Electroanalysis最新文献

{"title":"Enhancing Melatonin Analysis: Unveiling A Novel Polymer-Based Electrochemical Sensor for Human Fluid Matrices and Pharmaceutical Samples","authors":"Ümran Sofu,&nbsp;Gökçe Öztürk,&nbsp;Hamit Ali Reis,&nbsp;Fatih Erdemir,&nbsp;Dilek Kul","doi":"10.1002/elan.70039","DOIUrl":"10.1002/elan.70039","url":null,"abstract":"<p>In this study, a polymerized film of bromocresol purple was successfully formed on a glassy carbon electrode using cyclic voltammetry. Several parameters were investigated to optimize the polymerization process. The optimal conditions included 35 potential cycles in a 0.1 M phosphate buffer solution at pH 5.6 containing 0.1 M NaNO₃ and 5.0 × 10^–4M monomer, resulting in a stable poly(bromocresol purple) film on the electrode surface. Cyclic voltammetry and electrochemical impedance spectroscopy were used to characterize the modified electrode. The modified electrode showed a significant improvement in melatonin detection and was successfully applied for its analysis in phosphate buffer solution at pH 8.0. Melatonin was determined over linear ranges of 0.08–60 µM using differential pulse voltammetry, and 0.2–10 and 20–100 µM using square wave voltammetry, with corresponding detection limits of 24.4 and 51.8 nM, respectively. The developed methods were successfully applied to tablet dosage forms, human serum, and artificial urine samples, yielding satisfactory recoveries between 99.36% and 101.06%. The selectivity of the modified electrode was assessed in the presence of potential interfering substances commonly present in human body fluids, with a tolerance limit of ±3.9%. Furthermore, the modified electrode demonstrated excellent reproducibility and long-term stability.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Nanostructured Materials: Applications in Biosensors, Gas Sensors, and Chemical Sensors","authors":"Km. Supriya Das,&nbsp;Sourabh Satapathy,&nbsp;Kuladip Barman,&nbsp;Neha Singh,&nbsp;Shivani Kasana,&nbsp;Balak Das Kurmi,&nbsp;Preeti Patel","doi":"10.1002/elan.70027","DOIUrl":"10.1002/elan.70027","url":null,"abstract":"<p>Nanostructured materials (NSMs) have gained prominence in technological advancements due to their flexible physical, chemical, and biological properties with enhanced performance over their bulk counterparts. NSMs are categorized depending on their size, composition, shape, and origin. The aim of this review is to comprehensively examine the utilization of nanomaterials (NMs) in sensing and detection applications, specifically focusing on gas sensors, biosensors, and chemical sensors. Studying into the fundamental aspects, this review article explores the principles, basics, and mechanisms of gas sensor, biosensor, and the chemical sensor. It provides a detailed overview of various types of gas sensors, emphasizing the important role played by nanostructures in enhancing sensing capabilities. Additionally, the integration of NMs in biosensors is discussed, with a spotlight on biomedical applications. The review also addresses their application in chemical sensors, highlighting the mechanisms involved and exploring emerging trends. The synthesis methods, characterization techniques, challenges, and opportunities associated with the fabrication of NSMs are precisely examined. Through case studies, real-world applications are showcased, underscoring the successes and innovations achieved. This review highlights the pivotal role of nanostructured hard materials in advancing sensing and detection technologies while outlining potential directions for future research in the field.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroanalytical Sensing of Melatonin and its Applications in Pharmaceutics and Biology","authors":"Arely Barrera-Quiroz,&nbsp;Alia Méndez-Albores,&nbsp;Miguel A. González-Fuentes,&nbsp;Erika Méndez","doi":"10.1002/elan.70041","DOIUrl":"10.1002/elan.70041","url":null,"abstract":"<p>Melatonin (N-acetyl-5-methoxytryptamine) is a neuroendocrine hormone produced in the pineal gland and distributed throughout the body. It has an important role in human physiology in synchronizing biological processes in neuroscience for regulating sleep and mood, and in clinical diagnosis for managing sleep disorders and exploring its therapeutics. However, melatonin recently received special attention because it has been proposed as an adjuvant in treating SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the coronavirus responsible for the COVID-19 pandemic. Therefore, the sensitive detection of melatonin in pharmaceutical samples and