Journal of Neuro-Ophthalmology最新文献

{"title":"Dorsal Midbrain Syndrome Due to Complicated Posterior Reversible Encephalopathy Syndrome.","authors":"Seo-Young Choi, Hak-Jin Kim, Kwang-Dong Choi","doi":"10.1097/WNO.0000000000002486","DOIUrl":"10.1097/WNO.0000000000002486","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"440-441"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous Sinus Stenting With Concomitant Intracranial Pressure Monitoring in a Case of Fulminant Idiopathic Intracranial Hypertension.","authors":"Roy Raheb Khelo, Martina L Mustroph, Michael Dattilo, Nicholas M Boulis, Feras Akbik","doi":"10.1097/WNO.0000000000002456","DOIUrl":"10.1097/WNO.0000000000002456","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e76-e79"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Sensitivity, Specificity, and Predictive Values of Serum Angiotensin-Converting Enzyme and Lysozyme in the Diagnosis of Sarcoid Optic Neuropathy.","authors":"Emily R Daly, Kasey Cooper, Ryan D Walsh","doi":"10.1097/WNO.0000000000002468","DOIUrl":"10.1097/WNO.0000000000002468","url":null,"abstract":"<p><strong>Background: </strong>This study describes the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of serum angiotensin-converting enzyme (s-ACE), and serum lysozyme in the diagnosis of sarcoid optic neuropathy (SON).</p><p><strong>Methods: </strong>We retrospectively reviewed the electronic medical record (EMR) of adult patients evaluated by neuro-ophthalmologists at Froedtert Hospital and the Medical College of Wisconsin clinics with a diagnosis of optic neuropathy (ON) from January 1, 2012, through July 1, 2023, who had s-ACE and/or serum lysozyme levels assessed. Potential patients for inclusion were identified using institutional data search tools. We then manually reviewed the EMR of each patient to verify whether inclusion parameters were met, and to gather relevant demographic and clinical data including s-ACE and lysozyme levels, and ON etiology. For the diagnosis of \"Probable\" or \"Definite\" SON, we relied on previously published consensus criteria for the diagnosis of neurosarcoidosis from the Neurosarcoidosis Consortium Consensus Group. The sensitivity, specificity, PPV, and NPV of s-ACE and lysozyme in the diagnosis of SON were calculated. For patients determined to meet criteria for a diagnosis of SON, we extracted additional data from the EMR including tissue biopsy location/s and findings; whether sarcoidosis diagnosis was already established before presentation with ON; whether the patient was taking corticosteroids or ACE-inhibitor (ACE-I) therapy at the time of laboratory evaluation; cerebrospinal fluid ACE (CSF-ACE) level; results of chest imaging; and results of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET) scans.</p><p><strong>Results: </strong>A total of 706 patients with ON were included. Of these 706 patients, 395 (56%) were women and 311 (44%) were men, with a median age of 51 years (range: 18-90). All 706 had an s-ACE level available, while 110 also had a lysozyme level available. Fourteen of the 706 (2%) patients met criteria for a diagnosis of \"Probable\" (n = 13) or \"Definite\" (n = 1) SON. Of these, 7 (50%) were women and 7 (50%) were men, with a median age of 42 years (range: 19-60). Seven of the 14 (50%) patients had a previously established diagnosis of sarcoidosis before presenting with ON. We found a sensitivity for s-ACE in diagnosing SON of 21.4%, and a specificity of 97%. The PPV of s-ACE was 12.5%, and the NPV was 98.4%. For lysozyme, we found a sensitivity of 33.3%, a specificity of 98%, PPV of 60%, and NPV of 94.3%.</p><p><strong>Conclusions: </strong>In diagnosing SON, we have found s-ACE to have a sensitivity of 21.4%, and a specificity of 97%. The PPV of s-ACE was 12.5% and the NPV was 98.4%. We have determined lysozyme in this setting to have a sensitivity of 33.3% and a specificity of 98%. The PPV of lysozyme was 60% and the NPV was 94.3%. The fact that s-ACE and lysozyme have low sensitivity for the diagnosis of SON in","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"357-362"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cobalt Toxic Optic Neuropathy in a MT-ND4 m.11778G>A Carrier.","authors":"Haoran C Li, Jonathan A Micieli","doi":"10.1097/WNO.0000000000002453","DOIUrl":"10.1097/WNO.0000000000002453","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e69-e72"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Uveitis and Optic Neuritis in Central Nervous System Demyelinating Disorders: A Multi-Institutional Cohort Study.","authors":"Jamie L Surgent-Nahay, Muhammad Z Chauhan, Alexander S Kwok, Jawad Muayad, Ahmed F Shakarchi, Omar M Solyman, Joseph G Chacko, Paul H Phillips, Ahmed B Sallam","doi":"10.1097/WNO.0000000000002462","DOIUrl":"10.1097/WNO.0000000000002462","url":null,"abstract":"<p><strong>Background: </strong>Uveitis and optic neuritis related to demyelinating disease share similar immune mechanisms and can have deleterious visual consequences. Data on uveitis incidence in patients with central nervous system (CNS) demyelinating diseases remain limited. Our objective was to assess the 5-year incidence of uveitis among patients with CNS demyelinating diseases with and without optic neuritis.