Electroanalysis最新文献

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Cover Picture: (Electroanalysis 3/2025)
IF 2.7 3区 化学
Electroanalysis Pub Date : 2025-02-26 DOI: 10.1002/elan.202580103
{"title":"Cover Picture: (Electroanalysis 3/2025)","authors":"","doi":"10.1002/elan.202580103","DOIUrl":"https://doi.org/10.1002/elan.202580103","url":null,"abstract":"<p>Cover picture provided by Dr. Elena Benito-Peña and Dr. Susana Campuzano. <i>Electroanalysis</i> covers all branches of electroanalytical chemistry, including both fundamental and application papers as well as reviews dealing with analytical voltammetry, potentiometry, new electrochemical sensors and detection schemes, nanoscale electrochemistry, advanced electromaterials, nanobioelectronics, point-of-care diagnostics, wearable sensors, and practical applications.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/elan.202580103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1,4-Xylenyl-Spaced Bis-Thiazole for Electrochemical Modulating Cobalt Ions Potentiometric Sensor Relies on Anova in Fresh and Canned Samples: Optimization and Sensitivity
IF 2.7 3区 化学
Electroanalysis Pub Date : 2025-02-25 DOI: 10.1002/elan.12031
Maysa R. Mostafa, Refaie M. Kassab, Sami A. Al-Hussain, Magdi E. A. Zaki, Zeinab A. Muhammad, Gehad G. Mohamed
{"title":"1,4-Xylenyl-Spaced Bis-Thiazole for Electrochemical Modulating Cobalt Ions Potentiometric Sensor Relies on Anova in Fresh and Canned Samples: Optimization and Sensitivity","authors":"Maysa R. Mostafa,&nbsp;Refaie M. Kassab,&nbsp;Sami A. Al-Hussain,&nbsp;Magdi E. A. Zaki,&nbsp;Zeinab A. Muhammad,&nbsp;Gehad G. Mohamed","doi":"10.1002/elan.12031","DOIUrl":"https://doi.org/10.1002/elan.12031","url":null,"abstract":"<p>This article uses bis-dihydrazothiazolone derivative called 1,4-xylenyl-spaced bis-thiazole as an ionophore for assessment of trace cobalt(II) ions using an electrochemical potentiometric carbon sensor with tricresyl phosphate as a binder and graphite as base material.The microstructure and morphology were assessed using a scanning electron microscope and energy-dispersive X-ray spectroscopy. In addition, the elemental analyses as well as infrared, mass, and <sup>1</sup>H- and <sup>13</sup>C-nuclear magnetic resonance were used to determine ionophore structure. The influence of variables such as pH, lifetime, content percentage, and others were modified. Under ideal conditions, it performed an efficient response within 6 s and pH 2.0–7.5 throughout a range from 5.0 × 10<sup>−3</sup> to 1.0 × 10<sup>−8</sup> M for 69 days with 1.0 × 10<sup>−8</sup> M of the detection limit. Also, cobalt(II) ion was determined in many different samples such as water, fresh and canned fish, rice, mushroom, sesame, and <i>Nigella sativa</i> seed. Atomic absorption spectroscopy was used for the determination of cobalt(II) ions in these samples and provided evidence for the feasibility of the proposed approach as a cobalt(II) ion detection method. The recovery percentages for potentiometric sensor ranged from 98.18% to 99.75% with low relative standard deviation values &lt;5. Statistical validation analysis was reported by analysis of variance (ANOVA) and design expert programs, ANOVA single value, and <i>F-</i> and <i>t</i>-tests at 95% confidence limits.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1,4-Xylenyl-Spaced Bis-Thiazole for Electrochemical Modulating Cobalt Ions Potentiometric Sensor Relies on Anova in Fresh and Canned Samples: Optimization and Sensitivity
IF 2.7 3区 化学
Electroanalysis Pub Date : 2025-02-25 DOI: 10.1002/elan.12031
Maysa R. Mostafa, Refaie M. Kassab, Sami A. Al-Hussain, Magdi E. A. Zaki, Zeinab A. Muhammad, Gehad G. Mohamed
