斜坡病变所致第6、12期脑神经麻痹（Godtfredsen综合征）。

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuro-Ophthalmology Pub Date : 2025-05-15 DOI:10.1097/WNO.0000000000002233

Rhys T Ishihara, Zhenyang Zhao, Sibi Rajendran, Ardalan Sharifi, Alexander Tseng, Zachary DeZeeuw, David S Baskin, Andrew G Lee

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引用次数: 0

摘要

背景：Godtfredsen综合征（GS）最初由Erik Godtfredsen博士于1946年描述，是脑神经（CN）第6和第12麻痹的组合。GS最常见的病因是斜坡病变。方法：回顾性分析GS病例系列。结果：纳入3例患者：1)38岁女性伴有斜坡乳腺癌转移；2) 35岁女性，伴有斜坡脊索瘤；3) 72岁女性，部分硬脑膜动静脉瘘栓塞，累及舌下管。结论：GS是CN第6和第12麻痹的合并，最常见的是由于斜坡病变。临床医生应该意识到这种罕见的颅神经病变组合，定位的意义，以及斜坡病变的鉴别诊断。

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Combined 6th and 12th Cranial Nerve Palsies (Godtfredsen Syndrome) due to Clival Lesions.

Background: Godtfredsen syndrome (GS), originally described by Dr. Erik Godtfredsen in 1946, is the combination of cranial nerve (CN) 6th and 12th palsies. The most common etiology of GS is a lesion of the clivus.

Methods: A retrospective case series of GS is described.

Results: Three patients were included: 1) a 38-year-old woman with a clival breast cancer metastasis; 2) a 35-year-old woman with a clival chordoma; and 3) a 72-year-old woman with a partially embolized dural arteriovenous fistula involving the hypoglossal canal.

Conclusions: GS is a combination of CN 6th and 12th palsies and most commonly is due to a lesion in the clivus. Clinicians should be aware of this uncommon combination of cranial nerve findings, the localizing significance, and the differential diagnosis of clival lesions.

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来源期刊

Journal of Neuro-Ophthalmology 医学-临床神经学

CiteScore

2.80

自引率

13.80%

发文量

593

审稿时长

6-12 weeks

期刊介绍： The Journal of Neuro-Ophthalmology (JNO) is the official journal of the North American Neuro-Ophthalmology Society (NANOS). It is a quarterly, peer-reviewed journal that publishes original and commissioned articles related to neuro-ophthalmology.