Journal of Neuro-Ophthalmology最新文献

{"title":"Mixed Reality Glasses with Picture-in-Picture Navigation for Patients with Homonymous Hemianopic Visual Field Loss.","authors":"Edsel B Ing, Ishaan Roy, Mahdi Tavakoli, Imran Jivraj, Alberto L Galvez Ruiz","doi":"10.1097/WNO.0000000000002343","DOIUrl":"10.1097/WNO.0000000000002343","url":null,"abstract":"<p><strong>Background: </strong>The visual rehabilitation options for patients with homonymous hemianopia (HH) are limited. We developed prototype software for commercially available mixed reality glasses (MRG) to help patients with HH better navigate their visual environment.</p><p><strong>Methods: </strong>Unlike virtual reality, mixed reality allows users to see the actual environment with superimposed holograms. We developed software on the Unity platform for the Microsoft HoloLens 2 MRG to enable real-time picture-in-picture navigation (PIPN). With PIPN, a miniaturized view of the visual environment is transposed into the intact visual field in patients with HH. WebSockets was used for real-time communication between the MRG and remote interface. External calibration controls were developed with the Streamlit web-based interface. In this crossover study, patients with HH were tested on a timed obstacle course with and without the MRG and asked to rate the utility of PIPN on a linear analog scale.</p><p><strong>Results: </strong>We transposed 52 diagonal degrees of the full field as a picture-in-picture into the intact hemifield of patients with HH. Five patients with HH were tested and on average rated the MRG as 19.7% more helpful for ambulation ( P = 0.028). On average, walk times with the MRG were 6 seconds slower than walk times without the MRG, but this was not statistically significant.</p><p><strong>Conclusions: </strong>We developed working prototype software for PIPN on a commercially available MRG. PIPN is a viable rehabilitation option to improve ambulatory navigation for patients with HH and will continue improving with hardware and software advancements.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"215-218"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Induced Intracranial Hypertension: The Adverse Effects of Acne Medications and Topical Retinoids.","authors":"Jacqueline K Shaia, Jenna R Rock, Rishi P Singh, Katherine E Talcott, Devon A Cohen","doi":"10.1097/WNO.0000000000002236","DOIUrl":"10.1097/WNO.0000000000002236","url":null,"abstract":"<p><strong>Background: </strong>Tetracyclines and vitamin A derivatives, major components in acne care and antiaging products, have been associated with the development of drug-induced intracranial hypertension (DIIH). Treatment practices and longitudinal visual outcomes have been highly understudied in DIIH. The purpose of this study was to provide management guidelines for DIIH and report visual outcomes of patients with DIIH.</p><p><strong>Methods: </strong>This was a single institute ophthalmology center case-control study where patients were seen between June 1, 2012, and September 1, 2023, in the United States. Patients with an International Classification of Disease (ICD) code for IIH and meeting the IIH diagnostic criteria who were taking a tetracycline or a vitamin A derivative during their diagnosis were included in this study. Patients were stratified into the following 3 categories: tetracyclines only, vitamin A derivatives only, or both, and compared with Kruskal-Wallis rank-sum tests. Poor visual outcomes were evaluated for and defined as a visual field mean deviation (peripheral visual measure) of -7 dB or greater. Individuals were followed for up to 1.5 years after diagnosis.</p><p><strong>Results: </strong>Among patients with IIH (n = 839), DIIH occurred in 8.10% of them (n = 68) with 83% taking the medication for acne. 88% of cases were female, and patients had a mean age of 24.96 years. DIIH medications were taken for an average length of 25.79 weeks before diagnosis of IIH. 20.5% of patients with DIIH were not treated with any IIH medication and were discontinued from the inducing drug. 3 patients had a poor visual outcome on follow-up with all of them taking a vitamin A derivative ( P < 0.05). Patients identified as having a poor visual outcome did not report discontinuing the DIIH drug ( P < 0.05).</p><p><strong>Conclusions: </strong>We propose treatment guidelines highlighting that patients taking a DIIH medication who develop headaches or visual changes should be immediately referred to ophthalmology, removal of the offending agent, and close monitoring by ophthalmology for vision loss. Importantly, vitamin A DIIH may have more severe visual outcomes, but further research is needed to corroborate this finding.