Journal of Microscopy and Ultrastructure最新文献

{"title":"A study of stromal collagen in oral lichen planus, carcinoma in situ, early invasive squamous cell carcinoma, and normal mucosa using picrosirius red stain","authors":"D. Nandini, V. Ramya, Vikram S. Amberkar, K. M. Mohan Kumar, G. Madhushankari","doi":"10.4103/jmau.jmau_83_21","DOIUrl":"https://doi.org/10.4103/jmau.jmau_83_21","url":null,"abstract":"Background and Objectives: Oral lichen planus (OLP) is a chronic disease of uncertain cause commonly affecting oral cavity. Although the WHO has designated OLP as a “potentially malignant disorder,” controversies exist regarding its malignant potential. Collagen forms the principal component of stroma or extracellular matrix and its role in carcinogenesis is widely studied in other premalignancies. Although collagen at the basal complex of OLP is widely explored, studies on collagen in the connective tissue stroma are not reported to date. We aimed to observe the nature of collagen in connective tissue stroma of OLP using picrosirius red stain (PSR) under polarized microscope and compare with buccal mucosa without any pathology related to exposure to tobacco and other oral carcinogens, carcinoma in situ (Ca in situ), and early invasive squamous cell carcinoma (EISCC). Materials and Methods: Eighty samples were observed, with twenty samples in each study group. Two 4–6-μ thick sections were obtained from the archival blocks. One section was stained with hematoxylin and eosin for confirming the diagnosis, whereas PSR staining was done for the other section. Both sections were analyzed using a polarizing microscope for evaluating the polarization colors of collagen. The images captured were stored on a computer. Five nonoverlapping fields were selected from each section in all groups and the thickness of five collagen fibers from each section was measured in microns using image analysis software and the polarizing color was also noted. The values obtained were compared using Kruskal–Wallis H-test and Chi-square test. We also used Mann–Whitney U-test for intergroup comparison. Results: The mean width of thick as well as thin fibers was more in controls than Ca in situ, OLP, and EISCC in decreasing order. Mature fibers were predominant in the controls than Ca in situ, OLP, and EISCC in decreasing order. Immature fibers were predominant in EISCC, followed by OLP, Ca in situ, and controls. Comparison of collagen in OLP and Ca in situ showed no statistically significant result in terms of thickness and polarization colors confirming a similarity in the nature of collagen in these two lesions. Conclusion: The stromal collagen of OLP was comparable to Ca in situ suggesting a change in the structure and organization of collagen probably attributed to the role of inflammatory mediators. A study with bigger sample size is recommended to evaluate the role of collagen in malignant transformation of OLP.","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 1","pages":"179 - 184"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44896688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal unilateral wilms' tumor: Radiopathological correlation","authors":"Ravikanth Reddy","doi":"10.4103/jmau.jmau_121_20","DOIUrl":"https://doi.org/10.4103/jmau.jmau_121_20","url":null,"abstract":"Wilms' tumor constitutes majority of malignant primary renal tumors in children. Outcomes of treatment are excellent in Wilms' tumor, with a cumulative survival rate of 87%. A combination of imaging and histopathology is needed for confirmation of Wilms' tumor. However, imaging alone can be used for screening, diagnostic workup, assessment of response to treatment, preoperative evaluation, and follow-up for recurrence. In malignant primary tumors such as Wilms' tumor, where the outcomes following treatment are excellent, management strategies are aimed at risk-based stratification approach, thereby improving the quality of life in children with high-grade tumors while maintaining extremely good outcomes in the pediatric age group with low-grade tumors. This case report describes a rare sonological appearance of multifocal unilateral Wilms' tumor in a 4-month-old infant.","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 1","pages":"190 - 192"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43098406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological Changes in the Background Renal Parenchyma in Neoplastic Nephrectomies and Nephroureterectomy: A 10-Year Single-Center Experience.","authors":"Reem A Al Zahrani","doi":"10.4103/jmau.jmau_87_21","DOIUrl":"https://doi.org/10.4103/jmau.jmau_87_21","url":null,"abstract":"<p><strong>Background: </strong>Nephrectomies and nephroureterectomies specimen with neoplastic diagnosis provide a great opportunity to examine the background kidney parenchyma. This will help in exploring any microscopic abnormality that may affect the functional capacity of the residual renal tissue and assess the possible need for nephrologist intervention in maximizing the function of the residual renal parenchyma.