{"title":"1,4-Xylenyl-Spaced Bis-Thiazole for Electrochemical Modulating Cobalt Ions Potentiometric Sensor Relies on Anova in Fresh and Canned Samples: Optimization and Sensitivity","authors":"Maysa R. Mostafa,&nbsp;Refaie M. Kassab,&nbsp;Sami A. Al-Hussain,&nbsp;Magdi E. A. Zaki,&nbsp;Zeinab A. Muhammad,&nbsp;Gehad G. Mohamed","doi":"10.1002/elan.12031","DOIUrl":"https://doi.org/10.1002/elan.12031","url":null,"abstract":"<p>This article uses bis-dihydrazothiazolone derivative called 1,4-xylenyl-spaced bis-thiazole as an ionophore for assessment of trace cobalt(II) ions using an electrochemical potentiometric carbon sensor with tricresyl phosphate as a binder and graphite as base material.The microstructure and morphology were assessed using a scanning electron microscope and energy-dispersive X-ray spectroscopy. In addition, the elemental analyses as well as infrared, mass, and <sup>1</sup>H- and <sup>13</sup>C-nuclear magnetic resonance were used to determine ionophore structure. The influence of variables such as pH, lifetime, content percentage, and others were modified. Under ideal conditions, it performed an efficient response within 6 s and pH 2.0–7.5 throughout a range from 5.0 × 10<sup>−3</sup> to 1.0 × 10<sup>−8</sup> M for 69 days with 1.0 × 10<sup>−8</sup> M of the detection limit. Also, cobalt(II) ion was determined in many different samples such as water, fresh and canned fish, rice, mushroom, sesame, and <i>Nigella sativa</i> seed. Atomic absorption spectroscopy was used for the determination of cobalt(II) ions in these samples and provided evidence for the feasibility of the proposed approach as a cobalt(II) ion detection method. The recovery percentages for potentiometric sensor ranged from 98.18% to 99.75% with low relative standard deviation values &lt;5. Statistical validation analysis was reported by analysis of variance (ANOVA) and design expert programs, ANOVA single value, and <i>F-</i> and <i>t</i>-tests at 95% confidence limits.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Solid-State Potentiometric Platform for Vonoprazan Fumarate Determination in Pharmaceutical Dosage Form and Spiked Human Plasma
IF 2.7 3区 化学
Electroanalysis Pub Date : 2025-02-25 DOI: 10.1002/elan.12035
Maha M. Abou El-Alamin, Dina A. Mohamed, Amir S. Farag
{"title":"Green Solid-State Potentiometric Platform for Vonoprazan Fumarate Determination in Pharmaceutical Dosage Form and Spiked Human Plasma","authors":"Maha M. Abou El-Alamin,&nbsp;Dina A. Mohamed,&nbsp;Amir S. Farag","doi":"10.1002/elan.12035","DOIUrl":"https://doi.org/10.1002/elan.12035","url":null,"abstract":"<p>Vonoprazan fumarate (VPZ), a potent potassium-competitive acid blocker, has gained prominence recently for its efficacy in acid-related disorders, surpassing traditional proton pump inhibitors in acid suppression. Combining molecular modeling simulations with electrochemical sensors represents a cutting-edge approach in analytical chemistry. Molecular docking guided the selection of calix[8]arene as the optimal ionophore due to its superior affinity for VPZ, supported by robust docking scores and hydrophobic interactions. The final sensor configuration, incorporating calix[8]arene, sodium tetraphenylborate, and dioctyl phthalate, exhibited outstanding electroanalytical characteristics, including improved slope, enhanced potential stability, and rapid response times. Notably, the developed solid-contact sensors demonstrated a Nernstian response with a slope of 58.587 over a concentration range of 1 × 10<sup>−8</sup>–1 × 10<sup>−2</sup> M, achieving an impressive low detection limit of 3.09 × 10<sup>−9</sup> M. The developed method offers a cost-effective and environmentally sustainable solution for precise monitoring of VPZ, promising significant advancements in pharmaceutical quality control.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Solid-State Potentiometric Platform for Vonoprazan Fumarate Determination in Pharmaceutical Dosage Form and Spiked Human Plasma
IF 2.7 3区 化学
Electroanalysis Pub Date : 2025-02-25 DOI: 10.1002/elan.12035
Maha M. Abou El-Alamin, Dina A. Mohamed, Amir S. Farag