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"177-182"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Macular Neuroretinopathy After COVID-19 Infection in a Patient With Multiple Sclerosis.","authors":"Joshua Pasol, Melissa R Ortega","doi":"10.1097/WNO.0000000000002155","DOIUrl":"10.1097/WNO.0000000000002155","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e107-e108"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Literature Commentary.","authors":"","doi":"10.1097/WNO.0000000000002357","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002357","url":null,"abstract":"<p><p>In this issue of JNO , Drs. Deborah I. Friedman and Mark L. Moster discuss the following 4 articles: Panzo N, Ong J, Memon H, Carrabba NV, Waisberg E, Zaman N, Lee VA, Sarker P, Vogt AZ, Laylani N, Tavakkoli A, Lee AG. The potential role of retinal slip in National Football League (NFL) officiating and its effect on on-field decision making: mechanisms and countermeasures. Eye (Lond) 2025;39:478-483.Klefter ON, Hansen MS, Lykkebirk L, Subhi Y, Brittain JM, Jensen MR, Døhn UM, Fana V, Wiencke AK, Heegaard S, Terslev L, Hamann S. Combining paracentral acute middle maculopathy and peripapillary fluid as biomarkers in anterior ischemic optic neuropathy. Am J Ophthalmol 2025;271:329-336.Ghorbani H, Özturan G, Albonico A, Barton JJS. Reading words vs seeing font or handwriting style: a study of hemifield processing. Exp Brain Res 2025; 18;24:45.Newman NJ, Biousse V, Yu-Wai-Man P, Carelli V, Vignal-Clermont C, Montestruc F, Taiel M, Sahel JA. Meta-analysis of treatment outcomes for patients with m.11778G > A MT-ND4 Leber hereditary optic neuropathy. Surv Ophthalmol. 2025;70:283-295.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":"45 2","pages":"249-252"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Disc Cupping in Neuromyelitis Optica Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease, and Multiple Sclerosis and Its Relationship With Optical Coherence Tomography Parameters: A Multicenter Study.","authors":"Tais Estrela, Hadas Stiebel-Kalish, Leigh Rettenmaier, Amanda D Henderson, Elias Sotirchos, Yana Said, Gelareh Ahmadi, Deena A Tajfirouz, Eoin P Flanagan, Nanthaya Tisavipat, Ryan Gise, Bart K Chwalisz, John J Chen","doi":"10.1097/WNO.0000000000002204","DOIUrl":"10.1097/WNO.0000000000002204","url":null,"abstract":"<p><strong>Background: </strong>Although cupping of the optic nerve is classically a sign of glaucomatous optic neuropathy, it has been shown that cupping can sometimes occur after an episode of optic neuritis (ON). The purpose of this study was to compare cupping in patients after ON from multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), or myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and to investigate the relationship between cupping and retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thinning.</p><p><strong>Methods: </strong>This was a retrospective cohort involving patients (≥18 years) with ON from 3 institutions. Patients were eligible if they had optical coherence tomography (Cirrus, OCT) performed ≥6 months after a single unilateral ON. The amount of thinning and cupping was estimated from the difference in the OCT parameters between affected and unaffected eyes. Univariable and multivariable regressions were used to investigate the relationship between cupping and ON etiology. Pearson correlation was used to investigate the relationship between cupping and RNFL and GCC.</p><p><strong>Results: </strong>Eighty-six subjects (MS: 35, NMOSD: 26, and MOGAD: 25) were included. There was no significant difference in gender and race between the groups, and most patients (86.1%) were female. Patients with NMOSD were significantly older than patients with MS or MOGAD ( P = 0.002). In the univariate model, cupping was significantly higher in the NMOSD group ( P = 0.017); however, after adjusting for age, GCC, and RNFL of the affected eye, the difference was no longer statistically significant ( P = 0.949). The correlation between cupping asymmetry and RNFL and GCC of the affected eye was inversely strong in patients with MS (R = -0.60 and R = -0.64, respectively), inversely moderate in patients with MOGAD (R = -0.34 and R = -0.40, respectively), and weak in patients with NMOSD (R = -0.03 and R = -0.17, respectively).</p><p><strong>Conclusions: </strong>Our results demonstrated that cupping after ON is correlated with RNFL and GCC thinning; although cupping was overall greater in the NMOSD group, once adjusted for age, RNFL, and GCC, it did not differ among patients with MS, NMOSD, and MOGAD.