Journal of Neuroendocrinology最新文献

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Correction to abstract title "Efficacy and safety of [177Lu]Lu-edotreotide vs. everolimus in patients with grade 1 or grade 2 gastroenteropancreatic neuroendocrine tumours: COMPETE phase 3 trial".
IF 3.3 4区 医学
Journal of Neuroendocrinology Pub Date : 2025-04-02 DOI: 10.1111/jne.70025
{"title":"Correction to abstract title \"Efficacy and safety of [177Lu]Lu-edotreotide vs. everolimus in patients with grade 1 or grade 2 gastroenteropancreatic neuroendocrine tumours: COMPETE phase 3 trial\".","authors":"","doi":"10.1111/jne.70025","DOIUrl":"https://doi.org/10.1111/jne.70025","url":null,"abstract":"","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70025"},"PeriodicalIF":3.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of clinical parameters and exosomal lncRNA NEAT1_1 in MEN1-related non-functioning pancreatic neuroendocrine tumors.
IF 3.3 4区 医学
Journal of Neuroendocrinology Pub Date : 2025-04-02 DOI: 10.1111/jne.70024
Jerena Manoharan, Max Albers, Natalia Khizanishvili, Norman Krasser-Gercke, Maxime Schmitt, Ioannis Mintziras, Sabine Wächter, Anja Rinke, Yutong Gao, Jörg W Bartsch, Moritz Jesinghaus, Pietro Di Fazio, Detlef K Bartsch
{"title":"Prognostic value of clinical parameters and exosomal lncRNA NEAT1_1 in MEN1-related non-functioning pancreatic neuroendocrine tumors.","authors":"Jerena Manoharan, Max Albers, Natalia Khizanishvili, Norman Krasser-Gercke, Maxime Schmitt, Ioannis Mintziras, Sabine Wächter, Anja Rinke, Yutong Gao, Jörg W Bartsch, Moritz Jesinghaus, Pietro Di Fazio, Detlef K Bartsch","doi":"10.1111/jne.70024","DOIUrl":"https://doi.org/10.1111/jne.70024","url":null,"abstract":"<p><p>Non-functioning pancreatic neuroendocrine tumors (NF-pNETs) significantly contribute to the premature death of multiple endocrine neoplasia type 1 (MEN1) patients. Reliable prognostic markers are not yet available. MicroRNAs (miRNA) and long-non-coding (lnc) RNAs, transported by extracellular vesicles, are emerging as new prognostic tools. This study aimed to analyze the clinical characteristics, the exosomal-miRNA 451 (exo-miR451) and the lnc-RNA nuclear paraspeckle assembly transcript 1 (NEAT1_1, 3.7 kB) in the mild and aggressive courses of MEN1-NFpNET disease. Patient characteristics were assessed regarding an aggressive course of disease. In addition, exo-miR451 and exo-lnc-NEAT1_1 expression levels were quantified in serum by RT-qPCR and correlated with clinical data. Immunohistochemistry results of STAT3 (signal transducer and activator of transcription 3), regulated by NEAT1, were performed in NF-pNET tissue and correlated with exo-lnc-NEAT1_1 expression. Among 66 MEN1 patients with NF-pNETs, 13 (20%) had an aggressive disease course. No significant differences in patient characteristics were observed between those with aggressive (n = 13) and mild (n = 53) disease (all p > .5). Exosomal miRNA-451 was dysregulated in 55% (n = 23) of cases, showing a trend toward higher upregulation in the aggressive group (36% vs. 19%), although this difference was not statistically significant (p = .215). Exo-NEAT1_1 was overexpressed in 42% (16/38) of patients, without significant differences between groups (p = .0523). However, exo-NEAT1_1 expression strongly correlated with STAT3 immunohistochemical staining (p = .001). Although no prognostic marker could be identified, we show for the first time that the STAT3-NEAT1 pathway plays a role in MEN1-associated NF-pNET tumorigenesis.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70024"},"PeriodicalIF":3.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of feminization hormone therapy on the brain of transgender women: A hypothesis.
