Journal of Neuro-Ophthalmology最新文献

{"title":"Association Between Peripapillary Hyperreflective Ovoid Mass-Like Structures and Optic Nerve Head Morphology in Eyes With Optic Disc Edema.","authors":"Munekatsu Ito, Eri Nakano, Kenji Suda, Miho Tagawa, Manabu Miyata, Shinya Nakao, Akinari Yamamoto, Satoshi Kashii, Akitaka Tsujikawa","doi":"10.1097/WNO.0000000000002472","DOIUrl":"10.1097/WNO.0000000000002472","url":null,"abstract":"<p><strong>Background: </strong>Peripapillary hyper-reflective ovoid mass-like structures (PHOMS) are commonly observed in optic disc swelling of various etiologies, but the factors contributing to their formation have not been fully elucidated. This study aimed to investigate the association between the presence of PHOMS and optical coherence tomography (OCT) parameters in eyes with optic disc edema secondary to various diseases.</p><p><strong>Methods: </strong>This retrospective study included patients who underwent orbital and head MRI to determine the underlying cause of optic disc edema at the Department of Ophthalmology, Kyoto University Hospital, between April 2018 and March 2024. The data of the patients with optic disc edema detected using swept-source OCT were included in the analysis. The scleral canal diameter (SCD), peripapillary choroidal thickness, and optic nerve head height were measured. The background characteristics and OCT parameters of the eyes with and without PHOMS were compared. The associations between PHOMS and OCT parameters were determined using univariable and multivariable regression analyses based on generalized estimation equations.</p><p><strong>Results: </strong>Fifty-one eyes of 41 patients (22 males and 19 females) were included in this study. PHOMS were detected in 26 eyes (51%). Multivariable regression analysis revealed a trend toward an association between narrower SCD and increased risk of PHOMS, but the association was not statistically significant (β = -0.0028; 95% confidence interval, -0.49 to 0.91; P = 0.067).</p><p><strong>Conclusions: </strong>Narrower SCDs in eyes with optic disc edema were associated with a higher risk of developing PHOMS. The structural characteristics of the optic disc may play an important role in the development of PHOMS in eyes with secondary optic disc edema.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"402-407"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home Monitoring of Visual Functions in Neuro-Ophthalmic Diseases Using an AI-Assisted Virtual Reality Platform.","authors":"Amanda Tran, Tamara Juvier-Riesgo, Henar Albertos-Arranz, Liliana Rosello-Rodriguez, Giselle Ricur, Carlos E Mendoza-Santiesteban","doi":"10.1097/WNO.0000000000002461","DOIUrl":"10.1097/WNO.0000000000002461","url":null,"abstract":"<p><strong>Background: </strong>This study evaluates the feasibility and acceptability of a virtual reality platform (VRP) for home monitoring of visual function in patients with neuro-ophthalmic conditions.</p><p><strong>Methods: </strong>Fifteen patients with nonarteritic anterior ischemic optic neuropathy (NAAION), optic neuritis, or papilledema were enrolled and monitored remotely over 12 weeks. Visual acuity, color vision, and visual field testing were collected 3 times per week using the VRP. Compliance and satisfaction levels were analyzed.</p><p><strong>Results: </strong>A total of 21 eyes were included (38.1% NAAION, 42.9% optic neuritis, 19% papilledema). Most participants (71.4%) found weekly VRP use easy, and all felt confident using it at home. While 86% reported no technical issues, 21%-28% experienced transient symptoms such as blurred vision or dizziness. Compliance was highest in the NAAION group, with 75% completing the full 12-week period. In the optic neuritis group, 55.6% remained after Week 1 and 44.4% continued through Week 8. The papilledema group discontinued by Week 4. Main reasons for discontinuation included time constraints, scheduling conflicts, and stable vision after improvement. In general, visual acuity and visual field indices (mean deviation and pattern SD [PSD]) showed no significant changes over time, confirming good VRP'S reproducibility for home monitoring. This VRP also detected cases of visual function worsening, enabling earlier rescheduling of clinical appointments.</p><p><strong>Conclusion: </strong>The VRP is a feasible and well-accepted tool for home-based visual monitoring in neuro-ophthalmic patients as an alternative to in-person eye examinations. This approach enables early detection of changes and can improve long-term management.