Electroanalysis最新文献

{"title":"Cover Picture: (Electroanalysis 4/2025)","authors":"","doi":"10.1002/elan.202580104","DOIUrl":"https://doi.org/10.1002/elan.202580104","url":null,"abstract":"<p>Cover picture provided by Dr. Elena Benito-Peña and Dr. Susana Campuzano. <i>Electroanalysis</i> covers all branches of electroanalytical chemistry, including both fundamental and application papers as well as reviews dealing with analytical voltammetry, potentiometry, new electrochemical sensors and detection schemes, nanoscale electrochemistry, advanced electromaterials, nanobioelectronics, point-of-care diagnostics, wearable sensors, and practical applications.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/elan.202580104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Picture: (Electroanalysis 4/2025)","authors":"","doi":"10.1002/elan.202580104","DOIUrl":"https://doi.org/10.1002/elan.202580104","url":null,"abstract":"<p>Cover picture provided by Dr. Elena Benito-Peña and Dr. Susana Campuzano. <i>Electroanalysis</i> covers all branches of electroanalytical chemistry, including both fundamental and application papers as well as reviews dealing with analytical voltammetry, potentiometry, new electrochemical sensors and detection schemes, nanoscale electrochemistry, advanced electromaterials, nanobioelectronics, point-of-care diagnostics, wearable sensors, and practical applications.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/elan.202580104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical Sensor for Carboxypeptidase Y Using a 4-Aminonaphthol-Conjugated Peptide Substrate Lacking a Free Carboxyl Group at the C-Terminus","authors":"Hyeryeong Lee,&nbsp;Seonhwa Park,&nbsp;Haesik Yang","doi":"10.1002/elan.12044","DOIUrl":"https://doi.org/10.1002/elan.12044","url":null,"abstract":"<p>Carboxypeptidase Y (CPY) is a serine carboxypeptidase crucial for understanding protein processing, degradation pathways, and intracellular transport, yet no electrochemical detection method has been reported. Here, we present the first electrochemical sensor for CPY, leveraging its ability to cleave 4-aminonaphthol (AN)-conjugated succinyl-Leu–Leu-Val-Tyr (Suc-LLVY-AN) even in the absence of a free carboxyl group at the C-terminus. Upon proteolysis, the electroactive species AN is released and detected using electrochemical–enzymatic redox cycling. We optimized pH, temperature, and incubation time to maximize the signal-to-background ratio. Under optimal conditions (pH 7.4, 37°C, 30 min), the sensor achieved a detection limit of 0.2 µg/mL in phosphate-buffered saline, outperforming a comparable fluorescence-based method (0.6 µg/mL). Even in artificial saliva, the sensor maintained favorable sensitivity (0.5 µg/mL), demonstrating its potential for complex sample analysis. Selectivity tests against other proteases confirmed high specificity, as only CPY effectively cleaved the Suc-LLVY-AN substrate. Overall, this novel electrochemical approach offers enhanced sensitivity and specificity for CPY detection, broadening the scope of electrochemical protease sensors and providing a valuable tool for diverse biochemical and diagnostic applications.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tungsten Selenide Quantum Dot-Based Electrocatalytic Detection of Lamivudine","authors":"Fungai D. Chibaya,&nbsp;Usisipho Feleni,&nbsp;Thabo T. I. Nkambule,&nbsp;Ntuthuko W. Hlongwa","doi":"10.1002/elan.12038","DOIUrl":"https://doi.org/10.1002/elan.12038","url":null,"abstract":"<p>\u0000Lamivudine (LAM) is an antiviral drug used against hepatitis, human immunodeficiency virus, and acquired immunodeficiency syndrome. Due to the increasing occurrence of antiviral drugs in wastewaters around the globe, and the health hazards and risks associated with the inherent human and ecosystem exposure, researchers have taken advantage of the reactivity of these antiviral drugs and their affinity to form various bonds with novel nanoparticles, to foster more convenient and environmentally friendly methods of wastewater monitoring of antivirals using nanomaterials in sensor fabrication. The deviation from the conventional methods of wastewater monitoring seeks to overcome the inefficiency, tediousness, and complexity of sample preparation of the conventional methods. In the current research work, a colloidal synthesis method was developed and used to synthesize L-cysteine-functionalized tungsten diselenide quantum dots (L-cyst-WSe₂QDs) for the monitoring of LAM in water. Characterization of nanoparticles was done using different spectroscopy methods, transmission electron microscopy (TEM), and X-ray diffraction (XRD) patterns. Successful capping and functionalization of QDs was demonstrated by Fourier-transform infrared spectroscopy. Small-angle X-ray scattering and zetasizer analytical studies corroborated the formation of QDs of sizes less than 10 nm. High-resolution TEM, XRD, and small-angle electron diffraction confirmed the highly crystalline nature of the QDs. The L-cyst-WSe₂QDs were bound by Nafion to a preactivated glassy carbon (GC) electrode, and the fabricated sensor exhibited excellent electrochemical sensing efficiency as compared to previously reported WSe₂ sensors and other various sensors used to detect LAM, presenting high sensitivity and good selectivity with the