Journal of Neuroendocrinology最新文献

{"title":"Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin-releasing hormone neurons in female mice","authors":"J. Rudolph Starrett,&nbsp;Xi Chen,&nbsp;Devon Krasner,&nbsp;Chrystian D. Phillips,&nbsp;Suzanne M. Moenter","doi":"10.1111/jne.70281","DOIUrl":"10.1111/jne.70281","url":null,"abstract":"<p>Kisspeptin neurons in the rostral hypothalamus are hypothesized to initiate preovulatory gonadotropin-releasing hormone (GnRH) surges by causing estradiol-dependent activation of GnRH neuron action potential firing and subsequent GnRH release. To determine if estradiol or ovarian cycle stage modulate functional connectivity in this circuit, anteroventral-periventricular (AVPV) area kisspeptin neurons were photostimulated while recording firing and/or evoked synaptic currents from preoptic area GnRH neurons in acutely-prepared mouse brain slices. Slices were prepared 2-days post ovariectomy (OVX) and OVX plus estradiol during the morning or afternoon, or in the afternoon on diestrus, proestrus, or 1-week post OVX, or 6-weeks post OVX with or without 1-week of estradiol replacement. Photostimulation induced a sustained, frequency-dependent increase in GnRH neuron firing rate. This neuromodulatory-typical response was not different in diestrous versus proestrous mice but was blunted in 1-week OVX mice, suggesting ovarian steroids are needed for maintenance. Neuromodulatory responses were infrequent in 6-week OVX mice with or without 1 week of estradiol treatment. A minority of GnRH neurons exhibited a rapid increase in firing rate typical of fast synaptic transmission. Monosynaptic connectivity was similarly low among hormonal states and consistently GABAergic. Interestingly, evidence of fast-synaptic transmission was not required for GnRH neurons to exhibit an increase in firing rate, suggesting neuromodulatory transmission can occur in this system without fast-synaptic co-transmission. Fast-synaptic transmission was, however, associated with greater increases in firing rate, but only during proestrus, indicating GnRH neuron responsiveness to AVPV kisspeptin neuron activation is dependent on both hormone milieu and synaptic connectivity.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estradiol regulates L-type calcium channel-dependent social behavior deficits during cocaine abstinence in female rats","authors":"Violet M. Kimble,&nbsp;Mary Zanda,&nbsp;Hayde Sanchez,&nbsp;Clare Flannery,&nbsp;Jane R. Taylor,&nbsp;Anjali Rajadhyaksha,&nbsp;Nii A. Addy","doi":"10.1111/jne.70280","DOIUrl":"10.1111/jne.70280","url":null,"abstract":"<p>Social withdrawal during cocaine abstinence is a significant predictor of relapse, yet the neuroendocrine mechanisms underlying this vulnerability remain poorly understood, particularly in females. Estradiol, a potent neuromodulator of mesocorticolimbic circuitry, regulates dopamine-dependent processes that encode social motivation. L-type calcium channels (LTCCs) similarly regulate neuronal excitability and plasticity in corticolimbic regions implicated in addiction and affective regulation, and estradiol interacts with LTCC signaling through both membrane-initiated and transcriptional mechanisms. However, whether estradiol and LTCCs functionally converge to regulate social behavior during cocaine abstinence is unknown. Here, we used a preclinical behavioral pharmacology approach to examine this interaction in female Sprague–Dawley rats. Ovariectomized (OVX) rats with or without 17β-estradiol replacement underwent jugular catheterization and self-administered cocaine (0.5 mg/kg/inf, FR1) or saline for 10 days, followed by 17 days of forced abstinence. Social preference was assessed using a three-chamber social interaction test, with systemic isradipine (1.2 mg/kg, i.p.) administered 15 min prior to testing. Cocaine abstinence significantly reduced social preference in intact females. LTCC blockade with isradipine restored social preference, but this effect was dependent on ovarian hormone status: isradipine normalized social behavior in sham-operated and OVX + E2 rats but not in OVX rats lacking estradiol. Multiple linear regression confirmed that ovarian hormone status and isradipine treatment, but not total cocaine intake, significantly predicted social preference, with a robust hormone × isradipine interaction explaining 44.6% of behavioral variance. These findings demonstrate that estradiol does not simply protect against abstinence-related social deficits but rather biases neural signaling such that social behavior becomes sensitive to LTCC-dependent mechanisms. This work identifies a functional estradiol–LTCC interaction regulating social motivation during cocaine abstinence and highlights the importance of hormonal state in shaping sex-specific addiction vulnerability.