Electroanalysis最新文献_第8页

MXene-Based Electrochemical Sensors: Design Strategies and Application Advances for the Detection of Biological Small Molecules 基于mxene的电化学传感器：生物小分子检测的设计策略与应用进展

IF 2.3 3区化学

Electroanalysis Pub Date : 2025-12-23 DOI: 10.1002/elan.70087

Sitong Chen, Huan Yang, Fangxu Shen, Anran Li, Shuangxing Wen, Shiping Gao, Yunyang Bai, Kai Li, Yuqing Lin

{"title":"MXene-Based Electrochemical Sensors: Design Strategies and Application Advances for the Detection of Biological Small Molecules","authors":"Sitong Chen, Huan Yang, Fangxu Shen, Anran Li, Shuangxing Wen, Shiping Gao, Yunyang Bai, Kai Li, Yuqing Lin","doi":"10.1002/elan.70087","DOIUrl":"https://doi.org/10.1002/elan.70087","url":null,"abstract":"Precise detection of biomolecules is crucial for disease diagnosis. Traditional detection methods suffer from limitations such as slow results and high costs, restricting their practical application. While electrochemical sensors offer advantages such as rapid detection, ease of operation, and low cost, they are fundamentally constrained by electrode materials. Among numerous candidates, MXene stands out due to its unique 2D structure, enormous specific surface area, excellent conductivity, and abundant surface functional groups (e.g., the electron transfer rate constant of Ti3C2Tx exceeds that of conventional materials by 2–3 orders of magnitude), making it one of the ideal materials for electrochemical sensor fabrication. This article comprehensively reviews the latest advances in MXene-based electrochemical sensors for biomolecular detection. It systematically elucidates sensing principles, performance metrics, and material design strategies and for the first time distils a “design grammar” for MXene-based sensors. This establishes universal design principles linking material characteristics (e.g., terminal functional groups and heterostructures) to detection performance (e.g., achieving a glucose detection limit at the aM level). Analysis indicates these rules can guide the construction of sensing interfaces that simultaneously achieve ultrahigh sensitivity, selectivity, and stability. This design framework not only points the way for developing high-performance MXene sensors but also provides a critical theoretical framework and practical guide for rational optimization and novel sensing interface design in electroanalytical chemistry, advancing its practical applications in clinical diagnostics and personalized medicine.","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145825322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Paraquat in Real Samples Using a Printed PET-Based Electrode Modified With Molecularly Imprinted Polymer and Carbonaceous Material 用分子印迹聚合物和碳质材料修饰的pet基电极测定实际样品中的百草枯

IF 2.3 3区化学

Electroanalysis Pub Date : 2025-12-17 DOI: 10.1002/elan.70090

Malena Karla Lombello Coelho de Souza, Daniela Nunes da Silva, Scarlat Ohanna Dávila da Trindade, Thaís Cristina de Oliveira Cândido, Lucas Franco Ferreira, Arnaldo César Pereira

{"title":"Determination of Paraquat in Real Samples Using a Printed PET-Based Electrode Modified With Molecularly Imprinted Polymer and Carbonaceous Material","authors":"Malena Karla Lombello Coelho de Souza, Daniela Nunes da Silva, Scarlat Ohanna Dávila da Trindade, Thaís Cristina de Oliveira Cândido, Lucas Franco Ferreira, Arnaldo César Pereira","doi":"10.1002/elan.70090","DOIUrl":"https://doi.org/10.1002/elan.70090","url":null,"abstract":"In this work, a disposable screen-printed carbon electrode (SPCE) modified with multiwalled carbon nanotubes (MWCNTs) and molecularly imprinted polymer (MIP) was developed for the determination of Paraquat (PQ) in water and food samples, using adsorptive square wave voltammetry. The MIP was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), and the results confirmed its composition and chemical bonds. Under optimized conditions, the sensor exhibited two linear response ranges (6.3–200 and 200–500 μmol L−1), with R2 = 0.99 and sensitivities of 0.13 and 0.10 µA/µmol L−1, respectively. The limits of detection and quantification were 3.46 and 6.30 μmol L−1. The method validation demonstrated precision, accuracy, stability, and sensitivity for PQ. Recoveries in water samples showed recovery values between 95.1% and 98.58%, while for food samples (acerola and apple), recoveries were between 83.9% and 97.3%. These results suggest the potential application of the sensor for PQ analysis in food and environmental control.","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/elan.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145824633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Paraquat in Real Samples Using a Printed PET-Based Electrode Modified With Molecularly Imprinted Polymer and Carbonaceous Material 用分子印迹聚合物和碳质材料修饰的pet基电极测定实际样品中的百草枯

