Journal of Neuro-Ophthalmology最新文献

{"title":"Comment: Optic Nerve Sheath Compartmentation as a Mechanism for Idiopathic Intracranial Hypertension Without Papilledema.","authors":"Hanspeter E Killer, Achmed Pircher","doi":"10.1097/WNO.0000000000002540","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002540","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Progression of Vitreous Detachment Leading to Exacerbation of Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy.","authors":"Hugo Wu, Anas Alkhabaz, Fannie Nadeau, Yaping Joyce Liao","doi":"10.1097/WNO.0000000000002549","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002549","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features of Acquired Esotropia and Surgical Management in a Real-World Cohort of Myopic Patients.","authors":"Michael J Gilhooley, Omran Sarwani, Gillian Johnson, Indran Davagnanam, Aditi Das, Katie Williams","doi":"10.1097/WNO.0000000000002520","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002520","url":null,"abstract":"<p><strong>Background: </strong>The global increase in myopia prevalence has led to greater interest in associated esotropias. While myopic patients can present with common or special forms of strabismus (e.g., \"heavy eye syndrome\"), the relative incidence of associated strabismus and best surgical approaches are not widely understood. The purpose of this study was to present a \"real-world\" cohort of myopic patients with esotropia to determine what diagnostic features are important and how best to treat esotropia in myopia.</p><p><strong>Methods: </strong>A retrospective case-note review of adults seen at Moorfields Eye Hospital identified 68 cases as follows: age ≥ 18 years, spherical equivalent ≥3.00D, and diagnosis of esotropia. Demographics, orthoptics, refraction, MRI axial length and angle between the lateral and superior rectus muscles (LR:SR angle), surgical technique, and 3-month postoperative outcomes were recorded.</p><p><strong>Results: </strong>At presentation, mean age = 42.4 ± 2.2 years, median refraction = -8.25D, median deviation = 20 prism dioptres (PD) (near and distance) horizontal and vertical 4PD near and 3.5PD distance. There was no correlation between horizontal deviation and spherical equivalent (r = -0.044, P = 0.76). Median axial length was 27.30 mm and LR:SR angle 107.5° by MRI. Thirty-seven patients underwent surgery, 29 unilateral horizontal recess-resect (n = 9/29 fixed sutures, n = 20/29 adjustable), and n = 1 Yokoyama. Median postoperative horizontal deviation was 6PD near (all esodeviation) and 3PD distance (20% exodeviation, 80% esodeviation, 2 patients had a postoperative vertical deviation, and n = 9 required a second procedure).</p><p><strong>Conclusions: </strong>In this large, real-world, clinically and radiographically characterized cohort of myopic patients, the incidence of special strabismus was low and there was no association between refraction and size of deviation. Unilateral recess-resect procedures provided good outcomes with both adjustable and fixed sutures. This cohort will aid in the everyday management of this increasing clinical problem and form the basis of the further randomized, prospective trials that are greatly needed in this area.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study on the Correlation Between Clinical Features of Chronic Relapsing Inflammatory Optic Neuropathy and Myelin Oligodendrocyte Glycoprotein Antibodies.","authors":"Xin Zhang","doi":"10.1097/WNO.0000000000002519","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002519","url":null,"abstract":"<p><strong>Background: </strong>To compare clinical characteristics, cerebrospinal fluid (CSF) findings, relapse patterns, MRI features, visual outcomes, and optical coherence tomography (OCT) structural changes between MOG-IgG-positive and seronegative patients with chronic relapsing inflammatory optic neuritis (CRION).</p><p><strong>Methods: </strong>I retrospectively reviewed patients diagnosed with CRION at the First Affiliated Hospital of Zhejiang Chinese Medical University between January 2015 and December 2021. All patients fulfilled established CRION diagnostic criteria, including recurrent optic neuritis, seronegativity for aquaporin-4 antibodies, optic nerve enhancement on MRI, and steroid-responsive relapse. Clinical, radiologic, CSF, and OCT data were compared between MOG-IgG-positive and seronegative patients.