Journal of Neuroendocrinology最新文献

{"title":"Periestropause enhances hypoxia-induced panic and microglial remodelling without altering respiratory control.","authors":"Angela Cristina Nicola, Luana Tenório-Lopes, Luis Gustavo A Patrone, Mariana Bernardes-Ribeiro, Heloisa H Vilela-Costa, Daniele Gandra, Ana Clara Campideli-Santana, Raphael E Szawka, Kênia C Bícego, Rita Cássia M Dornelles, Luciane H Gargaglioni","doi":"10.1111/jne.70254","DOIUrl":"10.1111/jne.70254","url":null,"abstract":"<p><p>Perimenopause is characterised by irregular reproductive cycles and hormonal fluctuations, notably decreased estradiol (E₂), which are linked to increased susceptibility to panic disorder and neuroinflammation. We examined whether panic-related respiratory and behavioural responses to respiratory challenges vary across reproductive stages. Female rats with regular estrous cycles (RC), representing reproductive cyclicity, and rats in periestropause (PE), a stage similar to perimenopause, were exposed to normoxia, hypoxia, and hypercapnia. Ventilation (V̇_E) and metabolism (V̇O₂) were measured during diestrus in RC and PE rats. Additionally, to measure levels of neuroinflammation, microglial reactivity in the Locus coeruleus (LC) in response to hypoxia-induced panic-like attacks was assessed. Under normoxia, there were no differences in V̇_E or V̇O₂ between groups. Hypercapnia increased V̇_E in both groups by elevating respiratory frequency (f_R) and tidal volume (V_T), without changing body temperature (Tb). Hypoxia also raised V̇_E in both groups, primarily driven by increased f_R, and hypoxia-induced hypothermia occurred in RC and PE females. Both hypercapnia and hypoxia elevated the V̇_E/V̇O₂ ratio. Exposure to 7% O₂ heightened panic-like behaviours in PE rats. Hypoxia increased LC microglial number, density, and mean soma size, while decreasing arborization area. PE rats also showed a higher microglial morphological index and a shorter nearest neighbour distance (NND). Jump frequency and freezing duration positively correlated with the morphological index and negatively with arborization area. These findings suggest that respiratory regulation remains intact, but behavioural and neuroimmune responses are amplified during the transition to estropause, heightening vulnerability to panic and anxiety-related disorders in ageing females.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 9","pages":"e70254"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dlk1-deficient mice achieve puberty despite low body weight and low levels of leptin and kisspeptin","authors":"Delanie B. Macedo,&nbsp;Sidney A. Pereira,&nbsp;Meijiao Wang,&nbsp;Han Kim Kyeol,&nbsp;Rona S. Carroll,&nbsp;Ana Claudia Latronico,&nbsp;Ana Paula Abreu,&nbsp;Ursula B. Kaiser","doi":"10.1111/jne.70248","DOIUrl":"https://doi.org/10.1111/jne.70248","url":null,"abstract":"<p>Loss-of-function mutations in <i>DLK1</i>, encoding Delta Like Non-Canonical Notch Ligand 1, have been linked to central precocious puberty (CPP) and increased body fat in girls, suggesting a role in the connection between metabolism and reproduction. <i>DLK1</i> is located in the imprinted region of human chromosome 14, and mice lacking Dlk1 exhibit growth retardation and metabolic changes, phenotypes that overlap with Temple syndrome, an imprinting disorder associated with precocious puberty. However, the mechanisms by which <i>DLK1</i> influences pubertal timing remain unclear. We investigated pubertal timing in <i>Dlk1</i> knockout (KO) mice with either global or selective central nervous system (CNS) deletion of <i>Dlk1</i>, compared with control mice. Puberty onset and body weight were assessed, along with potential mediators of pubertal timing, including leptin and kisspeptin. <i>Dlk1</i>KO females reached puberty at the same age as controls, despite lower body weight. <i>Dlk1</i>KO males had delayed preputial separation but, like females, reached puberty at significantly lower body weight. Serum leptin and hypothalamic <i>Socs3</i> mRNA, a downstream leptin effector, were lower peri-pubertally in <i>Dlk1</i>KO females than in controls. <i>Kiss1</i> mRNA levels in the mediobasal hypothalamus were significantly lower in <i>Dlk1</i>KO females at puberty onset. Selective <i>Dlk1</i> deletion in neurons and glial cells did not affect pubertal timing. These findings suggest that peripheral sources of Dlk1 contribute to the metabolic and endocrine regulation of pubertal timing. The absence of Dlk1 appears to alter the metabolic milieu in which puberty occurs, allowing activation of the reproductive axis despite low body weight and reduced hypothalamic kisspeptin expression.