Journal of Neuro-Ophthalmology最新文献

{"title":"Fooled by Steroids: Optic Nerve Sheath Meningioma Masquerading as Optic Perineuritis.","authors":"Emma M Tsai, Kambiz Ameli, Amanda C Maltry, Collin M McClelland, Michael S Lee","doi":"10.1097/WNO.0000000000002497","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002497","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Finsterer \"Ophthalmoplegia Is Not Uncommon in Carriers of DOK7 Variants\".","authors":"Thilan P Subasinghe Arachchige, Karl K Ng, Kate E Ahmad","doi":"10.1097/WNO.0000000000002524","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002524","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmoplegia Is Not Uncommon in Carriers of DOK7 Variants.","authors":"Josef Finsterer","doi":"10.1097/WNO.0000000000002523","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002523","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Reliable and Reproducible Is Optical Coherence Tomography in Idiopathic Intracranial Hypertension? When Agreement Deteriorates in Advanced Papilledema.","authors":"Vineet S Kumar, Chiamaka J P Okeke, Grant C Goodfellow, John T Reaves, Luke W Barrick, Laiba A Khalil, David I Kaufman","doi":"10.1097/WNO.0000000000002530","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002530","url":null,"abstract":"<p><strong>Background: </strong>Optical coherence tomography (OCT)-derived peripapillary retinal nerve fiber layer (pRNFL) thickness is central to monitoring papilledema in idiopathic intracranial hypertension (IIH). However, the structural distortion caused by optic disc edema impairs automated segmentation accuracy, particularly in advanced disease. The magnitude of discrepancy between automated and manually corrected pRNFL measurements across Frisén grades has not been fully characterized.</p><p><strong>Methods: </strong>In this retrospective observational study conducted at a tertiary neuro-ophthalmology clinic, 62 eyes were analyzed, including 32 eyes from 16 patients with IIH and 30 non-IIH control eyes from 15 control participants. Papilledema severity was graded by a masked neuro-ophthalmologist using the Frisén scale (Grades 1-5). pRNFL thickness was measured using the Heidelberg SPECTRALIS spectral domain OCT system. Automated segmentation outputs were independently reviewed and manually corrected by 2 masked graders: a clinical neuro-ophthalmology fellow and an ophthalmology resident, both with neuro-ophthalmology experience. Agreement between automated and manually corrected measurements was assessed using linear mixed-effects models. Intergrader reliability was evaluated with intraclass correlation coefficients (ICCs), stratified by the Frisén grade.</p><p><strong>Results: </strong>No statistically significant differences between automated and manually corrected pRNFL measurements were observed at Frisén Grade 1 (mean difference -1.1 µm, P > 0.05) or Grade 2 (-15.6 µm, P > 0.05). A trend toward significance emerged at Grade 3 (29.9 µm, P < 0.1), with large, statistically significant divergence at Grades 4 (182.4 µm, P < 0.001) and 5 (158.7 µm, P < 0.001). Sector-specific analysis revealed greater discrepancy in the temporal superior, temporal inferior, and nasal inferior sectors at Grade 3, with increasing nasal superior involvement at Grades 4-5. Intergrader ICC was good in control eyes (0.892) and lower-grade papilledema (Grades 1-2: ICC = 0.807) but decreased to moderate at higher grades (Grades 3-5: ICC = 0.449).</p><p><strong>Conclusions: </strong>In this exploratory study, automated OCT segmentation demonstrated substantial divergence from manually corrected pRNFL measurements in higher-grade papilledema, with discrepancies exceeding 150 µm in advanced disease. The reliability of manual correction decreased to moderate levels with increasing Frisén grade. These findings underscore the need to interpret OCT-derived pRNFL measurements cautiously and in conjunction with the clinical examination in higher-grade papilledema.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial Epidermoid Cyst Mimicking a Congenital Fourth Nerve Palsy: A Case of Delayed Decompensation.","authors":"Amanda Tran, Jonathan A Micieli","doi":"10.1097/WNO.0000000000002527","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002527","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Visual Outcomes of Optic Neuritis in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.","authors":"Takhmina Abdul, Arina Nisanova, Anjalee Chopra, Ryan Bugsch, Akash Virupakshaiah, Naga Pradyumna Kothapalli, Ketaki Milind Panse, Emmanuelle Waubant, Nailyn Rasool, Shannon J Beres, Yin Allison Liu","doi":"10.1097/WNO.0000000000002516","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002516","url":null,"abstract":"<p><strong>Background: </strong>Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a neuro-immunological disorder that can cause optic neuritis (ON) and significant visual impairment. Our objective was to investigate clinical characteristics and visual outcomes in children with MOGAD-ON.</p><p><strong>Methods: </strong>Retrospective cohort study of MOG-IgG-positive children (onset age 18 years and younger) meeting 2023 international MOGAD panel criteria who presented with ON and received neuro-ophthalmic care between 2003 and 2023 at 3 academic centers in Northern California was conducted. We captured demographic and clinical characteristics, disease course, and presenting MOG-IgG titers through chart review. Ophthalmic metrics, including logarithmic minimum angle of resolution best-corrected visual acuity (logMAR BCVA), retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer thicknesses, and automated visual field mean deviation (AVF MD) at diagnosis, 1-month, 6-month, 1-year, and final (2+ years) visits, were obtained.</p><p><strong>Results: </strong>This study included 49 ON-affected eyes of 29 patients (20 with bilateral involvement), with 19 (66%) being female. The median age at first diagnosis was 9 years (range 1-18). The median follow-up was 40 months (0-119). Age younger than 8 years at MOGAD onset was predictive of recurrent ON (β1=-1.61, P = 0.03). LogMAR BCVA improved from 1.4 at diagnosis to 0.2 at 1 month and 0.07 at the final visit (P < 0.0001). In total, 29 eyes (59%) of 22 patients (76%) achieved complete visual recovery (BCVA LogMAR 0). RNFL thickness decreased from mean 130 µm at diagnosis to 6 months (65 µm, P < 0.05). Average AVF MD improved from -12.8 dB at diagnosis to -5.4 dB at the final visit (P = 0.02). Higher presenting MOG-IgG titers were associated with worse presenting visual fields (r = -0.96, P = 0.04).</p><p><strong>Conclusions: </strong>Children with MOGAD-associated ON often return to normal visual acuity despite significant optic atrophy. Most RNFL thinning occurs in the first 6 months but continues beyond 2 years after MOGAD onset. Younger children were at greater risk of ON relapse. A prospective longitudinal study on pediatric MOGAD-ON is warranted to validate these findings and identify biomarkers for visual outcome prediction.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monocular Temporal Hemianopia: MRI Correlation.","authors":"Phillip H Kim, Taylor A Robinson, Lanning B Kline","doi":"10.1097/WNO.0000000000002499","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002499","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abducens and Facial Nerve Enhancement in Facial Colliculus Syndrome.","authors":"Stefaan Van Hoe, Anne-Sophie Monté, Michel Van Lint, Laurens J L De Cocker","doi":"10.1097/WNO.0000000000002515","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002515","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Hemorrhagic Stroke Followed by Bilateral Optic Neuritis in MOG Antibody-Associated Disease.","authors":"Victoria Leung, Jim S Xie, Edward Margolin","doi":"10.1097/WNO.0000000000002492","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002492","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmology Meets Vision Rehabilitation-A Festschrift in Tübingen Honoring Susanne Trauzettel-Klosinski.","authors":"Klara Landau, Jonathan C Horton, Kathleen Digre","doi":"10.1097/WNO.0000000000002509","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002509","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}