biological fluids (such as blood, saliva, breast milk, and urine) is important to ensure proper dosage or optimize treatment and to determine endogenous levels, even in pharmacological research and safety. In that sense, this review focuses on the recent development of electrochemical sensors for melatonin, emphasizing the use of modified electrodes to enhance sensitivity and selectivity. Different electrode materials, including screen-printed carbon (SPE), glassy carbon (GC), boron-doped diamond (BDD), and carbon paste electrodes (CPE), are explored for their effectiveness in melatonin detection. Additionally, the application of voltammetric techniques, such as differential pulse voltammetry (DPV) and square wave voltammetry (SWV) is highlighted for their ability to provide high-resolution detection with minimal interference. Other electrochemical techniques, including cyclic voltammetry (CV) and chronoamperometry (CA), are also discussed in their role for melatonin sensing. These electrochemical techniques provide significant benefits, such as fast, sensitive, and affordable detection, making them essential tools in pharmaceuticals, clinical diagnostics, and biological research. On the other hand, this article explores the detection of synthetic melatonin, both individually and in the presence of interfering substances, such as serotonin, dopamine, and acetaminophen, with a focus on the challenges and techniques for distinguishing melatonin from other compounds in complex biological matrices, such as urine, blood, saliva, and pharmaceutical tablets.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-Engineered Core–Shell CeO2@C Spheres with Controllable Oxygen Vacancies for High-Rate and Ultralong-Cycling Aqueous Zinc-Ion Batteries","authors":"Kun Liang,&nbsp;Lang Huang,&nbsp;Peng Jiang,&nbsp;Yi Wang,&nbsp;Siyu Cai,&nbsp;Guichuan Jiang,&nbsp;Fang Chen,&nbsp;Defeng Liu","doi":"10.1002/elan.70045","DOIUrl":"10.1002/elan.70045","url":null,"abstract":"<p>Aqueous zinc ion batteries (AZIBs) have attracted much attention due to their high safety and low cost. Electrode materials built on cerium oxides are emerging as compelling cathode options for AZIBs. These materials combine high theoretical capacity, abundant oxygen vacancy active sites, and minimal environmental impact, but their poor intrinsic electrical conductivity and rapid decay in cycling stability due to volume expansion during cycling have severely limited practical applications. Herein, a spherical CeO₂@C composite with a core–shell structure was developed through a combination of coating and controlled pyrolysis process. The uniform carbon layer encapsulation can simultaneously enhance the electronic conductivity and alleviate the bulk deformation of CeO₂@C composite. Benefit from the enhanced interfacial charge transport effect and oxygen vacancy modulation facilitated by the carbon layer, the CeO₂@C cathode delivers a capacity of 358.3 mAh g⁻¹ at 1 A g⁻¹. Moreover, the capacity retention rate of assembled AZIB with CeO₂@C cathode is as high as 65.0% after 10 000 cycles. The results of XRD and XPS spectroscopy demonstrate that the coated carbon layer effectively enhances the electrochemistry and structure stability by suppressing the irreversible Ce³⁺/Ce⁴⁺ redox variations and alleviating lattice stress induced by Zn²⁺ embedding/disembedding. This work presents a novel approach to enhance the performance of cerium-oxide cathode and presents a versatile core–shell synergistic strategy to inform the architectural design of diverse metal–oxide electrodes.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing Stripping Electroanalytical Techniques using Au/Hg Amalgam Microelectrodes for Quantification and Speciation Studies of Cd(II) and Pb(II)","authors":"Elise Rotureau,&nbsp;Sinourou Koné,&nbsp;José Paulo Pinheiro","doi":"10.1002/elan.70040","DOIUrl":"10.1002/elan.70040","url":null,"abstract":"<p>Solid microelectrodes offer several advantages, including the ability to perform localized measurements and resistance to deterioration in complex matrices like sediments and hydrogels. This study explores, for the first time, the application of gold/mercury amalgamated microelectrodes for sensing trace metal ions (Pb(II) and Cd(II)) at nanomolar levels and performing speciation analysis in solutions. This investigation represents a preliminary step toward implementing electrochemical sensors in porous and heterogeneous media. Stripping chronopotentiometry (SCP), which provides in-depth insights into metal speciation analysis, is compared with the classical