Journal of Neuro-Ophthalmology最新文献

{"title":"Initial Macular Ganglion Cell Changes During Conversion of Leber Hereditary Optic Neuropathy.","authors":"Thomas R Hedges, David Dombrovsky, Oluchukwu Onwuka, Laurel N Vuong, Yosbelkys Martin-Paez, Carlos Mendoza-Santiesteban","doi":"10.1097/WNO.0000000000002384","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002384","url":null,"abstract":"<p><strong>Background: </strong>We investigated the initial macular ganglion cell complex (GCC) changes in a group of patients during the conversion from normal vision to visual loss from Leber hereditary optic neuropathy (LHON).</p><p><strong>Methods: </strong>Optical coherence tomography scans from 17 eyes of 10 patients with genetically confirmed LHON obtained within 12 weeks of visual symptom onset were analyzed. The thickness of the GCC was measured in 6 macular sectors: superior nasal (SN), inferior nasal (IN), superior temporal, inferior temporal (IT), superior (SUP), and inferior (INF). Receiver operating characteristic (ROC) curves and area under the ROC curve (AUROC) analyses with DeLong comparison were used to evaluate the predictive reliability of GCC thinning in each sector.</p><p><strong>Results: </strong>Selective, nasal (perifoveal) GCC thinning was observed in most LHON eyes during the early stages, with the SN and IN sectors showing the highest AUROC values. Thinning in these sectors provided significantly greater predictive value for the presence of LHON than other sectors.</p><p><strong>Conclusions: </strong>Nasal GCC thinning is a reliable early indicator of the conversion from normal vision to visual loss in LHON as demonstrated in 10 of 17 eyes. This pattern of GCC loss provides insights into the disease mechanism and highlights the utility of OCT analysis for early diagnosis. The nasal GCC loss suggests selective vulnerability of ganglion cells serving the foveal region in LHON. Early identification of nasal GCC changes may facilitate timely intervention as gene therapy and other treatments become increasingly accessible.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the Rundle Curve Still Valuable in Managing Thyroid Eye Disease?","authors":"Michael S Lee, Amina I Malik, Andrew G Lee, Gregory P Van Stavern","doi":"10.1097/WNO.0000000000002387","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002387","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Serous Chorioretinopathy occurs in High Frequency in Myelin Oligodendrocyte Glycoprotein Antibody Disease, Seropositive and Seronegative Neuromyelitis Optica Spectrum Disorders compared to Multiple Sclerosis and Healthy Controls.","authors":"Bianca Knaack, Janine Rolfs, Hanna G Zimmermann, Vivek R Patel, Lukas G Reeß, Charlotte Bereuter, Jan Schroeter, Nadja Siebert, Klemens Ruprecht, Judith Bellmann-Strobl, Friedemann Paul, Alexander U Brandt, Frederike C Oertel","doi":"10.1097/WNO.0000000000002355","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002355","url":null,"abstract":"<p><strong>Background: </strong>Neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) are autoimmune inflammatory disorders of the central nervous system. Central serous chorioretinopathy (CSCR) is characterized by a serous retinal detachment with leakage of fluid through the retinal pigment epithelium accumulating under the retina. This study investigated a potential association between CSCR and these neuroinflammatory disorders.</p><p><strong>Methods: </strong>We included people with aquaporin-4 immunoglobulin G (AQP4-IgG) seropositive NMOSD (N = 39), multiple sclerosis (MS, N = 39), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD, N = 13), seronegative NMOSD (SN-NMOSD, N = 9), and healthy controls (HC, N = 30). Using optical coherence tomography (OCT), we assessed CSCR frequency and the thickness of the peripapillary retinal nerve fiber layer (pRNFL).</p><p><strong>Results: </strong>There was a higher CSCR frequency (21.3%) throughout all investigated subgroups (AQP4-IgG seropositive NMOSD, MOGAD, and SN-NMOSD) than in the HC group (p = 0.048), with a significant association between CSCR and arterial hypertension frequency but not with these diagnoses, retinal neuroaxonal loss, or history of optic neuritis.</p><p><strong>Conclusion: </strong>The high frequency of CSCR suggests a potential benefit of routine monitoring of CSCR in patients with NMOSD and MOGAD using the OCT technology, a reliable method to detect and monitor CSCR in patients with neuroinflammatory disorders. Further research is necessary to establish the underlying pathophysiology and potential effects on vision.