2013 6th International Conference on Biomedical Engineering and Informatics最新文献_第7页

Epigenetic profiling of DNA methylation changes associated with chronic alcohol consumption: A 12-year follow-up study DNA甲基化变化与慢性饮酒相关的表观遗传学分析:一项为期12年的随访研究

2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746989

Julia Tzu-Ya Weng, L. S. Wu, Yi-Cheng Chen, P. W. Hsu, Chau-Shoun Lee, A. Cheng

{"title":"Epigenetic profiling of DNA methylation changes associated with chronic alcohol consumption: A 12-year follow-up study","authors":"Julia Tzu-Ya Weng, L. S. Wu, Yi-Cheng Chen, P. W. Hsu, Chau-Shoun Lee, A. Cheng","doi":"10.1109/BMEI.2013.6746989","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6746989","url":null,"abstract":"Alcoholism has always been a major public health concern in Taiwan, especially in the aboriginal communities. DNA methylation has recently been found to be associated with alcoholism. Since 1986, we have been following up on the mental health conditions of four major aboriginal peoples of Taiwan. In the current study, we attempted to profile the effect of chronic alcohol exposure on the epigenome. Clinical interviews were performed on 993 aboriginal people at phase 1 (1986), and followed up through phase 2 (1990-1992), and phase 3 (2003-2009) with DNA preparations at phases 2 and 3. Selected individuals for the present study included males from the phase 1 normal cohort who remained normal at phase 2 and became dependent on alcohol by phase 3 (n=10) and control subjects that have not had any drinking problems throughout the study (n=10). We assessed changes in DNA methylation in the blood collected at phases 2 and 3. Preliminary data show that 201 and 254 genes contain sites that are differentially methylated between the two collection time points in the control and case subjects, respectively. Among the list of genes differentially methylated in the case group, the methylation levels of 6 genes were found to correlate with alcohol consumption. These include genes involved in neurogenesis (NPDC1) and inflammation (HERC5) as well as alcoholism-associated genes ADCY9, CKM, and PHOX2A. Our study identified genes that are associated with chronic alcohol consumption at the epigenetic level. The results offer a comprehensive epigenomic map that helps enhance our understanding of alcohol-induced damages.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129210935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The content and distribution of trace elements in normal, benign and cancerous breast tissues 正常、良性和癌性乳腺组织中微量元素的含量和分布

2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746928

Cheng-Lin Liu, Hua Xu, Xiaohua Wang, Dongming Zhang, Xinyi Zhang, Xudong Wu, Dongliang Chen, W. Xu

{"title":"The content and distribution of trace elements in normal, benign and cancerous breast tissues","authors":"Cheng-Lin Liu, Hua Xu, Xiaohua Wang, Dongming Zhang, Xinyi Zhang, Xudong Wu, Dongliang Chen, W. Xu","doi":"10.1109/BMEI.2013.6746928","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6746928","url":null,"abstract":"The relative content, distribution and relation of trace elements (such as Zn, Fe, Cu, Mn, Cr, Ni) in normal, benign and malign breast tissue are analyzed, and their changes affect to the progress of tumor growth and the difference of tumor are studied. The trace elements in the breast tissue of healthy, patients women with benign or malignant tumors are measured with X-ray fluorescence analysis based on synchrotron radiation at Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, China. The relative contents of trace elements in three kinds of tissue are extremely different. The relative contents of Zn and Fe in the malign breast tissue are obvious higher than that of the normal and benign tissue, while the relative contents of Zn and Fe in the benign tissue is lower than that of the normal one. The relative content of Cu in normal tissue is lower than that of tumor tissue, which is equal. The contents of Ca and K in the healthy breast tissue are obvious higher than that of the diseased tissue. The content of S, Cr, Mn, Ni and Se in the normal tissue is lower than in malign tissue but highest in the benign tissue. There is negative correlation of relative content of P, which is the equal content in the normal and benign tissue is higher than that of malign tissue. Cu and Zn is a part of antagonism trace element in body, as well as Zn and Se. Their ratio can show the progress of tumor growth. Cu can adjust the metabolizability of Fe, which is related to tumor by promoting the translation and multiplication of free radical, so Cu/Fe can be the sign of tumor progress. The distribution of trace elements is centralization in malign tissue and diffuseness in benign tissue. Both the relative content and the relationship of the trace element are different in the tissue of normal, benign, malignant tumor of breast. Those changes can show the cancerous character of breast tissue.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127611456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analysis of genomes phylogeny using distance method based on similarity metric 基于相似性度量的距离法基因组系统发育分析