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 9","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of metabolic, reproductive, and gut microbiota alterations in a comparative study of different preclinical models of polycystic ovary syndrome.","authors":"Nisha H Khobragade, Devang B Sheth, Chirag A Patel, Jayesh V Beladiya, Sandip Patel, Mittal Dalal, Sandip Dholakia","doi":"10.1111/jne.70247","DOIUrl":"10.1111/jne.70247","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is a multifaceted, complex metabolic and endocrine disease where gut flora is considered an important factor in causing PCOS. This study aimed to identify a suitable PCOS model that contributes to gut microbial dysbiosis and metabolic and hormonal disturbances. Prepubertal SD rats were administered with normal control (NC), dihydrotestosterone (DHT), DHT with fructose (F), DHT+ high fat diet (HFD) for 91 days, dehydroepiandrosterone (DHEA), DHEA with fructose, DHEA with HFD for 30 days, sodium valproate (SV), sodium valproate with fructose, and sodium valproate with HFD for 21 days. The estrous cycles were assessed over this timeframe. At the end of the experiment, superoxide dismutase and uterine and ovarian morphology were evaluated, along with hormone levels, lipid profiles, and 16S rRNA genomic sequencing. All models exhibited PCOS characteristics, including hormonal imbalances, insulin resistance (p ≤ .001), multiple follicular cysts on ultrasonography, and histological alterations. Gut microbial dysbiosis was observed across all PCOS-induced groups; however, the DHT alone group showed more pronounced alterations in microbial composition than the other experimental groups. Specifically, the DHT alone group exhibited reduced abundance of Firmicutes and increased abundance of Proteobacteria. Among the evaluated models, the DHT-only model showed more pronounced metabolic, hormonal, reproductive, and gut microbial alterations and may serve as a suitable model for PCOS research.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 9","pages":"e70247"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining dynamic changes in prefrontal connectivity and internalizing symptoms during the first and third trimesters of pregnancy.","authors":"Emily B K Thomas, Micah A Williams, Patrick Breheny, Abigél Miskolczi, Ö Ece Demir-Lira","doi":"10.1111/jne.70252","DOIUrl":"10.1111/jne.70252","url":null,"abstract":"<p><p>Pregnancy is characterized by pronounced neuroplasticity and heightened risk for psychopathology. While previous research has primarily examined postpartum depression, less work has investigated changes in internalizing symptoms measured dimensionally across the peripartum period. Furthermore, limited research has identified functional changes in the prefrontal cortex (PFC) across pregnancy, a brain area implicated in psychopathology. Understanding the dynamic changes in internalizing symptoms and PFC neuroconnectivity throughout pregnancy and their interrelations is crucial for early identification of perinatal psychopathology. This pre-registered longitudinal study examined changes in and associations between internalizing symptoms and PFC functional connectivity throughout the first and third trimesters of pregnancy. Pregnant individuals recruited from a community sample of females engaged in prenatal care (N = 60, M_age = 32.31, SD = 5.34, 90% White, 91.7% non-Hispanic/Latine) completed structured clinical interviews assessing mood and anxiety symptoms and resting-state functional near-infrared spectroscopy measuring PFC connectivity during the first and third trimesters of pregnancy. From the first to third trimester, longitudinal results revealed a significant decrease in symptoms of distress and fear and significant increases in neuroconnectivity anchored in left medial frontal areas of the PFC. Cross-sectionally, higher first trimester fear was associated with lower within-region right medial PFC and higher within-region left medial PFC connectivity. Longitudinal decreases in distress from first to third trimester were associated with increased connectivity between left medial and right lateral PFC, alongside weakened connectivity between bilateral medial frontal regions. These findings demonstrate that internalizing symptoms relate to prefrontal connectivity from first to third trimester in a community sample of pregnant women. Examining internalizing symptoms dimensionally across pregnancy allows for characterization of the full range of symptoms that impact pregnant individuals. Future research should explore prevention and intervention implications of the relations between neural profiles and internalizing symptoms during pregnancy to improve long-term outcomes for the mother and child.