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clocks and steroids interaction across the life span.","authors":"Violetta Pilorz, Pi-Shan Chang, Sylvia A Newbold, Elisa Nied, Valerie Simonneaux, Mariana Astiz, Hugh D Piggins","doi":"10.1111/jne.70291","DOIUrl":"https://doi.org/10.1111/jne.70291","url":null,"abstract":"<p><p>The circadian system enables organisms to anticipate daily environmental changes and to align physiology and behaviour with the external light-dark cycle. In mammals, this temporal organisation is coordinated by the central pacemaker in the suprachiasmatic nucleus (SCN), which synchronises peripheral clocks through humoral and neural signals throughout the body. The circadian clock and steroid hormones are linked through a reciprocal, multi-level regulatory relationship. While the SCN and peripheral clocks shape the temporal pattern of steroid secretion, steroid hormones feed back onto the SCN and peripheral clocks, thereby modifying clock gene expression, phase, amplitude, synchrony, and network coherence. This interaction is dynamic across the lifespan, as both the clock and the steroid environment change during development, reproductive life, and ageing. During prenatal and early postnatal development, maternal glucocorticoids (GCs) and other perinatal steroid signals provide time-dependent cues that may shape the maturation and long-term function of the circadian system. During reproductive life in females, ovarian steroids dynamically remodel clocks within the hypothalamic-pituitary-ovarian (HPO) axis, coordinating reproductive timing with circadian signals from the SCN. In parallel, GCs interact with the reproductive axis and may influence fertility in a time-of-day- and cycle-stage-dependent manner. Disruption of this temporal coordination, for example, by shift work, may impair reproductive and endocrine function. With advancing age, both circadian and endocrine rhythms lose robustness, leading to weakened coordination between the SCN and peripheral clocks, as well as reduced synchrony among cellular clocks within peripheral tissues. These changes contribute to disturbed sleep-wake rhythms, reproductive ageing, and altered stress responsiveness. This review discusses the interaction between steroid hormones and circadian clocks across the life span, highlighting reciprocal regulation as a key mechanism linking temporal organisation to physiology and health.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 10","pages":"e70291"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic intratumour heterogeneity in digestive high-grade neuroendocrine neoplasms.","authors":"Siren Morken, Halfdan Sorbye, Wei Deng, Hatice Toprak Dogramaci, Andreas Venizelos, Lene Weber Vestermark, Per Pfeiffer, Geir Olav Hjortland, Christian Kersten, Eva Hofsli, Hege Elvebakken, Anne Couvelard, Inger Marie Bowitz Lothe, Aurel Perren, Stian Knappskog","doi":"10.1111/jne.70296","DOIUrl":"10.1111/jne.70296","url":null,"abstract":"<p><p>Digestive high-grade neuroendocrine neoplasms (HG-NEN) are rare and heterogeneous tumours with an aggressive biology and limited treatment efficacy. Genetic intratumour heterogeneity (ITH) is a mechanism of progression and treatment resistance in other cancers, yet unexplored in digestive HG-NEN. Next-generation sequencing with a 360-cancer gene panel was performed on 51 digestive HG-NEN, suitable for multiregional sampling. The mutational status of each sample within a patient was assessed to calculate an ITH-index, defined as the average number of discordant mutations across all pair-wise comparisons between samples. An ITH-index based on primary tumour samples was calculated for chemotherapy-naïve cases: 28 neuroendocrine carcinomas (NEC), 9 mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) and 3 neuroendocrine tumour grade 3 (NET G3). Median ITH-index in NEC/MiNEN was 5, with a wide range (0-98.8). Greater heterogeneity was associated with right-sided colonic primaries (p = .005) and higher tumour mutational burden (r = 0.74, p < .001). Median overall survival was 7 months longer in NEC/MiNEN with median ITH-index above compared to below median (22.5 vs. 15.5 months, p = .077), driven mostly by patients with locoregional disease. Response to first-line chemotherapy was not influenced by median ITH-index. No heterogeneity was found among driver mutations in BRAF and KRAS. NET G3 displayed low heterogeneity (ITH-index 2-3). Higher ITH-index was not associated with shorter survival or treatment response, suggesting that genetic ITH is not the primary resistance mechanism in digestive NEC/MiNEN. Moving towards targeted treatment strategies, our data indicate that a single biopsy may underestimate ITH. BRAF and KRAS may be favourable targets as they displayed no heterogeneity.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 10","pages":"e70296"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific hormonal trajectories reveal an early neuroendocrine vulnerability window preceding menopausal depressive symptoms.","authors":"Jialin Zhang, Yong Yang, Yunpeng Li, Qin Liu, Yuqun Zhang","doi":"10.1111/jne.70288","DOIUrl":"https://doi.org/10.1111/jne.70288","url":null,"abstract":"<p><p>Depressive symptoms show marked sex differences in prevalence and symptom profiles, with sex hormones thought to play a key role. However, systematic evaluations of age-related hormone variation across the adult lifespan remain limited. We analyzed data from 8421 adults (4204 males and 4217 females) drawn from the National Health and Nutrition Examination Survey (NHANES) collected between 2013 and 2016. Estradiol and testosterone levels, along with depressive symptoms assessed using the Patient Health Questionnaire-9 (PHQ-9), were included in the analysis. Participants were stratified by decade-based age groups, and group means were