Journal of Neuro-Ophthalmology最新文献

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Optic Nerve Sheath Meningiomas: A Retrospective Cohort Study Comparing Outcomes in Treated Versus Observed Patients. 视神经鞘脑膜瘤:一项回顾性队列研究,比较治疗与观察患者的结果。
IF 2 4区 医学
Journal of Neuro-Ophthalmology Pub Date : 2025-01-08 DOI: 10.1097/WNO.0000000000002309
Marko Chi-Wei Tien, Heather M McDonald, Elizabeth Wei, Jonathan A Micieli, Edward A Margolin
{"title":"Optic Nerve Sheath Meningiomas: A Retrospective Cohort Study Comparing Outcomes in Treated Versus Observed Patients.","authors":"Marko Chi-Wei Tien, Heather M McDonald, Elizabeth Wei, Jonathan A Micieli, Edward A Margolin","doi":"10.1097/WNO.0000000000002309","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002309","url":null,"abstract":"<p><strong>Background: </strong>The rarity of optic nerve sheath meningiomas (ONSMs) complicates the guidelines surrounding optimal treatment strategies and prognostic factors. There are limited data on the visual outcomes of those treated with radiotherapy versus those observed without treatment. This study aimed to characterize the clinical and radiographic presentations of patients diagnosed with ONSMs and to identify factors predicting improvement in visual function after treatment.</p><p><strong>Methods: </strong>This is a retrospective case series of 26 patients who presented to 2 tertiary neuro-ophthalmology practices for 10 years with the presumptive diagnosis of ONSM. Demographic, clinical, investigative, radiologic, treatment, and outcome data were collected. Visual improvement was defined as improvement in visual acuity (VA) by ≥2 Snellen lines or visual field (VF) mean deviation (MD) improvement by ≥2 dB. Statistical analyses were performed to compare patients who experienced improvement in visual function with those who did not poststereotactic radiotherapy to identify pretreatment predictors of visual recovery.</p><p><strong>Results: </strong>Seventeen patients underwent radiotherapy (16 received 54 Gy in 30 fractions and 1 received 50 Gy in 25 fractions) and 4 elected observation. Five were lost to follow-up. Visual function improvement was seen in 10 patients who underwent radiotherapy. Pretreatment VA (logMAR 0.492 vs 1.42, P = 0.025), tumor size (8.50 vs 18.3 mm, P = 0.028), and a decrease in tumor size postradiotherapy (P = 0.009 for VA and 0.035 for VF MD improvement) were significantly associated with objective visual improvement.</p><p><strong>Conclusions: </strong>Pretreatment VA and tumor size may predict improvement in visual function in patients with ONSMs treated with radiotherapy. Future larger scale studies that include these data may be able to draw more definite conclusions.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Risk of Kidney Stone Development in Patients With Idiopathic Intracranial Hypertension Treated With Carbonic Anhydrase Inhibitors. 评估特发性颅内高压患者使用碳酸酐酶抑制剂后发生肾结石的风险
IF 2 4区 医学
Journal of Neuro-Ophthalmology Pub Date : 2024-12-27 DOI: 10.1097/WNO.0000000000002307
Jawad Muayad, Saif Aldeen Alryalat, Osama Al Deyabat, Asad Loya, Andrew G Lee
{"title":"Assessing the Risk of Kidney Stone Development in Patients With Idiopathic Intracranial Hypertension Treated With Carbonic Anhydrase Inhibitors.","authors":"Jawad Muayad, Saif Aldeen Alryalat, Osama Al Deyabat, Asad Loya, Andrew G Lee","doi":"10.1097/WNO.0000000000002307","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002307","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of idiopathic intracranial hypertension (IIH) is rising with the global obesity epidemic. Carbonic anhydrase inhibitors (CAIs), such as acetazolamide, have been shown to be effective in IIH but can also lead to kidney stone formation. This study evaluates the risk of kidney stone development in patients with IIH treated with CAIs.