Electroanalysis最新文献

{"title":"Synthesis of Agcl Cube/Porous Carbon Nanotubes Composition for Nonenzymatic Electrochemically Sensing H2O2 Released from Cancer Cells","authors":"Na Zhang,&nbsp;Yilin Wu,&nbsp;Yan Wang,&nbsp;Yongxiang Su,&nbsp;Xvsheng Xie,&nbsp;Hongyan Wang,&nbsp;Keying Zhang,&nbsp;Rongli Jiang","doi":"10.1002/elan.12039","DOIUrl":"10.1002/elan.12039","url":null,"abstract":"<p>The abnormal expression of hydrogen peroxide (H₂O₂) in living cells is closely related to the occurrence and development of tumor diseases. It is a kind potential marker for tumor diagnosis and treatment of tumor diseases. Therefore, it is very meaningful to develop high selective and sensitive method for real-time detecting H₂O₂ released from cancer cells. Herein, an AgCl cube/porous carbon nanotube composite nanomaterials was successfully fabricated and employed to construct a non-enzymatic electrochemical H₂O₂ sensor. Test results showed that the proposed sensor displayed the high sensitivity with the detection limit of 5.3 × 10⁻⁹ mol/L (S/N = 3). Importantly, it can accurately analyze H₂O₂ in milk samples and achieve real-time determination of H₂O₂ secreted from living cancer cells. In addition, the established sensor exhibited good stability and anti-interference ability. This strategy offers a potential way to diagnose tumor diseases.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoporous Gold Thin-Film Microelectrode for Nitrite Detection in Microalgae-Growing Media","authors":"Douglas P. M. Saraiva,&nbsp;Leonardo M. A. Ribeiro,&nbsp;Monalisa R. Bettim,&nbsp;Breno P. Espósito,&nbsp;Mauro Bertotti","doi":"10.1002/elan.12032","DOIUrl":"10.1002/elan.12032","url":null,"abstract":"<p>Nitrite indicates nitrogen availability in aquatic ecosystems, with primary productivity and ecological balance implications. However, excessive nitrite accumulation poses significant risks to aquatic life, necessitating reliable detection methods. Electrochemical approaches offer flexibility and adaptability crucial for varied research needs, and nanoporous electrode surface modification emerges as a promising strategy to enhance sensitivity and precision in nitrite detection. In this study, a sensitive sensor is developed utilizing gold microelectrodes modified with nanoporous gold to detect nitrite. At optimized conditions, the sensor has a linear response (<i>R</i>² = 0.994) in the nitrite concentration range from 50 to 1 mmol L⁻¹ and a detection limit of 8.9 nmol L⁻¹ following the 3σ/s method. The results show that the proposed sensor can perform electrochemical detection with high repeatability (relative standard deviation (RSD) = 2%, <i>n</i> = 7) and reproducibility (RSD = 2%, <i>n</i> = 8). The concentration of nitrite in tap water and microalgae-growing media samples was determined, and the results agreed with those from the Griess method. These findings challenge conventional surface area, sensitivity, and detection limit assumptions, highlighting the nuanced relationship between electrode surface morphology and detection limit and presenting some evidence that the highest sensitivity does not always reflect on the lowest detection limit.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasensitive Electrochemical Aptasensor for Alpha-Fetoprotein Detection Based on Cadmium Telluride/Cadmium Selenide/Polyaniline-Cosensitized Structure","authors":"Jiajia Wang,&nbsp;Chun Kan,&nbsp;Mengping Gao,&nbsp;Baokang Jin","doi":"10.1002/elan.12037","DOIUrl":"https://doi.org/10.1002/elan.12037","url":null,"abstract":"<p>\u0000In this paper, a water-soluble highly electrochemical signal cadmium telluride (CdTe)/cadmium selenide (CdSe)/polyaniline nanocomposite was developed through a fast and convenient method, and then the nanocomposite-modified glassy carbon electrode was prepared for the determination of alpha-fetoprotein (AFP). This aptasensor was constructed by covalently immobilizing NH₂-functionalized AFP-specific aptamer on nanocomposite with plenty of carboxylic groups. This electrochemical biosensor via the layer-by-layer method could evidently increase the steric hindrance of the sensing electrode and effectively depress the electron transfer, leading to obviously decreased current intensity. The