plotted to characterize age-related hormone levels and depressive symptom severity. Differences between groups were examined using independent t-tests and one-way ANOVA with Bonferroni correction. Decade-based age stratification was used because it reflects major endocrine transition stages across adulthood. Compared to the non-depressed group, both male and female participants aged 28-57 showed altered hormone trajectories. Notably, in females, estradiol levels began to abnormally elevate in the 28-37 age range and were associated with depressive symptom severity in the 38-57 age range among the depressed group. Within the PHQ-9 item-level analysis, depressed females exhibited significantly higher fatigue and lower insomnia scores compared to depressed males (p < .05). In the non-depressed groups, males scored significantly lower on all depressive symptoms except for psychomotor changes and self-harm or suicidal ideation compared to females (all p < .05). Estradiol showed a clear midlife inflection with pronounced instability emerging between ages 28 and 47. Our findings reveal sex- and age-specific trajectories of hormones and depressive symptoms across adulthood, with early estradiol variation emerging in female and externalizing features predominating in males at distinct life stages. These previously underrecognized patterns suggest an early neuroendocrine sensitive window, underscoring the need for mechanism-focused longitudinal studies and highlighting opportunities for earlier, sex-tailored clinical strategies.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 10","pages":"e70288"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milk and infant plasma hormone concentrations predict sweet and fat taste acceptance and later food intake","authors":"Ana Luz Kruger,&nbsp;Agustina Malpeli,&nbsp;Marisa Sala,&nbsp;Carla Casado,&nbsp;Ignacio Mendez,&nbsp;Lucrecia Fotia,&nbsp;Mercedes López,&nbsp;María Silvina Faquini,&nbsp;Daniel Castrogiovanni,&nbsp;Helgi Schioth,&nbsp;Sophie Nicklaus,&nbsp;Mario Perello,&nbsp;María F. Andreoli","doi":"10.1111/jne.70282","DOIUrl":"10.1111/jne.70282","url":null,"abstract":"<p>Early-life exposure to metabolic hormones may influence the development of taste acceptance and subsequent intake of hyperpalatable foods (HPF) in infants, but evidence integrating hormonal, behavioral, and dietary data in humans is limited. Therefore, our objective was to determine whether concentrations of insulin, leptin, cortisol, and liver-expressed antimicrobial peptide 2 (LEAP2) in human milk and infant plasma at 6 months predict infant sweet and fat taste acceptance and HPF intake later in infancy. In this prospective cohort study, human milk and infant plasma were collected at 6 months and analysed for insulin, leptin, cortisol, and LEAP2. At 18 months, sweet and fat taste acceptance were assessed using ingestion ratio (IR; motivational drive) and liking ratio (LR; hedonic response). HPF intake was quantified from standardized 24-h dietary recalls. Associations were evaluated using multivariable linear regression. Eighty two mother–infant pairs were enrolled, of which 28 completed follow-up and were included in the final analysis. Milk LEAP2 was positively associated with fat IR (<i>p</i> = .037). Milk insulin was inversely associated with sweet IR (<i>p</i> = .003) and LR (<i>p</i> = .020), while milk leptin was positively associated with sweet IR (<i>p</i> = .013) and LR (<i>p</i> = .018) and inversely associated with HPF intake consumption (<i>p</i> = .001). Milk cortisol was positively associated with fat (<i>p</i> = .043) and sweet IR (<i>p</i> = .014). In contrast, infant plasma LEAP2 was inversely associated with fat IR (<i>p</i> = .018) and HPF intake (<i>p</i> = .002) but positively associated with sweet IR (<i>p</i> = .005) and LR (<i>p</i> = .023). Infant plasma cortisol was directly associated with HPF intake (<i>p</i> = .006) and inversely associated with sweet and IR (<i>p</i> = .004) and fat LR (<i>p</i> = .009). Milk-derived and endogenous metabolic hormones were differentially associated with taste acceptance and HPF intake, identifying specific hormonal pathways that may shape early feeding behavior and later food intake. Clinical Trial Registry: This study was registered at clinicaltrials.gov as NCT05798676. https://clinicaltrials.gov/study/NCT05798676.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13631378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported measures in hypothalamic–pituitary diseases","authors":"Susan M. Webb,&nbsp;Alicia Santos,&nbsp;Queralt Asla,&nbsp;Rebeca Marín,&nbsp;Anna Aulinas","doi":"10.1111/jne.70269","DOIUrl":"10.1111/jne.70269","url":null,"abstract":"<p>Modern medicine centres its focus on the central stakeholder, the patient, to deliver a more patient-centred and holistic care and improve quality of care, emphasizing the importance of communication between healthcare providers and patients. To learn how the patient experiences and evaluates outcome of any health intervention, different tools have been developed, known as PREMs (Patient-Reported Experience Measures) and PROMs (Patient-Reported Outcome Measures). PREMs reflect the patient's personal experience when being cared for, like whether the professionals explained things clearly, or if they felt they were treated