IF 3.3 4区 医学
Journal of Neuroendocrinology Pub Date : 2025-03-27 DOI: 10.1111/jne.70026
Leire Zubiaurre-Elorza, Carme Uribe, Alberto Marcos, Rosa Fernández, Eduardo Pásaro, Mª Cruz Rodríguez Del Cerro, Sarah M Burke, Antonio Guillamon
{"title":"The effects of feminization hormone therapy on the brain of transgender women: A hypothesis.","authors":"Leire Zubiaurre-Elorza, Carme Uribe, Alberto Marcos, Rosa Fernández, Eduardo Pásaro, Mª Cruz Rodríguez Del Cerro, Sarah M Burke, Antonio Guillamon","doi":"10.1111/jne.70026","DOIUrl":"https://doi.org/10.1111/jne.70026","url":null,"abstract":"<p><p>Gender-affirming hormone therapy (GAHT) is a medical treatment used to help transgender individuals align their physical appearance with their gender identity. GAHT in transgender women (TW) has been found to lead to a reduction in brain tissue with an expansion of the ventricles. We discuss an animal model studying the effects of GAHT that suggests dehydration of brain tissue and an alteration in the relative concentration of brain metabolites. We hypothesize that estradiol, acting on astrocytes, alters cerebral blood flow, water metabolism, and metabolite concentration and argue that these changes could explain the higher risk of stroke observed in GAHT-treated TW compared to untreated cisgender men. Future studies should clarify the mechanisms underlying the brain tissue changes induced by GAHT.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70026"},"PeriodicalIF":3.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of membrane estrogen receptor alpha on the negative feedback of estrogens on luteinizing hormone secretion. 膜雌激素受体α在雌激素对黄体生成素分泌的负反馈中的作用。
IF 3.3 4区 医学
Journal of Neuroendocrinology Pub Date : 2025-03-27 DOI: 10.1111/jne.70016
Mélanie C Faure, Rebeca Corona, Laura Vandries, Charlotte Deconinck, Françoise Lenfant, Céline Gérard, Jean-Michel Foidart, Charlotte A Cornil
{"title":"Role of membrane estrogen receptor alpha on the negative feedback of estrogens on luteinizing hormone secretion.","authors":"Mélanie C Faure, Rebeca Corona, Laura Vandries, Charlotte Deconinck, Françoise Lenfant, Céline Gérard, Jean-Michel Foidart, Charlotte A Cornil","doi":"10.1111/jne.70016","DOIUrl":"https://doi.org/10.1111/jne.70016","url":null,"abstract":"<p><p>Estrogen receptor alpha (ERα) is critical for reproduction, but the relative contributions of its nuclear and membrane signaling are unclear.The present study investigated the role of membrane ERα (mERα) using two complementary approaches: a mouse model lacking mERα signaling (C451A-ERα mice) and estetrol (E<sub>4</sub>), a natural estrogen described to prevent membrane ERα activation in different cell types. While ovariectomy (OVX) induced a comparable luteinizing hormone (LH) increase in both wild-type and C451A-ERα females, C451A-ERα females failed to respond to chronic estradiol (E<sub>2</sub>) (1 μg) exposure, indicating dysregulated negative feedback. This lack of LH regulation in C451A-ERα females was mirrored by an absence of change in the number of neurons immunoreactive (ir) for kisspeptin (Kp) in both the rostral periventricular area of the third ventricle (RP3V) and the arcuate nucleus (ARC), for progesterone receptor (PR)-ir nuclei in the preoptic area and hypothalamus, and for neurokinin 3 receptor (NK<sub>3</sub>R) in the ARC. Interestingly, increasing the dose of E<sub>2</sub> to 5 μg restored normal negative feedback and normal numbers of Kp-ir neurons and PR-ir nuclei, but not the surface covered by Kp-ir fibers and the number of NK<sub>3</sub>R-ir neurons in the ARC. By contrast, E<sub>4</sub> mimicked the negative feedback of E<sub>2</sub> on circulating LH in OVX WT females following both acute and chronic treatment and potentiated rather than blocked