Journal of Neuro-Ophthalmology最新文献

{"title":"A Great Conversation With Thomas Hedges.","authors":"Rachel A Calix, George T Park, Kathleen B Digre","doi":"10.1097/WNO.0000000000002374","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002374","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Cranial Neuropathies.","authors":"Alexander S Fein, Scott N Grossman, Cinthi Pillai, Doria M Gold","doi":"10.1097/WNO.0000000000002375","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002375","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Chronic Immunotherapy in Idiopathic Recurrent Neuroretinitis and Idiopathic Recurrent Papillitis: Describing a Potential New Phenotype.","authors":"Minjun Hur, Natthapon Rattanathamsakul, Samuel Jang, Collin M McClelland, Deena A Tajfirouz, Kevin D Chodnicki, Andrew McKeon, Sean J Pittock, Eoin P Flanagan, Anastasia Zekeridou, John J Chen","doi":"10.1097/WNO.0000000000002371","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002371","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic cases of recurrent optic disc edema, which we termed idiopathic recurrent papillitis (IRP), share similar features with idiopathic recurrent neuroretinitis (IRN). This raises the possibility that they may be in the same spectrum of disease, in which long-term immunotherapies have been suggested to reduce relapses. We sought to characterize IRN and IRP, including the treatment effects of immunotherapy.</p><p><strong>Methods: </strong>This retrospective, multicenter cohort study included patients with either IRN or papillitis (all without retrobulbar optic nerve enhancement on MRI during the acute attack) who were diagnosed at Mayo Clinic or University of Minnesota between January 2015 and October 2023. Demographics, age at first attack, and annualized relapse rates (ARRs) on and off long-term immunotherapy for patients on immunotherapy >6 months were recorded.</p><p><strong>Results: </strong>Among 30 patients, 17 (56.7%) patients had a neuroretinitis attack at least once, out of whom 10 (58.8%) patients had both neuroretinitis and papillitis attacks. Thirteen (43.3%) patients had only papillitis attacks. The median age of first attack was 34 years (interquartile range [IQR] 28-42) in neuroretinitis and 38 years (IQR 28-49) in papillitis (P = 0.91). The median number of attacks for all patients was 3.5 (IQR 3-5). Out of 15 patients who were on immunotherapy for 6 months or longer, 10 (66.7%) patients had at least 1 relapse with a median ARR on therapy of 0.28 attacks/year (IQR 0-0.54), which was not significantly different from off therapy (P = 0.74). Among immunotherapies, mycophenolate mofetil had the lowest median ARR (0 attacks/year, IQR 0-0.29), followed by intravenous immunoglobulin (0.49 attacks/year, IQR 0.25-0.74), methotrexate (0.49 attacks/year, IQR 0.29-0.87), rituximab/ocrelizumab (0.68 attacks/year, IQR 0.34-1.47), and azathioprine (0.75 attacks/year, IQR 0-2.17).</p><p><strong>Conclusions: </strong>There is significant overlap between IRN and IRP, suggesting they are in the same spectrum of disease. Most long-term immunotherapies other than mycophenolate did not seem to be effective in reducing the number of relapses, although further prospective studies are required to assess this.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Diagnosing Neuro-Ophthalmology Diseases Based on Case Reports: DeepSeek vs ChatGPT.","authors":"Yeganeh Madadi, Mohammad Delsoz, Priscilla A Lao, Joseph W Fong, T J Hollingsworth, Siamak Yousefi","doi":"10.1097/WNO.0000000000002373","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002373","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment: Diagnosing Neuro-Ophthalmology Diseases Based on Case Reports: DeepSeek vs ChatGPT.","authors":"Xiaole Li, Jingyi He, Jim S Xie, Rahul A Sharma","doi":"10.1097/WNO.0000000000002372","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002372","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 51st Annual Meeting of the North American Neuro-Ophthalmology Society in Tucson, Arizona.","authors":"Meagan D Seay, Kathleen B Digre","doi":"10.1097/WNO.0000000000002368","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002368","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmology and Neuro-Otology Highlights From the 2025 American Academy of Neurology Annual Meeting.","authors":"Aileen A Antonio, Nailyn Rasool, Nancy J Newman","doi":"10.1097/WNO.0000000000002369","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002369","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed Reality Glasses with Picture-in-Picture Navigation for Patients with Homonymous Hemianopic Visual Field Loss.","authors":"Edsel B Ing, Ishaan Roy, Mahdi Tavakoli, Imran Jivraj, Alberto L Galvez Ruiz","doi":"10.1097/WNO.0000000000002343","DOIUrl":"10.1097/WNO.0000000000002343","url":null,"abstract":"<p><strong>Background: </strong>The visual rehabilitation options for patients with homonymous hemianopia (HH) are limited. We developed prototype software for commercially available mixed reality glasses (MRG) to help patients with HH better navigate their visual environment.