technique of square wave anodic stripping voltammetry (SWASV). It was found that the complete metal depletion during the reoxidation step in SCP resulted in superior linearity ranges for both calibration and signal variation with deposition times compared to SWASV. While the results for Cd(II) are promising, the SCP signal for Pb(II) displays two discernible peaks, which may complicate speciation studies. SCP at Scanned deposition potential for the Cd/NTA system was successfully used to extract the thermodynamic stability constant. The positive findings for Cd(II) demonstrate the effectiveness of (S)SCP for Au/Hg microelectrode and open new prospects, such as immersing this probe in a hydrogel matrix for a detailed in situ investigation of the Cd status within the material.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen Vacancy-Engineered Porous Nicu MOF@LDHs for Highly Sensitive Electrochemical Glucose Sensing","authors":"Yujing Zhong,&nbsp;Nan Zhang,&nbsp;Qiulin Lyu,&nbsp;Muhammad Waqas,&nbsp;Chengzhou Liu,&nbsp;Liujie Lu,&nbsp;Shiyin Xu,&nbsp;Youjun Fan,&nbsp;Guang Liu,&nbsp;Wei Chen","doi":"10.1002/elan.70036","DOIUrl":"10.1002/elan.70036","url":null,"abstract":"<p>Metal-organic frameworks (MOFs) and layered double hydroxides (LDHs) have emerged as highly efficient platforms for electrochemical sensors due to their simplicity, rapid response, low cost, and elevated sensitivity. However, the underlying mechanism of their interaction in electrochemical sensors is still unclear. Herein, the porous composite of MOF-supported LDHs (NiCu MOF@LDHs) is successfully fabricated using a simple hydrothermal method. Interestingly, the integration of LDHs and MOFs synergistically enhanced the hierarchical structure of the composite, leading to an increased specific surface area and improved electrical conductivity. Thus, the NiCu MOF@LDHs/GCE presents excellent glucose sensing features, including a good linear range (4.9504–1.1701 mM and 1.1701–2.8248 mM), a low detection limit (1.4249 μM, S/N = 3). Specifically, the sensor exhibited enhanced sensitivities (1071.1 and 545.2 µA mM^–1 cm^–2) and high selectivity in the presence of common interfering species including dopamine, hydrogen peroxide, ascorbic acid, L-arginine, and sodium chloride. Furthermore, the NiCu MOF@LDHs/GCE sensor demonstrated excellent performance in the practical detection of glucose levels in human serum, appreciating its potential for real-time applications. This work not only highlights the unique structural and functional properties of the NiCu MOF@LDHs composite but also paves the way for its future applications in glucose sensing and electrochemical biosensing.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sample Preparation before Voltammetric Determination of Ionic Form of Ti(IV) in Organic-Rich Matrix - Critical Point of Analysis","authors":"Beata Krasnodębska-Ostręga,&nbsp;Jakub Warowny,&nbsp;Monika Sadowska,&nbsp;Emilia Skarżyńska","doi":"10.1002/elan.70038","DOIUrl":"10.1002/elan.70038","url":null,"abstract":"<p>The applicability of adsorptive stripping voltammetry with hanging mercury drop electrode (HMDE) electrode has been studied for the determination of the ionic form of Ti(IV) in samples requiring specific pretreatment and decomposition of the organic matrix before measurement. Application of the mixture of conc. HNO₃ and conc. HCl (3:4) for sample decomposition in a closed microwave system using two-stage program with a maximum temperature 210°C, and next dilution in solution preventing hydrolysis, containing 0.05 mmol L⁻¹ KClO₃ and 0.24 mmol L⁻¹ mandelic acid in deionized water (supporting electrolyte) allows to determine single ng of Ti(IV) in the plant leaves extract and fertilizer containing significant amounts of inorganic salts, surface compounds, and chelates. Determination was done after short deposition (<i>t</i>_d = 60–90s, <i>E</i>_d = −0.150 V) with negative-going potential scan. The method was validated by the recovery study of Ti at the ng level (complete recovery – 102%).