the effects of E<sub>2</sub> when administered along with it. E<sub>4</sub> also mimicked the stimulatory effects of E<sub>2</sub> on the number of PR-ir nuclei in several preoptic and hypothalamic regions and the percentage of area covered by Kp-ir material in the ARC, as well as its inhibitory action on the number of Kp-ir neurons in the ARC. Therefore, the C451A-ERα mutation interferes with the control of the negative feedback through distinct mechanisms differing by their dose-dependency to E<sub>2</sub>. By contrast, E<sub>4</sub> mimicked all effects of E<sub>2</sub> on the negative feedback and the associated neural circuits, indicating that E<sub>4</sub> acts as a weak ERα agonist in this context. Together, these results suggest that C451A-ERα modifies the sensitivity to E<sub>2</sub>, impacting the negative feedback of E<sub>2</sub> on LH regulation.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70016"},"PeriodicalIF":3.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early testosterone exposure during development advances myelination and affects neurogenesis of the vocal control motor path in male zebra finches (Taeniopygia guttata).
IF 3.3 4区 医学
Journal of Neuroendocrinology Pub Date : 2025-03-23 DOI: 10.1111/jne.70022
Adriana Diez, Kevin G Young, Scott A MacDougall-Shackleton
{"title":"Early testosterone exposure during development advances myelination and affects neurogenesis of the vocal control motor path in male zebra finches (Taeniopygia guttata).","authors":"Adriana Diez, Kevin G Young, Scott A MacDougall-Shackleton","doi":"10.1111/jne.70022","DOIUrl":"https://doi.org/10.1111/jne.70022","url":null,"abstract":"<p><p>Birdsong learning and production is mediated through a vocal control circuit that exhibits ubiquitous and profound sex differences. In zebra finches (Taeniopygia guttata) only males sing, and sex differences in both neuroanatomy and myelination of this circuit emerge during the first 3 months of life as song learning is taking place. Song crystallization occurs at the onset of sexual maturity, at a time when neuron recruitment to the vocal control region HVC is reduced and the myelination of the projection from HVC to the motor nucleus RA (robust nucleus of arcopallium) rapidly develops. Prior work demonstrated that experimental testosterone treatment early in song development disrupted song learning, potentially by leading to premature song crystallization, but the effects of testosterone on neurogenesis and myelination of the vocal control system are little studied. We implanted male zebra finches with blank or testosterone pellets around Day 35 at the onset of the sensorimotor phase of song development. We examined the effects of early testosterone treatment on song development, myelination, and neurogenesis (doublecortin labeled cells) of the motor path of the vocal control circuit (HVC to RA). We also quantified singing consistency at two ages in adulthood. Testosterone treatment accelerated changes in myelin within HVC and in the projection from HVC to RA and accelerated age-related changes in doublecortin-labeled cells in HVC. Song and syllable stereotypy increased with age, but we did not detect an effect of hormone treatment. These results are consistent with the hypothesis that the testosterone exposure during development initiates processes that normally occur at sexual maturity, including changes in neurogenesis and myelination of the motor control path of the vocal control system.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70022"},"PeriodicalIF":3.3,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corticosteroid-regulated gene transcription in SH-SY5Y-derived neurons: Insights into the mineralocorticoid and glucocorticoid receptor-mediated response.