ultrahigh sensitivity of this immunoassay is derived from the two primary reasons as follows. First, the CdTe/CdSe multiple-sensitized and cosensitized structure could maximize speed of charge transfer processes between electrodes and the electroactive species, dramatically promote electron transfer, and effectively inhibit the electron–hole recombination, resulting in the significantly enhanced electrochemical current intensity of the sensing electrode. Second, the electrocatalytic oxidation of K₃Fe(CN)₆, which makes the CdTe/CdSe change from a lower-energy to higher-energy states (CdTe/CdSe QDs)*, reduces the activation energy of the reaction and the (CdTe/CdSe QDs)* more likely to oxidize, accelerating the transfer of electrons. Scanning electron microscope, transmission electron microscope, and X-ray photoelectron spectroscopy were used to characterize the material. Electrochemical impedance spectroscopy was used to observe the loading process of the material. Differential pulse voltammetry was used as a method of measurement. The immunosensor exhibited a wide linear range from 1.0 to 10.0 μg/mL for target AFP detection, with a low detection limit of 1.0 pg/mL (S/N = 3). To evaluate the analytical reliability, reproducibility, specificity, and stability, the proposed immunosensor was applied to human AFP-spiked serum samples, and acceptable results were obtained, indicating that the method can be readily extended to other bioaffinity assays of clinical or environmental significance.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143581575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Voltammetric Studies Concerning a Phenyl Trisilanol Polyhedral Oligosilsesquioxane Modified with Phosphate and Methylene Blue for Pyridoxine Detection","authors":"Murilo Santos Peixoto,&nbsp;Devaney Ribeiro do Carmo","doi":"10.1002/elan.12036","DOIUrl":"https://doi.org/10.1002/elan.12036","url":null,"abstract":"<p>This study describes the synthesis of a phenyl trisilanol polyhedral oligosilsesquioxane (POSS) employing calcium and its subsequent modification by phosphate and methylene blue for electrochemical applications. Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy, and scanning electron microscopy, were employed to characterize the developed material. The obtained POSS was characterized by cyclic coltammetry employing a graphite paste electrode, exhibiting well-defined redox pairs. The modified graphite paste electrode demonstrated an adequate electrocatalytic response for pyridoxine. Regarding catalytic pyridoxine electro-oxidation, the modified electrode exhibited a linear response ranging from 7.0 × 10⁻⁶ to 1.0 × 10⁻³ mol L⁻¹, with a limit of detection of 3.24 × 10⁻⁶ mol L⁻¹. The studied material, therefore, comprises a potential candidate for the development of electrochemical sensors for pyridoxine detection.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Picture: (Electroanalysis 3/2025)","authors":"","doi":"10.1002/elan.202580103","DOIUrl":"https://doi.org/10.1002/elan.202580103","url":null,"abstract":"<p>Cover picture provided by Dr. Elena Benito-Peña and Dr. Susana Campuzano. <i>Electroanalysis</i> covers all branches of electroanalytical chemistry, including both fundamental and application papers as well as reviews dealing with analytical voltammetry, potentiometry, new electrochemical sensors and detection schemes, nanoscale electrochemistry, advanced electromaterials, nanobioelectronics, point-of-care diagnostics, wearable sensors, and practical applications.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/elan.202580103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1,4-Xylenyl-Spaced Bis-Thiazole for Electrochemical Modulating Cobalt Ions Potentiometric Sensor Relies on Anova in Fresh and Canned Samples: Optimization and Sensitivity","authors":"Maysa R. Mostafa,&nbsp;Refaie M. Kassab,&nbsp;Sami A. Al-Hussain,&nbsp;Magdi E. A. Zaki,&nbsp;Zeinab A. Muhammad,&nbsp;Gehad G. Mohamed","doi":"10.1002/elan.12031","DOIUrl":"https://doi.org/10.1002/elan.12031","url":null,"abstract":"<p>This article uses bis-dihydrazothiazolone derivative called 1,4-xylenyl-spaced bis-thiazole as an ionophore for assessment of trace cobalt(II) ions using an electrochemical