Electroanalysis最新文献

{"title":"MXene-Based Nanocomposites in Forensic Science: Drug Sensing, DNA Biosensing, Fingerprint Visualization, and Biomarker Identification","authors":"S. Periyanayagi, Daniel Raja Femil Selta, A. Leggins","doi":"10.1002/elan.70201","DOIUrl":"https://doi.org/10.1002/elan.70201","url":null,"abstract":"<p>Novel approaches for improving the sensitivity, specificity, and flexibility of evidence analysis techniques have become feasible through integrating the two-dimensional (2D) nanomaterials with forensic science. This review aims to comprehensively examine the structural properties of MXene-based nanocomposites and assess their capabilities across four major forensic domains: drug sensing, DNA biosensing, latent fingerprint visualization, and biomarker identification. In addition, owing to its remarkable surface-to-volume ratio, adaptable chemical composition of surface, and electrical conductivity, MXenes have emerged as widely recognized nanomaterials. These properties have enabled the development of highly effective sensing platforms for multiple forensic applications, including drug residue analysis, DNA biosensing, latent fingerprint detection, and biomarker monitoring. A systematic review of peer-reviewed literature published between 2018 and 2025 was conducted, analyzing MXene synthesis strategies (including top-down HF etching and bottom-up chemical vapor deposition), nanocomposite formulations (MXene-polymer, MXene-metal, and MXene-carbon hybrids), and their performance metrics in electrochemical, fluorescence-based, and SERS-based detection platforms. Recent advancements have demonstrated the accuracy of MXene-based electrochemical biosensing devices in detecting proteins and biomarkers—such as thrombin—as well as miRNAs and drugs, even within complex biological matrices. Key findings reveal that MXene-based composites achieve detection limits ranging from sub-nanomolar to low-nanogram-per-milliliter levels for illicit drugs in biofluids, while MXene-DNA hybrid hydrogels enable picomolar thrombin detection suitable for blood-derived forensic samples. MXene nanocomposites coupled with fluorescent nanosheets also demonstrate superior latent fingerprint contrast on challenging substrates, including glass, metal, and plastic. In addition, the signal transition stability of portable forensic sensors has been improved using MXene–DNA hydrogels and MXene polymer composites. Furthermore, studies employing turn-on fluorescence biosensors and MXene-functionalized immunosensors demonstrate their versatility in fast and accurate sensing of genetic material and synthetic cannabinoids. Carbon-based nanomaterials such as carbon dots and graphene further support these efforts by enabling advanced forensic imaging techniques, particularly for enhancing latent fingerprint improvements and SERS-based analyte detections. This review highlights the recent developments in the applications of MXenes in forensic science, focusing on their ability to transform future analytical platforms. The evidence presented demonstrates that MXene-based platforms offer superior sensitivity, portability, and selectivity compared to conventional forensic techniques, underscoring their transformative potential for next-generation on-site forensic analysis. The unique potenti","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-aqueous Molecularly Imprinted Polymer/Polyoxometalate Nanocomposite Film With Enhanced Sensitivity for Ampicillin Detection","authors":"Yaobin Yang,&nbsp;Xinyu Wang,&nbsp;Xiaoshu Qu,&nbsp;Yanwei Ma","doi":"10.1002/elan.70192","DOIUrl":"https://doi.org/10.1002/elan.70192","url":null,"abstract":"<p>Electrostatic layer-by-layer (LbL) self-assembly for preparing composite films electrode has shown great potential in high-performance electrochemical sensors owing to its precise nanoscale control over film construction and enhanced long-term stability of the films. However, most multifunctional materials that can be incorporated into composite films through electrostatic LbL self-assembly are water-soluble, which