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"164-169"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11688507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial Hypertension Secondary to Styloidogenic Jugular Venous Compression.","authors":"Hyder Shah, Brian van Adel, Amadeo R Rodriguez","doi":"10.1097/WNO.0000000000002170","DOIUrl":"10.1097/WNO.0000000000002170","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e127-e128"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papilledema Due to Immune Checkpoint Inhibitor-Associated Subdural Effusions.","authors":"Eleanor Burton, Christopher J Sears, Hetal J Ray","doi":"10.1097/WNO.0000000000002160","DOIUrl":"10.1097/WNO.0000000000002160","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e112-e113"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Atrophy From Retrograde Transsynaptic Axonal Degeneration Following Pediatric Brain Injury.","authors":"Jack Jonathan Maran, Cynthia Sharpe, David Perry, Helen V Danesh-Meyer, Sarah Hull","doi":"10.1097/WNO.0000000000002228","DOIUrl":"10.1097/WNO.0000000000002228","url":null,"abstract":"<p><strong>Background: </strong>The patterns of optic atrophy due to retrograde transsynaptic degeneration (RTSD) have not been well characterized in children. This study aimed to characterize optic atrophy in pediatric patients with focal intracerebral lesions.</p><p><strong>Methods: </strong>A retrospective review of children with optic atrophy and focal intracerebral lesions was conducted. Ophthalmic data were recorded, including visual acuity, color vision, formal automated visual fields and optical coherence tomography (OCT) of the peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell layer.</p><p><strong>Results: </strong>Six patients (83.33% male) were included. The mean visual acuity (VA) of all eyes was 0.30 logMAR (20/40 Snellen), with no significant difference in the mean logMAR VA in the ipsilateral eye to the location of the lesion compared with the contralateral eye (0.30 vs 0.30, P = 1.000). Color vision (available in 5 patients) was normal in 2, mildly reduced in one and markedly reduced in 2. Bitemporal optic disc pallor was observed in 5 out of 6 patients. OCT data revealed that pRNFL thickness was most significantly diminished in the temporal (95% CI: -44.71 to -14.18 µm, P = 0.0021), inferotemporal (95% CI: -75.06 to -5.17 µm, P = 0.0294), and superotemporal (95% CI: -76.82 to -18.51 µm, P = 0.0055) sectors. Average pRNFL thickness was significantly reduced compared with normative data in both the ipsilateral (95% CI: -40.76 to -11.69 µm, P = 0.0003) and the contralateral eye (95% CI: -38.46 to -5.83 µm, P = 0.0063). When only nasal and temporal data were analyzed, mean pRNFL thickness was still diminished compared with normative data (95% CI: -33.01 to -9.77 µm, P = 0.0012).</p><p><strong>Conclusions: </strong>Children presenting with optic atrophy, particularly with bitemporal optic atrophy, should have neuroimaging to exclude any underlying serious intracranial pathology.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"197-203"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Typical Clinical Phenotypes and Genotype in a Chinese Family With Congenital Fibrosis of the Extraocular Muscles Type 1.","authors":"Yan-Ting Li, Qi-Ying Sun, Guang Yang","doi":"10.1097/WNO.0000000000002209","DOIUrl":"10.1097/WNO.0000000000002209","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"257-259"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Inter-Eye Asymmetry of Disc Area Explain Differences in Onset of Nonarteritic Anterior Ischemic Optic Neuropathy?","authors":"Shonar Singh, Florian H Guillot, Amanda D Henderson, Andrew R Carey","doi":"10.1097/WNO.0000000000002241","DOIUrl":"10.1097/WNO.0000000000002241","url":null,"abstract":"<p><strong>Background: </strong>Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in individuals over the age of 50 years. It is associated with conventional vascular risk factors and structural vulnerabilities including \"disc-at-risk.\" We aim to ascertain if a correlation exists between optic nerve head size and the onset of NAION.</p><p><strong>Methods: </strong>We performed a retrospective chart review of patients with an ICD-10 diagnosis of unilateral or bilateral NAION who underwent optical coherence tomography (OCT) and visual field testing. The primary outcome measure was the disc area as measured on OCT at a follow-up (minimum 6 months after acute vision loss) of the involved (or first involved for bilateral cases) vs fellow eye. The secondary outcome was the cup-to-disc ratio (CDR) of the first vs fellow eye.</p><p><strong>Results: </strong>Seventy-three patients were included, of which 58 (79%) had unilateral and 15 (21%) had bilateral NAION, with a median follow-up of 23 months. Between the first eye involved and the fellow eye, there were no statistically significant differences in the mean disc area (1.69 ± 0.29 vs 1.71 ± 0.29, P = 0.7). However, average CDR (0.41 ± 0.20 vs 0.28 ± 0.18, P < 0.001) and vertical CDR (0.42 ± 0.20 vs 0.28 ± 0.19, P < 0.0001) were significantly larger in the involved eye.</p><p><strong>Conclusions: </strong>Despite no statistically significant differences in the disc area between the affected eye and the fellow eye, CDR was larger in eyes with a history of NAION compared with fellow eyes. Further research is required to elucidate local factors that may increase the risk of NAION in one eye relative to the other.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"204-208"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}