{"title":"Green Solid-State Potentiometric Platform for Vonoprazan Fumarate Determination in Pharmaceutical Dosage Form and Spiked Human Plasma","authors":"Maha M. Abou El-Alamin,&nbsp;Dina A. Mohamed,&nbsp;Amir S. Farag","doi":"10.1002/elan.12035","DOIUrl":"https://doi.org/10.1002/elan.12035","url":null,"abstract":"<p>Vonoprazan fumarate (VPZ), a potent potassium-competitive acid blocker, has gained prominence recently for its efficacy in acid-related disorders, surpassing traditional proton pump inhibitors in acid suppression. Combining molecular modeling simulations with electrochemical sensors represents a cutting-edge approach in analytical chemistry. Molecular docking guided the selection of calix[8]arene as the optimal ionophore due to its superior affinity for VPZ, supported by robust docking scores and hydrophobic interactions. The final sensor configuration, incorporating calix[8]arene, sodium tetraphenylborate, and dioctyl phthalate, exhibited outstanding electroanalytical characteristics, including improved slope, enhanced potential stability, and rapid response times. Notably, the developed solid-contact sensors demonstrated a Nernstian response with a slope of 58.587 over a concentration range of 1 × 10<sup>−8</sup>–1 × 10<sup>−2</sup> M, achieving an impressive low detection limit of 3.09 × 10<sup>−9</sup> M. The developed method offers a cost-effective and environmentally sustainable solution for precise monitoring of VPZ, promising significant advancements in pharmaceutical quality control.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Metal Electrode and Concentration Redox Couple Effect on Electrical Circuit Parameters for Heterocharge System: Potential Application for Lithium-Ion Battery
IF 2.7 3区 化学
Electroanalysis Pub Date : 2025-02-20 DOI: 10.1002/elan.12024
Farid Taherkhani
{"title":"Effect of Metal Electrode and Concentration Redox Couple Effect on Electrical Circuit Parameters for Heterocharge System: Potential Application for Lithium-Ion Battery","authors":"Farid Taherkhani","doi":"10.1002/elan.12024","DOIUrl":"https://doi.org/10.1002/elan.12024","url":null,"abstract":"<p>The analytical solution has been expanded to describe the circuit parameters of a redox couple with a charge of +1 and 0 for electrochemical reaction in the presence of supporting electrolyte as a potential application in lithium-ion battery. The Gouy–Chapman–Stern theory has been developed to comprehend the capacitance behavior as a function of the difference in electrical potential between the solution and metal parameters (<i>E</i><sub>eq</sub> variable). Finite-element simulations have been employed to explore various electrochemical system configurations, enhancing electrical storage energy by engineering the types of metal electrode and concentration heterocharge redox couple and supporting electrolyte. The initial guess for the Randles circuit parameters has been implemented by Matlab code developing, deriving them from the electrical current response versus time in a frequency-dependent sinusoidal wave function. Subsequently, the optimization problem regarding fitting of the circuit parameters has been performed through open-source Python code for electrochemical impedance spectroscopy using the initial Randles circuit parameter guess. The semianalytical method revealed a minimum in capacitance behavior near the zero value of the <i>E</i><sub>eq</sub> variable. Additionally, the numerical method showed that the capacitance behavior regarding the <i>E</i><sub>eq</sub> variable remains constant for high concentrations of the supporting electrolyte. The charge transfer coefficient demonstrated a monotonic behavior versus <i>E</i><sub>eq</sub> for all electrochemical reactions occurring on the parallel microdisk. A simulation result regarding general trend for capacitance versus <i>E</i><sub>eq</sub> variable is consistent with the available experimental data.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Metal Electrode and Concentration Redox Couple Effect on Electrical Circuit Parameters for Heterocharge System: Potential Application for Lithium-Ion Battery
IF 2.7 3区 化学
Electroanalysis Pub Date : 2025-02-20 DOI: 10.1002/elan.12024
Farid Taherkhani