IF 2.3 3区化学

Electroanalysis Pub Date : 2025-12-17 DOI: 10.1002/elan.70090

Malena Karla Lombello Coelho de Souza, Daniela Nunes da Silva, Scarlat Ohanna Dávila da Trindade, Thaís Cristina de Oliveira Cândido, Lucas Franco Ferreira, Arnaldo César Pereira

{"title":"Determination of Paraquat in Real Samples Using a Printed PET-Based Electrode Modified With Molecularly Imprinted Polymer and Carbonaceous Material","authors":"Malena Karla Lombello Coelho de Souza, Daniela Nunes da Silva, Scarlat Ohanna Dávila da Trindade, Thaís Cristina de Oliveira Cândido, Lucas Franco Ferreira, Arnaldo César Pereira","doi":"10.1002/elan.70090","DOIUrl":"https://doi.org/10.1002/elan.70090","url":null,"abstract":"In this work, a disposable screen-printed carbon electrode (SPCE) modified with multiwalled carbon nanotubes (MWCNTs) and molecularly imprinted polymer (MIP) was developed for the determination of Paraquat (PQ) in water and food samples, using adsorptive square wave voltammetry. The MIP was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), and the results confirmed its composition and chemical bonds. Under optimized conditions, the sensor exhibited two linear response ranges (6.3–200 and 200–500 μmol L−1), with R2 = 0.99 and sensitivities of 0.13 and 0.10 µA/µmol L−1, respectively. The limits of detection and quantification were 3.46 and 6.30 μmol L−1. The method validation demonstrated precision, accuracy, stability, and sensitivity for PQ. Recoveries in water samples showed recovery values between 95.1% and 98.58%, while for food samples (acerola and apple), recoveries were between 83.9% and 97.3%. These results suggest the potential application of the sensor for PQ analysis in food and environmental control.","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/elan.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145824446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming Infection Management with Organic Bioelectronic Materials and Devices 用有机生物电子材料和器件改造感染管理

IF 2.3 3区化学

Electroanalysis Pub Date : 2025-12-08 DOI: 10.1002/elan.70088

Atefeh Shafaat, Delphine Greco, Susanne Löffler, Agneta Richter-Dahlfors

{"title":"Transforming Infection Management with Organic Bioelectronic Materials and Devices","authors":"Atefeh Shafaat, Delphine Greco, Susanne Löffler, Agneta Richter-Dahlfors","doi":"10.1002/elan.70088","DOIUrl":"https://doi.org/10.1002/elan.70088","url":null,"abstract":"Synergies between the emerging field of organic bioelectronics and microbiology are paving the way for significant advances in biomedical research and medical technology. While in vitro models of infections form the foundation of our current understanding, they cannot replicate the complexity of biological systems. Organic bioelectronics, utilizing conjugated conducting polymers, bridge the gap between abiotic and biotic environments using ions and electrons as charge carriers. Polymer formulations can be easily tuned so that desirable electrochemical properties can be achieved and deposited for use as surface coatings, hydrogels, or 3D composites to monitor or control in vitro as well as in vivo systems. In this review, we explore the role of organic bioelectronics in infection management, highlighting their potential for modeling, detection, prevention, and treatment. These technologies offer new strategies to control microbial colonization, improve infection diagnostics, and enhance therapeutic approaches while addressing challenges such as antibiotic resistance.","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/elan.70088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming Infection Management with Organic Bioelectronic Materials and Devices 用有机生物电子材料和器件改造感染管理

