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Adaptive fuzzy PID control for polymerase chain reactions 聚合酶链反应的自适应模糊PID控制
2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746959
Xufeng Peng, Zhang-wei Chen, He Mao
{"title":"Adaptive fuzzy PID control for polymerase chain reactions","authors":"Xufeng Peng, Zhang-wei Chen, He Mao","doi":"10.1109/BMEI.2013.6746959","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6746959","url":null,"abstract":"The main problem of PCR (Polymerase Chain Reaction) temperature control is that periodic change of the temperature leads to the changes in system characteristics, which requires PID (Proportion Integration Differentiation) parameters adjusted automatically. This article has researched various PID turning methods at home and abroad, based on which an adaptive fuzzy PID control method is proposed. Factors affecting the performance of the fuzzy controller are analyzed, and parameters that need to be adjusted to optimize the controller are determined as well. Finally, in this paper, an experiment is conducted to compare the performance of a PID controller and the adaptive fuzzy PID controller, which testifies that after using the adaptive fuzzy PID control method, the heating and cooling rate, the overshoot and the accuracy have all been improved significantly, and this adaptive fuzzy control method can satisfy the demand of PCR temperature control.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131307884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel method for SNP detection based on combinative analysis of primer extension and ligation 一种基于引物延伸和连接组合分析的SNP检测新方法
2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746982
Chengguang Mao, Xiaoting Qian, Pengfeng Xiao
{"title":"A novel method for SNP detection based on combinative analysis of primer extension and ligation","authors":"Chengguang Mao, Xiaoting Qian, Pengfeng Xiao","doi":"10.1109/BMEI.2013.6746982","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6746982","url":null,"abstract":"We described a novel method that combined primer extension and ligation for simultaneously detecting a set of single nucleotide variations. To verify the feasibility of this method, seven synthetic templates containing seven KRAS mutation sites and one template without mutation were detected by four primer extension cycles and one ligation reaction in the present of labeled or unlabeled nucleotides. The primer extension cycles and ligation reaction would give three sets of fluorescent signals. By combining the three set of fluorescent signals, each mutations could be discriminated with great accuracy. The results demonstrated that all the mutation sites were discriminated with great accuracy. This method had the potential in simultaneous discriminating various SNPs in a microarray as long as a set of combinations of labeled/unlabeled nucleotides were designed appropriately. It will provide researcher with a high-throughput, time-saving, and labor-saving diagnosis tool.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130333309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
An image identification method for Biochips based on photonic crystal encoded beads 一种基于光子晶体编码珠的生物芯片图像识别方法
2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746916
S. Dong, Junjie Yuan, Xiaoxia Wang, Xingqun Zhao, Xiangwei Zhao, Zhongze Gu
{"title":"An image identification method for Biochips based on photonic crystal encoded beads","authors":"S. Dong, Junjie Yuan, Xiaoxia Wang, Xingqun Zhao, Xiangwei Zhao, Zhongze Gu","doi":"10.1109/BMEI.2013.6746916","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6746916","url":null,"abstract":"As a new kind of liquid biochip, Photonic crystal (PC) encoded beads chip utilizes the structure color of PC and the fluorescence label to encode and detect biomolecules respectively. In this paper, the mechanism and the optical structure of the detection instrument for PC encoded beads chip are described. Then the mathematical morphology algorithm and Otsu method is used to enhance the image quality followed by beads identification with statistical identification algorithm, which lay the basis for quantification analysis of the beads chip.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130475130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated assessment of small bowel motility function based on three-dimensional zero-mean normalized cross correlation 基于三维零均值归一化互相关的小肠运动功能自动评估
2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6747050
A. Taniguchi, A. Furukawa, S. Kanasaki, T. Tateyama, Yenwei Chen