</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Sensitive Electrochemical Sensor Based on Zn Porphyrin for Environmental Monitoring of Glyphosate","authors":"Fatma Rejab,&nbsp;Nour Elhouda Dardouri,&nbsp;Ahlem Rouis,&nbsp;Mosaab Echabaane,&nbsp;Nicole Jaffrezic-Renault,&nbsp;Hamdi Ben Halima","doi":"10.1002/elan.70037","DOIUrl":"10.1002/elan.70037","url":null,"abstract":"<p>Glyphosate (Gly) is one of the most widely used herbicides in modern agriculture, and its potential risks continue to be a subject of considerable discussion. In this present work, a novel electrochemical sensor was developed using an indium tin oxide (ITO) electrode modified with a zinc (II) metalloporphyrin complex, [5,10,15,20-tetrayltetrakis(2-methoxybenzene-4,1-diyl) tetraisonicotinateporphyrinato] zinc (II) (ZnTMIPP), for the selective detection of glyphosate. The ZnTMIPP complex was synthesized and thoroughly characterized using UV–vis and FTIR spectrometry, and ¹H NMR spectroscopy to confirm its structure and purity. The sensing platform was prepared by drop-casting the ZnTMIPP onto the surface of a cleaned ITO electrode, forming a uniform and stable film. Electrochemical evaluation of the sensor was performed using cyclic voltammetry under optimized experimental conditions, revealing a sensitive response to glyphosate, with a wide linear detection range from 10^–8 to 10^–5 M and a low detection limit of 4.14 nM. Furthermore, the modified electrode demonstrated excellent selectivity versus glyphosate metabolite and other pesticides, reproducibility, and stability, highlighting its potential as a cost-effective and efficient platform for glyphosate monitoring in real water samples and fruit juice.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical Quantification of Gallic Acid: The Role of Voltammetric Parameter Optimization via Multivariate Experimental Design","authors":"Regiani Maria Leopoldina Martins Sandrini,&nbsp;Bruno Guzzo da Silva,&nbsp;Camilo Andrea Angelucci","doi":"10.1002/elan.70033","DOIUrl":"10.1002/elan.70033","url":null,"abstract":"<p>The increasing demand for pomegranate-based supplements highlights the need for accurate quantification of bioactive compounds such as gallic acid (GA), a phenolic marker associated with antioxidant effects. This study evaluates how square wave voltammetry (SWV) parameters—frequency, potential increment, and pulse amplitude—directly influence the current response associated with GA electrooxidation on gold electrodes in an acidic medium. Cyclic voltammetry and SWV were used, with parameter optimization performed via central composite rotatable design and response surface methodology. Frequency and amplitude showed the greatest influence on the current signal, while potential increment had a minor effect. The optimized conditions (180 Hz, 5 mV, and 25.5 mV) enabled GA quantification in powdered pomegranate and commercial supplements, with concentrations of 0,6105 mmol L⁻¹ e 0,7106 mmol L⁻¹, respectively. The method exhibited linearity from 10 to 100 µmol L⁻¹, with limits of detection and quantification of 5.03 and 16.78 µmol L⁻¹. This optimized electrochemical approach offers a fast, sensitive, and reliable tool for quality control in natural products.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/elan.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Electrochemical Sensor for the Detection of Bisphenols Based on Mxene Embedded with Aminated Carbon Nanotubes","authors":"Chunying Liu,&nbsp;Yuyuan Sun,&nbsp;Shaopeng Chang,&nbsp;Jing Jin,&nbsp;Jiayin Hu,&nbsp;Jin Zhao","doi":"10.1002/elan.70028","DOIUrl":"10.1002/elan.70028","url":null,"abstract":"<p>Bisphenols (BPs), hazardous endocrine-disrupting chemicals pervasive in environments, require sensitive monitoring methods to mitigate their health risks. Herein, an electrode material, MXene embedded with amino-functionalized multiwalled carbon nanotubes (MXene/NH₂-MWCNTs), was fabricated via electrostatic self-assembly for developing an electrochemical sensor toward BPs. The electrode material was characterized detailedly using transmission electron microscopy, scanning electron microscopy, X-ray diffraction analysis, infrared spectroscopy, and electrochemical measurements. The MXene/NH₂-MWCNTs composite exhibited significantly enhanced BP sensing performance compared to its individual components, owing to the synergistic combination of MXene's abundant active sites and NH₂-MWCNTs’ exceptional conductivity. Under optimal conditions, MXene/NH₂-MWCNTs modified glassy carbon electrode exhibited wide linear detection ranges of 0.1–300 μM for bisphenol A (BPA), 0.25–200 μM for bisphenol B (BPB), and 0.25–150 μM for bisphenol F (BPF), with relative lower detection limits of 17.53 nM for BPA, 18.43 nM for BPB, and 19.32 nM for BPF, respectively. In addition, the developed sensors showed high selectivity, reproducibility, and long-term stability were satisfactorily applicable in real environmental water samples. This work provides a versatile platform for monitoring emerging contaminants in environmental analysis.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}