with dignity and are indicators of the care process, i.e., communication, access, environment, coordination, etc. and are used to improve service quality and patient-centredness. PROMs are linked to clinical outcomes and reflect the patient's feelings about their health and may include, among others, pain scales, mobility questionnaires or psychosocial inventories. They are used to assess the effectiveness of treatment, like before and after surgery and focus on symptoms, functioning, and health-related quality of life (HRQoL). This review summarizes available information on PREMs, PROMs and HRQoL in patients with hypothalamic–pituitary diseases, specifically, Cushing disease, acromegaly, prolactinoma, non-functioning pituitary adenoma, hypopituitarism (including adult growth hormone and arginine vasopressin deficiencies) and craniopharyngioma. On the whole, hormone dysfunction and mass control after medical or surgical treatment improves HRQoL, but it often remains worse than in healthy control population. Additionally, it is important to ask the patients what affects them most, since the identification and relevance of complaints and experiences are often different among pituitary patients and healthcare providers.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversies in NEN: An ENETS position statement on the role of liver transplantation (LT) in patients with advanced small-intestinal and pancreatic NETs.","authors":"Peter Stålberg, Mairéad G McNamara, Simona Grozinsky-Glasberg, Andreas Pascher, Beata Kos-Kudla, Timm Denecke, Nehara Begum, Wendy Martin, Stephanie Alband, Clarisse Dromain, Raj Srirajaskanthan, Eric Baudin","doi":"10.1111/jne.70250","DOIUrl":"https://doi.org/10.1111/jne.70250","url":null,"abstract":"<p><p>Liver transplantation (LT) may offer survival or symptomatic benefit for highly selected patients with advanced, well-differentiated small-intestinal or pancreatic neuroendocrine tumours and unresectable liver-dominant metastases. However, its role remains controversial, as LT is rarely curative, recurrence is common, and benefits must be weighed against perioperative risk, lifelong immunosuppression, alternative therapies, and organ allocation ethics. This ENETS position statement summarises current evidence and expert consensus, reframing LT within a transplant-benefit model rather than fixed eligibility criteria. It outlines biologically informed selection principles and multidisciplinary assessment, as well as addressing the need for standardised characterisation, prospective registries, and long-term outcome data to better define the net clinical benefit of LT in this rare patient population.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 10","pages":"e70250"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13626967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioids and the oxytocin system: Mechanistic interactions altering maternal neuroplasticity.","authors":"Lauren M Richardson, Alexa H Veenema, Susanne Brummelte","doi":"10.1111/jne.70293","DOIUrl":"10.1111/jne.70293","url":null,"abstract":"<p><p>Due to the ongoing opioid epidemic, there has been a rise in the use of medications for opioid use disorder (MOUD) during pregnancy. This paper examines how buprenorphine (BUP), the new golden standard for MOUD, may disrupt maternal care through dysregulation of the oxytocin (OXT) system. OXT is central to parturition, lactation, caregiving, and coordinating activity across the maternal brain network (MBN), including the paraventricular (PVN) and supraoptic nucleus, medial preoptic area, and nucleus accumbens. The endogenous opioid system normally regulates OXT release, with μ-opioid receptor (μOR) and κ-opioid receptor (κOR) signaling influencing OXT neurons. BUP has a unique mechanism of action as it is a partial μOR agonist and a κOR antagonist, which may lead to complex interactions with endogenous opioids and subsequently the OXT system during pregnancy. In line with this, recent preclinical research suggests that BUP exposure during gestation results in reduced maternal motivation and inconsistent pup-directed care in rodent models. Therefore, this paper will explore the possible underlying mechanisms of how BUP exposure may dysregulate the OXT system and thus play a role in the observed maternal care deficits. In particular, we propose that chronic BUP exposure dampens PVN OXT output, disrupts synchrony across the MBN, and constrains OXT-driven neuroplasticity. Further, we will discuss the potential of postpartum OXT administration to restore maternal behaviors by re-engaging OXT signaling and network activity in both clinical and preclinical models. By integrating receptor, network, and behavioral evidence, this review provides a framework for understanding BUP's impact on maternal care through oxytocinergic disruptions and for potential translational interventions.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 10","pages":"e70293"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to 'Marine flatworms as windows into the evolution of bilaterian neuropeptide signalling'.","authors":"","doi":"10.1111/jne.70283","DOIUrl":"10.1111/jne.70283","url":null,"abstract":"","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 10","pages":"e70283"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}