{"title":"Automated assessment of small bowel motility function based on three-dimensional zero-mean normalized cross correlation","authors":"A. Taniguchi, A. Furukawa, S. Kanasaki, T. Tateyama, Yenwei Chen","doi":"10.1109/BMEI.2013.6747050","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6747050","url":null,"abstract":"In this paper, we propose an automated method for assessment of small bowel contraction movement based on a three-dimensional zero-mean normalized cross correlation method (3D-ZNCC) with cine-MRI. The correlation value between frames is proportional to area change of the small bowel and the temporal area change can be used as a measure of the small bowel contraction movement. In the conventional two-dimensional zero-mean normalized correlation (2D-ZNCC) method, only frame A and frame B are used for calculation of correlation between frame A and frame B. Since a complex shape change of the intestine is irregular, it was difficult to detect contraction movement. In order to solve this problem, we propose to use 3D ZNCC, in which sequence frames are used for correlation calculations instead of single frame. Since not only spatial changes, but also temporal changes are included, we can detect the contraction movement correctly. Experimental results show that our method is better than conventional method.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"449 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133564571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Analysis of gene expression in different cell types 基因在不同细胞类型中的表达分析
2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746933
Yanning Cai, X. Dai
{"title":"Analysis of gene expression in different cell types","authors":"Yanning Cai, X. Dai","doi":"10.1109/BMEI.2013.6746933","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6746933","url":null,"abstract":"Cellular states are plastic, and even terminally differentiated cells can be reprogrammed to pluripotency by ectopic expression of selected transcription factors, yet it remains inefficient in practice. Cell reprogramming is remarkable for its potential to impact research and therapies because induced pluripotent stem (iPS) cells are similar to embryo stem (ES) cells in many aspects so that they are suitable substitute for ES cells. Since distinct gene expression pattern is one of the most important features of specific cell state, we analyze the relationship between gene expression and the cell state. In this paper, we chose human ES cells, iPS cells, and fibroblasts to compare. Our results show that iPS cells have an ES cell-like expression pattern and suggest that those genes which have distinct expression intensities in different cell states perform significant function in cell fate regulation. What's more, genome-wide occupancy maps have revealed the correlation between the ectopic expression factors and the gene expression intensities.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114299344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A phase-based active contour model for segmentation of breast ultrasound images 基于相位的乳腺超声图像主动轮廓分割模型
2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746913
Lingyun Cai, Yuanyuan Wang
{"title":"A phase-based active contour model for segmentation of breast ultrasound images","authors":"Lingyun Cai, Yuanyuan Wang","doi":"10.1109/BMEI.2013.6746913","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6746913","url":null,"abstract":"Due to the speckle noises, low contrast and blurry boundaries in breast ultrasound (BUS) images, extraction of the boundaries in BUS images is always a challenging task. To solve this problem, a novel phase-based active contour (PBAC) model is proposed. First, we utilize the local phase information and apply the phase asymmetry approach to form a new edge indicator, which dramatically increases the robustness to intensity inhomogeneous. Then, a novel phase-based edge indicator is incorporated into a various level set formulation with the local region-based segmentation energy. Experiments are performed on both synthetic and real BUS images. The results show that the proposed PBAC model outperforms the state-of-art methods both qualitatively and quantitatively.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129351370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
A high performance continuous-time sigma-delta modulator with a 2 MHz bandwidth hybrid loop filter for wireless healthcare applications 具有2 MHz带宽混合环路滤波器的高性能连续时间sigma-delta调制器，用于无线医疗保健应用
2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746973
Jhin-Fang Huang, W. Lai, Fan-Tsai Kao, Kun-Jie Huang, Kao-Lung Chen, Ron-Yi Liu
{"title":"A high performance continuous-time sigma-delta modulator with a 2 MHz bandwidth hybrid loop filter for wireless healthcare applications","authors":"Jhin-Fang Huang, W. Lai, Fan-Tsai Kao, Kun-Jie Huang, Kao-Lung Chen, Ron-Yi Liu","doi":"10.1109/BMEI.2013.6746973","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6746973","url":null,"abstract":"A continuous-time (CT) sigma-delta (ΣΔ) modulator clocked at 128 MHz with a hybrid active-passive loop filter is presented for wireless and wearable technologies in healthcare systems. The proposed 5th-order loop filter architecture mainly consists of two passive integrators, three active integrators, 2-bit flash analog-to-digital converter (ADC), and a current steering digital-to-analog converter (DAC). To erase the summation amplifier used in the chain of integrators with weighted feedforward summation (CIFF) topology, the capacitive feedforward structure is employed. In addition, local feedback resistors are designed to form the bridge-T network to reduce the chip area. The prototype chip is fabricated with TSMC 0.18 μm CMOS technology. Under the supply voltage of 1.8 V, measured results have achieved a dynamic range of 67 dB over a 2 MHz signal bandwidth, a SNDR of 63.3 dB, an ENOB of 10.2 bits, IM3 of 60 dB and a power dissipation of 9.52 mW including 8.1 mW of analog power. Including pads, the chip area is 0.8365 (1.195 × 0.7) mm2.