poses a major barrier to the widespread application of high-performance nonaqueous solvent materials as modification materials in electrochemical sensors. Herein, the solubility of molecularly imprinted polymer (MIP) synthesized via bulk polymerization was constantly enhanced by optimizing the molar ratio of functional monomer to cross-linker and replacing the reaction solvent, which enabled their more stable immobilization onto films. Consequently, the novel nanocomposite films containing nonaqueous MIP and Dawson-type phosphotungstic polyoxometalate (P₂W₁₈) were successfully fabricated using the electrostatic LbL self-assembly method. The MIPs, P₂W₁₈ and nanocomposite films were characterized using Fourier transform infrared (FT-IR), thermogravimetric analysis (TG), ultraviolet-visible spectroscopy (UV-Vis), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Electrochemical sensing performance of the composite film electrode for ampicillin was evaluated using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). The MIP-P₂W₁₈ nanocomposite film electrode exhibited superior selectivity and sensitivity over P₂W₁₈-only film electrode, which is attributable to the high recognition capability of MIPs via their specific recognition cavities. Electrochemical results showed that the nanocomposite film electrode had excellent electrochemical activity for ampicillin detection, including a broad linear concentration range (1.0 × 10⁻¹²–1.0 × 10⁻⁷ M) and a low limit of detection (1.5 × 10⁻¹² M). This is a significant improvement over our earlier work (1.0 × 10⁻¹⁰ M) and successfully achieved picomolar-level detection. Moreover, the MIP-P₂W₁₈ nanocomposite film electrode exhibited outstanding signal discrimination ability against potential interfering species, reliable current retention capability during 50 continuous use and robust current responses after 5 weeks. The nanocomposite film electrode could also detect ampicillin in river water and milk samples with high recovery, making it a promising sensing tool for the analysis of trace substances.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binding Properties and Sensitivity of the Electrochemical Aptasensor for Aflatoxin M1 Detection in Milk","authors":"Lenka Bábelová,&nbsp;Cyril Slabý,&nbsp;Tibor Hianik","doi":"10.1002/elan.70200","DOIUrl":"https://doi.org/10.1002/elan.70200","url":null,"abstract":"<p>We report a sensitive aptamer-based biosensor for electrochemical detection of aflatoxin M1 (AFM1). The DNA aptamers specific to AFM1 in a molecular beacon configuration were modified at 3′-terminal by redox probe methylene blue (MB) and by thiol group at 5′ terminal. The aptamers immobilized at the gold surface changed the conformation in the presence of AFM1, which resulted in a decrease in the current amplitude due to increased distance between MB and the sensing surface. The limit of detection (LOD) of the aptasensor in buffer and in 10× diluted milk sample has been determined as 2.92 and 8.63 ng/L, respectively, which is below the maximum permissible limit (MPL) for AFM1 in milk established by EU (50 ng/L). The analysis of the binding of AFM1 to the aptamers by adsorption isotherms showed that, in the case of buffer, the Langmuir model described this binding well. However, in milk, the satisfactory results were obtained only using the Freundlich adsorption model. This is evidence that in addition to the specific adsorption of the AFM1 to the aptamer binding sites, certain physical adsorption of milk components such as caseins took place.