</p><p><strong>Aim: </strong>Evaluation of this part of the kidney is overlooked in different centers around the world.</p><p><strong>Method: </strong>A total of 124 specimens of nephrectomies and nephroureterectomies performed at King Abdulaziz University Hospital between January 2010 and December 2019 were reviewed. The microscopic findings in the nonneoplatic parenchyma were documented. Furthermore, the extent to which these findings were initially identified, investigated, and reported was measured.</p><p><strong>Results: </strong>Hypertensive and diabetic nephropathy were among the most common findings in the diseased kidney. The nonneoplastic kidney was well sampled in 95% of the cases and mentioned in the report in 25% of the cases.</p><p><strong>Conclusion: </strong>Although, the evaluation of this part of the kidney is essential, and of great help for the patient prognosis, and quality of kidney function, it is overlooked in different centers around the world, and the causes behind this requires further exploration.</p>","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 2","pages":"103-106"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/62/JMAU-11-103.PMC10337669.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic Adrenal Rest in Paratubal Region: A Rare Lesion in a Rare Location.","authors":"Indranil Chakrabarti,&nbsp;Nabanita Das","doi":"10.4103/jmau.jmau_139_20","DOIUrl":"https://doi.org/10.4103/jmau.jmau_139_20","url":null,"abstract":"<p><p>Ectopic adrenal rests (EAT) are rare lesions comprising predominantly adrenocortical tissue in various locations. Here, we report a case of EAT in the paratubal location which was incidentally detected in a salpingo-oophorectomy specimen from a 21-year-old female. The identification of these lesions is extremely essential as it can be associated with hyperplasia and neoplasia.</p>","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 2","pages":"118-120"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/ff/JMAU-11-118.PMC10337672.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of p53 as Potential Biomarker in Oral Submucous Fibrosis: An Immunohistochemical Study.","authors":"K A Kamala,&nbsp;Sujata R Kanetkar,&nbsp;Kailash D Datkhile,&nbsp;S Sankethguddad","doi":"10.4103/jmau.jmau_23_21","DOIUrl":"https://doi.org/10.4103/jmau.jmau_23_21","url":null,"abstract":"<p><strong>Background: </strong>Oral submucous fibrosis (OSMF) is potentially malignant disorder known to transform into oral cancer. The malignant transformation is often associated with changes at the genetic level that in turn is reflected by the altered expression of proteins related to cell cycle, proliferation, and apoptosis. Expression of p53 tumor suppressor gene is one of the common findings in human cancers including the oral cancer. Therefore, the early detection of potentially malignant OSMF has been crucial in the inhibition of oral cancer.</p><p><strong>Aim and objectives: </strong>To determine the main pathological logical factors and expression of aberrant p53 in OSMF, oral squamous cell carcinomas (OSCC) and in normal patients, to study correlation between p53 expression with clinical staging and histological grading of OSMF.</p><p><strong>Materials and methods: </strong>An immunohistochemical (IHC) study was performed for p53 expression on 35 cases of OSMF, 10 cases of OSCC with history of habits and 10 normal patients without any habits.</p><p><strong>Results: </strong>The expression of p53 showed a significant difference between normal oral mucosa, OSMF and OSCC samples.</p><p><strong>Conclusion: </strong>The study demonstrated a high incidence of p53 over expression in OSMF and OSCC. The results indicate that p53 over expression may play a role in pathogenesis of OSMF and in the development of Oral squamous cell carcinoma. With early detection of the high-risk patients with OSMF, we can expect to develop more intensive treatment modalities, leading to the reduction in cancer transformation rate from OSMF.</p>","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 2","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/9d/JMAU-11-75.PMC10337671.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Report on Histopathology of Odontogenic Keratocyst in Third Dimension: Three-Dimensional Video and Images.","authors":"Sandhya Tamgadge,&nbsp;Avinash Tamgadge","doi":"10.4103/jmau.jmau_1_21","DOIUrl":"https://doi.org/10.4103/jmau.jmau_1_21","url":null,"abstract":"<p><strong>Introduction: </strong>Odontogenic keratocyst (OKC) is a developmental odontogenic cyst of the jaws that causes extensive destruction even before the clinical manifestations are evident. It is a well-known entity among private practitioners as it has a high recurrence rate and requires meticulous treatment planning. Unfortunately, clinicians have less understood its basic histopathology.</p><p><strong>Objective: </strong>This article highlights the preliminary attempt of an author in designing third dimension of histopathological aspect of OKC so that it is easily understood by oral pathologists, general pathologists, nonpathologists, students, and even patients too.