</p><p><strong>Results: </strong>Forty-eight patients (77 affected eyes) were included, of whom 30 (62.5%) were MOG-IgG positive and 18 (37.5%) were seronegative. MOG-IgG-positive patients were younger at onset and more likely to present with ocular pain, bilateral involvement, and optic disc swelling. They had more frequent intraorbital and canalicular optic nerve involvement on MRI, a shorter interval to the second attack (3.44 ± 2.52 vs 13.84 ± 1.12 months, P < 0.001), a higher annualized relapse rate (0.478 ± 0.35 vs 0.175 ± 0.24 relapses/person-year, P < 0.001), and a higher proportion receiving immunosuppressive therapy (86.7% vs 55.6%). Seronegative patients had higher CSF protein and IgG levels and thinner average, superior, and nasal peripapillary retinal nerve fiber layer thickness on follow-up OCT. Visual acuity at nadir and at the final follow-up did not differ significantly between groups, and no cases of legal blindness were observed.</p><p><strong>Conclusions: </strong>MOG-IgG-positive and seronegative CRION patients exhibit distinct clinical, radiologic, relapse, and structural profiles. MOG-IgG positivity identifies a subgroup with earlier and more frequent relapses requiring close monitoring and potential early maintenance immunotherapy, whereas seronegative CRION is associated with greater structural optic nerve damage despite lower relapse frequency. These findings emphasize the heterogeneity of CRION and support antibody-based stratification for clinical management.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Cell Arteritis Presenting as Bilateral Ocular Ischemia With Hypotony.","authors":"Kate J Bryce, Hao M Lee, Richard J Symes","doi":"10.1097/WNO.0000000000002508","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002508","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"iCare HOME2 Monitoring of Diurnal Ocular Perfusion Pressure in Patients With Nonarteritic Ischemic Optic Neuropathy.","authors":"Benjamin V Packard, Meghan Sharma, Andy Renschler, Catherine J Johnson, Chase E Paulson, Blessing S Ofori-Atta, Susan Chortkoff, Sravanthi Vegunta, Barbara M Wirostko, Judith E A Warner","doi":"10.1097/WNO.0000000000002450","DOIUrl":"10.1097/WNO.0000000000002450","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated time-of-day differences in intraocular pressure (IOP), mean arterial pressure (MAP), and ocular perfusion pressure (OPP) in eyes affected by nonarteritic anterior ischemic optic neuropathy (NAION), and compared these measures between NAION-affected and unaffected eyes at each time period.</p><p><strong>Methods: </strong>Adults aged 18-90 years with a confirmed diagnosis of NAION were enrolled in this nonrandomized prospective observational cohort study. Participants were trained to measure blood pressure (BP) and IOP using an automated BP cuff and the iCare HOME2 rebound tonometer. In participants with only 1 eye affected by NAION, the unaffected eye was used as a control. Measurements were collected at 7 predefined daily time points (4:00, 6:00, 9:00, 12:00, 15:00, 18:00, and 21:00) for at least 7 consecutive days. MAP and OPP were calculated as 1/3 systolic + 2/3 diastolic pressure and 2/3 × (MAP - IOP), respectively. Early morning (4:00, 6:00), midday (9:00, 12:00, 15:00), and evening (18:00, 21:00) measurements were compared using linear mixed-effects models. The main outcome measures were intraday measurements of IOP, MAP, and OPP.</p><p><strong>Results: </strong>A total of 27 eyes of 15 patients were included in the study. Among NAION-affected eyes, mean OPP and MAP were lowest in the early morning. No IOP elevations were noted in the early waking hours. On average, OPP was 1.69 mm Hg higher and MAP was 2.70 mm Hg higher at midday than in the morning, while IOP increased by 0.76 mm Hg (all 95% confidence interval [CI]). In the evening, OPP was 1.83 mm Hg higher and MAP was 2.49 mm Hg higher than in the morning (both 95% CI). Evening IOP was 0.31 mm Hg lower than in the morning, but this difference was not statistically significant ( P = 0.08).</p><p><strong>Conclusions: </strong>Early morning low OPP in nonglaucomatous eyes with NAION seems to be correlated with low MAP, rather than elevated IOP. These findings help support a role for impaired local perfusion in the early waking hours in the pathogenesis of NAION and highlight the potential utility of IOP and BP diurnal monitoring in at-risk patients.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"363-368"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homonymous Hemianopia Unveiled: A Treatable Manifestation of Cerebral Convexity Arachnoid Cysts.","authors":"Daniel García-Pérez","doi":"10.1097/WNO.0000000000002455","DOIUrl":"10.1097/WNO.0000000000002455","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e73-e75"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health Assessment and Suitability for Cognitive-Behavioral Therapy Among Patients With Idiopathic Intracranial Hypertension.","authors":"Fannie Nadeau, Mathieu Fradet, Heather E Moss","doi":"10.1097/WNO.0000000000002449","DOIUrl":"10.1097/WNO.0000000000002449","url":null,"abstract":"<p><strong>Background: </strong>High rates of mental health conditions have been reported among patients with idiopathic intracranial hypertension (IIH). Cognitive-behavioral therapy (CBT) has been suggested as a complementary treatment to help manage anxiety and headache pain in IIH. This study aims to assess the mental health of IIH patients through a psychiatric interview and to evaluate their suitability and interest in CBT.