neonates over 3 years at a tertiary neonatal intensive care unit (NICU). Participants were categorized into \"classic HIE\" (acidemia present) and \"non-classic HIE\" (no acidemia but presenting with clinical encephalopathy). Cardiac (Troponin-I), renal (urea/creatinine), hepatic (ALT/AST), and hematological (neutrophil-to-lymphocyte ratio [NLR]) biomarkers were evaluated to predict HIE severity and short-term outcomes.ResultsOf the cohort, 54.8% (n = 228) were classified into the non-classic HIE group. Within this group, 49.1% presented with mild, 43.4% with moderate, and 7.5% with severe clinical features, confirming systemic hypoxia despite \"normal or near-normal\" initial blood gases. Significant elevations in cardiac Troponin-I and AST were observed in the mild-to-severe classic HIE groups compared to the non-classic cohort (<i>p</i> < 0.001). Troponin-I showed high performance (AUC = 0.711) in predicting moderate-to-severe HIE across both cohorts. The NLR was significantly higher in all infants with clinical evidence of moderate-to-severe hypoxic insult.ConclusionsMulti-organ biomarkers, particularly Troponin-I and NLR, offer valuable adjunctive metrics reflecting the severity of systemic hypoxic insults. They assist in identifying asphyxiated neonates when early blood gases are inconsistently captured or fail to show fetal acidemia.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261460891"},"PeriodicalIF":1.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal vascular malperfusion and short-term outcomes: Does low grade matter?","authors":"Nestor Fernando Correa-Molano, Anggi Margarita Vélez-Bohórquez, Martin Alonso Rondón, Mercedes Olaya-C","doi":"10.1177/19345798261459413","DOIUrl":"https://doi.org/10.1177/19345798261459413","url":null,"abstract":"<p><p>IntroductionThis study aimed to evaluate the possible associations between specific fetal vascular malperfusion (FVM) findings-beyond standard high- and low-grade criteria-and fetal and neonatal clinical complications in a tertiary high-complexity hospital.MethodsWe conducted a retrospective, observational, descriptive cohort study of 706 placentas, correlating routine histological findings with maternal conditions and fetal and neonatal outcomes. Bivariate and multivariate logistic regression analyses were performed to explore potential associations between detailed microscopic features and clinical variables.ResultsA high frequency of FVM was observed in this high-risk population. Several histologic features were found to be associated with adverse perinatal outcomes, including cases classified as low-grade FVM. Similar patterns of association were observed between FVM and maternal pre-pregnancy conditions as well as gestational complications.DiscussionBecause FVM is typically diagnosed only after delivery, its clinical impact may be underrecognized. Our findings suggest a potential increased risk of neonatal and fetal complications in both low- and high-grade FVM. We highlight the importance of considering the temporal progression of fetal circulatory obstruction, from leukocyte stasis to calcified thrombi.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261459413"},"PeriodicalIF":1.0,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early cerebral hemodynamic assessment using resistive index and its correlation with neonatal outcomes.","authors":"Ting-An Hsia, Chia-Sui Chou, Wei-Yu Chen, Pei-Chen Tsao, Yu-Sheng Lee, Mei-Jy Jeng","doi":"10.1177/19345798261459420","DOIUrl":"https://doi.org/10.1177/19345798261459420","url":null,"abstract":"<p><p>BackgroundCerebral blood flow (CBF) is critical for neonatal brain health, and disruption of autoregulation may predispose infants to brain injury. The resistive index (RI) of the anterior cerebral artery (ACA), measured via Doppler ultrasonography, is a widely used non-invasive marker of CBF, but its relationship with vital parameters in critically ill neonates remains uncertain.MethodsThis retrospective study at Taipei Veterans General Hospital from January 2022 to December 2024 included neonates admitted to the NICU with ACA Doppler ultrasonography within 24 h of birth. RI values were stratified into three groups: low (<0.6), normal (0.6-0.8), and high (>0.8). Clinical characteristics, resuscitation needs, Apgar scores, blood gas analyses, and short- and long-term outcomes were compared across groups.ResultsAmong 898 admissions, 386 neonates met the inclusion criteria (mean gestational age 35 ± 4 weeks, mean birth weight 2382 ± 847 g), abnormal RI was identified in 25.1% (low RI: 4.1%, high RI: 21.0%). Abnormal RI correlated with significantly lower pH, higher pCO₂, lower 5-min Apgar scores, and greater need for delivery room intubation (<i>p</i> < 0.01). After adjusting for gestational age, birth weight, and evaluation timing, low RI remained independently associated with increased risks of systemic hypotension and fluid resuscitation (<i>p</i> < 0.05).ConclusionAbnormal ACA RI within 24 h of birth is associated with cerebral hemodynamic instability in critically ill neonates. Early RI assessment may provide insights into neonatal hemodynamic status and serve as a supplemental clinical indicator for identifying high-risk infants in the NICU.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261459420"},"PeriodicalIF":1.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated echocardiography and lung ultrasound assessment of lung recruitment in preterm infants using high frequency ventilation: A prospective, single-arm, protocol-driven cohort study.","authors":"Marwa Mohammed Farag, Mohamed Hazem Gouda, Aly Mohamed Abdel-Mohsen, Mohamed Hany Ahmed","doi":"10.1177/19345798261461225","DOIUrl":"https://doi.org/10.1177/19345798261461225","url":null,"abstract":"<p><p>BackgroundLung recruitment maneuvers (LRM) during high-frequency oscillatory ventilation (HFOV) lack bedside standardized monitoring.AimTo evaluate the efficacy and safety of FiO₂-guided LRM in preterm infants with moderate-to-severe respiratory-distress syndrome (RDS) using integrated functional echocardiography (FE) and lung ultrasound (LUS). Also, we hypothesized that a standardized LUS score can accurately guide successful recruitment.MethodsThis a prospective, single-arm, protocol-driven cohort study that was conducted at a tertiary NICU (Alexandria University), and 70 preterm infants (GA 32-37 weeks) requiring HFOV within 24 h of life were included. Integrated LUS and FE were performed at three phases: pre-initiation, maintenance pressure (opening), and pre-weaning. Lung aeration was quantified using a standardized 12-zone LUS protocol (0-3 points per zone) based on international consensus. Hemodynamics were assessed via tricuspid regurgitation (TR) gradient, superior vena cava (SVC) flow, and right ventricular myocardial performance index (RV-MPI).ResultsLRM led to significant improvements in oxygenation and lung aeration. Mean LUS scores decreased significantly from 23.13 ± 1.33 (pre-initiation) to 19.94 ± 1.67 (maintenance) and 3.70 ± 2.49 (pre-weaning) (<i>p</i> < 0.001). FE demonstrated a significant reduction in TR gradient (<i>p</i> < 0.001), while SVC flow and RV-MPI remained stable, indicating preserved myocardial function. Pre-weaning LUS scores were significantly associated with weaning success from HFOV.ConclusionsFiO₂-guided LRM is effective and safe in late-preterm infants with RDS. Integrated bedside imaging confirms that recruitment improves lung aeration without compromising hemodynamics. A standardized LUS score is a reliable tool for identifying optimal lung opening and guiding the weaning process.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261461225"},"PeriodicalIF":1.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of N-acetylcysteine and combined vitamin E and C therapy in hyperoxia-induced lung injury in neonatal rats.","authors":"Birgul Mutlu, Nejat Narli, Mehmet Satar, Hacer Yapicioglu, Derya Gumurdulu, Ferda Ozlu","doi":"10.1177/19345798261459416","DOIUrl":"https://doi.org/10.1177/19345798261459416","url":null,"abstract":"<p><p>BackgroundHyperoxia-induced lung injury is a key contributor to the development of bronchopulmonary dysplasia in preterm infants, primarily through oxidative stress and impaired antioxidant defense mechanisms.ObjectiveTo evaluate the protective effects of N-acetylcysteine (NAC) and combined vitamin E and C therapy on oxidative stress, antioxidant capacity, and lung histopathology in a