</p><p><strong>Methodology: </strong>Preliminary three-dimensional (3D) images and videos on histopathological aspect of OKC were designed by the author using 3DMax (Autodesk Media and Entertainment) and Adobe Premiere Pro 5.5 software which is a video editing software (Adobe Systems) based on two-dimensional descriptions mentioned in the literature.</p><p><strong>Results: </strong>Internal cellular architecture of OKC was created in a lifelike manner through 3D animation video and images.</p><p><strong>Conclusion: </strong>Histopathological aspect of all oral lesions should be explained in third dimension too.</p>","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 2","pages":"121-123"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/a4/JMAU-11-121.PMC10337673.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light Microscopy and Ultrastructure of Body Wall in Leech <i>Haemadipsa zeylanica</i>.","authors":"Usha Anilkumar,&nbsp;Anita S Jadhav","doi":"10.4103/jmau.jmau_45_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_45_22","url":null,"abstract":"<p><strong>Background information: </strong>Leeches are widely distributed worldwide in a diversity of habitats, such as freshwater, seas, desert, and oases. Since literature does not have an elaborate study on histology of leeches, thus emphasis is given to study the histology.</p><p><strong>Aim: </strong>The aim of this study is to examine the histology of free-living leeches <i>Haemadipsa</i> <i>zeylanica</i> under light microscopy and extended to ultrastructural study under transmission electron microscopy.</p><p><strong>Materials and methods: </strong>Tissue was fixed in 10% formalin, dehydrated with alcohol, infiltrated and embedded in wax, and thin section was cut using a rotary microtome. Sections were stained with hematoxylin and eosin.</p><p><strong>Results: </strong>The epithelial layer of cells in <i>H. zeylanica</i> had a thin layer of cuticles covering it. In light microscopy, the epidermis has three types of epidermal cells, namely, glandular cells (Type I, Type II, and Type III), supporting cells (Type IV), and pigment cells (Type V). When the three glandular cells of the body wall of <i>H. zeylanica</i> epidermis were examined under an electron microscope, three types of distinct electron-dense granules were identified. Type I cells with granules, Type II cells with course granules close to the dermis were identified as pear-shaped secretory cells, and Type III cells with electron-dense granules.</p>","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 2","pages":"81-86"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/f8/JMAU-11-81.PMC10337674.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9820455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental Dysfunction and Acute Toxoplasmosis: The Role of Melatonin in Relation to Inflammatory Cytokines Interleukin-10 and Interleukin-12.","authors":"Azhar H Al-Kuraishi,&nbsp;Hatham Ibraheem Khalil,&nbsp;Huda Hameed Hassan,&nbsp;Hayder M Al-Kuraishy","doi":"10.4103/jmau.jmau_122_20","DOIUrl":"https://doi.org/10.4103/jmau.jmau_122_20","url":null,"abstract":"Objective: The objective of this study was to elucidate the potential role of anti-inflammatory interleukin (IL)-10 and pro-inflammatory (IL-12) cytokines as well as melatonin (MEL) in the development of placental dysfunction in the pregnant women with acquired toxoplasmosis (TOX). Materials and Methods: This case–control study was carried out at the Department of Clinical Parasitology in teamwork with the Department of Gynecology and Obstetrics, Al-Yarmouk Teaching Hospital, College of Medicine, Al-Mustansiriyah University, Baghdad, Iraq, from September 2018 to February 2019. The recruited patients and healthy controls were allocated into two groups – Group A: pregnant women with acute TOX (n = 45) and Group B: healthy pregnant women (n = 25). Anti-Toxoplasma (Toxo) immunoglobulin M (IgM), serum and placental as well as serum–placental (SP) ratio of MEL, IL-10, and IL-12 were measured. SPSS version 20.00 was used for data analysis. Results: Anti-Toxo IgM serum level and IL-12 serum levels were higher compared with controls (P = 0.001). Both MEL and IL-10 serum levels were lower in the pregnant women with acute TOX compared with controls (P = 0.002 and P = 0.002), respectively. Besides, Both MEL and IL-10 placental levels were lower in the pregnant women with acute TOX compared with controls (P = 0.001). As well, placental IL-12 level was higher in the pregnant women with acute TOX compared with controls (P = 0.001). SP ratio of MEL was higher in the pregnant women with acute TOX compared with controls (P = 0.001). Conclusion: MEL and anti-inflammatory IL-10 are reduced in the pregnant women with acute TOX, while IL-12 is increased. SP ratio of MEL but not of IL-10 or IL-12 is elevated in the pregnant women with acute TOX reflecting the risk of PD.","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 2","pages":"87-91"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/c0/JMAU-11-87.PMC10337677.