Journal of Neuroendocrinology最新文献

{"title":"Mechanisms of intrinsic osmolality and sodium detection by magnocellular neurosecretory neurons.","authors":"Sandra Salgado-Mozo, Anzala Murtaz, Joshua C Wyrosdic, Julie O'Reilly-Fong, Cristian Zaelzer, Mary P LaPierre, Charles W Bourque","doi":"10.1111/jne.70091","DOIUrl":"https://doi.org/10.1111/jne.70091","url":null,"abstract":"<p><p>The maintenance of extracellular fluid (ECF) osmolality and sodium concentration ([Na⁺]_o) near optimal \"set point\" values sustains physiological functions and prevents pathological states such as hypo- and hypernatremia. The peptide hormones vasopressin (antidiuretic hormone) and oxytocin (a natriuretic hormone in rats) play key roles in this process. These hormones are synthesized by hypothalamic magnocellular neurosecretory cells (MNCs) that project to the neurohypophysis and are released into the systemic circulation in response to rises in ECF osmolality or [Na⁺]_o. These homeostatic responses are highly sensitive. For example, vasopressin release is elicited by an increase in ECF osmolality as small as ≥1%. The osmotic and sodium-dependent control of vasopressin and oxytocin release at the neurohypophysis is directly regulated by the electrical activity of MNCs. This regulation involves an array of mechanisms that include synaptic inputs from the brain and periphery, the effects of chemicals released by glial cells, and intrinsic sensory properties of MNCs. These overlapping mechanisms may offer an important degree of redundancy for the homeostatic control of vasopressin and oxytocin release and contribute to the high sensitivity of these responses. Recent work has shown that the intrinsic sodium sensitivity and osmosensitivity of MNCs play an important role in the control of these neurons in vivo. This review provides an update of our current understanding of the molecular and cellular mechanisms that contribute to the cell-autonomous sensory properties of MNCs.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70091"},"PeriodicalIF":4.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin neural responses distinguish social novelty from familiarity but not kin from non-kin in male spiny mice.","authors":"Christian Janmil Esquilin-Rodriguez, Brandon A Fricker, Aubrey M Kelly","doi":"10.1111/jne.70089","DOIUrl":"https://doi.org/10.1111/jne.70089","url":null,"abstract":"<p><p>In most species, individuals must be able to identify threats, peers, and potential mates to survive. The distinction of kin from non-kin and novel conspecifics from familiars is essential to the successful categorization of these identities. Although oxytocin (OXT) signaling has been implicated in social recognition, little is known about the contributions of distinct OXT-producing cell groups to distinguishing conspecific type. To determine whether OXT-producing neuronal populations differentially respond to novelty or kinship status, we conducted immediate early gene tests in male spiny mice (Acomys dimidiatus), a communally breeding species that we previously showed distinguishes between novelty and kinship status. Immunohistochemical analysis of brain tissue revealed that the OXT cell populations in the paraventricular nucleus of the hypothalamus and the anterior hypothalamus did not differentially respond to the kinship or novelty status of same-sex conspecifics. However, while OXT-producing neurons in the bed nucleus of the stria terminalis did not distinguish between kin and non-kin spiny mice, this cell group was more responsive to familiar than novel conspecifics. These results suggest that extrahypothalamic OXT neurons may be involved in aspects of processing the novelty status of a conspecific.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70089"},"PeriodicalIF":4.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep in neurodegenerative diseases: A focus on melatonin, melanin-concentrating hormone and orexin.","authors":"Simon J Guillot, Pierre-Hervé Luppi, Luc Dupuis, Matei Bolborea","doi":"10.1111/jne.70085","DOIUrl":"https://doi.org/10.1111/jne.70085","url":null,"abstract":"<p><p>Sleep and circadian rest-activity rhythm alterations are recognised as inherent clinical features of various neurodegenerative diseases. Traditionally viewed as secondary manifestations of neurodegeneration, recent studies have revealed that disruptions in circadian rhythm and sleep-wake cycles can precede clinical symptoms and significantly contribute to the underlying pathophysiological progression. In this review, we summarise recent research on the impact of sleep and circadian rhythm alterations in ageing and major neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and frontotemporal dementia, highlighting the roles of melatonin, orexin, and melanin-concentrating hormone (MCH) systems as key regulators at the intersection of sleep and neurodegeneration. We argue that sleep and circadian alterations may serve as early biomarkers and therapeutic targets for these diseases.