</p><p><strong>Methods: </strong>Retrospective cohort study using a health records aggregate. We identified patients aged ≥18 years using diagnostic codes to arrange into 3 study groups: a composite CNS demyelinating disease cohort, a multiple sclerosis (MS) cohort, and a neuromyelitis optica/myelin oligodendrocyte glycoprotein antibody-associated disease cohort, each stratified by presence or absence of optic neuritis. We matched each study group based on demographics, clinical comorbidities, medications, and encounter visits.</p><p><strong>Results: </strong>After matching, the 5-year cumulative incidence of any uveitis among patients with optic neuritis in the CNS demyelinating disease group was 1.09% (95% confidence intervals [CI] 0.950-1.25) compared with 0.610% (95% CI 0.501-0.743) in those without optic neuritis (log-rank P < 0.0001), with a hazard ratio (HR) of 1.99 (95% CI 1.57-2.52). The 5-year cumulative incidence of any uveitis among patients with optic neuritis in patients with MS was 0.986% (95% CI 0.846-1.15) compared to 0.543% (95% CI 0.437-0.676) in those without optic neuritis (log-rank P < 0.0001), with a HR of 1.95 (95% CI 1.51-2.53). Although patients with neuromyelitis optica/myelin oligodendrocyte glycoprotein antibody-associated disease showed similar trends, there was no statistical significance. Intermediate uveitis demonstrated the strongest associations with optic neuritis across study groups.</p><p><strong>Conclusions: </strong>Optic neuritis is a clinically meaningful risk factor for uveitis in patients with CNS demyelinating disease, underscoring the need for careful ophthalmic surveillance in this population.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"350-356"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effects of Steroid Therapy on Visual Acuity, Visual Field, and Optical Coherence Tomography-Optical Coherence Tomography Angiography Parameters in Nonarteritic Anterior Ischemic Optic Neuropathy.","authors":"Ahmet Özdemir, Abdülcemal Gürpınar, İnci Güngör","doi":"10.1097/WNO.0000000000002477","DOIUrl":"10.1097/WNO.0000000000002477","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the effects of systemic corticosteroid therapy on visual and structural outcomes in patients with nonarteritic anterior ischemic optic neuropathy (NA-AION) treated with systemic corticosteroids vs those untreated, using optical coherence tomography (OCT) and OCT angiography (OCTA).</p><p><strong>Methods: </strong>This retrospective study included 72 subjects: 23 steroid-treated patients with NA-AION, 24 untreated patients, and 25 age- and sex-matched healthy controls. All participants underwent comprehensive ophthalmic evaluation, including best-corrected visual acuity (BCVA), visual field testing, OCT, and OCTA imaging. Macular and peripapillary vessel densities were quantitatively analyzed. Additional analyses using analysis of covariance (ANCOVA) were performed to adjust for baseline visual acuity, age, sex, and systemic comorbidities.</p><p><strong>Results: </strong>Baseline BCVA did not differ significantly between the patient groups. Greater unadjusted improvement in visual acuity was observed in the steroid-treated group ( P = 0.031). However, after adjustment for baseline visual acuity and covariates, ANCOVA revealed only a borderline trend favoring steroid therapy (F(2,65) = 2.51, P = 0.089, partial η 2 =0.072). Similarly, mean deviation in visual field testing showed a modest but nonsignificant improvement after adjustment (F(1,30) = 2.19, P = 0.149, partial η 2 =0.068). OCT demonstrated significant thinning of the retinal nerve fiber layer and ganglion cell-inner plexiform layer in both NA-AION groups compared with controls, with no significant differences between treated and untreated patients. OCTA revealed reduced vessel density in all macular and peripapillary sectors in NA-AION eyes relative to controls ( P < 0.001), without significant intergroup differences.</p><p><strong>Conclusions: </strong>Systemic corticosteroid therapy in NA-AION may be associated with greater functional improvement in visual acuity and visual field parameters; however, these findings should be interpreted with caution given the influence of baseline visual acuity and the retrospective study design. The absence of corresponding differences in structural and vascular OCT and OCTA parameters suggests that any potential functional benefit may occur independently of measurable microvascular restoration. Further prospective, controlled studies are required to clarify the role of corticosteroids in the management of NA-AION.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"376-384"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Literature Commentary.","authors":"","doi":"10.1097/WNO.0000000000002504","DOIUrl":"10.1097/WNO.0000000000002504","url":null,"abstract":"<p><p>In this issue, we are very glad to welcome Kimberly Gokoffski, MD, PhD from UC Irvine as a commentator. Doctors Moster and Gokoffski review the following 4 articles.Boudot de la Motte M, Gavoille A, Papeix C, et al. Treatment discontinuation in patients with myelin oligodendrocyte glycoprotein antibody-associated disease. JAMA Neurol . 2026. Ayupov, T, Moreno-Juan, V, Curtoni, S. et al. Cell-type-targeted mitochondrial transplantation rescues cell degeneration. Nature . 