IF 2.3 3区化学

Electroanalysis Pub Date : 2025-12-08 DOI: 10.1002/elan.70088

Atefeh Shafaat, Delphine Greco, Susanne Löffler, Agneta Richter-Dahlfors

{"title":"Transforming Infection Management with Organic Bioelectronic Materials and Devices","authors":"Atefeh Shafaat, Delphine Greco, Susanne Löffler, Agneta Richter-Dahlfors","doi":"10.1002/elan.70088","DOIUrl":"https://doi.org/10.1002/elan.70088","url":null,"abstract":"Synergies between the emerging field of organic bioelectronics and microbiology are paving the way for significant advances in biomedical research and medical technology. While in vitro models of infections form the foundation of our current understanding, they cannot replicate the complexity of biological systems. Organic bioelectronics, utilizing conjugated conducting polymers, bridge the gap between abiotic and biotic environments using ions and electrons as charge carriers. Polymer formulations can be easily tuned so that desirable electrochemical properties can be achieved and deposited for use as surface coatings, hydrogels, or 3D composites to monitor or control in vitro as well as in vivo systems. In this review, we explore the role of organic bioelectronics in infection management, highlighting their potential for modeling, detection, prevention, and treatment. These technologies offer new strategies to control microbial colonization, improve infection diagnostics, and enhance therapeutic approaches while addressing challenges such as antibiotic resistance.","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/elan.70088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterojunction of CuS/MnS Employed with Multiwalled Carbon Nanotubes in Molecularly Imprinted Sensor for Selective and Sensitive Determination of Trichlorfon Residual 基于多壁碳纳米管的cu /MnS异质结分子印迹传感器选择性灵敏测定敌百虫残留

IF 2.3 3区化学

Electroanalysis Pub Date : 2025-12-07 DOI: 10.1002/elan.70086

Li Zhang, Qian Zhao, Xinman Tu, Xinjie Yang, Xinding Lv, Shuiying Xiong

{"title":"Heterojunction of CuS/MnS Employed with Multiwalled Carbon Nanotubes in Molecularly Imprinted Sensor for Selective and Sensitive Determination of Trichlorfon Residual","authors":"Li Zhang, Qian Zhao, Xinman Tu, Xinjie Yang, Xinding Lv, Shuiying Xiong","doi":"10.1002/elan.70086","DOIUrl":"https://doi.org/10.1002/elan.70086","url":null,"abstract":"The abuse of trichlorfon leading a threat to human health through the food chain, it is great important to establish a selective and sensitive determination method for trichlorfon residual. Herein, a functional molecularly imprinted electrochemical sensor was constructed using CuS/MnS heterojunction and multiwalled carbon nanotubes (MWCNTs). CuS/MnS possesses a highly efficient electron transfer capacity via ion exchange interactions at a given potential, resulting in a favorable signal response. Meanwhile, the signal transmitting efficiency was further promoted by the large specific surface area of MWCNTs. In the preparation of electrochemical sensor, the CuS/MnS was modified on the electrode surface with MWCNTs, and covered by molecularly imprinted layer. The sensor was first incubated into an indicator solution containing potassium ferricyanide, producing a distinct initial signal. Once the target was present, it was identified and captured by the imprinted cavity, which blocked the electron pathway, and the potassium ferricyanide signal subsequently reduced with a measurable level. Under the optimized conditions, the two-stage linear ranges were 1.0–10 and 10–100 nM, with a detection limit of 0.37 nM. In contrast to other complex electrochemical beacons, this work induced heterojunctions and MWCNTs to obtain a satisfactory result via synergistic effect. Furthermore, the recovery rates of 93.70%–105.18% in the real sample assays suggest a prospective application of the proposed sensor in monitoring of pesticide residuals.","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Electrochemical Genosensor for Zika Virus Detection in Biological Samples Based on Cysteamine-Graphene Quantum Dots Bilayer 基于半胱氨酸-石墨烯量子点双分子层的新型生物样品寨卡病毒检测电化学基因传感器

