Electroanalysis最新文献

{"title":"A Simple and Sensitive Imprinted Electrochemical Sensor for Detection of Bongkrekic Acid in Food","authors":"Shengpan Xu,&nbsp;Feihu Mu,&nbsp;Wansu Wu,&nbsp;Lingxiu Tao,&nbsp;Chang Pan,&nbsp;Benlin Dai","doi":"10.1002/elan.70208","DOIUrl":"https://doi.org/10.1002/elan.70208","url":null,"abstract":"<p>Bongkrekic acid (BKA) is a highly toxic chemical substance harmful to humans. In this work, a sensitive, selective, and inexpensive imprinted electrochemical sensor for the determination of BKA was developed. The gold nanoparticles-modified ITO electrode (AuNPs/ITO electrode) increases the specific surface area and conductivity ensuring high sensitivity of the sensor. Subsequently, a molecular-imprinted polymer film (MIP) was prepared on the surface of the AuNPs/ITO electrode through in situ electro-polymerization. The BKA-polydopamine MIP (BKA-PDA-MIP) can specifically recognize BKA ensures the high selectivity of the sensor. The higher the BKA concentration, the more occupation on the MIP/AuNPs/ITO electrode surface, so that leads to the lower electron-transfer rate and the smaller the DPV signal. This imprinted electrochemical sensor exhibited a satisfactory detection range from 1 to 400 ng mL⁻¹ and a low detection limit (LOD) of 0.542 ng mL⁻¹. Furthermore, the proposed sensor was successfully applied to detect BKA in real food samples, indicating a good application prospect in actual sample determination.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Simple and Sensitive Imprinted Electrochemical Sensor for Detection of Bongkrekic Acid in Food","authors":"Shengpan Xu,&nbsp;Feihu Mu,&nbsp;Wansu Wu,&nbsp;Lingxiu Tao,&nbsp;Chang Pan,&nbsp;Benlin Dai","doi":"10.1002/elan.70208","DOIUrl":"https://doi.org/10.1002/elan.70208","url":null,"abstract":"<p>Bongkrekic acid (BKA) is a highly toxic chemical substance harmful to humans. In this work, a sensitive, selective, and inexpensive imprinted electrochemical sensor for the determination of BKA was developed. The gold nanoparticles-modified ITO electrode (AuNPs/ITO electrode) increases the specific surface area and conductivity ensuring high sensitivity of the sensor. Subsequently, a molecular-imprinted polymer film (MIP) was prepared on the surface of the AuNPs/ITO electrode through in situ electro-polymerization. The BKA-polydopamine MIP (BKA-PDA-MIP) can specifically recognize BKA ensures the high selectivity of the sensor. The higher the BKA concentration, the more occupation on the MIP/AuNPs/ITO electrode surface, so that leads to the lower electron-transfer rate and the smaller the DPV signal. This imprinted electrochemical sensor exhibited a satisfactory detection range from 1 to 400 ng mL⁻¹ and a low detection limit (LOD) of 0.542 ng mL⁻¹. Furthermore, the proposed sensor was successfully applied to detect BKA in real food samples, indicating a good application prospect in actual sample determination.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Electrocatalytic Mechanism of SrO/Monolayer C3N4 Composite for Vanillin Detection","authors":"Haibo Pan,&nbsp;Yongbo Qi,&nbsp;Fengzhen Xu,&nbsp;Yuanjie Xu","doi":"10.1002/elan.70198","DOIUrl":"https://doi.org/10.1002/elan.70198","url":null,"abstract":"<p>Synthesis at low temperature and interface characteristics in electrocatalysis for nanocomposites are alternative challenge up to date. A SrO nanoparticles (NPs)/g-C₃N₄ nanosheets (SrO/ng-C₃N₄) composite was prepared by a feasible one-pot synthesis at 80 °C without post-sintering, where SrO NPs (with diameters of 20 ∼ 50 nm) were loaded onto ng-C₃N₄ nanosheets to form an efficient electrocatalyst. By the aid of XPS and FT-IR analysis, it confirms that SrO NPs were anchored in proximity to the s-triazine units of ng-C₃N₄ via Sr<span></span>N bonds. Based on the surface charge characteristics, the electrostatic adsorption between SrO/ng-C₃N₄ and vanillin as a catalysant was verified. C₇H₅O₂⁻ anions after the hydrolyzation and ionization of vanillin in PBS solution were adsorbed on the surface of positively charged SrO/ng-C₃N₄ before electro-oxidation. The electrocatalytically active centers, i.e., oxygen vacancies on the surface of SrO NPs, facilitate in the oxidation of vanillin, and