</p><p><strong>Methods: </strong>Unlike virtual reality, mixed reality allows users to see the actual environment with superimposed holograms. We developed software on the Unity platform for the Microsoft HoloLens 2 MRG to enable real-time picture-in-picture navigation (PIPN). With PIPN, a miniaturized view of the visual environment is transposed into the intact visual field in patients with HH. WebSockets was used for real-time communication between the MRG and remote interface. External calibration controls were developed with the Streamlit web-based interface. In this crossover study, patients with HH were tested on a timed obstacle course with and without the MRG and asked to rate the utility of PIPN on a linear analog scale.</p><p><strong>Results: </strong>We transposed 52 diagonal degrees of the full field as a picture-in-picture into the intact hemifield of patients with HH. Five patients with HH were tested and on average rated the MRG as 19.7% more helpful for ambulation ( P = 0.028). On average, walk times with the MRG were 6 seconds slower than walk times without the MRG, but this was not statistically significant.</p><p><strong>Conclusions: </strong>We developed working prototype software for PIPN on a commercially available MRG. PIPN is a viable rehabilitation option to improve ambulatory navigation for patients with HH and will continue improving with hardware and software advancements.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"215-218"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Induced Intracranial Hypertension: The Adverse Effects of Acne Medications and Topical Retinoids.","authors":"Jacqueline K Shaia, Jenna R Rock, Rishi P Singh, Katherine E Talcott, Devon A Cohen","doi":"10.1097/WNO.0000000000002236","DOIUrl":"10.1097/WNO.0000000000002236","url":null,"abstract":"<p><strong>Background: </strong>Tetracyclines and vitamin A derivatives, major components in acne care and antiaging products, have been associated with the development of drug-induced intracranial hypertension (DIIH). Treatment practices and longitudinal visual outcomes have been highly understudied in DIIH. The purpose of this study was to provide management guidelines for DIIH and report visual outcomes of patients with DIIH.</p><p><strong>Methods: </strong>This was a single institute ophthalmology center case-control study where patients were seen between June 1, 2012, and September 1, 2023, in the United States. Patients with an International Classification of Disease (ICD) code for IIH and meeting the IIH diagnostic criteria who were taking a tetracycline or a vitamin A derivative during their diagnosis were included in this study. Patients were stratified into the following 3 categories: tetracyclines only, vitamin A derivatives only, or both, and compared with Kruskal-Wallis rank-sum tests. Poor visual outcomes were evaluated for and defined as a visual field mean deviation (peripheral visual measure) of -7 dB or greater. Individuals were followed for up to 1.5 years after diagnosis.</p><p><strong>Results: </strong>Among patients with IIH (n = 839), DIIH occurred in 8.10% of them (n = 68) with 83% taking the medication for acne. 88% of cases were female, and patients had a mean age of 24.96 years. DIIH medications were taken for an average length of 25.79 weeks before diagnosis of IIH. 20.5% of patients with DIIH were not treated with any IIH medication and were discontinued from the inducing drug. 3 patients had a poor visual outcome on follow-up with all of them taking a vitamin A derivative ( P < 0.05). Patients identified as having a poor visual outcome did not report discontinuing the DIIH drug ( P < 0.05).</p><p><strong>Conclusions: </strong>We propose treatment guidelines highlighting that patients taking a DIIH medication who develop headaches or visual changes should be immediately referred to ophthalmology, removal of the offending agent, and close monitoring by ophthalmology for vision loss. Importantly, vitamin A DIIH may have more severe visual outcomes, but further research is needed to corroborate this finding.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"177-182"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Macular Neuroretinopathy After COVID-19 Infection in a Patient With Multiple Sclerosis.","authors":"Joshua Pasol, Melissa R Ortega","doi":"10.1097/WNO.0000000000002155","DOIUrl":"10.1097/WNO.0000000000002155","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e107-e108"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}