neonatal rat model of hyperoxia-induced lung injury.MethodsA total of 36 neonatal rats were randomly assigned to four groups: control (room air, <i>n</i> = 9), hyperoxia (<i>n</i> = 9), hyperoxia + NAC (<i>n</i> = 8), and hyperoxia + vitamin E + C (<i>n</i> = 10). Hyperoxia exposure (90% ± 10% O₂) was maintained from postnatal days 3-14. Treatments were administered intraperitoneally (NAC 150 mg/kg/day, vitamin E 25 IU/day, vitamin C 1 mg/kg/day). Oxidative stress parameters (TOS, OSI, and LOOH), antioxidant markers (TAS, paraoxonase, and arylesterase), and histopathological findings were evaluated in serum and lung tissue.ResultsHyperoxia significantly increased oxidative stress markers, with higher TOS levels observed in both serum and lung tissue compared to the control group (<i>p</i> < 0.001). NAC and vitamin E + C treatments significantly increased TAS levels compared to the hyperoxia group (<i>p</i> < 0.05). Serum OSI levels were significantly reduced in both treatment groups (<i>p</i> = 0.002 and <i>p</i> = 0.032). Additionally, arylesterase levels were significantly higher in the vitamin group compared to all other groups (<i>p</i> < 0.001). Histopathological evaluation demonstrated reduced inflammatory cell infiltration and lower fibrosis scores in the treatment groups.ConclusionN-acetylcysteine and combined vitamin E and C therapy attenuate hyperoxia-induced lung injury by reducing oxidative stress and improving lung histopathology in neonatal rats. These findings support antioxidant strategies as adjunctive approaches for BPD-related lung injury.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261459416"},"PeriodicalIF":1.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postnatal predictors of mortality and derivation of a novel risk score in congenital diaphragmatic hernia: A 21-year-single-center cohort study.","authors":"Jaikrith Patil, Prakash Amboiram, Umamaheswari Balakrishnan, Madhu Ramasundram, Ashok Chandrasekaran","doi":"10.1177/19345798261459415","DOIUrl":"https://doi.org/10.1177/19345798261459415","url":null,"abstract":"<p><p>BackgroundCongenital diaphragmatic hernia is an important cause of neonatal morbidity and mortality, primarily because of pulmonary hypoplasia and pulmonary hypertension. Early postnatal risk stratification may improve prognostication and guide escalation of care. We aimed to identify early postnatal predictors of mortality and to derive a simple bedside mortality risk score for neonates with isolated congenital diaphragmatic hernia.MethodsWe conducted a retrospective cohort study of newborns with isolated congenital diaphragmatic hernia admitted to a tertiary-care NICU within 6 h of life between 2004 and 2025. Clinical and physiologic variables, including Day-1 oxygenation, inotrope requirement and preoperative pneumothorax, were extracted from the medical records. Receiver operating characteristic analysis and Firth penalized logistic regression were performed. A bedside score, the Neonatal Congenital Diaphragmatic Hernia Mortality Risk Score (NCMRS-6), was derived from early predictors and internally evaluated using bootstrap resampling.Results66 newborns were included, of whom 52 (78.8%) survived to discharge. Non-survivors had a significantly higher Day-1 oxygenation index than survivors (median 64.0 vs 6.3; <i>p</i> < 0.001) and more frequent inotropic requirement (100% vs 40.4%; <i>p</i> < 0.001). Preoperative pneumothorax was also more common among non-survivors (46.2% vs 7.7%; <i>p</i> = 0.003). Day-1 oxygenation index alone showed excellent discrimination for mortality (area under the curve 0.945). The NCMRS-6, combining Day-1 oxygenation index tiers, inotrope requirement, and preoperative pneumothorax, demonstrated an area under the curve of 0.964 (95% confidence interval 0.894-1.000). A threshold of at least four points yielded 92.3% sensitivity and 90.4% specificity.ConclusionsDay-1 oxygenation index, inotrope requirement and preoperative pneumothorax are important early predictors of mortality in isolated congenital diaphragmatic hernia. The NCMRS-6 is a simple bedside risk-stratification tool with promising discriminatory ability, but external validation is required before broader clinical application.