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70085"},"PeriodicalIF":4.1,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of androgen and estrogen receptor mRNA expression in adult mouse hippocampus.","authors":"Malte Schöbe, Bianka Brunne, Roland A Bender","doi":"10.1111/jne.70086","DOIUrl":"https://doi.org/10.1111/jne.70086","url":null,"abstract":"<p><p>In hippocampus, androgens and estrogens influence neuronal plasticity via a range of nuclear or membrane-bound receptors. While much work has focused on determining their functions, a certain vagueness about the cellular expression of established receptors has remained. Moreover, novel candidates, such as the androgen-responsive zinc-transporter ZIP9, need to be inserted into the emerging picture. We used highly-sensitive RNAscope in situ hybridization and quantitative real-time PCR to examine the cellular and total hippocampal mRNA expression of androgen (AR, ZIP9) and estrogen receptors (ERα, ERβ, GPER1) in adult mouse hippocampus, considering sex and estrous cycle as variables. (1) Androgen receptors are more abundantly expressed than estrogen receptors. (2) AR and ZIP9 mRNA regularly co-localize in hippocampal neurons, but ZIP9 mRNA is more homogenously distributed and also expressed in astrocytes and microglia. (3) ERα and GPER1 are the predominant estrogen receptors (ERβ mRNA was very low), but exhibit differential expression patterns: GPER1 mRNA is preferentially expressed in glutamatergic neurons, while ERα is specifically expressed in a subpopulation of GABAergic interneurons. Both receptors were barely detectable in astrocytes and microglia. (4) ZIP9 mRNA expression varies during the estrous cycle, being significantly down-regulated if serum E2 is high, whereas ERα mRNA expression was generally higher in females. We provide a comprehensive cellular and quantitative expression analysis of androgen and estrogen receptors in adult mouse hippocampus, including for the first time mRNA expression data on ZIP9. Our data underline the necessity to consider sex and estrous cycle when studying sex hormone functions.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70086"},"PeriodicalIF":4.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in the diagnosis of gastro-entero-pancreatic neuroendocrine neoplasms: Potential benefits and current limitations.","authors":"Elettra Merola, Giuseppe Fanciulli, Giovanni Mario Pes, Maria Pina Dore","doi":"10.1111/jne.70087","DOIUrl":"https://doi.org/10.1111/jne.70087","url":null,"abstract":"<p><p>Neuroendocrine neoplasms (NENs), once considered rare, are now increasingly diagnosed worldwide, with gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) accounting for the majority of cases (55%-70%). NENs are characterized by considerable heterogeneity, driven by factors such as tumor differentiation, Ki-67 index, primary tumor location, somatostatin receptor status, and disease stage. International guidelines advocate for a multidisciplinary approach to ensure individualized treatment strategies. Given the disease's complexity, artificial intelligence (AI) may offer substantial support in the management of NENs. AI is playing an increasingly prominent role in medicine by enabling advanced diagnostic capabilities through machine learning and deep learning algorithms, particularly in imaging. However, current literature on AI applications in NENs is limited, and their routine use in clinical practice has yet to be established. This narrative review aims to provide a comprehensive overview of the potential roles of AI in the diagnosis of GEP-NENs, while also addressing the associated biases and ethical considerations of medical AI implementation.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70087"},"PeriodicalIF":4.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticotropin-releasing factor type 1 receptors in the rat nodose ganglion are involved in the transduction of stress-induced visceral sensory signals to the brain.","authors":"Asuka Mano-Otagiri, Tamotsu Shibasaki, Atsushi Sakai, Yoshihiko Kakinuma","doi":"10.1111/jne.70082","DOIUrl":"https://doi.org/10.1111/jne.70082","url":null,"abstract":"<p><p>Corticotropin-releasing factor (CRF) plays roles in stress-related responses through its type 1 (CRF₁) and type 2 receptors. Both CRF and CRF₁ are expressed in the rat colon. Peripheral CRF administration and various stressors increase colonic motility and defecation. Stress induces CRF release in the colon, suggesting CRF may mediate stress-related responses of the colon. The vagal nodose ganglion (NG) transduces visceral information, including colonic sensation, to the brain. However, it remains unclear whether the CRF/CRF₁ system is involved in vagal afferent functions. This study, therefore, aimed to clarify the involvement of the CRF/CRF₁ system in relaying visceral sensory information to the brain and the effect of stress exposure on vagal nerve function. The experiments were conducted in male rats. First, CRF₁-like immunoreactivity (CRF₁-LI) was characterized in the NG. Second, the effects of vagotomy on CRF₁-LI in the NG, intraperitoneally administered CRF-induced fecal output, and c-Fos expression in the nucleus tractus solitarius (NTS) were evaluated. Subsequently, a fast blue retrograde tracer was microinjected into the proximal colon. Finally, we analyzed CRF- or