IF 3.3 4区 医学
Journal of Neuroendocrinology Pub Date : 2025-03-19 DOI: 10.1111/jne.70021
Justina F Lugenbühl, Clara Snijders, Cameron D Pernia, Marina Soliva Estruch, Gunter Kenis, Nikolaos P Daskalakis
{"title":"Corticosteroid-regulated gene transcription in SH-SY5Y-derived neurons: Insights into the mineralocorticoid and glucocorticoid receptor-mediated response.","authors":"Justina F Lugenbühl, Clara Snijders, Cameron D Pernia, Marina Soliva Estruch, Gunter Kenis, Nikolaos P Daskalakis","doi":"10.1111/jne.70021","DOIUrl":"https://doi.org/10.1111/jne.70021","url":null,"abstract":"<p><p>Post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) are debilitating stress-related psychiatric disorders that can develop following exposure to traumatic events or chronic stress in some individuals. The neurobiological processes leading to disease remain largely unknown. Among others, these disorders are characterized by a dysregulated hypothalamic-pituitary-adrenal axis, which is regulated by the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). This leads to altered downstream corticosteroid-induced gene expression. In vitro models are promising tools to investigate specific neurobiological underpinnings of the stress response in the brain. Here, we investigated the suitability of SH-SY5Y-derived neurons as a cost-efficient system to study the role of GR and MR in the neuronal stress response. SH-SY5Y-derived neurons were characterized, exposed to corticosteroids, and analyzed on transcriptomic and proteomic levels. We show that (i) these neurons express sufficient and seemingly functional GR and MR to allow the study of corticosteroid-induced transcription, (ii) three corticosteroids cortisol, dexamethasone, and aldosterone, induced similar transcriptomic effects, (iii) the antagonist spironolactone mildly attenuated the effects of dexamethasone in FKBP5, DUSP1, and SUPV3L1. Mifepristone did not significantly alter the effect of aldosterone. (iv) Integrating transcriptomic alterations of these corticosteroid-exposed neurons with those of iPSC-derived neurons exposed to dexamethasone showed concordant corticosteroid-induced effects in the two in vitro systems. To determine translational validity, we compared the gene expression in these neurons with the transcriptome of postmortem brain samples from individuals with PTSD and MDD, yielding stronger negative correlations of corticosteroid effects in SH-SY5Y-derived neurons with PTSD signatures than with MDD signatures. Upon further refinement and validation, SH-SY5Y-derived neurons may serve as a simplistic tool to study neuronal corticosteroid-induced gene expression and the implicated molecular networks around GR and MR. Strengthening our insight into these receptors' functions improves our understanding of the hypothalamic-pituitary-adrenal axis, which is commonly altered in stress-related psychiatric disorders such as PTSD and MDD.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70021"},"PeriodicalIF":3.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seasonal regulation of Tsh-β, Dio2, Dio3, and GnRH-I mRNA expressions in Eurasian tree sparrow (Passer montanus) under natural conditions.
IF 3.3 4区 医学
Journal of Neuroendocrinology Pub Date : 2025-03-19 DOI: 10.1111/jne.70023
Bidisha Kataki, Anand S Dixit
{"title":"Seasonal regulation of Tsh-β, Dio2, Dio3, and GnRH-I mRNA expressions in Eurasian tree sparrow (Passer montanus) under natural conditions.","authors":"Bidisha Kataki, Anand S Dixit","doi":"10.1111/jne.70023","DOIUrl":"https://doi.org/10.1111/jne.70023","url":null,"abstract":"<p><p>Seasonal transitions in avian reproductive cycles are governed by neuroendocrine adaptability. The molecular mechanisms behind seasonal regulation are still not fully understood in many species and remain an important area of ongoing research. Despite recognizing the importance of regulatory genes, gaps persist in comprehending the exact molecular processes that control the transitions between different reproductive phases. We investigated the expression patterns of Tsh-β (Thyroid-stimulating hormone subunit beta), Dio2 (Iodothyronine deiodinase 2), Dio3 (Iodothyronine deiodinase 3), and GnRH-I (Gonadotropin-releasing hormone I) mRNAs in regulating reproduction in both sexes of the Eurasian tree sparrow (Passer montanus). Adult tree sparrows (n = 4 for each sex) were procured from the wild, and mRNA expression of Tsh-β, Dio2, Dio3, and GnRH-I, along with gonadal size and body weight, was examined on a monthly basis for 1 year. Results revealed distinct annual cycles of Tsh-β, Dio2, Dio3, and GnRH-I mRNA expression and gonadal size in both sexes. Significantly higher expressions of Tsh-β, Dio2, and GnRH-I mRNA were observed during the breeding phase (April-May), while Dio3 expression was reported higher during the non-breeding phase. The synchronization in the pattern of increase in the Tsh-β, Dio2, and GnRH-I during the breeding phase is associated with gonadal growth, suggesting their potential involvement in regulating seasonal reproduction in tree sparrows. Thus, the control of the reproductive cycle in tree sparrows involves the actions of Tsh-β and Dio2/Dio3 leading to the activation and deactivation of GnRH-I via the HPG (hypothalamic-pituitary-gonadal) axis.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70023"},"PeriodicalIF":3.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive chemoanatomical mapping, and the gonadal regulation, of seven kisspeptin neuronal populations in the mouse brain.