</p><p><strong>Methods: </strong>Participants with IIH were recruited from Stanford Byers Eye Institute. Demographic and clinical characteristics were collected, and participants completed self-rated scales for depression (PHQ-9), anxiety (GAD-7), headaches (HIT-6), and disability (WHODAS-12). Diagnostic and Statistical Manual of Mental Disorders, 5th edition diagnoses, patient's suitability for CBT (SSCT scale), and preferred therapy focus were identified through a formal psychiatric interview.</p><p><strong>Results: </strong>Fifty-three participants were enrolled and completed surveys, and 43 participants went on to have the psychiatric interview (mean age 38 years, 91% female). Among them, 76.7% had a GAD-7 score ≥5, indicating at least mild anxiety, and 76.7% of participants had a PHQ-9 score ≥5, indicating at least mild depression. In total, 81.4% of participants suffered from a mood, anxiety, or trauma- and stressor-related disorder. Participants who had received a venous stent or VP shunt had higher anxiety levels (average GAD-7 11.75 vs 6.52; P = 0.007); 81.4% were interested in CBT, and 83.7% were deemed good candidates for CBT (SSCT ≥ 30). Anxiety management most often emerged as their favored therapeutic focus.</p><p><strong>Conclusions: </strong>Our results confirm the high prevalence of mental health conditions and symptoms among patients with IIH. A majority of patients are interested in CBT, and many would likely benefit from this approach. CBT should therefore be considered in the therapeutic management of IIH. Further research is warranted to validate the efficacy of this intervention in this specific clinical population.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"396-401"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13477830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors and Social Determinants of Health for Retinal Artery Occlusion in the National Institutes of Health All of Us Program.","authors":"Boyoung Michelle Kim, Timothy T Xu, Kenny Y Wang, Zhongwei Peng, John J Chen","doi":"10.1097/WNO.0000000000002490","DOIUrl":"10.1097/WNO.0000000000002490","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have identified inequities in stroke epidemiology. Given retinal artery occlusion (RAO) is a stroke equivalent, we investigated risk factors and social determinants of health (SDOH) associated with RAO.</p><p><strong>Methods: </strong>This was a retrospective case-control study. The case group consisted of all patients diagnosed with RAO in the National Institutes of Health All of Us database from November 1992 to November 2020. The control group consisted of all patients without a diagnosis of RAO during that time frame. Associations of predictors of RAO were estimated using logistic regression models.</p><p><strong>Results: </strong>There were 384 patients with an RAO diagnosis and 328,639 participants in the non-RAO group. Median age at RAO diagnosis was 66 years (interquartile range [IQR] 57-72). Median age at study was 74 years (IQR 67-81) for the RAO group and 58 years (IQR 42-69) for the control group. Age- and sex-adjusted multivariable analysis revealed factors positively associated with RAO, including older age {odds ratio [OR]: 2.19 (95% confidence interval [CI]: 2.01-2.39), P < 0.001}, male sex (OR: 1.54 [95% CI: 1.25-1.89], P < 0.001), Black race (OR: 1.62 [95% CI: 1.24-2.09], P < 0.001), military/Veterans Affairs insurance (OR: 2.44 [95% CI: 1.61-3.66], P < 0.001), and Medicaid (OR: 1.51 [95% CI: 1.06-2.15], P = 0.022). Having a college/advanced degree (OR: 0.76 [95% CI: 0.59-0.98], P = 0.031), annual household income between $50,000 and $100,000 (OR: 0.72 [95% CI: 0.52-0.98], P = 0.035), and annual household income between $100,000 and $200,000 (OR: 0.48 [95% CI: 0.32-0.70], P < 0.001) were protective against RAO.</p><p><strong>Conclusions: </strong>These findings confirm previously described associations between RAO and cardiovascular comorbidities and identified novel associations between RAO and SDOH, including Black race and Medicaid insurance. Stroke risk around the time of RAO was high in this cohort.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"335-342"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Hidden Culprit in Optic Neuritis: Mitochondrial Complex I Deficiency Due to a Novel NDUFS1 Mutation.","authors":"Prabhjit Kaur, Arushi Saini, Aastha Takkar, Sanjhi Paliwal, Gayatri Lal, Vikas Bhatia, Jaspreet Sukhija, Vivek Lal","doi":"10.1097/WNO.0000000000002475","DOIUrl":"10.1097/WNO.0000000000002475","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e94-e95"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}