stress-induced phosphorylation of cyclic AMP-response element-binding protein (pCREB) in the NG. CRF₁ mRNA and CRF₁-LI were detected, and CRF₁-LI accumulated on the proximal side of the ligated region of the nerve trunk, and CRF₁-LI was detected in most cholinergic neurons. CRF₁ siRNA suppressed the expression of CRF₁-LI in the NG. Subdiaphragmatic vagotomy decreased the number of CRF₁-positive cells in the NG while it did not affect CRF-induced fecal output. CRF-induced c-Fos expression in the NTS was suppressed by vagotomy. A neuronal tracing study showed that approximately half of CRF₁-positive cells expressed fast blue in the NG. Intraperitoneal CRF, a selective CRF₁ agonist, or immobilization stress induced pCREB expression and increases in CRF₁-positive cells in the NG. In contrast, a CRF₁ antagonist reduced the immobilization-induced increase in the expression of pCREB in the NG. These results suggest that the CRF/CRF₁ system is involved in the signal transduction of colonic sensory information to the central nervous system via the NG.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70082"},"PeriodicalIF":4.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative hepatic ultrasonography in patients with gastrointestinal and pancreatic neuroendocrine neoplasms without preoperative evidence of liver metastases.","authors":"L Viganò, M Maruccio, F Faustini, I Frigerio, F Gavazzi, R De Robertis Lombardi, F Scopelliti, G Capretti, A Ammirabile, M D'Onofrio, A Giardino, G Ferrillo, M Rodari, P Regi, F Procopio, R Salvia, A Lania, G Butturini, L Landoni, G Torzilli, A Zerbi","doi":"10.1111/jne.70079","DOIUrl":"10.1111/jne.70079","url":null,"abstract":"<p><p>In patients with gastroenteric and pancreatic neuroendocrine neoplasms (GEP-NENs), the risk of liver metastases is high, but the accuracy of standard imaging for detecting small hepatic nodules is limited. This raises concerns about the adequacy of staging in cM0 patients. This study aims to determine the percentage of cM0 GEP-NEN patients with occult liver metastases that can be identified using intraoperative ultrasound (IOUS) during surgery for the primary tumor. A prospective study was conducted at three high-volume centers between October 2020 and December 2023. Patients who underwent surgery for GEP-NENs staged as cM0 based on CT and PET/CT (MRI in selected cases) were included. IOUS was systematically performed, in combination with contrast-enhanced IOUS (CE-IOUS) and biopsy when necessary. The ground truth was the result of a contrast-enhanced CT or MRI performed 6 months after surgery. A total of 51 cM0 GEP-NEN patients were enrolled. IOUS detected suspicious liver nodules in seven patients (14%). Three were classified as metastatic based on the IOUS pattern, CE-IOUS pattern, and biopsy, respectively, while four were classified as non-metastatic based on biopsy (n = 2) or CE-IOUS pattern (n = 2). At six-month follow-up imaging, two patients (4%) were confirmed as metastatic (the suspicious metastasis at CE-IOUS was not confirmed). GEP-NENs G3 and those with necrosis had a higher risk of metastases (one-third of patients, p < 0.05 compared to G1-2 and non-necrotic neoplasms). IOUS, combined with CE-IOUS and biopsy, achieved 100% sensitivity, 98% accuracy, and 100% negative predictive value. IOUS, along with CE-IOUS and biopsy, provides accurate staging in GEP-NENs, identifying occult metastases in approximately 4% of cM0 cases. Due to the low incidence of occult metastases, routine use of IOUS cannot be recommended. It should be considered selectively in aggressive tumors, which have shown a significantly higher risk of liver involvement.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70079"},"PeriodicalIF":4.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell transcriptomic analysis reveals a metastasis-associated PCSK1⁺ neuroendocrine subpopulation in pancreatic neuroendocrine tumors.","authors":"Xiaolei Yin, Xiaopeng Li, Lili Mi, Jiaojiao Hou, Fei Yin","doi":"10.1111/jne.70084","DOIUrl":"https://doi.org/10.1111/jne.70084","url":null,"abstract":"<p><p>Pancreatic neuroendocrine tumors (PNETs) are uncommon malignancies characterized by significant clinical heterogeneity and a pronounced tendency for liver metastasis. Despite this, the cellular mechanisms driving PNET progression remain inadequately elucidated, especially concerning neuroendocrine subpopulations. We analyzed publicly available single-cell RNA sequencing (scRNA-seq) data from 27 samples, including adjacent normal tissues (NT), primary tumors (PT), and hepatic metastases (HM), to explore the heterogeneity of neuroendocrine cells. Our downstream analyses encompassed copy number variation (CNV) inference, pseudotime trajectory modeling using CytoTRACE2 and Monocle3, Single-Cell Regulatory Network Inference and Clustering (SCENIC), cell-cell communication analysis via CellChat, and external validation with bulk RNA-seq datasets. We identified a distinct PCSK1⁺ neuroendocrine cell subpopulation, predominantly found in HM, which exhibited a high CNV burden, low differentiation potential, and significant transcriptional divergence from the NEUROD1⁺ neuroendocrine cells prevalent in primary