Journal of Neuro-Ophthalmology最新文献

{"title":"Racial and Ethnic Disparities in Severe Ischemic Manifestations and Tocilizumab Use Among Patients With Giant Cell Arteritis: A Nationwide Retrospective Cohort Study Using TriNetX.","authors":"Daniel M Markowitz, Jose S Pulido, Jirat Nimworaphan, John J Chen, Robert C Sergott","doi":"10.1097/WNO.0000000000002458","DOIUrl":"10.1097/WNO.0000000000002458","url":null,"abstract":"<p><strong>Background: </strong>Giant cell arteritis (GCA) has traditionally been recognized as more common in White populations, but there is limited understanding of its epidemiology and severe ischemic manifestations in other racial and ethnic groups. This study investigated racial and ethnic differences in GCA ischemic manifestations and tocilizumab use.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using the TriNetX U.S. Collaborative Network. Age- and sex-matched cohorts of non-Hispanic White (hereafter referred to as White), non-Hispanic Black or African American (Black), non-Hispanic Asian (Asian), and Hispanic or Latino (Hispanic) patients diagnosed with GCA were analyzed for differences in severe clinical manifestations within 1 month of GCA diagnosis (ischemic optic neuropathy, blindness/low vision, central retinal artery occlusion, stroke, aortic aneurysm and dissection, acute myocardial infarction) and tocilizumab use within 1 year.</p><p><strong>Results: </strong>Compared with White patients, Black patients had lower odds of ischemic optic neuropathy (odds ratio [OR]: 0.46, 95% confidence interval [CI]: 0.33-0.65), higher stroke risk (OR: 1.68, 95% CI: 1.16-2.43), and were less likely to receive tocilizumab (OR: 0.44, 95% CI: 0.33-0.59). Hispanic patients had lower odds of ischemic optic neuropathy (OR: 0.61, 95% CI: 0.37-0.98) and receiving tocilizumab (OR: 0.51, 95% CI: 0.34-0.74) compared with White patients. Additionally, compared with White patients, Asian patients were less likely to be diagnosed with blindness/low vision (OR: 0.45, 95% CI: 0.27-0.76), had similar odds of ischemic optic neuropathy, and had no significant differences in tocilizumab use.</p><p><strong>Conclusions: </strong>There may be significant differences in severe ischemic manifestations of GCA among non-White patients compared with White patients. There also appear to be differences in treatment with tocilizumab between Black and White patients and between Hispanic and White patients, but not between Asian and White patients.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Cavernous Sinus Thrombosis in a Patient With Sinonasal Mucosal Melanoma With Orbital Extension.","authors":"Zahra A Markatia, Lucy I Mudie, George A Villatoro, Michael T Yen","doi":"10.1097/WNO.0000000000002465","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002465","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Progressive External Ophthalmoplegia Associated With the m.14484T>C Leber Hereditary Optic Neuropathy Mutation.","authors":"Sun-Young Oh, Joonhong Park, Jae-Hwan Choi, Jinhong Shin, Haeng-Jin Lee","doi":"10.1097/WNO.0000000000002439","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002439","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between a Chiasm and a Hard Place.","authors":"Sofia A John, Sara Krachmalnick, Marianna B Ruzinova, Maggie E Pohlmeier, Francisco J Garcia-Ferrer, Gregory P Van Stavern, Leanne Stunkel","doi":"10.1097/WNO.0000000000002445","DOIUrl":"10.1097/WNO.0000000000002445","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Prognosticators of Optic Nerve Imaging in Malignant Pseudotumor Cerebri Syndrome.","authors":"Alexandria L Chaulk, Jennifer L McCarty, Rajan P Patel, Alice Z Chuang, Ore-Ofe Ooa Adesina","doi":"10.1097/WNO.0000000000002464","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002464","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment: Prognosticators of Optic Nerve Imaging in Malignant Pseudotumor Cerebri Syndrome.","authors":"Jigna Motwani, Rohan Nalawade, Virender Sachdeva","doi":"10.1097/WNO.0000000000002463","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002463","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jugular Vein Occlusion-Induced Intracranial Hypertension Mimicking Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulator-Associated Intracranial Hypertension: A Diagnostic Pitfall.","authors":"Anne Crouzet, Sokaina Ouhnia, Clémence Hoche, Raoul K Khanna","doi":"10.1097/WNO.0000000000002437","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002437","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cobalt Toxic Optic Neuropathy in a MT-ND4 m.11778G>A Carrier.","authors":"Haoran C Li, Jonathan A Micieli","doi":"10.1097/WNO.0000000000002453","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002453","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saccadic Pulses as a Major Sign of Internuclear Ophthalmoplegia in Multiple Sclerosis.","authors":"Katarina Tešija, Luka Crnošija, Mašan Sredanović, Tereza Gabelić, Mario Habek","doi":"10.1097/WNO.0000000000002443","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002443","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Uveitis and Optic Neuritis in Central Nervous System Demyelinating Disorders: A Multi-Institutional Cohort Study.","authors":"Jamie L Surgent-Nahay, Muhammad Z Chauhan, Alexander S Kwok, Jawad Muayad, Ahmed F Shakarchi, Omar M Solyman, Joseph G Chacko, Paul H Phillips, Ahmed B Sallam","doi":"10.1097/WNO.0000000000002462","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002462","url":null,"abstract":"<p><strong>Background: </strong>Uveitis and optic neuritis related to demyelinating disease share similar immune mechanisms and can have deleterious visual consequences. Data on uveitis incidence in patients with central nervous system (CNS) demyelinating diseases remain limited. Our objective was to assess the 5-year incidence of uveitis among patients with CNS demyelinating diseases with and without optic neuritis.</p><p><strong>Methods: </strong>Retrospective cohort study using a health records aggregate. We identified patients aged ≥18 years using diagnostic codes to arrange into 3 study groups: a composite CNS demyelinating disease cohort, a multiple sclerosis (MS) cohort, and a neuromyelitis optica/myelin oligodendrocyte glycoprotein antibody-associated disease cohort, each stratified by presence or absence of optic neuritis. We matched each study group based on demographics, clinical comorbidities, medications, and encounter visits.</p><p><strong>Results: </strong>After matching, the 5-year cumulative incidence of any uveitis among patients with optic neuritis in the CNS demyelinating disease group was 1.09% (95% confidence intervals [CI] 0.950-1.25) compared with 0.610% (95% CI 0.501-0.743) in those without optic neuritis (log-rank P < 0.0001), with a hazard ratio (HR) of 1.99 (95% CI 1.57-2.52). The 5-year cumulative incidence of any uveitis among patients with optic neuritis in patients with MS was 0.986% (95% CI 0.846-1.15) compared to 0.543% (95% CI 0.437-0.676) in those without optic neuritis (log-rank P < 0.0001), with a HR of 1.95 (95% CI 1.51-2.53). Although patients with neuromyelitis optica/myelin oligodendrocyte glycoprotein antibody-associated disease showed similar trends, there was no statistical significance. Intermediate uveitis demonstrated the strongest associations with optic neuritis across study groups.</p><p><strong>Conclusions: </strong>Optic neuritis is a clinically meaningful risk factor for uveitis in patients with CNS demyelinating disease, underscoring the need for careful ophthalmic surveillance in this population.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}