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123818194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Tumor classification via a simultaneous structure sparse representation model 基于同步结构稀疏表示模型的肿瘤分类
2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6747005
Yafeng Li
{"title":"Tumor classification via a simultaneous structure sparse representation model","authors":"Yafeng Li","doi":"10.1109/BMEI.2013.6747005","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6747005","url":null,"abstract":"Cancer diagnosis is an important clinical application of gene expression microarray technology. This paper proposes a new model for tumor classification. The key idea is to implement the similar joint decomposition approach in the context of sparse coding with subsequences of gene expression data (SGED). Based on this idea, we formulate a simultaneous structure sparse model for tumor classification. Finally, experimental results in five tumor gene expression datasets show that the proposed method outperforms sparse representation method.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121968620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A simple numerical treatment of aperture integrals involved in the open-ended coaxial line method for validating the dielectric properties of tissue-equivalent liquid 用于验证组织等效液体介电特性的开放式同轴线法中孔径积分的简单数值处理
2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746952
Kang Zhang, Tong Wu, Jun-heng Teng
{"title":"A simple numerical treatment of aperture integrals involved in the open-ended coaxial line method for validating the dielectric properties of tissue-equivalent liquid","authors":"Kang Zhang, Tong Wu, Jun-heng Teng","doi":"10.1109/BMEI.2013.6746952","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6746952","url":null,"abstract":"The open-ended coaxial line method is attractive to the dielectric property measurement of tissue-equivalent liquid used in the Specific Absorption Rate (SAR) test. To evaluate the probe aperture admittance which is in a variational form, a full numerical treatment to the involved aperture integrals is presented. In this technique, the singular static integral on the source domain is converted into a well-posed line integral over the circumference boundary, which gives the formulation well suited for numerical implementation. The calculations are verified with the reported results for several coaxial probes.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127976401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Delicate seperation of Doppler blood flow and vessel wall beat signals by using the EEMD-based algorithm 利用基于eemd的算法对多普勒血流和血管壁搏动信号进行精细分离
2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746938
Wenjing Lin, Yufeng Zhang, Zhiguo Jia, Han Chen, Kexin Zhang, Zhiyao Li
{"title":"Delicate seperation of Doppler blood flow and vessel wall beat signals by using the EEMD-based algorithm","authors":"Wenjing Lin, Yufeng Zhang, Zhiguo Jia, Han Chen, Kexin Zhang, Zhiyao Li","doi":"10.1109/BMEI.2013.6746938","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6746938","url":null,"abstract":"Based on the ensemble empirical mode decomposition (EEMD) time-frequency analysis for avoiding mode mixing, an algorithm to delicately separate the Doppler blood flow and vessel wall beat signals is proposed in this paper. Firstly, the proper amplitude of added noise and number of ensemble average for noise cancellation are estimated, and then the mixed Doppler ultrasound signal is decomposed into IMFs by using EEMD method. Finally, the IMFs around the division between the blood flow and vessel wall signals are delicately separated using soft-threshold denoising method. Experiments on both computer simulated with WBSR of 20dB, 40dB and 70dB as well as real human carotid Doppler ultrasound signals are carried out to compare the proposed method with the high pass filter, the original empirical mode decomposition (EMD) method and the improved EMD delicate separation method. It is shown that method proposed in this paper provides the highest accuracy of extracting blood flow signals by elimination of the mode mixture, especially for those signals with larger wall-to-blood signal ratio.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"07 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129489090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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