tumors. The trajectory analysis delineated a developmental continuum commencing from the NEUROD1⁺ subpopulation and culminating in the PCSK1⁺ subpopulation. SCENIC analysis identified ATF6 as a pivotal transcriptional regulator within the PCSK1⁺ subpopulation, while KEGG enrichment of its target genes indicated involvement in stress-related signaling pathways. Furthermore, cell-cell communication analysis demonstrated that fibroblasts were the predominant signaling source to the PCSK1⁺ subpopulation in both primary tumors (PT) and hepatic metastases (HM), with conserved ligand-receptor interactions, including the CD99-CD99 and collagen-integrin axes. Our study identifies a metastasis-enriched, terminally differentiated PCSK1⁺ subpopulation and elucidates its potential regulatory and microenvironmental characteristics. These findings enhance our understanding of the cellular states linked to the progression of PNETs and lay the groundwork for subsequent mechanistic investigations.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70084"},"PeriodicalIF":4.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association rule mining of clinical and biomarker data in neuroendocrine tumors: A prospective study on disease progression","authors":"Ulrich Peter Knigge,&nbsp;Magnus Kjellman,&nbsp;Henning Grønbæk,&nbsp;Espen Thiis-Evensen,&nbsp;Camilla Schalin-Jäntti,&nbsp;Staffan Welin,&nbsp;Halfdan Sørbye,&nbsp;Maria del Pilar Schneider,&nbsp;Roger Belusa,&nbsp;The Nordic NET Biomarker Group","doi":"10.1111/jne.70069","DOIUrl":"10.1111/jne.70069","url":null,"abstract":"<p>There is an unmet need for new methods to predict disease course in patients with neuroendocrine tumors (NET). We investigated 92 putative cancer-related plasma proteins including chromogranin A (CgA) and clinical parameters at the time of diagnosis to identify early factors associated with progressive (PD) or stable disease (SD). Patients with NET grade 1 and 2 of the small intestine (siNET) and pancreas (pNET) were included in this prospective study. Blood samples were obtained at the time of diagnosis before tumor-related therapy was initiated. During 3 years of follow-up, SD or PD was determined according to current clinical practice by each investigator. Association rule mining (ARM) was used to identify combinations of biomarkers and clinical parameters associated with SD or PD. Altogether, 115 patients with siNET and 30 with pNET with complete clinical and biomarker data were included in the analysis representing 3 years of follow-up. Several novel plasma proteins and clinical factors were associated with either PD or SD. In siNET, CgA (&gt;4 upper limits of normal [ULN]) was the most frequent biomarker associated with PD. Females, in contrast to males, with CgA &gt;4 ULN showed a high risk of progression (PPV 100%, NPV 63%). In the siNET cohort, Carboxypeptidase E (CPE) was a discriminating factor between SD and PD. CPE &lt;3.03 was associated with SD, whereas CPE &gt;3.14 was associated with PD (<i>p</i> = 0.003). In the pNET cohort, among clinical variables, only the presence of liver metastasis was associated with PD. CgA was not among the top biomarkers associated with PD. Several parameters, both clinical and biomarker data, as well as combinations of these, were associated with PD or SD 3 years after diagnosis. We identified novel biomarkers improving the association with PD or SD. [Correction added on 28 August 2025, after first online publication: Abstract has been updated.]</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"37 10","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.70069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life as a predictor for survival in patients with small intestinal neuroendocrine tumours.","authors":"Håkan Ohlsson, Martin Nilsson, Anna Sundlöv, Marlene Malmström, Martin Almquist","doi":"10.1111/jne.70081","DOIUrl":"https://doi.org/10.1111/jne.70081","url":null,"abstract":"<p><p>Health-related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survival in patients with siNET. We included 85 patients with advanced siNET who completed the validated HRQoL instruments, EORTC QLQ-C30 and GI.NET21. We used Cox proportional hazards to calculate the hazard ratio (HR) of survival according to the QLQ-C30 summary score, adjusting for clinical variables selected with causal inference. Flexible parametric modelling using cubic splines was used to illustrate the time-dependent relationship between HRQoL and OS. The QLQ-C30 summary score was correlated with overall survival (OS) with an adjusted HR of 0.62 (95% CI 0.46-0.83, p < .001) for each 10-point increase in summary score. Compared to a model using only clinical variables, the summary score increased predictive accuracy by eight percentage units and improved model fit. The inclusion of GI.NET21 with the summary score yielded similar results. HRQoL predicts overall survival in patients with siNET, providing additional information to clinical variables. Measuring HRQoL might be useful when following patients with siNET.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70081"},"PeriodicalIF":4.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}