IF 2.3 3区化学

Electroanalysis Pub Date : 2025-12-07 DOI: 10.1002/elan.70085

Luiz F. G. Luz, Márcia M. C. N. Soares, Ana G. Brito-Madurro, João M. Madurro

{"title":"Advanced Electrochemical Genosensor for Zika Virus Detection in Biological Samples Based on Cysteamine-Graphene Quantum Dots Bilayer","authors":"Luiz F. G. Luz, Márcia M. C. N. Soares, Ana G. Brito-Madurro, João M. Madurro","doi":"10.1002/elan.70085","DOIUrl":"10.1002/elan.70085","url":null,"abstract":"This paper describes a novel electrochemical genosensor designed for rapid and simplified detection of Zika virus DNA, using the biological dye safranin as a biomolecular intercalator. The genosensor uses a gold-printed circuit board as electrode, modified with a bilayer formed by cysteamine and graphene quantum dots to immobilize oligonucleotide probes specifically designed for the detection of the Zika virus. The genosensor construction was monitored by scanning electron microscopy (SEM), dynamic force microscope (DFM), and Fourier transform infrared (FTIR). Electrochemical detection was carried out based on differential pulse voltammetry, monitoring the peak current of the DNA intercalator (safranin). The genosensor demonstrated high sensitivity, detecting 1.2 pg mL−1, selectivity against other arboviruses (chikungunya and dengue) and good stability for at least 45 days. These parameters indicate potential for use of this genosensor in medical diagnostic testing for Zika virus, aiming at early screening of patients, especially in epidemic situations.","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/elan.70085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterojunction of CuS/MnS Employed with Multiwalled Carbon Nanotubes in Molecularly Imprinted Sensor for Selective and Sensitive Determination of Trichlorfon Residual 基于多壁碳纳米管的cu /MnS异质结分子印迹传感器选择性灵敏测定敌百虫残留

IF 2.3 3区化学

Electroanalysis Pub Date : 2025-12-07 DOI: 10.1002/elan.70086

Li Zhang, Qian Zhao, Xinman Tu, Xinjie Yang, Xinding Lv, Shuiying Xiong

{"title":"Heterojunction of CuS/MnS Employed with Multiwalled Carbon Nanotubes in Molecularly Imprinted Sensor for Selective and Sensitive Determination of Trichlorfon Residual","authors":"Li Zhang, Qian Zhao, Xinman Tu, Xinjie Yang, Xinding Lv, Shuiying Xiong","doi":"10.1002/elan.70086","DOIUrl":"https://doi.org/10.1002/elan.70086","url":null,"abstract":"The abuse of trichlorfon leading a threat to human health through the food chain, it is great important to establish a selective and sensitive determination method for trichlorfon residual. Herein, a functional molecularly imprinted electrochemical sensor was constructed using CuS/MnS heterojunction and multiwalled carbon nanotubes (MWCNTs). CuS/MnS possesses a highly efficient electron transfer capacity via ion exchange interactions at a given potential, resulting in a favorable signal response. Meanwhile, the signal transmitting efficiency was further promoted by the large specific surface area of MWCNTs. In the preparation of electrochemical sensor, the CuS/MnS was modified on the electrode surface with MWCNTs, and covered by molecularly imprinted layer. The sensor was first incubated into an indicator solution containing potassium ferricyanide, producing a distinct initial signal. Once the target was present, it was identified and captured by the imprinted cavity, which blocked the electron pathway, and the potassium ferricyanide signal subsequently reduced with a measurable level. Under the optimized conditions, the two-stage linear ranges were 1.0–10 and 10–100 nM, with a detection limit of 0.37 nM. In contrast to other complex electrochemical beacons, this work induced heterojunctions and MWCNTs to obtain a satisfactory result via synergistic effect. Furthermore, the recovery rates of 93.70%–105.18% in the real sample assays suggest a prospective application of the proposed sensor in monitoring of pesticide residuals.","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox Mechanisms and Detection and Quantification of Kynurenic Acid and Kynurenine on Carbon Electrodes 犬尿酸和犬尿氨酸在碳电极上的氧化还原机制及检测与定量

IF 2.3 3区化学

Electroanalysis Pub Date : 2025-12-07 DOI: 10.1002/elan.70075

José A. M. Nascimento, José G. S. Neto, Wellington E. Rodrigues, Katia C. S. Freitas, Vagner B. dos Santos, Severino Carlos B. Oliveira