lowest reported limit of detection (LOD) of 0.1 nM using the square wave voltammetry (SWV) technique in wastewater effluents. This work provided a lower LOD than previous reports on electrochemical sensing of LAM using differential pulse voltammetry and SWV. Though the electrochemical behavior of LAM on L-cyst-WSe₂QDs/GC was established for the first time through this current study, LAM was irreversibly reduced at negative potentials, validating a previously established characteristic response. The sensor exhibited high reproducibility with an excellent stability by retaining 87.2% sensor functionality and stability after 7 days. The reduction peak current of LAM presented a linear range of 2–10 pM with a correlation coefficient of 0.993. The application of the LAM sensor in the determination of LAM in real wastewater samples exhibited excellent recoveries ranging between 94.6% and 99.9%, thereby demonstrating the suitability of the sensor for application in real time.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/elan.12038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzyme-Modified Microelectrodes for Measurement of Glutamate: Characterization and Applications","authors":"Nadiah Alyamni,&nbsp;Clarice Cook,&nbsp;Jandro L. Abot,&nbsp;Alexander G. Zestos","doi":"10.1002/elan.12041","DOIUrl":"https://doi.org/10.1002/elan.12041","url":null,"abstract":"<p>Glutamate is a critical neurotransmitter in the central nervous system that plays a key role in numerous physiological processes and neurological disorders. Traditional methods of glutamate detection have low spatiotemporal resolution, while electrochemical methods are limited due to glutamate not being readily redox active at unmodified carbon electrode surfaces. This study presents the development of a glutamate oxidase-modified microelectrode for the sensitive, real-time detection of glutamate using fast-scan cyclic voltammetry (FSCV) with a triangle waveform. Here, we employed a chitosan-hydrogel coating to immobilize glutamate oxidase onto carbon-fiber microelectrodes, enabling selective metabolism of glutamate to hydrogen peroxide. The metabolism to hydrogen peroxide facilitates indirect detection with high sensitivity across a concentration range relevant to physiological concentrations. We utilized FSCV for detection, which enhanced temporal resolution and chemical selectivity, allowing for the codetection of glutamate with other neurotransmitters such as dopamine and norepinephrine. We performed proof-of-concept validation and testing utilizing both biological fluids and complex food samples, demonstrating the enzyme-modified microelectrode's broad applicability in clinical diagnostics and food quality assessment. The sensor showed excellent stability, resistance to fouling, and retained over 90% of its initial response after multiple uses. This work highlights the potential of this biosensor as a versatile tool for minimally invasive, biocompatible, rapid, and accurate glutamate measurement in a wide variety of samples for a diverse set of applications.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Entity Electrochemistry in Motion","authors":"Emily Dominique,&nbsp;Christophe Renault","doi":"10.1002/elan.12040","DOIUrl":"https://doi.org/10.1002/elan.12040","url":null,"abstract":"<p>Single entity electrochemistry (SEE) finds exciting application in analytical chemistry. Multiple methodologies have been tailored to measure conventional quantities such as concentration and size for a large variety of particles. Intense effort is also dedicated to investigation of chemical dynamics in electro-catalysis. This mini-review will focus its attention to the analysis of motion of particles at the interface and near the interface. The velocity of particles and types of motion (lateral, transversal, and rotational) will be discussed for a wide range of particles including solid metal and polystyrene particles as well as soft liquid droplets and gas bubbles. A new perspective on motion in SEE will be given by discussing the motion of phase boundaries within solid particles as well as soft liquid droplets and gas bubbles.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Highly Sensitive Gold and Bismuth Nanoparticle-Modified Amperometric Sensor for Ceftriaxone Detection: Experimental and Density Functional Theory Insights","authors":"Mahmoud Elrouby,&nbsp;Doaa S. Ameer,&nbsp;Adila E. Mohamed,&nbsp;Atiat A. Montaser","doi":"10.1002/elan.12042","DOIUrl":"https://doi.org/10.1002/elan.12042","url":null,"abstract":"<p>The detection of pharmaceutical contaminants, such as Ceftriaxone (CTRX), in water sources is a critical environmental and public health concern. Conventional detection methods often suffer from limited sensitivity and stability, making the accurate quantification of low CTRX concentrations challenging. To overcome these limitations, a novel amperometric sensor was developed using a carbon paste electrode (CPE) modified with gold and bismuth nanoparticles (Au-BiNPs). The synergistic electrocatalytic properties of these nanoparticles significantly enhance the sensitivity and stability of CTRX detection in complex environments. The Au-BiNPs-modified CPE (Au-BiNPs/CPE) exhibited excellent electrocatalytic activity toward the oxidation of CTRX, achieving a low detection limit of 