further the overpotential of the electrocatalyst by SrO/ng-C₃N₄ toward vanillin is reduced. A detail eletro-oxidation process of vanillin was identified by UV–vis spectra and differential pulse voltammetry analysis. Based on the Laviron equation, two electrons transfer from vanillin during the oxidation reaction, and speculates the reaction mechanism. Under optimal conditions, vanillin oxidation current is linear to its concentration in the range of 2.0 × 10⁻⁸ to 1.4 × 10⁻⁵M, with a detection limit of 6.7 nM (S/N = 3). The limit value complies with the requirements of the World Health Organization and the Chinese Health Standard. As-prepared sensor applied for the quantification of vanillin in milk samples is long-term stable, selective, and feasible.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Sensor Platforms for Statin Monitoring in Biological Matrices: Materials-Driven Innovations","authors":"Sara Ranjbari,&nbsp;Prashant Kesharwani,&nbsp;Amirhossein Sahebkar","doi":"10.1002/elan.70203","DOIUrl":"https://doi.org/10.1002/elan.70203","url":null,"abstract":"<p>Statins are among the most widely prescribed lipid-lowering agents for the prevention and management of cardiovascular diseases. However, drug–drug interactions, interindividual pharmacokinetic variability, and chemical instability can compromise therapeutic efficacy and increase the risk of adverse effects. These challenges underscore the need for robust, sensitive, and real-time analytical platforms capable of monitoring statin concentrations in biological and pharmaceutical matrices. Recent advances in functional materials and sensor engineering have driven the development of highly selective and rapid statin detection technologies. This review critically evaluates emerging sensor platforms, including electrochemical, optical, and gravimetric systems, with particular emphasis on the role of nanostructured and hybrid materials in enhancing signal transduction, sensitivity, and operational stability. Applications in clinically relevant samples such as serum, plasma, and urine are systematically compared, highlighting key analytical performance parameters including detection limits, selectivity, response time, and reproducibility. Finally, current challenges and future perspectives are discussed, focusing on materials integration, device miniaturization, and translational strategies to facilitate the deployment of statin sensors in point-of-care and real-world monitoring applications.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Sensor Platforms for Statin Monitoring in Biological Matrices: Materials-Driven Innovations","authors":"Sara Ranjbari,&nbsp;Prashant Kesharwani,&nbsp;Amirhossein Sahebkar","doi":"10.1002/elan.70203","DOIUrl":"https://doi.org/10.1002/elan.70203","url":null,"abstract":"<p>Statins are among the most widely prescribed lipid-lowering agents for the prevention and management of cardiovascular diseases. However, drug–drug interactions, interindividual pharmacokinetic variability, and chemical instability can compromise therapeutic efficacy and increase the risk of adverse effects. These challenges underscore the need for robust, sensitive, and real-time analytical platforms capable of monitoring statin concentrations in biological and pharmaceutical matrices. Recent advances in functional materials and sensor engineering have driven the development of highly selective and rapid statin detection technologies. This review critically evaluates emerging sensor platforms, including electrochemical, optical, and gravimetric systems, with particular emphasis on the role of nanostructured and hybrid materials in enhancing signal transduction, sensitivity, and operational stability. Applications in clinically relevant samples such as serum, plasma, and urine are systematically compared, highlighting key analytical performance parameters including detection limits, selectivity, response time, and reproducibility. Finally, current challenges and future perspectives are discussed, focusing on materials integration, device miniaturization, and translational strategies to facilitate the deployment of statin sensors in point-of-care and real-world monitoring applications.