potentiometric carbon sensor with tricresyl phosphate as a binder and graphite as base material.The microstructure and morphology were assessed using a scanning electron microscope and energy-dispersive X-ray spectroscopy. In addition, the elemental analyses as well as infrared, mass, and ¹H- and ¹³C-nuclear magnetic resonance were used to determine ionophore structure. The influence of variables such as pH, lifetime, content percentage, and others were modified. Under ideal conditions, it performed an efficient response within 6 s and pH 2.0–7.5 throughout a range from 5.0 × 10⁻³ to 1.0 × 10⁻⁸ M for 69 days with 1.0 × 10⁻⁸ M of the detection limit. Also, cobalt(II) ion was determined in many different samples such as water, fresh and canned fish, rice, mushroom, sesame, and <i>Nigella sativa</i> seed. Atomic absorption spectroscopy was used for the determination of cobalt(II) ions in these samples and provided evidence for the feasibility of the proposed approach as a cobalt(II) ion detection method. The recovery percentages for potentiometric sensor ranged from 98.18% to 99.75% with low relative standard deviation values &lt;5. Statistical validation analysis was reported by analysis of variance (ANOVA) and design expert programs, ANOVA single value, and <i>F-</i> and <i>t</i>-tests at 95% confidence limits.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1,4-Xylenyl-Spaced Bis-Thiazole for Electrochemical Modulating Cobalt Ions Potentiometric Sensor Relies on Anova in Fresh and Canned Samples: Optimization and Sensitivity","authors":"Maysa R. Mostafa,&nbsp;Refaie M. Kassab,&nbsp;Sami A. Al-Hussain,&nbsp;Magdi E. A. Zaki,&nbsp;Zeinab A. Muhammad,&nbsp;Gehad G. Mohamed","doi":"10.1002/elan.12031","DOIUrl":"https://doi.org/10.1002/elan.12031","url":null,"abstract":"<p>This article uses bis-dihydrazothiazolone derivative called 1,4-xylenyl-spaced bis-thiazole as an ionophore for assessment of trace cobalt(II) ions using an electrochemical potentiometric carbon sensor with tricresyl phosphate as a binder and graphite as base material.The microstructure and morphology were assessed using a scanning electron microscope and energy-dispersive X-ray spectroscopy. In addition, the elemental analyses as well as infrared, mass, and ¹H- and ¹³C-nuclear magnetic resonance were used to determine ionophore structure. The influence of variables such as pH, lifetime, content percentage, and others were modified. Under ideal conditions, it performed an efficient response within 6 s and pH 2.0–7.5 throughout a range from 5.0 × 10⁻³ to 1.0 × 10⁻⁸ M for 69 days with 1.0 × 10⁻⁸ M of the detection limit. Also, cobalt(II) ion was determined in many different samples such as water, fresh and canned fish, rice, mushroom, sesame, and <i>Nigella sativa</i> seed. Atomic absorption spectroscopy was used for the determination of cobalt(II) ions in these samples and provided evidence for the feasibility of the proposed approach as a cobalt(II) ion detection method. The recovery percentages for potentiometric sensor ranged from 98.18% to 99.75% with low relative standard deviation values &lt;5. Statistical validation analysis was reported by analysis of variance (ANOVA) and design expert programs, ANOVA single value, and <i>F-</i> and <i>t</i>-tests at 95% confidence limits.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Solid-State Potentiometric Platform for Vonoprazan Fumarate Determination in Pharmaceutical Dosage Form and Spiked Human Plasma","authors":"Maha M. Abou El-Alamin,&nbsp;Dina A. Mohamed,&nbsp;Amir S. Farag","doi":"10.1002/elan.12035","DOIUrl":"https://doi.org/10.1002/elan.12035","url":null,"abstract":"<p>Vonoprazan fumarate (VPZ), a potent potassium-competitive acid blocker, has gained prominence recently for its efficacy in acid-related disorders, surpassing traditional proton pump inhibitors in acid suppression. Combining molecular modeling simulations with electrochemical sensors represents a cutting-edge approach in analytical chemistry. Molecular docking guided the selection of calix[8]arene as the optimal ionophore due to its superior affinity for VPZ, supported by robust docking scores and hydrophobic interactions. The final sensor configuration, incorporating calix[8]arene, sodium tetraphenylborate, and dioctyl phthalate, exhibited outstanding electroanalytical characteristics, including improved slope, enhanced potential stability, and rapid response times. Notably, the developed solid-contact sensors demonstrated a Nernstian response with a slope of 58.587 over a concentration range of 1 × 10⁻⁸–1 × 10⁻² M, achieving an impressive low detection limit of 3.09 × 10⁻⁹ M. The developed method offers a cost-effective and environmentally sustainable solution for precise monitoring of VPZ, promising significant advancements in pharmaceutical quality control.