IF 3.3 4区 医学
Journal of Neuroendocrinology Pub Date : 2025-03-18 DOI: 10.1111/jne.70019
Vito S Hernández, Mario A Zetter, Oscar R Hernández-Pérez, Rafael Hernández-González, Ignacio Camacho-Arroyo, Robert P Millar, Lee E Eiden, Limei Zhang
{"title":"Comprehensive chemoanatomical mapping, and the gonadal regulation, of seven kisspeptin neuronal populations in the mouse brain.","authors":"Vito S Hernández, Mario A Zetter, Oscar R Hernández-Pérez, Rafael Hernández-González, Ignacio Camacho-Arroyo, Robert P Millar, Lee E Eiden, Limei Zhang","doi":"10.1111/jne.70019","DOIUrl":"10.1111/jne.70019","url":null,"abstract":"<p><p>Kisspeptinergic signaling is well-established as crucial for the regulation of reproduction, but its potential broader role in brain function is less understood. This study investigates the distribution and chemotyping of kisspeptin-expressing neurons within the mouse brain. RNAscope single, dual, and multiplex in situ hybridization methods were used to assess kisspeptin mRNA (Kiss1) expression and its co-expression with other neuropeptides, excitatory and inhibitory neurotransmitter markers, and sex steroid receptors in wild-type intact and gonadectomized young adult mice. Seven distinct kisspeptin neuronal chemotypes were characterized, including two novel kisspeptin-expressing groups described for the first time, that is, the Kiss1 population in the ventral premammillary nucleus and the nucleus of the solitary tract. Kiss1 mRNA was also observed to localize in both somatic and dendritic compartments of hypothalamic neurons. High androgen receptor expression and changes in medial amygdala and septo-hypothalamic Kiss1 expression following GDX in males, but not in females, suggest a role for androgen receptors in regulating kisspeptin signaling. This study provides a detailed chemoanatomical map of kisspeptin-expressing neurons, highlighting their potential functional diversity. The discovery of a new kisspeptin-expressing group and gonadectomy-induced changes in Kiss1 expression patterns suggest broader roles for kisspeptin in brain functions beyond those of reproduction.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70019"},"PeriodicalIF":3.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypotheses in light detection by vertebrate ancient opsin in the bird brain.