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 9","pages":"e70252"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional maturation of oxytocin neurons: A principal component analysis of postnatal development.","authors":"Yuko Maejima, Manabu Suzuki, Wataru Matsuoka, Yoichi Ueta, Kenju Shimomura","doi":"10.1111/jne.70260","DOIUrl":"10.1111/jne.70260","url":null,"abstract":"<p><p>Oxytocin (Oxt) is a neuropeptide critical for higher brain functions, with its physiological functions dependent on the activity of Oxt-producing neurons in the paraventricular nucleus (PVN). However, the postnatal maturation process of these neurons remains poorly understood, particularly whether it involves a uniform trajectory or a dynamic functional reorganization. Here, we investigated the electrophysiological maturation of PVN Oxt neurons in rats using a multifaceted approach including electrophysiology, principal component analysis (PCA), and f-I curve fitting. Our analysis revealed a highly heterogeneous maturation timeline for individual electrophysiological parameters. While action potential amplitude and half-width matured relatively early, the resting membrane potential (RMP) and firing threshold showed a much more protracted maturation. To comprehensively capture this, we applied PCA and found that the first principal component (PC1) exhibited a striking inverted U-shaped pattern over time. This pattern suggests a dynamic transition through three distinct functional states: an initial immature state, an intermediate transitional state, and a later mature state. Furthermore, f-I curve fitting provided mechanistic insights, identifying a \"high-gain\" state around postnatal Day 7, characterized by high firing threshold (I_th) and gain (k). This period temporally overlaps with peak Oxt receptor expression, hinting at a critical window for experience-dependent circuit refinement. Our findings provide a new perspective on neuronal maturation as a complex process of dynamic functional reorganization. The identified \"high-gain\" state may represent a critical period for Oxt system development, offering a crucial foundation for understanding neurodevelopmental disorders and developing targeted early interventions.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 9","pages":"e70260"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neurosteroid paradigm in perinatal depression: From pathophysiology to precision therapeutics.","authors":"Nevena V Radonjić, Khatiya C Moon, Kristina M Deligiannidis","doi":"10.1111/jne.70253","DOIUrl":"10.1111/jne.70253","url":null,"abstract":"<p><p>Neurosteroids and their role in the pathophysiology of perinatal depression have been in the focus of scientific investigation for several decades. Recently, two synthetic analogs of the neurosteroid allopregnanolone-brexanolone and zuranolone-received approval in the United States for the treatment of postpartum depression (PPD) exhibiting a rapid, long-lasting antidepressant effect through a novel mechanism of action. These developments mark a milestone in psychiatric research and advancement in available treatment options. In this review, we examine the role of neurosteroids in perinatal depression, with particular emphasis on their impact on network states and functional connectivity. We synthesize current clinical experience with brexanolone and zuranolone in the treatment of PPD, highlighting efficacy and practical considerations. Finally, we explore emerging precision medicine approaches that leverage the heterogeneity of clinical presentations and treatment responses in PPD to guide the development of targeted therapeutic strategies for this widely prevalent and debilitating condition.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 9","pages":"e70253"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13538743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grief as a neuroendocrine transition: Insights from perinatal loss.","authors":"Clare Killikelly, Eva-Maria Stelzer, Rita T Amiel Castro","doi":"10.1111/jne.70262","DOIUrl":"10.1111/jne.70262","url":null,"abstract":"<p><p>Grief is an all-encompassing human experience that reverberates across mind, brain, and body. Historically, the scientific study of grief has been rooted primarily in psychological frameworks. Pioneering work has begun to elucidate how attachment loss is encoded not only psychologically but also biologically, and this may be particularly significant during the perinatal period.