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"343-349"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levator Myokymia in Congenital Oculomotor Nerve Palsy.","authors":"Paromita Dutta, Uddeshya Yadav, Harsha S Pagad, Parul Jain, Kartika Anand, Samapika P Tripathy","doi":"10.1097/WNO.0000000000002498","DOIUrl":"10.1097/WNO.0000000000002498","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"442-443"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmology and Neuro-Otology at the 2026 American Academy of Neurology Annual Meeting.","authors":"Aileen A Antonio, Nancy J Newman, Meagan D Seay","doi":"10.1097/WNO.0000000000002506","DOIUrl":"10.1097/WNO.0000000000002506","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"448-450"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DOK7 Congenital Myasthenia Syndrome Presenting as an Isolated Complex Ophthalmoplegia.","authors":"Thilan P Subasinghe Arachchige, Karl K Ng, Kate Eliza Ahmad","doi":"10.1097/WNO.0000000000002459","DOIUrl":"10.1097/WNO.0000000000002459","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e80-e81"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrence of Inherited Nuclear and Mitochondrial DNA Optic Neuropathies.","authors":"Benson S Chen, Benjamin I Meyer, Nancy J Newman","doi":"10.1097/WNO.0000000000002466","DOIUrl":"10.1097/WNO.0000000000002466","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e91-e93"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of the Criteria to Diagnose Idiopathic Intracranial Hypertension: An Algorithm.","authors":"Vineet S Kumar, Luke W Barrick, Courtney R Webster, Chiamaka J Okeke, Laiba A Khalil, Sunita Yedavally, David I Kaufman","doi":"10.1097/WNO.0000000000002496","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002496","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic intracranial hypertension (IIH) is a condition characterized by elevated intracranial pressure that can cause a variety of symptoms, including transient visual obscurations, pulsatile tinnitus, and progressive visual loss. Lumbar punctures (LPs) have traditionally been considered necessary for diagnostic confirmation. However, with the rapid advances in neuroimaging and strengthened clinical assessment criteria, there have been discussions about whether LP is necessary in all suspected IIH cases. This study aimed to determine whether, in appropriately selected patients, IIH could be reliably diagnosed without LP by integrating detailed clinical evaluation with MRI/MRV findings.</p><p><strong>Methods: </strong>A retrospective chart review was conducted on 100 consecutive patients diagnosed with IIH in our neuro-ophthalmology clinic over 9 years (2016-present). Inclusion criteria required a high clinical suspicion of IIH with no alternative etiology, a complete neuro-ophthalmologic examination before LP, and no prior history of IIH or LP. Ninety-six patients underwent LP, whereas 4 declined. A literature review was additionally performed, which incorporated 3 studies (n = 363) evaluating the use of LP in suspected IIH cases. Clinical course, diagnostic changes, and management alterations after LP were assessed.</p><p><strong>Results: </strong>Ninety-six patients in our neuro-ophthalmology clinic underwent LP. Of the 96 patients, none had a change in diagnosis or altered management after LP. Four patients in our clinic refused LP. The 4 patients managed without LP experienced no complications or alternative diagnoses. Our thorough literature review showed that in 295 patients who underwent LP, 0/295 patients had an alternative diagnosis or unexpected finding based on LP results. For the remaining 68 patients who did not undergo LP, there were no complications in treatment, and improvement was made without LP. These combined findings from both the literature and our own clinical findings informed the development of a clinical algorithm recommending LP primarily for patients with atypical features or concern for secondary causes, helping improve patient care and comfort while prioritizing safety.</p><p><strong>Conclusion: </strong>In patients with high clinical suspicion for IIH, as described in this manuscript, with supportive neuroimaging, LP may be safely deferred without compromising diagnostic accuracy or patient care. Using a clinically driven algorithm may reduce unnecessary invasive procedures while maintaining patient safety, although LP remains warranted when atypical features or secondary etiologies are suspected.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OCT and OCT-Angiography Structural Insights into Methanol-Induced Optic Neuropathy: Lessons From a 2025 Outbreak in São Paulo, Brazil.","authors":"Felipe A Casseb Dos Santos, Fábio Ejzenbaum, Gabriel C de Andrade, Victor Cvintal, Davi C Wu, Maria Auxiliadora M Frazão","doi":"10.1097/WNO.0000000000002495","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002495","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Eyelid Elevation From Partial Oculomotor Nerve Activation During Stereoencephalography.","authors":"Fawad A Khan, Parth C Patel, Colin N Curtis","doi":"10.1097/WNO.0000000000002521","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002521","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paracentral Acute Middle Maculopathy and Retinal Ischemic Perivascular Lesions in Patients With Retinal Migraines.","authors":"Adrien Henry, Valérie Touitou, Claire Meyniel","doi":"10.1097/WNO.0000000000002522","DOIUrl":"https://doi.org/10.1097/WNO.0000000000002522","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}