{"title":"Redox Mechanisms and Detection and Quantification of Kynurenic Acid and Kynurenine on Carbon Electrodes","authors":"José A. M. Nascimento, José G. S. Neto, Wellington E. Rodrigues, Katia C. S. Freitas, Vagner B. dos Santos, Severino Carlos B. Oliveira","doi":"10.1002/elan.70075","DOIUrl":"https://doi.org/10.1002/elan.70075","url":null,"abstract":"This work, for the first time, investigated and compared electrochemical and thermodynamic properties of kynurenic acid (KYNA) and kynurenine (KYN) in aqueous electrolytes, on glassy carbon electrodes (GCE) and disposable screen-printed carbon electrodes (SPCEs). Both GCE and SPCEs were electrochemically pretreated to activate and functionalize their surfaces. The experiments were performed using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). Overall, the voltammetric data for KYNA on GCE and SPCE were convergent and indicated an irreversible, pH-dependent anodic process, associated with the withdrawal of one electron from the hydroxy group at C4, with the formation of a KYNA• radical. The KYNA• radical can polymerize on the electrode, causing passivation of its surface, and/or react with water, leading to the formation of quinone derivatives. The electrooxidation of KYNA occurred at high potentials, and its process was most easily identified by pulse voltammetric techniques. An electrooxidation mechanism of KYNA in aqueous media on carbon electrodes was proposed. The oxidation of KYN at SPCE occurred in a single, irreversible, pH-dependent step, with the removal of one electron from the 2-aminobenzoyl group, forming a cation radical intermediate. The radicals combined to form electroactive dimers. Establishing and comparing the electrochemical properties of KYNA and KYN are important data for understanding their redox reactions, redox stability, and metabolism in biological systems. Electroanalytical methods have been proposed for the detection and quantification of KYNA and KYN on SPCEs. For KYNA, the proposed method used SWV at pH = 7.00 and presented limit of detection (LOD) = 0.782 µmol L−1. For the proposed method for detection and quantification of KYN, DPV was used at pH = 0.30, and a LOD = 0.304 µmol L−1 was obtained.","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox Mechanisms and Detection and Quantification of Kynurenic Acid and Kynurenine on Carbon Electrodes 犬尿酸和犬尿氨酸在碳电极上的氧化还原机制及检测与定量

IF 2.3 3区化学

Electroanalysis Pub Date : 2025-12-07 DOI: 10.1002/elan.70075

José A. M. Nascimento, José G. S. Neto, Wellington E. Rodrigues, Katia C. S. Freitas, Vagner B. dos Santos, Severino Carlos B. Oliveira

{"title":"Redox Mechanisms and Detection and Quantification of Kynurenic Acid and Kynurenine on Carbon Electrodes","authors":"José A. M. Nascimento, José G. S. Neto, Wellington E. Rodrigues, Katia C. S. Freitas, Vagner B. dos Santos, Severino Carlos B. Oliveira","doi":"10.1002/elan.70075","DOIUrl":"https://doi.org/10.1002/elan.70075","url":null,"abstract":"This work, for the first time, investigated and compared electrochemical and thermodynamic properties of kynurenic acid (KYNA) and kynurenine (KYN) in aqueous electrolytes, on glassy carbon electrodes (GCE) and disposable screen-printed carbon electrodes (SPCEs). Both GCE and SPCEs were electrochemically pretreated to activate and functionalize their surfaces. The experiments were performed using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). Overall, the voltammetric data for KYNA on GCE and SPCE were convergent and indicated an irreversible, pH-dependent anodic process, associated with the withdrawal of one electron from the hydroxy group at C4, with the formation of a KYNA• radical. The KYNA• radical can polymerize on the electrode, causing passivation of its surface, and/or react with water, leading to the formation of quinone derivatives. The electrooxidation of KYNA occurred at high potentials, and its process was most easily identified by pulse voltammetric techniques. An electrooxidation mechanism of KYNA in aqueous media on carbon electrodes was proposed. The oxidation of KYN at SPCE occurred in a single, irreversible, pH-dependent step, with the removal of one electron from the 2-aminobenzoyl group, forming a cation radical intermediate. The radicals combined to form electroactive dimers. Establishing and comparing the electrochemical properties of KYNA and KYN are important data for understanding their redox reactions, redox stability, and metabolism in biological systems. Electroanalytical methods have been proposed for the detection and quantification of KYNA and KYN on SPCEs. For KYNA, the proposed method used SWV at pH = 7.00 and presented limit of detection (LOD) = 0.782 µmol L−1. For the proposed method for detection and quantification of KYN, DPV was used at pH = 0.30, and a LOD = 0.304 µmol L−1 was obtained.","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0