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Literature Commentary.","authors":"","doi":"10.1097/WNO.0000000000002385","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002385","url":null,"abstract":"<p><p>In this issue of JNO, Drs. Deborah I. Friedman and Mark L. Moster discuss the following 4 articles: Shir D, Lee N, McCarter SJ, Ramanan VK, Botha H, Knopman DS, Petersen RC, Boeve BF, Day GS, Graff-Radford NR, Jones DT, Murray ME, Nguyen AT, Reichard RR, Dickson DW, Tajfirouz D, Machulda MM, Whitwell JL, Josephs KA, Graff-Radford J. Longitudinal evolution of posterior cortical atrophy: diagnostic delays, overlapping phenotypes, and clinical outcomes. Neurology. 2025;104:e213559.Fariselli L, Marzoli BS, Morlino S, Pinzi V, Pedone C, De Martin E, Romeo A, Tramacere I, Marchetti M. Hypofractionated radiosurgery (25 Gy/5 fractions) for optic nerve sheath meningiomas: results from an exploratory phase 2 prospective trial. Int J Radiat Oncol Biol Phys. 2025:S0360-3016(25)00432-8 (epub ahead of print).Dinoto A, Cacciaguerra L, Vorasoot N, Redenbaugh V, Lopez-Chiriboga SA, Valencia-Sanchez C, Guo K, Thakolwiboon S, Horsman SE, Syc-Mazurek SB, Tisavipat N, Mandrekar J, Tajfirouz D, Eggenberger ER, Pless ML, Chodnicki K, Tillema JM, Pittock SJ, Chen JJ, Flanagan EP. Clinical features and factors associated with outcome in late adult-onset myelin oligodendrocyte glycoprotein antibody-associated disease. Neurology. 27;104:e213557.Park HE, Shin HJ, Lee AG. Neuro-ophthalmic findings of visual snow syndrome in Korea. Jpn J Ophthalmol. 2025. doi: 10.1007/s10384-025-01196-1 (epub ahead of print).</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Horizontal Reversal of Vision Metamorphopsia Caused by Cerebellar Glioma.","authors":"Ema V Karakoleva, Chloe Shields, R Clayton Bishop, Shreya Bhatt, Ali A Firozvi, Jake Sanford, Vishal Jain, Ejaz A Shamim","doi":"10.1097/WNO.0000000000002392","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002392","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Racial, Ethnic, and Socioeconomic Disparities in Idiopathic Intracranial Hypertension.","authors":"Jane J Huang, Daniel Lovasz, Minchan Shi, Florian H Guillot, James B Davis, Amanda D Henderson","doi":"10.1097/WNO.0000000000002388","DOIUrl":"10.1097/WNO.0000000000002388","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic intracranial hypertension (IIH) disproportionately affects young, Black, female patients. However, there are limited data characterizing baseline and outcome features of IIH across racial and socioeconomic groups. This study aimed to compare presenting features, initial MRI findings, and visual outcomes of IIH from different racial, ethnic, and insured groups.</p><p><strong>Methods: </strong>We conducted a retrospective chart review of patients with IIH seen at an academic quaternary care center between July 1, 2013, and September 30, 2023. Patient characteristics collected were self-reported race and ethnicity, insurance status, age, and sex. Clinical features included lumbar puncture (LP) opening pressure; body mass index (BMI); visual acuity (VA), visual field mean deviation, and average retinal nerve fiber layer (RNFL) thickness at presentation and follow up; MRI findings; presence of symptoms (headaches, diplopia, transient visual obscurations, pulsatile tinnitus), treatment(s); and adherence to follow-up recommendations. Patients were excluded if they were already treated for IIH before initial presentation or if diagnostic data were incomplete. Linear, mixed effect, and logistic regression models were used to evaluate differences between racial, ethnic, and insurance status groups. Statistical significance was set at P < 0.05.</p><p><strong>Results: </strong>Our study included 241 patients. There were no statistically significant differences in BMI, presence of symptoms of high intracranial pressure, visual function, or RNFL thickness at initial evaluation between groups stratified by race, ethnicity, and insurance status. Black patients were more likely to have Medicaid coverage, whereas White patients were more likely to have private insurance (Medicaid: 38% Black vs 14% White; private: 47% Black vs 67% White, P < 0.001). Black patients were more likely to have posterior globe flattening on initial MRI, and patients with Medicare coverage had significantly worse VA outcomes than those with Medicaid coverage. There were no other statistically significant differences in presenting features, clinical outcomes, or adherence to follow-up recommendations across patient subgroups.