2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746987

Li-qian Zhou, Zhe Li

引用次数: 0

Quantifying stage progress of cirrhotic livers based on statistic shape models 基于统计形状模型量化肝硬化分期进展

2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6747054

Yenwei Chen, Chunhua Dong, X. Han, T. Tateyama, S. Kanasaki, A. Furukawa

引用次数: 0

Spike trains synchrony with different coupling strengths in a hippocampus CA3 small-world network model 海马CA3小世界网络模型中不同耦合强度的脉冲序列同步

2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746947

Dexuan Qi, Zhenguo Xiao

引用次数: 0

Automatic hookworm image detection for wireless capsule endoscopy using hybrid color gradient and contourlet transform 基于混合颜色梯度和轮廓波变换的无线胶囊内窥镜钩虫图像自动检测

2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746918

Honghan Chen, Junzhou Chen, Qiang Peng, Ganglu Sun, Tao Gan

引用次数: 21

Antioxidant of protein hydrolysates produced from eel head by enzymatic hydrolysis 酶法水解鳗鱼头蛋白水解产物的抗氧化性

2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746980

Hua Liu, Li Zhao

引用次数: 0

An ultrasound approach to digitizie bony landmarks in navigation assisted total hip arthroplasty 导航辅助全髋关节置换术中数字化骨标记的超声方法

2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746960

P. Shang, Xueling Bai

{"title":"An ultrasound approach to digitizie bony landmarks in navigation assisted total hip arthroplasty","authors":"P. Shang, Xueling Bai","doi":"10.1109/BMEI.2013.6746960","DOIUrl":"https://doi.org/10.1109/BMEI.2013.6746960","url":null,"abstract":"An imageless Computer-Assisted Navigation System (iCNS) in Total Hip Arthroplasty (THA) has been shown to help increase the accuracy of cup placement. iCNS relies on the location of the Anterior Superior Iliac Spines (ASISs) and the Pubic Symphysis (PS) to establish the pelvic coordinate system for operation. However, palpated location of these landmarks can be the inaccuracy in establishing the pelvic coordinate system due to the substantial amount of the soft tissue and may increase the possibility of misalignment of the hip prostheses, resulting in the failure of THA. The objective of this study was to initially evaluate an alternative solution in palpating the bony landmarks using an ultrasound probe. Bony landmarks on pelvis were measured using 3 methods, manual palpating probe of the iCNS, two ultrasound modes (“surface” ultrasound mode, “point” ultrasound mode). The X (Right), Y (Anterior) and Z (Superior) coordinates of IASIS, RASIS, PS, and the acetabular Abduction and Anteversion of cup orientation were calculated in the pelvic coordinate system established on the bony landmarks to assess the potential effect on calculating the cup orientation using landmarks obtained from different methods. The results show the cup orientation did not generate significantly different values from two ultrasound modes and manual palpation, which approves these two ultrasound methods can be an alternative solution to digitizie bony landmarks in navigation assisted total hip arthroplasty.","PeriodicalId":163211,"journal":{"name":"2013 6th International Conference on Biomedical Engineering and Informatics","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127551128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Improvement of performances of solid-state nanopores by modification of gold nanoparticles 金纳米粒子改性对固态纳米孔性能的改善

2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746940

Song Ying, Lei Wang, Wenyuan Zhao, C. Hou, Lingzhi Wu, Quanjun Liu

引用次数: 0

Low-cost circuit design of EEG signal acquisition for the brain-computer interface system 脑机接口系统中脑电信号采集的低成本电路设计

2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI: 10.1109/BMEI.2013.6746942

Lei Zhang, Xiao-jing Guo, Xiao-pei Wu, Beng-yan Zhou

引用次数: 15