IF 3.3 4区 医学
Journal of Neuroendocrinology Pub Date : 2025-03-16 DOI: 10.1111/jne.70020
Tyler J Stevenson, Timothy A Liddle, Simone L Meddle, Jonathan H Pérez, Stuart N Peirson, Russell G Foster, Gaurav Majumdar
{"title":"Hypotheses in light detection by vertebrate ancient opsin in the bird brain.","authors":"Tyler J Stevenson, Timothy A Liddle, Simone L Meddle, Jonathan H Pérez, Stuart N Peirson, Russell G Foster, Gaurav Majumdar","doi":"10.1111/jne.70020","DOIUrl":"https://doi.org/10.1111/jne.70020","url":null,"abstract":"<p><p>Extra-retinal photoreception is common across fish and avian species. In birds, the hypothalamus contains non-visual photoreceptors that detect light and regulate multiple endocrine systems. To date, light-dependent control of seasonal reproduction is one of the most well-studied systems that require deep brain photoreception. However, the precise photoreceptor(s) that detect light and the neuroendocrine connection between opsin-expressing cells and the gonadotropin-releasing hormone-1 (GnRH1) system remain poorly defined. In the past couple of decades, two opsin molecules have been proposed to link light detection with seasonal reproduction in birds: neuropsin (Opn5) and vertebrate ancient opsin (VA opsin). Only VA opsin is expressed in GnRH1 cells and has an absorption spectrum that matches the action spectrum of the avian photoperiodic reproductive response. This perspective describes how the annual change in daylength, referred to as photoperiod, regulates the neuroendocrine control of seasonal reproduction. The opsin genes are then outlined, and the cellular phototransduction cascade is described, highlighting the common feature of hyperpolarization in response to light stimulation. We then discuss the latest evidence using short-hairpin RNA to temporarily knock down VA opsin and Opn5 on transcripts involved in the neuroendocrine regulation of reproduction. Based on emerging data, we outline three theoretical scenarios in which VA opsin might regulate GnRH1 synthesis and release in birds. The models proposed provide a series of testable hypotheses that can be used to improve our understanding of avian light detection by VA opsin or other opsin-expressing cells in the brain.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70020"},"PeriodicalIF":3.3,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control.
IF 3.3 4区 医学
Journal of Neuroendocrinology Pub Date : 2025-03-10 DOI: 10.1111/jne.70007
Limei Zhang, Vito Salvador Hernández, Mario Alberto Zetter, Oscar Rene Hernández-Pérez, Rafael Hernández-González, Ignacio Camacho-Arroyo, Lee E Eiden, Robert P Millar
{"title":"Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control.","authors":"Limei Zhang, Vito Salvador Hernández, Mario Alberto Zetter, Oscar Rene Hernández-Pérez, Rafael Hernández-González, Ignacio Camacho-Arroyo, Lee E Eiden, Robert P Millar","doi":"10.1111/jne.70007","DOIUrl":"10.1111/jne.70007","url":null,"abstract":"<p><p>Kisspeptin (KP) signaling in the brain is defined by the anatomical distribution of KP-producing neurons, their fibers, receptors, and connectivity. Technological advances have prompted a re-evaluation of these chemoanatomical aspects, originally studied in the early years after the discovery of KP and its receptor Kiss1r. Previously, we characterized (Hernández et al. bioRxiv 2024) seven KP neuronal populations in the mouse brain at the mRNA level, including two novel populations, and examined their response to gonadectomy. In this study, we mapped KP fiber distribution in rats and mice using immunohistochemistry under intact as well as short- and long-term post-gonadectomy conditions. Kiss1r mRNA expression was examined via RNAscope, in relation to vesicular GABA transporter (Slc32a1) in whole mouse brain, and to KP and vesicular glutamate transporter 2 (Slc17a6), Kiss1, and Slc32a1 in hypothalamic RP3V and arcuate regions. We identified KP fibers in 118 brain regions, primarily in extra-hypothalamic areas associated with sensorial processing and behavioral state control. KP-immunoreactive fiber density and distribution were largely unchanged by gonadectomy. Kiss1r was expressed prominently in sensorial and state control regions such as the septal nuclei, the suprachiasmatic nucleus, locus coeruleus, hippocampal layers, thalamic nuclei, and cerebellar structures. Co-expression of Kiss1r and Kiss1 was observed in hypothalamic neurons, suggesting both autocrine and paracrine KP signaling mechanisms. These findings enhance our understanding of KP signaling beyond reproductive functions, particularly in sensorial processing and behavioral state regulation. This study opens new avenues for investigating KP's role in controlling complex physiological processes, including those unrelated to reproduction.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70007"},"PeriodicalIF":3.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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