</p><p><strong>Methods: </strong>A retrospective cohort study using the TriNetX database was performed to compare patients with IIH treated with CAIs vs. untreated controls. Propensity score matching (PSM) balanced demographic and clinical variables. The primary outcome was kidney stone incidence for 3 time intervals: 1 year, 1-2 years, and 2-3 years, identified using International Classification of Diseases-10 codes. Risk ratios (RRs) with 95% confidence intervals (CIs) assessed the association between CAI treatment and kidney stone formation.</p><p><strong>Results: </strong>The study evaluated 23,182 patients with IIH treated with CAIs compared with 50,080 untreated controls. After applying PSM, each group was balanced to include 22,464 patients. The treated group had a significantly higher risk of developing kidney stones than the control group, with an RR of 1.49 (95% CI: 1.22-1.84) at 1 year, 2.24 (95% CI: 1.61-3.12) at 1-2 years, and 1.51 (95% CI: 1.05-2.18) at 2-3 years. Sensitivity analysis of patients treated with at least 500 mg of acetazolamide shared this elevated trend, and the risk remained persistently high at 2-3 years (RR: 2.18, 95% CI: 1.13-4.20). Subgroup analysis revealed higher risks in males, while Black or African American patients had a lower risk.</p><p><strong>Conclusions: </strong>Carbonic anhydrase inhibitor use in patients with IIH may increase kidney stone risk, particularly in certain populations. Further research is needed to understand the mechanisms behind this risk and to optimize treatment strategies.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unilateral Hemianopia: An Uncommon Presentation of Functional Neurologic Disorder in Pediatrics. 单侧偏视:儿科功能性神经障碍的一种罕见表现。
IF 2 4区 医学
Journal of Neuro-Ophthalmology Pub Date : 2024-12-26 DOI: 10.1097/WNO.0000000000002312
Javier García-Bardera, Patricia Robles-Amor, Mireia García-Bermúdez, Marco Antonio Pascual-Santiago, Blanca Domingo-Gordo
{"title":"Unilateral Hemianopia: An Uncommon Presentation of Functional Neurologic Disorder in Pediatrics.","authors":"Javier García-Bardera, Patricia Robles-Amor, Mireia García-Bermúdez, Marco Antonio Pascual-Santiago, Blanca Domingo-Gordo","doi":"10.1097/WNO.0000000000002312","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002312","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visual Functions in Patients With Leber Hereditary Optic Neuropathy (LHON). Leber遗传性视神经病变(LHON)患者的视觉功能。
IF 2 4区 医学
Journal of Neuro-Ophthalmology Pub Date : 2024-12-24 DOI: 10.1097/WNO.0000000000002237
Robin Francomme, Quentin Lenoble, Vasily Smirnov, Muriel Boucart
{"title":"Visual Functions in Patients With Leber Hereditary Optic Neuropathy (LHON).","authors":"Robin Francomme, Quentin Lenoble, Vasily Smirnov, Muriel Boucart","doi":"10.1097/WNO.0000000000002237","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002237","url":null,"abstract":"<p><strong>Background: </strong>Most of the data on visual functions in Leber hereditary optic neuropathy (LHON) is based on patient questionnaires. Our study assessed the impact of LHON on visual function by testing facial recognition and execution of purposeful actions.</p><p><strong>Methods: </strong>Twelve participants with LHON with central scotoma ranging from 5° to 20° and 12 unaffected age-matched controls were involved in our study. In the face recognition test, participants were asked to recognize the sex and the facial expression of photographs of faces increasing in size to simulate approaching faces. In the purposeful action test, they were asked to manipulate real objects while their eye movements were recorded.</p><p><strong>Results: </strong>Although most patients were able to recognize the correct sex of a face at a size corresponding to a 1-m viewing distance, recognition of facial expressions was severely impaired. Patients were slower than control subjects in executing purposeful tasks. A dynamic strategy to sample information needed for the execution of a task was documented in a longer scanpath and in higher frequency of saccades and fixation eye movements in patients than in control subjects.</p><p><strong>Conclusions: </strong>Face perception is strongly impaired in patients with LHON. In addition, although the selection and manipulation of real objects to execute a task are slowed, they can be performed efficiently using peripheral vision.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restricted Diffusion in Bilateral Superior Ophthalmic Vein Thrombosis. 双侧眼上静脉血栓扩散受限。