2026;653:221-231. Yang DL, Cao Q, Liu F, et al. Quantification of vascular burden on cranial vessel wall MRI and ophthalmic complications in giant cell arteritis. ACR Open Rheumatol . 2026;8:e90066. Fogg, LG, Tom, E, Policarpo, M, et al . The visual system of the longest-living vertebrate, the Greenland shark. Nat Commun . 2026;17:39.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"436-439"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Orbital Approach to Superior Oblique Myokymia: Superior Oblique Myectomy and Trochlear Resection.","authors":"Susan Luo, Salma A Dawoud, Gerald J Harris","doi":"10.1097/WNO.0000000000002417","DOIUrl":"10.1097/WNO.0000000000002417","url":null,"abstract":"<p><strong>Background: </strong>We describe the outcomes and long-term follow-up of treatment with anterior orbitotomy with superior oblique myectomy and trochlear resection for superior oblique myokymia.</p><p><strong>Methods: </strong>Single-center case report and long-term follow-up of 3 previously published cases of superior oblique myokymia treated with superior oblique myectomy and trochlear resection. Previously reported patients were contacted for long-term follow-up. A fourth patient's complex clinical course is detailed. The surgical procedure is described and contrasted with alternative approaches.</p><p><strong>Results: </strong>Four patients with refractory oscillopsia were treated. Symptom duration before presentation to the authors ranged from 10 to 22 years. All 4 patients had failed medical therapy; 3 of 4 had recurrent myokymia after prior superior oblique tenectomy; 1 of 4 had persistent symptoms despite 3 transcranial microvascular decompressions. After superior oblique myectomy and trochlear resection, all 4 patients reported sustained, complete resolution of oscillopsia in postoperative follow-up of 22, 17, 16, and 2 years. Three of 4 patients did not require additional strabismus surgery. Three of 4 patients reported mild postsurgical supra- and infratrochlear hypesthesia but deemed the symptoms not bothersome.</p><p><strong>Conclusions: </strong>Superior oblique myectomy and trochlear resection is a surgical option for patients with superior oblique myokymia unresponsive to, or intolerant of, medical therapy. It can be used if superior oblique tenectomy fails, or it can be considered as primary surgical management. Further strabismus surgery may be required after this procedure. If used primarily, compensatory inferior oblique weakening should be planned, as it is following primary superior oblique tenectomy. In our view, the orbital approach is preferable to transcranial microvascular decompression.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"324-328"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should Patients With Ocular Myasthenia Gravis Be Started on Immunosuppression to Prevent Generalization?","authors":"Thirugnanam N Umapathi, Sui H Wong, Andrew G Lee, Gregory P Van Stavern","doi":"10.1097/WNO.0000000000002467","DOIUrl":"10.1097/WNO.0000000000002467","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"428-435"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Media Coverage of Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) After Semaglutide Use: A Content Analysis of News Reporting Accuracy and Framing.","authors":"Donya Mahiny, Sara KamaliZonouzi, Samira Jafari, Jonathan A Micieli","doi":"10.1097/WNO.0000000000002454","DOIUrl":"10.1097/WNO.0000000000002454","url":null,"abstract":"<p><strong>Background: </strong>In July 2024, a matched cohort study reported an association between semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), and nonarteritic anterior ischemic optic neuropathy (NAION), a rare optic neuropathy. The study prompted widespread media coverage. Given the media's role in shaping perceptions of drug safety, we conducted a content analysis of news reporting on this association.</p><p><strong>Methods: </strong>We performed a qualitative content analysis of English-language news articles published between July 3, 2024, and March 31, 2025. Articles were retrieved through LexisNexis and included if they discussed both GLP-1 RAs and NAION in a public-facing context. Articles were coded by 3 independent reviewers using a structured tool to assess scientific accuracy, causal language, framing of certainty, citation of the original study, quoted sources, and emotive or misleading language.</p><p><strong>Results: </strong>Seventy-one articles met inclusion criteria. Twenty-one percent used causal language, 80% used scientific language, and 48% contained misleading claims. Articles with causation errors were less likely to correctly define NAION (73% vs 92%), quote physicians (33% vs 63%), or mention study limitations (27% vs 66%). US articles had the lowest rate of causation errors (5%) and UK. articles had the highest (34%).</p><p><strong>Conclusions: </strong>Media coverage of the potential semaglutide-NAION link varied in accuracy and tone. Articles avoiding causation errors more often included expert input and contextualized uncertainty. These findings highlight the need for responsible health journalism in reporting emerging safety concerns.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"369-375"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}