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261459415"},"PeriodicalIF":1.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood glucose monitoring in stable small-for-gestational-age infants below 3rd percentile versus 3rd-10th percentiles on INTERGROWTH-21st charts: A quasi-randomized controlled trial.","authors":"Sulagna Dutta, Md Habibullah Sk, Bijan Saha, Mainak Banerjee","doi":"10.1177/19345798261459426","DOIUrl":"https://doi.org/10.1177/19345798261459426","url":null,"abstract":"<p><p>PurposeSmall-for-gestational-age (SGA) infants (birth weight <10^th percentile) routinely undergo blood glucose monitoring (BGM) to detect hypoglycaemia. However, application of the INTERGROWTH-21st 10^th percentile cut-off may increase SGA classification in certain populations, potentially leading to unnecessary monitoring. This study aimed to compare the safety and effectiveness of a 3^rd centile-based BGM strategy with the conventional 10^th centile approach in stable SGA infants.MethodsIn this quasi-randomized controlled trial conducted at a tertiary-care centre in India (July 2024-April 2025), inborn, hemodynamically stable infants of 35⁺⁰ to 42⁺⁰ weeks' gestation classified as SGA by INTERGROWTH-21st charts were enrolled within 1 hour of birth. Eligible infants were allocated to either a restricted monitoring strategy (<3^rd percentile) or a conventional monitoring strategy (3^rd-10^th percentile) using a predefined quasi-randomization method. Blood glucose was measured at predefined intervals during the first 72 h. The primary outcome was incidence of hypoglycaemia (<47 mg/dL) within 72 h. Secondary outcomes included time to full feeds, intravenous fluid requirement, sepsis, length of stay, and mortality.ResultsAmong 324 enrolled infants (162 per group), hypoglycaemia occurred in 10.5% in the 3^rd centile group and 13% in the 10^th centile group (<i>p</i> = 0.49). The absolute risk difference was 2.5% (95% CI 8.8% to 3.8%), confirming non-inferiority. No significant differences were observed in secondary outcomes.ConclusionA 3^rd centile-based BGM strategy was non-inferior to the conventional 10^th centile approach in stable SGA infants. Targeted monitoring based on severity of growth restriction may reduce unnecessary interventions without compromising short-term safety.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261459426"},"PeriodicalIF":1.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A curious case of maternal mirror syndrome secondary to fetal urinary ascites.","authors":"Jessica T Chen, Megan Smith, Alexis C Gimovsky","doi":"10.1177/19345798261459412","DOIUrl":"https://doi.org/10.1177/19345798261459412","url":null,"abstract":"<p><p>BackgroundMaternal mirror syndrome is a rare pregnancy complication causing maternal edema that mirrors that of a hydropic fetus. Isolated fetal ascites is also uncommon and has multiple possible etiologies, and has not traditionally been associated with maternal mirror syndrome.Case reportWe present a case of \"atypical maternal mirror syndrome\" in a fetus with isolated abdominal ascites to illustrate the possibility of mirror syndrome without fetal hydrops. A 32-year-old G1P0 had an ultrasound revealing significant fetal abdominal ascites with incompletely visualized fetal bladder dome. The patient developed pulmonary edema with oxygen requirements and underwent preterm delivery due to concern for mirror syndrome. The neonatal ascites was suspected to be secondary to bladder outlet obstruction due to hydrometrocolpos from an imperforate hymen. Although the fetus was not hydropic, our patient developed pulmonary edema, hemodilution, and maternal weight gain, and recovered quickly after delivery, many features of maternal mirror syndrome.ConclusionThis case illustrates an atypical presentation of maternal mirror syndrome in the setting of isolated fetal ascites rather than fetal hydrops. With the significant maternal and fetal morbidity associated with maternal mirror syndrome, clinicians should consider maternal mirror syndrome as a possible diagnosis even in the absence of fetal hydrops.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261459412"},"PeriodicalIF":1.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}