IF 2 4区 医学
Journal of Neuro-Ophthalmology Pub Date : 2024-12-20 DOI: 10.1097/WNO.0000000000002292
Abdullah El-Sayes, James J Armstrong, Edsel B Ing, Rahul A Sharma
{"title":"Restricted Diffusion in Bilateral Superior Ophthalmic Vein Thrombosis.","authors":"Abdullah El-Sayes, James J Armstrong, Edsel B Ing, Rahul A Sharma","doi":"10.1097/WNO.0000000000002292","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002292","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiphospholipid Antibody Syndrome: Concurrent Retinal Vein Occlusion and Homonymous Hemianopia From Ischemic Stroke. 抗磷脂抗体综合征:缺血性脑卒中并发视网膜静脉阻塞和同质性偏盲。
IF 2 4区 医学
Journal of Neuro-Ophthalmology Pub Date : 2024-12-18 DOI: 10.1097/WNO.0000000000002289
Hannah J Yu, Cina Karimaghaei, Tuan Anh Nguyen, Saif Aldeen Alryalat, Osama Al Deyabat, Garvin Davis, Andrew G Lee
{"title":"Antiphospholipid Antibody Syndrome: Concurrent Retinal Vein Occlusion and Homonymous Hemianopia From Ischemic Stroke.","authors":"Hannah J Yu, Cina Karimaghaei, Tuan Anh Nguyen, Saif Aldeen Alryalat, Osama Al Deyabat, Garvin Davis, Andrew G Lee","doi":"10.1097/WNO.0000000000002289","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002289","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optic Disc Drusen and Familial Exudative Vitreoretinopathy Phenotype: A Multimodal Imaging Perspective on a Rare Association. 视盘结节和家族性渗出性玻璃体视网膜病变表型:一种罕见关联的多模态成像视角。
IF 2 4区 医学
Journal of Neuro-Ophthalmology Pub Date : 2024-12-18 DOI: 10.1097/WNO.0000000000002304
Srikanta Kumar Padhy, Kasturi Chavan, Sohini Mandal, Subhadra Jalali, Raja Narayanan
{"title":"Optic Disc Drusen and Familial Exudative Vitreoretinopathy Phenotype: A Multimodal Imaging Perspective on a Rare Association.","authors":"Srikanta Kumar Padhy, Kasturi Chavan, Sohini Mandal, Subhadra Jalali, Raja Narayanan","doi":"10.1097/WNO.0000000000002304","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002304","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ophthalmoplegia in Seropositive Myasthenia Gravis and Concomitant Seropositive Anti-GQ1b Disease. 血清学阳性重症肌无力并发血清抗gq1b阳性疾病的眼麻痹。
IF 2 4区 医学
Journal of Neuro-Ophthalmology Pub Date : 2024-12-18 DOI: 10.1097/WNO.0000000000002240
Aroucha Vickers, Christy L Diuguid, Cory M Nichols, Paul H Janda, Michael Y Zhao, Rhys Ishihara, Saif Aldeen Alryalat, Andrew G Lee
{"title":"Ophthalmoplegia in Seropositive Myasthenia Gravis and Concomitant Seropositive Anti-GQ1b Disease.","authors":"Aroucha Vickers, Christy L Diuguid, Cory M Nichols, Paul H Janda, Michael Y Zhao, Rhys Ishihara, Saif Aldeen Alryalat, Andrew G Lee","doi":"10.1097/WNO.0000000000002240","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002240","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reversible Junctional Scotoma From Pituitary Adenoma During Pregnancy. 妊娠期垂体腺瘤所致的可逆性结膜暗斑。
IF 2 4区 医学
Journal of Neuro-Ophthalmology Pub Date : 2024-12-18 DOI: 10.1097/WNO.0000000000002295
Matthew J Norton, John J Brinkley
{"title":"Reversible Junctional Scotoma From Pituitary Adenoma During Pregnancy.","authors":"Matthew J Norton, John J Brinkley","doi":"10.1097/WNO.0000000000002295","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002295","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spot the Connection: A Case of Unilateral Roth Spots and Postflow Diversion Microhemorrhage. 发现联系:单侧罗斯斑和分流后微出血1例。
IF 2 4区 医学
Journal of Neuro-Ophthalmology Pub Date : 2024-12-18 DOI: 10.1097/WNO.0000000000002303
Liam T Mulcahy, Abdurehman Choudhry, Fionn O'Leary, Matthew T Crockett, Lisa McAnena
{"title":"Spot the Connection: A Case of Unilateral Roth Spots and Postflow Diversion Microhemorrhage.","authors":"Liam T Mulcahy, Abdurehman Choudhry, Fionn O'Leary, Matthew T Crockett, Lisa McAnena","doi":"10.1097/WNO.0000000000002303","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002303","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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