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile Construction of NiO–TiO2/g-C3N4 Heterostructures for High-Performance Oxygen Evolution Electrocatalysis","authors":"Samuel Chufamo Jikamo,&nbsp;P. Shyamala,&nbsp;Singupilla Sai Supriya,&nbsp;Sandhya Rani Nayak","doi":"10.1002/elan.70199","DOIUrl":"https://doi.org/10.1002/elan.70199","url":null,"abstract":"<p>The development of highly active and durable electrocatalysts for the oxygen evolution reaction (OER) is crucial for efficient hydrogen production via alkaline water splitting. However, the sluggish OER kinetics and limited activity of single-component catalysts necessitate the design of heterostructured materials with enhanced active sites, improved charge transfer, and long-term stability. In this work, NiO–TiO₂/g-C₃N₄ heterostructures were successfully synthesized and evaluated as advanced OER electrocatalysts. NiO–TiO₂ composites were initially prepared using a sol–gel method and subsequently integrated onto g-C₃N₄ nanosheets to form a heterostructure catalyst. The synthesized materials were comprehensively characterized using structural, morphological, compositional, optical, and electrochemical techniques. For electrochemical evaluation, 7 µL of catalyst suspension (1 mg mL⁻¹) was drop-cast onto a glassy carbon electrode. Using linear sweep voltammetry (LSV) technique, NiO–TiO₂/g-C₃N₄/GCE exhibited higher OER performance compared with g-C₃N₄/GCE, TiO₂/g-C₃N₄/GCE, RuO₂/GCE and NiO/g-C₃N₄/GCE, delivering an ultralow overpotential of 101 ± 1 mV versus reversible hydrogen electrode at 10 mA cm⁻² and a Tafel slope of 40 mV dec⁻¹. This enhancement is attributed to the synergistic coupling of NiO, TiO₂, and g-C₃N₄, which increases the specific surface area, exposes abundant active sites, enhances electrochemical conductivity, lowers charge–transfer resistance, and promotes rapid interfacial electron transfer, thereby accelerating OER performance. Furthermore, the catalyst demonstrated good durability after 2000 cycles and 12 h of operation, while post-OER Raman analysis revealed no obvious changes in the characteristic vibrational bands, confirming the structural stability of the heterostructure.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-aqueous Molecularly Imprinted Polymer/Polyoxometalate Nanocomposite Film With Enhanced Sensitivity for Ampicillin Detection","authors":"Yaobin Yang,&nbsp;Xinyu Wang,&nbsp;Xiaoshu Qu,&nbsp;Yanwei Ma","doi":"10.1002/elan.70192","DOIUrl":"https://doi.org/10.1002/elan.70192","url":null,"abstract":"<p>Electrostatic layer-by-layer (LbL) self-assembly for preparing composite films electrode has shown great potential in high-performance electrochemical sensors owing to its precise nanoscale control over film construction and enhanced long-term stability of the films. However, most multifunctional materials that can be incorporated into composite films through electrostatic LbL self-assembly are water-soluble, which poses a major barrier to the widespread application of high-performance nonaqueous solvent materials as modification materials in electrochemical sensors. Herein, the solubility of molecularly imprinted polymer (MIP) synthesized via bulk polymerization was constantly enhanced by optimizing the molar ratio of functional monomer to cross-linker and replacing the reaction solvent, which enabled their more stable immobilization onto films. Consequently, the novel nanocomposite films containing nonaqueous MIP and Dawson-type phosphotungstic polyoxometalate (P₂W₁₈) were successfully fabricated using the electrostatic LbL self-assembly method. The MIPs, P₂W₁₈ and nanocomposite films were characterized using Fourier transform infrared (FT-IR), thermogravimetric analysis (TG), ultraviolet-visible spectroscopy (UV-Vis), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Electrochemical sensing performance of the composite film electrode for ampicillin was evaluated using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). The MIP-P₂W₁₈ nanocomposite film electrode exhibited superior selectivity and sensitivity over P₂W₁₈-only film electrode, which is attributable to the high recognition capability of MIPs via their specific recognition cavities. Electrochemical results