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binding Properties and Sensitivity of the Electrochemical Aptasensor for Aflatoxin M1 Detection in Milk","authors":"Lenka Bábelová,&nbsp;Cyril Slabý,&nbsp;Tibor Hianik","doi":"10.1002/elan.70200","DOIUrl":"https://doi.org/10.1002/elan.70200","url":null,"abstract":"<p>We report a sensitive aptamer-based biosensor for electrochemical detection of aflatoxin M1 (AFM1). The DNA aptamers specific to AFM1 in a molecular beacon configuration were modified at 3′-terminal by redox probe methylene blue (MB) and by thiol group at 5′ terminal. The aptamers immobilized at the gold surface changed the conformation in the presence of AFM1, which resulted in a decrease in the current amplitude due to increased distance between MB and the sensing surface. The limit of detection (LOD) of the aptasensor in buffer and in 10× diluted milk sample has been determined as 2.92 and 8.63 ng/L, respectively, which is below the maximum permissible limit (MPL) for AFM1 in milk established by EU (50 ng/L). The analysis of the binding of AFM1 to the aptamers by adsorption isotherms showed that, in the case of buffer, the Langmuir model described this binding well. However, in milk, the satisfactory results were obtained only using the Freundlich adsorption model. This is evidence that in addition to the specific adsorption of the AFM1 to the aptamer binding sites, certain physical adsorption of milk components such as caseins took place.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocatalytic Activity of Pt–Au/Graphitic Carbon Nitride Toward C1–C3 Alcohol Oxidation","authors":"Muhammed Bekmezci,&nbsp;Mehmet Selcuk Erdogan,&nbsp;Ramazan Bayat,&nbsp;Fatih Sen","doi":"10.1002/elan.70195","DOIUrl":"https://doi.org/10.1002/elan.70195","url":null,"abstract":"<p>The development of efficient and highly durable materials for renewable energy conversion devices is crucial for meeting the future demand for clean and sustainable energy. In this study, platinum-gold nanoparticles (PtAu NPs) were synthesized using the chemical reduction method and decorated on a graphitic carbon nitride (g-C₃N₄) support material for use in alcohol oxidation studies. X-ray diffraction spectroscopy (XRD) was used to obtain information about the crystal structures of the synthesized nanostructures. According to the Debye Scherrer formula, the crystal size was obtained as approximately 6.05 nm. These nanocomposite structures, PtAu NPs and g-C₃N₄-supported PtAu NPs, were drop-cast onto glassy carbon electrodes and referred to as PtAu/GCE and PtAu@g-C₃N₄/GCE, respectively. Cyclic voltammetry and electrochemical impedance spectroscopy (EIS) were utilized for electrochemical studies. The PtAu@g-C₃N₄/GCE exhibits superior electrocatalytic performance, and the anodic peak currents of 21.13, 2.53, and 8.51 mA cm⁻² were obtained for methanol, ethanol, and 2-propanol as a result of electrochemical experiments, respectively. Also, in the long-term test (500 Cycles), PtAu@g-C₃N₄ exhibits better stability than PtAu. Thus, the catalyst we developed can be used with high efficiency in a wide range of alcohol oxidation applications, as it exhibits successful electrocatalytic performance in C1-, C2-, and C3-type alcohol oxidation applications.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocatalytic Activity of Pt–Au/Graphitic Carbon Nitride Toward C1–C3 Alcohol Oxidation","authors":"Muhammed Bekmezci,&nbsp;Mehmet Selcuk Erdogan,&nbsp;Ramazan Bayat,&nbsp;Fatih Sen","doi":"10.1002/elan.70195","DOIUrl":"https://doi.org/10.1002/elan.70195","url":null,"abstract":"<p>The development of efficient and highly durable materials for renewable energy conversion devices is crucial for meeting the future demand for clean and sustainable energy. In this study, platinum-gold nanoparticles (PtAu NPs) were synthesized using the chemical reduction method and decorated on a graphitic carbon nitride (g-C₃N₄) support material for use in alcohol oxidation studies. X-ray diffraction spectroscopy (XRD) was used to obtain information about the crystal structures of the synthesized nanostructures. According to the Debye Scherrer formula, the crystal size was obtained as approximately 6.05 nm. These nanocomposite structures, PtAu NPs and g-C₃N₄-supported PtAu NPs, were drop-cast onto glassy carbon electrodes and referred to as PtAu/GCE and PtAu@g-C₃N₄/GCE, respectively. Cyclic voltammetry and electrochemical impedance spectroscopy (EIS) were utilized for electrochemical studies. The PtAu@g-C₃N₄/GCE exhibits superior electrocatalytic performance, and the anodic peak currents of 21.13, 2.53, and 8.51 mA cm⁻² were obtained for methanol, ethanol, and 2-propanol as a result of electrochemical experiments, respectively. Also, in the long-term test (500 Cycles), PtAu@g-C₃N₄ exhibits better stability than PtAu. Thus, the catalyst we developed can be used with high efficiency in a wide range of alcohol oxidation applications, as it exhibits successful electrocatalytic performance in C1-, C2-, and C3-type alcohol oxidation applications.