{"title":"Effect of Metal Electrode and Concentration Redox Couple Effect on Electrical Circuit Parameters for Heterocharge System: Potential Application for Lithium-Ion Battery","authors":"Farid Taherkhani","doi":"10.1002/elan.12024","DOIUrl":"https://doi.org/10.1002/elan.12024","url":null,"abstract":"<p>The analytical solution has been expanded to describe the circuit parameters of a redox couple with a charge of +1 and 0 for electrochemical reaction in the presence of supporting electrolyte as a potential application in lithium-ion battery. The Gouy–Chapman–Stern theory has been developed to comprehend the capacitance behavior as a function of the difference in electrical potential between the solution and metal parameters (<i>E</i><sub>eq</sub> variable). Finite-element simulations have been employed to explore various electrochemical system configurations, enhancing electrical storage energy by engineering the types of metal electrode and concentration heterocharge redox couple and supporting electrolyte. The initial guess for the Randles circuit parameters has been implemented by Matlab code developing, deriving them from the electrical current response versus time in a frequency-dependent sinusoidal wave function. Subsequently, the optimization problem regarding fitting of the circuit parameters has been performed through open-source Python code for electrochemical impedance spectroscopy using the initial Randles circuit parameter guess. The semianalytical method revealed a minimum in capacitance behavior near the zero value of the <i>E</i><sub>eq</sub> variable. Additionally, the numerical method showed that the capacitance behavior regarding the <i>E</i><sub>eq</sub> variable remains constant for high concentrations of the supporting electrolyte. The charge transfer coefficient demonstrated a monotonic behavior versus <i>E</i><sub>eq</sub> for all electrochemical reactions occurring on the parallel microdisk. A simulation result regarding general trend for capacitance versus <i>E</i><sub>eq</sub> variable is consistent with the available experimental data.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rectified Ion Transport with Low-Cost Ionic Diodes Based on Sulfonated Poly-(Phenylene-Oxide)
IF 2.7 3区 化学
Electroanalysis Pub Date : 2025-02-19 DOI: 10.1002/elan.12033
Asandiswa Mfenguza, Luthando Tshwenya, Dimpo S. Sipuka, Oluchi V. Nkwachukwu, Keneiloe Khoabane Sikhwivhilu, Frank Marken, Omotayo A. Arotiba
{"title":"Rectified Ion Transport with Low-Cost Ionic Diodes Based on Sulfonated Poly-(Phenylene-Oxide)","authors":"Asandiswa Mfenguza,&nbsp;Luthando Tshwenya,&nbsp;Dimpo S. Sipuka,&nbsp;Oluchi V. Nkwachukwu,&nbsp;Keneiloe Khoabane Sikhwivhilu,&nbsp;Frank Marken,&nbsp;Omotayo A. Arotiba","doi":"10.1002/elan.12033","DOIUrl":"https://doi.org/10.1002/elan.12033","url":null,"abstract":"<p>Ionic rectifiers/diodes are devices with potential applications in water treatment (desalination) and sensors. Diode preparation sometimes involves expensive processes such as laser drilling and thus the need for simpler and low-cost methods. We developed a low-cost cation rectifying hybrid membrane ionic rectifier where a microporous sulfonated poly-(2,6-dimethyl phenylene oxide) (SPPO) was asymmetrically attached to a microhole region in a polypropylene adhesive tape substrate. Contact angle measurements showed that SPPO is hydrophilic with a 62° angle. In comparison, the polypropylene adhesive tape and SPPO within it are hydrophobic with angles of 101° and 87°, respectively, contributing to the diode's stability in water. Zeta potential measurements confirmed the negative charge of the SPPO surface in all electrolyte solutions. Scanning electron microscopy revealed that the punctured tape substrate has a 3–4 µm microhole and a thickness of about 25 µm. The SPPO membrane is ≈29 µm thick with a smooth cross-sectional surface. The effects of electrolyte, ionic strength and microhole diameter on ionic diode performance were investigated using cyclic voltammetry and chronoamperometry in a 4-electrode measurement cell. The reported ionic rectifier is simple to fabricate, and it shows good rectification even in high ionic strength media.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/elan.12033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of a Third-Generation Tyrosine Kinase Inhibitor with dsDNA: Electrochemical and Spectroscopic Studies
IF 2.7 3区 化学
Electroanalysis Pub Date : 2025-02-19 DOI: 10.1002/elan.12030
Kamila Koszelska, Monika Wypych, Mateusz Kciuk, Dariusz Guziejewski, Radovan Metelka, Sylwia Smarzewska