showed that the nanocomposite film electrode had excellent electrochemical activity for ampicillin detection, including a broad linear concentration range (1.0 × 10⁻¹²–1.0 × 10⁻⁷ M) and a low limit of detection (1.5 × 10⁻¹² M). This is a significant improvement over our earlier work (1.0 × 10⁻¹⁰ M) and successfully achieved picomolar-level detection. Moreover, the MIP-P₂W₁₈ nanocomposite film electrode exhibited outstanding signal discrimination ability against potential interfering species, reliable current retention capability during 50 continuous use and robust current responses after 5 weeks. The nanocomposite film electrode could also detect ampicillin in river water and milk samples with high recovery, making it a promising sensing tool for the analysis of trace substances.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Electrocatalytic Mechanism of SrO/Monolayer C3N4 Composite for Vanillin Detection","authors":"Haibo Pan,&nbsp;Yongbo Qi,&nbsp;Fengzhen Xu,&nbsp;Yuanjie Xu","doi":"10.1002/elan.70198","DOIUrl":"https://doi.org/10.1002/elan.70198","url":null,"abstract":"<p>Synthesis at low temperature and interface characteristics in electrocatalysis for nanocomposites are alternative challenge up to date. A SrO nanoparticles (NPs)/g-C₃N₄ nanosheets (SrO/ng-C₃N₄) composite was prepared by a feasible one-pot synthesis at 80 °C without post-sintering, where SrO NPs (with diameters of 20 ∼ 50 nm) were loaded onto ng-C₃N₄ nanosheets to form an efficient electrocatalyst. By the aid of XPS and FT-IR analysis, it confirms that SrO NPs were anchored in proximity to the s-triazine units of ng-C₃N₄ via Sr<span></span>N bonds. Based on the surface charge characteristics, the electrostatic adsorption between SrO/ng-C₃N₄ and vanillin as a catalysant was verified. C₇H₅O₂⁻ anions after the hydrolyzation and ionization of vanillin in PBS solution were adsorbed on the surface of positively charged SrO/ng-C₃N₄ before electro-oxidation. The electrocatalytically active centers, i.e., oxygen vacancies on the surface of SrO NPs, facilitate in the oxidation of vanillin, and further the overpotential of the electrocatalyst by SrO/ng-C₃N₄ toward vanillin is reduced. A detail eletro-oxidation process of vanillin was identified by UV–vis spectra and differential pulse voltammetry analysis. Based on the Laviron equation, two electrons transfer from vanillin during the oxidation reaction, and speculates the reaction mechanism. Under optimal conditions, vanillin oxidation current is linear to its concentration in the range of 2.0 × 10⁻⁸ to 1.4 × 10⁻⁵M, with a detection limit of 6.7 nM (S/N = 3). The limit value complies with the requirements of the World Health Organization and the Chinese Health Standard. As-prepared sensor applied for the quantification of vanillin in milk samples is long-term stable, selective, and feasible.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile Construction of NiO–TiO2/g-C3N4 Heterostructures for High-Performance Oxygen Evolution Electrocatalysis","authors":"Samuel Chufamo Jikamo,&nbsp;P. Shyamala,&nbsp;Singupilla Sai Supriya,&nbsp;Sandhya Rani Nayak","doi":"10.1002/elan.70199","DOIUrl":"https://doi.org/10.1002/elan.70199","url":null,"abstract":"<p>The development of highly active and durable electrocatalysts for the oxygen evolution reaction (OER) is crucial for efficient hydrogen production via alkaline water splitting. However, the sluggish OER kinetics and limited activity of single-component catalysts necessitate the design of heterostructured materials with enhanced active sites, improved charge transfer, and long-term stability. In this work, NiO–TiO₂/g-C₃N₄ heterostructures were successfully synthesized and evaluated as advanced OER electrocatalysts. NiO–TiO₂ composites were initially prepared using a sol–gel method and subsequently integrated onto g-C₃N₄ nanosheets to form a heterostructure catalyst. The synthesized materials were comprehensively characterized using structural, morphological, compositional, optical, and electrochemical techniques. For electrochemical evaluation, 7 µL of catalyst suspension (1 mg mL⁻¹) was drop-cast onto a glassy carbon electrode. Using linear sweep voltammetry (LSV) technique, NiO–TiO₂/g-C₃N₄/GCE