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Nonenzymatic Glucose Sensing Performance of CuO/Au-Decorated Multiwalled Carbon Nanotube Buckypaper","authors":"Shinhyun Kang,&nbsp;Min-Ho Kim,&nbsp;Sun-Chul Huh","doi":"10.1002/elan.70196","DOIUrl":"https://doi.org/10.1002/elan.70196","url":null,"abstract":"<p>Nonenzymatic electrochemical glucose sensors have attracted significant research interest owing to their superior stability, low cost, and independence from enzyme activity. In this study, buckypaper electrodes based on acid-treated multiwalled carbon nanotubes (a-MWCNTs) decorated with copper oxide (CuO) nanoparticles and gold (Au) nanoparticles were fabricated and systematically evaluated for nonenzymatic glucose sensing performance. MWCNTs were functionalized by acid treatment to introduce carboxyl and hydroxyl groups on the nanotube surface, followed by hydrothermal synthesis of CuO nanoparticles at various precursor concentrations (0.01, 0.03, and 0.05 M) and subsequent Au nanoparticle deposition by DC sputter coating. The morphological and structural properties of the fabricated nanocomposites were characterized by field-emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD). Electrochemical performance was evaluated by cyclic voltammetry (CV) and chronoamperometry in 0.1 M NaOH electrolyte. A key finding of this study is that Au nanoparticle incorporation promotes the formation of clustered CuO morphologies on the MWCNT surface, a phenomenon not observed in Au-free electrodes, thereby increasing the electrode-specific surface area and enhancing electrocatalytic activity. The optimized 0.05 M CuO/Au@a-MWCNTbuckypaper electrode achieved a glucose sensitivity of 730 µA mM⁻¹ cm⁻², which was approximately 1.2 times higher than the Au-free counterpart (599 µA mM⁻¹ cm⁻²). The electrode demonstrated a linear detection range of 0–10 mM (<i>R</i>² = 0.996) and a limit of detection (LoD) of 0.18 mM. Selectivity tests under simulated blood conditions confirmed excellent discrimination against sucrose and lactose, though further testing against physiologically relevant interferents such as ascorbic acid, uric acid, and dopamine is warranted. These results demonstrate the potential of CuO/Au@a-MWCNTbuckypaper as a high-performance electrode material for nonenzymatic electrochemical glucose biosensors.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Nonenzymatic Glucose Sensing Performance of CuO/Au-Decorated Multiwalled Carbon Nanotube Buckypaper","authors":"Shinhyun Kang,&nbsp;Min-Ho Kim,&nbsp;Sun-Chul Huh","doi":"10.1002/elan.70196","DOIUrl":"https://doi.org/10.1002/elan.70196","url":null,"abstract":"<p>Nonenzymatic electrochemical glucose sensors have attracted significant research interest owing to their superior stability, low cost, and independence from enzyme activity. In this study, buckypaper electrodes based on acid-treated multiwalled carbon nanotubes (a-MWCNTs) decorated with copper oxide (CuO) nanoparticles and gold (Au) nanoparticles were fabricated and systematically evaluated for nonenzymatic glucose sensing performance. MWCNTs were functionalized by acid treatment to introduce carboxyl and hydroxyl groups on the nanotube surface, followed by hydrothermal synthesis of CuO nanoparticles at various precursor concentrations (0.01, 0.03, and 0.05 M) and subsequent Au nanoparticle deposition by DC sputter coating. The morphological and structural properties of the fabricated nanocomposites were characterized by field-emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD). Electrochemical performance was evaluated by cyclic voltammetry (CV) and chronoamperometry in 0.1 M NaOH