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological, Clinical, and Histopathological Features of Salivary Gland Tumors among 150 Sudanese Patients: 10 Years' Experience.","authors":"Somaya T S Hamid,&nbsp;Mohammed A M Abdalla,&nbsp;Azza A Zulfu,&nbsp;Azza Ramadan,&nbsp;Musaab Ahmed,&nbsp;Mohamed H Ahmed","doi":"10.4103/jmau.jmau_113_20","DOIUrl":"https://doi.org/10.4103/jmau.jmau_113_20","url":null,"abstract":"<p><strong>Background and objectives: </strong>Salivary gland tumors (SGTs) are serious challenges to pathologists. Herein, we aimed to assess epidemiological and histopathological characteristics of SGTs among Sudanese patients.</p><p><strong>Materials and methods: </strong>This retrospective descriptive study was undertaken at The pathology department in Khartoum State between 2008 and 2018. Patient records, histopathological reports, and slides were retrieved; and re-examined by two histopathologists. Diagnoses were reclassified according to the 2017 WHO classification of SGTs.</p><p><strong>Results: </strong>Overall, 150 cases of Sudanese patients with SGT were included (90 [60%] males and 60 [40%] females). Among these, 105 were benign (70%) and 45 were malignant (30%). The parotid glands were the most common site for both benign and malignant tumors (77/150; 51%: 59 benign (76.6%) and 18 malignant [23.4%]). The next common site was the submandibular gland (54 [36%]: 38 benign [70.3%] and 16 malignant [29.7%]), followed by minor salivary glands (19 [12.7%]: 8 benign and 11 malignant [57.9%]). Benign gland entities included pleomorphic adenoma (88/105; 83.7%), oncocytoma (5/105; 4.8%), myoepithelioma (4/105; 3.8%), Whartin tumors (3/105; 2.9%), basal cell adenoma (3/105; 2.9%), and sialolipoma (2/105; 1.9%). Malignant gland entities included adenoid cystic carcinoma (12; 26.7%), mucoepidermoid carcinoma (10; 22,2%), acinic cell carcinoma (6; 13.3%), poorly differentiated carcinoma (4; 8.9%), adenocarcinoma NOS (not otherwise specified) (4; 8.9%), basal cell adenocarcinoma (3; 6.7%), carcinoma ex pleomorphic adenoma (3; 6.7%), polymorphous adenocarcinoma (2; 4.4%), salivary duct carcinoma (1; 2.2%), and epithelial-myoepithelial carcinoma (2.2%).</p><p><strong>Conclusions: </strong>SGTs shared several epidemiological and histopathological features, exhibiting high incidence in the parotid and submandibular glands, lower prevalence in minor glands, and greater male predominance.</p>","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 2","pages":"92-96"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/3d/JMAU-11-92.PMC10337678.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Correlation of Serum Histamine and Mast Cell Count with the Established Prognosticators in Oral Cancer.","authors":"Nabeel Rashid Hasan,&nbsp;Priyadarshini Dehuri,&nbsp;Amitabh Jena,&nbsp;Srikanta Kanungo","doi":"10.4103/jmau.jmau_138_20","DOIUrl":"https://doi.org/10.4103/jmau.jmau_138_20","url":null,"abstract":"<p><strong>Context: </strong>We undertook this study in view of the rising interest in the interactions between tumor cells and mast cells in the tumor microenvironment and the mounting evidence of the role of mast cells in the prognosis of various cancers.</p><p><strong>Aims: </strong>The aim of the study is to determine the prognostic utility of mast cells and their mediators in oral squamous cell carcinoma (OSCC).</p><p><strong>Settings and design: </strong>This is a cross-sectional analytical study. A total of 41 cases were studied for determining the correlation of mast cell counts with histopathological prognostic variables and 29 cases for determining the serum histamine levels and to further correlate the values with the histopathologic determinants.</p><p><strong>Subjects and methods: </strong>Mast cell assessment was done using Toluidine blue stain on tissue sections while histopathological prognostic factors were evaluated with routine stains. The serum histamine levels were obtained by sandwich enzyme linked immunosorbent assay (ELISA).</p><p><strong>Statistical analysis: </strong>Mann-Whitney <i>U</i>-test was used to test the difference between parameters and a Spearman correlation coefficient was used. <i>P</i> < 0.05 was considered significant for statistical analysis.</p><p><strong>Results: </strong>We found statistically significant correlations between increased median mast cell counts and higher grade of tumor, presence of lymphovascular invasion, greater depth of invasion, and presence of regional lymph node involvement. The serum histamine values correlated only with the depth of tumor invasion.</p><p><strong>Conclusions: </strong>Hence, as per our results, we suggest the use of mast cell counts in OSCC cases as a prognostic indicator in conjunction with other clinicopathological factors. At the same time, we acknowledge the fact that extensive studies are required to establish the role of mast cell mediators in the prognostic curve of oral cancer patients.</p>","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 2","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d9/02/JMAU-11-97.PMC10337676.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9820457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}