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Solid-State Potentiometric Platform for Vonoprazan Fumarate Determination in Pharmaceutical Dosage Form and Spiked Human Plasma","authors":"Maha M. Abou El-Alamin,&nbsp;Dina A. Mohamed,&nbsp;Amir S. Farag","doi":"10.1002/elan.12035","DOIUrl":"https://doi.org/10.1002/elan.12035","url":null,"abstract":"<p>Vonoprazan fumarate (VPZ), a potent potassium-competitive acid blocker, has gained prominence recently for its efficacy in acid-related disorders, surpassing traditional proton pump inhibitors in acid suppression. Combining molecular modeling simulations with electrochemical sensors represents a cutting-edge approach in analytical chemistry. Molecular docking guided the selection of calix[8]arene as the optimal ionophore due to its superior affinity for VPZ, supported by robust docking scores and hydrophobic interactions. The final sensor configuration, incorporating calix[8]arene, sodium tetraphenylborate, and dioctyl phthalate, exhibited outstanding electroanalytical characteristics, including improved slope, enhanced potential stability, and rapid response times. Notably, the developed solid-contact sensors demonstrated a Nernstian response with a slope of 58.587 over a concentration range of 1 × 10⁻⁸–1 × 10⁻² M, achieving an impressive low detection limit of 3.09 × 10⁻⁹ M. The developed method offers a cost-effective and environmentally sustainable solution for precise monitoring of VPZ, promising significant advancements in pharmaceutical quality control.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Metal Electrode and Concentration Redox Couple Effect on Electrical Circuit Parameters for Heterocharge System: Potential Application for Lithium-Ion Battery","authors":"Farid Taherkhani","doi":"10.1002/elan.12024","DOIUrl":"https://doi.org/10.1002/elan.12024","url":null,"abstract":"<p>The analytical solution has been expanded to describe the circuit parameters of a redox couple with a charge of +1 and 0 for electrochemical reaction in the presence of supporting electrolyte as a potential application in lithium-ion battery. The Gouy–Chapman–Stern theory has been developed to comprehend the capacitance behavior as a function of the difference in electrical potential between the solution and metal parameters (<i>E</i>_eq variable). Finite-element simulations have been employed to explore various electrochemical system configurations, enhancing electrical storage energy by engineering the types of metal electrode and concentration heterocharge redox couple and supporting electrolyte. The initial guess for the Randles circuit parameters has been implemented by Matlab code developing, deriving them from the electrical current response versus time in a frequency-dependent sinusoidal wave function. Subsequently, the optimization problem regarding fitting of the circuit parameters has been performed through open-source Python code for electrochemical impedance spectroscopy using the initial Randles circuit parameter guess. The semianalytical method revealed a minimum in capacitance behavior near the zero value of the <i>E</i>_eq variable. Additionally, the numerical method showed that the capacitance behavior regarding the <i>E</i>_eq variable remains constant for high concentrations of the supporting electrolyte. The charge transfer coefficient demonstrated a monotonic behavior versus <i>E</i>_eq for all electrochemical reactions occurring on the parallel microdisk. A simulation result regarding general trend for capacitance versus <i>E</i>_eq variable is consistent with the available experimental data.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}