electrolyte. A key finding of this study is that Au nanoparticle incorporation promotes the formation of clustered CuO morphologies on the MWCNT surface, a phenomenon not observed in Au-free electrodes, thereby increasing the electrode-specific surface area and enhancing electrocatalytic activity. The optimized 0.05 M CuO/Au@a-MWCNTbuckypaper electrode achieved a glucose sensitivity of 730 µA mM⁻¹ cm⁻², which was approximately 1.2 times higher than the Au-free counterpart (599 µA mM⁻¹ cm⁻²). The electrode demonstrated a linear detection range of 0–10 mM (<i>R</i>² = 0.996) and a limit of detection (LoD) of 0.18 mM. Selectivity tests under simulated blood conditions confirmed excellent discrimination against sucrose and lactose, though further testing against physiologically relevant interferents such as ascorbic acid, uric acid, and dopamine is warranted. These results demonstrate the potential of CuO/Au@a-MWCNTbuckypaper as a high-performance electrode material for nonenzymatic electrochemical glucose biosensors.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-Nitrided Ni@Ni3N/NCNTs Heterostructures for Sensitive and Portable Nonenzymatic Glucose Detection","authors":"He Lu,&nbsp;Ling Wang,&nbsp;Zhiyuan Chen,&nbsp;Haoyong Yin,&nbsp;Hui Wang,&nbsp;Shengji Wu","doi":"10.1002/elan.70197","DOIUrl":"https://doi.org/10.1002/elan.70197","url":null,"abstract":"<p>A heterostructured Ni@Ni₃N/NCNTs electrocatalyst was rationally designed via a MOF-derived strategy combined with controlled surface nitridation to achieve highly efficient nonenzymatic glucose sensing. In this architecture, metallic Ni nanoparticles anchored on a three-dimensional N-doped carbon nanotube framework were selectively converted into a thin Ni₃N surface layer, forming abundant Ni/Ni₃N heterointerfaces while preserving a conductive Ni core. Electrochemical studies reveal that the engineered heterointerfaces significantly reduce charge-transfer resistance and increase electrochemically active surface area, thereby promoting the generation of NiOOH species and facilitating glucose oxidation. As a result, the Ni@Ni₃N/NCNTs electrode exhibits a high sensitivity of 685.07 μA mM⁻¹cm⁻², a low detection limit of 0.34 μM, and a wide linear range of 1–7000 μM for nonenzymatic glucose detection. Furthermore, integration with a smartphone-enabled electrochemical platform enables portable and real-time glucose analysis, demonstrating the strong potential of this surface-engineered heterostructure for practical portable sensing applications.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-Nitrided Ni@Ni3N/NCNTs Heterostructures for Sensitive and Portable Nonenzymatic Glucose Detection","authors":"He Lu,&nbsp;Ling Wang,&nbsp;Zhiyuan Chen,&nbsp;Haoyong Yin,&nbsp;Hui Wang,&nbsp;Shengji Wu","doi":"10.1002/elan.70197","DOIUrl":"https://doi.org/10.1002/elan.70197","url":null,"abstract":"<p>A heterostructured Ni@Ni₃N/NCNTs electrocatalyst was rationally designed via a MOF-derived strategy combined with controlled surface nitridation to achieve highly efficient nonenzymatic glucose sensing. In this architecture, metallic Ni nanoparticles anchored on a three-dimensional N-doped carbon nanotube framework were selectively converted into a thin Ni₃N surface layer, forming abundant Ni/Ni₃N heterointerfaces while preserving a conductive Ni core. Electrochemical studies reveal that the engineered heterointerfaces significantly reduce charge-transfer resistance and increase electrochemically active surface area, thereby promoting the generation of NiOOH species and facilitating glucose oxidation. As a result, the Ni@Ni₃N/NCNTs electrode exhibits a high sensitivity of 685.07 μA mM⁻¹cm⁻², a low detection limit of 0.34 μM, and a wide linear range of 1–7000 μM for nonenzymatic glucose detection. Furthermore, integration with a smartphone-enabled electrochemical platform enables portable and real-time glucose analysis, demonstrating the strong potential of this surface-engineered heterostructure for practical portable sensing applications.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}