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 9","pages":"e70262"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of SCGN expression patterns in the anterior pituitary gland of mouse, pig, and human by single-cell transcriptomics","authors":"Cheng-Cheng Wang,&nbsp;Qi-Lin Zhang,&nbsp;Zhen-Le Zang,&nbsp;Hua-Chun Yin,&nbsp;Yu Pan,&nbsp;Yi-Fei Yu,&nbsp;Yi-Ming Li,&nbsp;Zhao-Yun Zhang,&nbsp;Song Li,&nbsp;Hui Yang","doi":"10.1111/jne.70249","DOIUrl":"10.1111/jne.70249","url":null,"abstract":"<p>Secretagogin (SCGN) is a calcium-binding protein implicated in neuroendocrine secretion. However, its expression profile in the anterior pituitary gland and potential species-specific differences remain poorly characterized. We analyzed scRNA-seq data from the pituitary glands of mice, rats, pigs, and humans, then combined it with validation by immunostaining to systematically elucidate the expression and distribution patterns of SCGN in the anterior pituitary gland. SCGN exhibited distinct species-specific expression patterns. In mice, SCGN transcripts were predominantly enriched in PIT1-lineage lactotropes and SF1-lineage gonadotropes, with immunofluorescence confirming high colocalization with LH, FSH, and PRL. In pigs, SCGN was primarily expressed in TPIT-lineage corticotropes, and immunofluorescence colocalization analysis confirmed the highest colocalization rate with ACTH. In humans, SCGN expression was confirmed in the anterior pituitary gland by immunohistochemistry, while scRNA-seq revealed predominant enrichment of its transcripts in PIT1-lineage lactotropes and somatotropes. Notably, comparative interspecies analysis indicated a high degree of similarity in SCGN enrichment within PIT1-lineage cells (particularly lactotropes) between mice and humans. In contrast, SCGN expression was undetectable in the rat anterior pituitary gland at both transcriptional and protein levels. Together, our findings suggest that SCGN may not be an essential or universal regulator of anterior pituitary hormone secretion. Instead, this study provides an informative negative example that highlights the interspecies divergence of the pituitary secretory machinery among mammals.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13500175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary functional hypothalamic amenorrhoea in the context of feeding and eating disorders or excessive exercise: Insights from non-athletic and elite athletic populations","authors":"Marianna Minnetti,&nbsp;Chiara Tarantino,&nbsp;Monica D'Amico,&nbsp;Emanuele Filice,&nbsp;Chiara Graziadio,&nbsp;Edoardo Mocini,&nbsp;Giuseppe Tiralongo,&nbsp;Daniele Gianfrilli,&nbsp;Andrea M. Isidori,&nbsp;Lorenzo M. Donini,&nbsp;Eleonora Poggiogalle,&nbsp;Maria Grazia Tarsitano,&nbsp;Talent Group","doi":"10.1111/jne.70242","DOIUrl":"10.1111/jne.70242","url":null,"abstract":"<p>Primary amenorrhoea is defined as the absence of menarche by the expected age, with or without delayed pubertal development in adolescents. It may result from anatomical, genetic, endocrine, and functional causes. Among the latter, we propose the term primary functional hypothalamic amenorrhoea (P-FHA) to describe primary amenorrhoea characterised by hypothalamic–pituitary–ovarian axis suppression in the absence of organic disease. P-FHA is frequently associated with low energy availability (LEA), particularly in individuals with feeding and eating disorders (FEDs) or excessive exercise, often within the spectrum of Relative Energy Deficiency in Sport (REDs). Despite its clinical relevance, P-FHA remains under-recognised, with limited dedicated research. This review aims to synthesise clinical studies addressing P-FHA in the context of FEDs or excessive exercise. A systematic literature search was conducted using PubMed, Web of Science, and Scopus. Studies focusing on P-FHA and its association with FEDs, excessive exercise, and REDs were included. Case reports and aggregated studies combining P-FHA and S-FHA were excluded to ensure specificity. Twenty-four studies addressing patients with P-FHA were identified. Available evidence suggests that the reported frequency of functional hypothalamic causes of primary amenorrhoea may have increased over time, although estimates varied substantially across populations and study designs. In patients with FEDs, the prevalence of PA ranged from 2.4% to 14.8%, while athlete cohorts reported frequencies ranging from 7.3% to 53.8%. FEDs and excessive exercise, including REDs-related conditions, emerged as major clinical settings. Data specifically addressing hormonal profiles or body composition in this context remain limited. P-FHA may represent an early clinical manifestation of chronic LEA occurring during a critical developmental window. Early recognition and multidisciplinary management are essential to minimise potential consequences on growth, skeletal health, reproductive function, body composition, and psychological well-being. Further prospective studies are needed to better define its epidemiology, neuroendocrine mechanisms, and optimal management strategies.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SSTR-PeRForm: A harmonized approach to somatostatin receptor PET response assessment in neuroendocrine tumors","authors":"Hannes Leupe,&nbsp;Christophe M. Deroose,&nbsp;Andreas Kjaer,&nbsp;Vikas Prasad,&nbsp;Valentina Ambrosini","doi":"10.1111/jne.70244","DOIUrl":"https://doi.org/10.1111/jne.70244","url":null,"abstract":"","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}