0.267 µM and a high sensitivity of 25.9 μA/μM cm². The sensor was optimized to operate at pH 4.0 using Britton–Robinson buffer, following a mixed adsorption–diffusion reaction mechanism. Furthermore, the electrode demonstrated remarkable reproducibility (relative standard deviation [RSD] = 3.0%) and repeatability (RSD = 1.5%). Stability and corrosion resistance were confirmed through Tafel polarization studies, underscoring the sensor's durability and long-term performance. Additionally, density functional theory calculations provided molecular-level insights into the CTRX oxidation mechanism, complementing the experimental findings and further validating the sensor's design. This study presents the first Au-BiNPs-modified CPE for the sensitive detection of CTRX, integrating experimental optimization with theoretical insights. The significant outcomes of this work lay the foundation for advanced sensor development, offering a reliable and efficient platform for the detection of antibiotics in environmental and clinical settings.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical Sensors for Enhanced and Rapid Detection of Illicit Drugs","authors":"Sumera Khizar,&nbsp;Nadia Zine,&nbsp;Monique Sigaud,&nbsp;Abdelhamid Elaissari,&nbsp;Abdelhamid Errachid","doi":"10.1002/elan.12034","DOIUrl":"https://doi.org/10.1002/elan.12034","url":null,"abstract":"<p>The consumption of illicit drugs is spread worldwide and remains a challenge for concerned authorities. Hence, it is vital to develop effective and precise methods for detecting these types of compounds in biological fluids, seized street samples, and wastewaters. Electrochemical sensors are extensively used for analysis in many fields and represent an exclusive prospect to permit inexpensive, fast, and accurate monitoring and detection simultaneously. Electrochemical approaches are mainly open to forensic investigation because of their high performance in turbid and complex matrices. In this minireview, recent electrochemical strategies applied to the detection of illicit drugs in different samples have been presented.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Agcl Cube/Porous Carbon Nanotubes Composition for Nonenzymatic Electrochemically Sensing H2O2 Released from Cancer Cells","authors":"Na Zhang,&nbsp;Yilin Wu,&nbsp;Yan Wang,&nbsp;Yongxiang Su,&nbsp;Xvsheng Xie,&nbsp;Hongyan Wang,&nbsp;Keying Zhang,&nbsp;Rongli Jiang","doi":"10.1002/elan.12039","DOIUrl":"10.1002/elan.12039","url":null,"abstract":"<p>The abnormal expression of hydrogen peroxide (H₂O₂) in living cells is closely related to the occurrence and development of tumor diseases. It is a kind potential marker for tumor diagnosis and treatment of tumor diseases. Therefore, it is very meaningful to develop high selective and sensitive method for real-time detecting H₂O₂ released from cancer cells. Herein, an AgCl cube/porous carbon nanotube composite nanomaterials was successfully fabricated and employed to construct a non-enzymatic electrochemical H₂O₂ sensor. Test results showed that the proposed sensor displayed the high sensitivity with the detection limit of 5.3 × 10⁻⁹ mol/L (S/N = 3). Importantly, it can accurately analyze H₂O₂ in milk samples and achieve real-time determination of H₂O₂ secreted from living cancer cells. In addition, the established sensor exhibited good stability and anti-interference ability. This strategy offers a potential way to diagnose tumor diseases.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoporous Gold Thin-Film Microelectrode for Nitrite Detection in Microalgae-Growing Media","authors":"Douglas P. M. Saraiva,&nbsp;Leonardo M. A. Ribeiro,&nbsp;Monalisa R. Bettim,&nbsp;Breno P. Espósito,&nbsp;Mauro Bertotti","doi":"10.1002/elan.12032","DOIUrl":"10.1002/elan.12032","url":null,"abstract":"<p>Nitrite indicates nitrogen availability in aquatic ecosystems, with primary productivity and ecological balance implications. However, excessive nitrite accumulation poses significant risks to aquatic life, necessitating reliable detection methods. Electrochemical approaches offer flexibility and adaptability crucial for varied research needs, and nanoporous electrode surface modification emerges as a promising strategy to enhance sensitivity and precision in nitrite detection. In this study, a sensitive sensor is developed utilizing gold microelectrodes modified with nanoporous gold to detect nitrite. At optimized conditions, the sensor has a linear response (<i>R</i>² = 0.994) in the nitrite concentration range from 50 to 1 mmol L⁻¹ and a detection limit of 8.9 nmol L⁻¹ following the 3σ/s method. The results show that the proposed sensor can perform electrochemical detection with high repeatability (relative standard deviation (RSD) = 2%, <i>n</i> = 7) and reproducibility (RSD = 2%, <i>n</i> = 8). The concentration of nitrite in tap water and microalgae-growing media samples was determined, and the results agreed with those from the Griess method. These findings challenge conventional surface area, sensitivity, and detection limit assumptions, highlighting the nuanced relationship between electrode surface morphology and detection limit and presenting some evidence that the highest sensitivity does not always reflect on the lowest detection limit.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}