exhibited higher OER performance compared with g-C₃N₄/GCE, TiO₂/g-C₃N₄/GCE, RuO₂/GCE and NiO/g-C₃N₄/GCE, delivering an ultralow overpotential of 101 ± 1 mV versus reversible hydrogen electrode at 10 mA cm⁻² and a Tafel slope of 40 mV dec⁻¹. This enhancement is attributed to the synergistic coupling of NiO, TiO₂, and g-C₃N₄, which increases the specific surface area, exposes abundant active sites, enhances electrochemical conductivity, lowers charge–transfer resistance, and promotes rapid interfacial electron transfer, thereby accelerating OER performance. Furthermore, the catalyst demonstrated good durability after 2000 cycles and 12 h of operation, while post-OER Raman analysis revealed no obvious changes in the characteristic vibrational bands, confirming the structural stability of the heterostructure.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MXene-Based Nanocomposites in Forensic Science: Drug Sensing, DNA Biosensing, Fingerprint Visualization, and Biomarker Identification","authors":"S. Periyanayagi,&nbsp;Daniel Raja Femil Selta,&nbsp;A. Leggins","doi":"10.1002/elan.70201","DOIUrl":"https://doi.org/10.1002/elan.70201","url":null,"abstract":"&lt;p&gt;Novel approaches for improving the sensitivity, specificity, and flexibility of evidence analysis techniques have become feasible through integrating the two-dimensional (2D) nanomaterials with forensic science. This review aims to comprehensively examine the structural properties of MXene-based nanocomposites and assess their capabilities across four major forensic domains: drug sensing, DNA biosensing, latent fingerprint visualization, and biomarker identification. In addition, owing to its remarkable surface-to-volume ratio, adaptable chemical composition of surface, and electrical conductivity, MXenes have emerged as widely recognized nanomaterials. These properties have enabled the development of highly effective sensing platforms for multiple forensic applications, including drug residue analysis, DNA biosensing, latent fingerprint detection, and biomarker monitoring. A systematic review of peer-reviewed literature published between 2018 and 2025 was conducted, analyzing MXene synthesis strategies (including top-down HF etching and bottom-up chemical vapor deposition), nanocomposite formulations (MXene-polymer, MXene-metal, and MXene-carbon hybrids), and their performance metrics in electrochemical, fluorescence-based, and SERS-based detection platforms. Recent advancements have demonstrated the accuracy of MXene-based electrochemical biosensing devices in detecting proteins and biomarkers—such as thrombin—as well as miRNAs and drugs, even within complex biological matrices. Key findings reveal that MXene-based composites achieve detection limits ranging from sub-nanomolar to low-nanogram-per-milliliter levels for illicit drugs in biofluids, while MXene-DNA hybrid hydrogels enable picomolar thrombin detection suitable for blood-derived forensic samples. MXene nanocomposites coupled with fluorescent nanosheets also demonstrate superior latent fingerprint contrast on challenging substrates, including glass, metal, and plastic. In addition, the signal transition stability of portable forensic sensors has been improved using MXene–DNA hydrogels and MXene polymer composites. Furthermore, studies employing turn-on fluorescence biosensors and MXene-functionalized immunosensors demonstrate their versatility in fast and accurate sensing of genetic material and synthetic cannabinoids. Carbon-based nanomaterials such as carbon dots and graphene further support these efforts by enabling advanced forensic imaging techniques, particularly for enhancing latent fingerprint improvements and SERS-based analyte detections. This review highlights the recent developments in the applications of MXenes in forensic science, focusing on their ability to transform future analytical platforms. The evidence presented demonstrates that MXene-based platforms offer superior sensitivity, portability, and selectivity compared to conventional forensic techniques, underscoring their transformative potential for next-generation on-site forensic analysis. The unique potenti","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}