Controversies in NEN: An ENETS position statement on the management of locally advanced neuroendocrine neoplasia of the small intestine and pancreas without distant metastases.

IF 4.1 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM
M E T Tesselaar, S Partelli, A J A T Braat, A Croitoru, A P Soares Santos, J Schrader, S Welin, E Christ, M Falconi, D K Bartsch
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引用次数: 0

Abstract

Locally advanced neuroendocrine neoplasms (NENs) are defined by extensive local invasion in the absence of distant metastases, although specific definitions may vary among study groups. While most patients with NENs present with localized or metastatic disease, a smaller subset is diagnosed with locally advanced tumors. Management of this subgroup remains particularly challenging, owing to the limited evidence base and lack of consensus regarding optimal therapeutic strategies. This guidance document synthesizes the current evidence and expert knowledge on the management of locally advanced NENs of the small intestine and pancreas, addressing four clinically relevant key questions that aim to inform best practice in these patients.

NEN的争议:ENETS关于小肠和胰腺局部晚期神经内分泌瘤无远处转移的处理立场声明。
局部晚期神经内分泌肿瘤(NENs)的定义是在没有远处转移的情况下广泛的局部侵袭,尽管具体的定义在不同的研究组可能有所不同。虽然大多数NENs患者表现为局部或转移性疾病,但一小部分患者被诊断为局部晚期肿瘤。由于有限的证据基础和缺乏关于最佳治疗策略的共识,这一亚组的管理仍然特别具有挑战性。本指导文件综合了目前关于小肠和胰腺局部晚期NENs管理的证据和专家知识,解决了四个临床相关的关键问题,旨在为这些患者的最佳实践提供信息。
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来源期刊
Journal of Neuroendocrinology
Journal of Neuroendocrinology 医学-内分泌学与代谢
CiteScore
6.40
自引率
6.20%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Journal of Neuroendocrinology provides the principal international focus for the newest ideas in classical neuroendocrinology and its expanding interface with the regulation of behavioural, cognitive, developmental, degenerative and metabolic processes. Through the rapid publication of original manuscripts and provocative review articles, it provides essential reading for basic scientists and clinicians researching in this rapidly expanding field. In determining content, the primary considerations are excellence, relevance and novelty. While Journal of Neuroendocrinology reflects the broad scientific and clinical interests of the BSN membership, the editorial team, led by Professor Julian Mercer, ensures that the journal’s ethos, authorship, content and purpose are those expected of a leading international publication.
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