</p><p><strong>Conclusions: </strong>There were no statistically significant differences in presenting symptoms of IIH, BMI, LP opening pressure, or adherence to follow-up based on race, ethnicity, or insurance status. Patients with Medicare coverage had worse VA outcomes than those with Medicaid coverage. Otherwise, visual outcomes were similar across groups.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Yield of Antiacetylcholine Receptor Antibodies Versus Antimuscle Kinase Antibodies in Ocular Myasthenia Gravis: A Meta-Analysis.","authors":"Edward Tran, Gautham Nair, Lulu L C D Bursztyn, J Alexander Fraser, Edsel B Ing","doi":"10.1097/WNO.0000000000002382","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002382","url":null,"abstract":"<p><strong>Background: </strong>Ocular myasthenia gravis (OMG) is an autoimmune disease characterized by autoantibodies targeting postsynaptic proteins at the neuromuscular junction, leading to weakness and fatigability of the levator palpebrae superioris, orbicularis oculi and extraocular muscles. Although OMG is primarily a clinical diagnosis, serological antibody testing, predominantly acetylcholine receptor (AChR) antibodies, is usually performed. The clinical utility of muscle-specific kinase (MuSK) antibodies is less well established in OMG. This meta-analysis evaluates the use of anti-AChR and anti-MuSK in patients with OMG and the relative costs of simultaneous vs sequential testing.</p><p><strong>Methods: </strong>Studies were extracted from Cumulative Index to Nursing and Allied Health Literature (CINAHL), Embase (Ovid), Medline (Ovid), and additional gray literature. A systematic review was conducted using Covidence with 2 independent reviewers for study selection and data extraction. The meta-analysis was conducted with R version 4.4.1 on RStudio, and the meta package. Depending on the level of heterogeneity, either a fixed-effects or random-effects model was used to pool the data. Funnel plots were used to assess publication bias.</p><p><strong>Results: </strong>The pooled analysis of 44 studies (n = 4,937 patients with OMG) revealed 59% (95% confidence interval [CI]: 52%-66%) positivity for anti-AChR, whereas the pooled analysis of 34 studies with (n = 3,380) showed 5% (95% CI: 2%-9%) positivity for anti-MuSK. From 62 studies (n = 5,180), 4 patients (0.1%) were doubly seropositive for anti-AChR and anti-MuSK. In patients with OMG positive for AChR antibodies, 5 studies (n = 527) reported a thymoma prevalence of 35% (95% CI: 3%-90%), underscoring the clinical value of anti-AChR testing. Four studies (n= 259) showed that anti-AChR positive patients had a 1.82 (95% CI: 1.15-2.88) times greater risk of progressing from OMG to generalized myasthenia gravis.</p><p><strong>Conclusions: </strong>Almost two-thirds (59%) of the patients with OMG tested positive for AChR antibodies, but MuSK antibodies were only detected in 5% of patients. Positivity for anti-AChR in OMG was associated with a worse prognosis, including a higher prevalence of thymomas and an increased risk of disease generalization. Given the relatively low prevalence of anti-MuSK and the higher cost of anti-MuSK testing, clinicians could consider a stepwise approach to the serological diagnosis of OMG, where anti-MuSK is ordered only if the initial anti-AChR returns negative.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial Regression of Myelinated Nerve Fiber Layer in a Patient With Nonarteritic Ischemic Optic Neuropathy.","authors":"Poojitha Balakrishnan, Cole Richardson, Michael S Vaphiades","doi":"10.1097/WNO.0000000000002389","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002389","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Concept of Luxury Perfusion in Nonarteritic Anterior Ischemic Optic Neuropathy.","authors":"Niv Levi, Edward Margolin","doi":"10.1097/WNO.0000000000002370","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002370","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Visual Spatial Information on Eye Position in a Patient With Pontomesencephalic Skew Torsion.","authors":"Tom Buelens, Sofia Belhoussine Drissi, François Willermain","doi":"10.1097/WNO.0000000000002386","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002386","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}