{"title":"Interaction of a Third-Generation Tyrosine Kinase Inhibitor with dsDNA: Electrochemical and Spectroscopic Studies","authors":"Kamila Koszelska,&nbsp;Monika Wypych,&nbsp;Mateusz Kciuk,&nbsp;Dariusz Guziejewski,&nbsp;Radovan Metelka,&nbsp;Sylwia Smarzewska","doi":"10.1002/elan.12030","DOIUrl":"https://doi.org/10.1002/elan.12030","url":null,"abstract":"<p>In the current study, an evaluation was conducted regarding potential interaction mechanisms occurring between ponatinib (<i>Pntb</i>), a tyrosine kinase inhibitor of third-generation and double-stranded deoxyribonucleic acid (dsDNA). The aim of these studies was to elucidate the mechanism underlying the interaction between <i>Pntb</i> and DNA. This understanding could not only shed light on the changes occurring within living organisms but also, in the future, facilitate the development of new drugs for cancer treatment and improve their therapeutic effectiveness. The interactions were examined using square wave voltammetry (SWV) and UV–Vis spectroscopy. In order to conduct voltammetric experiments, a glassy carbon electrode was used. The addition of dsDNA to ponatinib solution resulted in a decrease of current peaks of the latter and resulted in a positive peak potential shift, suggesting that the intercalative type of interaction is the most likely to occur. Studies with utilization of UV–Vis spectroscopy have revealed a hypochromic effect, resulting in lack of wavelength shift in absorption maximum, following the addition of DNA to ponatinib solution, and confirming that intercalation is the predominant interaction between <i>Pntb</i> and dsDNA. The calculated value of the binding constant for <i>Pntb</i>-dsDNA determined by SWV was equal to 1.71 × 10<sup>7</sup> M<sup>−1</sup>. The values calculated from UV–Vis spectroscopy, however, were 1.13 × 10<sup>7</sup> M<sup>−1</sup>.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of a Third-Generation Tyrosine Kinase Inhibitor with dsDNA: Electrochemical and Spectroscopic Studies
IF 2.7 3区 化学
Electroanalysis Pub Date : 2025-02-19 DOI: 10.1002/elan.12030
Kamila Koszelska, Monika Wypych, Mateusz Kciuk, Dariusz Guziejewski, Radovan Metelka, Sylwia Smarzewska
{"title":"Interaction of a Third-Generation Tyrosine Kinase Inhibitor with dsDNA: Electrochemical and Spectroscopic Studies","authors":"Kamila Koszelska,&nbsp;Monika Wypych,&nbsp;Mateusz Kciuk,&nbsp;Dariusz Guziejewski,&nbsp;Radovan Metelka,&nbsp;Sylwia Smarzewska","doi":"10.1002/elan.12030","DOIUrl":"https://doi.org/10.1002/elan.12030","url":null,"abstract":"<p>In the current study, an evaluation was conducted regarding potential interaction mechanisms occurring between ponatinib (<i>Pntb</i>), a tyrosine kinase inhibitor of third-generation and double-stranded deoxyribonucleic acid (dsDNA). The aim of these studies was to elucidate the mechanism underlying the interaction between <i>Pntb</i> and DNA. This understanding could not only shed light on the changes occurring within living organisms but also, in the future, facilitate the development of new drugs for cancer treatment and improve their therapeutic effectiveness. The interactions were examined using square wave voltammetry (SWV) and UV–Vis spectroscopy. In order to conduct voltammetric experiments, a glassy carbon electrode was used. The addition of dsDNA to ponatinib solution resulted in a decrease of current peaks of the latter and resulted in a positive peak potential shift, suggesting that the intercalative type of interaction is the most likely to occur. Studies with utilization of UV–Vis spectroscopy have revealed a hypochromic effect, resulting in lack of wavelength shift in absorption maximum, following the addition of DNA to ponatinib solution, and confirming that intercalation is the predominant interaction between <i>Pntb</i> and dsDNA. The calculated value of the binding constant for <i>Pntb</i>-dsDNA determined by SWV was equal to 1.71 × 10<sup>7</sup> M<sup>−1</sup>. The values calculated from UV–Vis spectroscopy, however, were 1.13 × 10<sup>7</sup> M<sup>−1</sup>.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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