Journal of invertebrate pathology最新文献

{"title":"Whole-genome insights into antibiotic resistance in Vibrio strains isolated from shrimp farms in Mexico","authors":"Laura E. Cota-Ortega ,&nbsp;Irais Ramírez-Sánchez ,&nbsp;Bruno Gomez-Gil ,&nbsp;Sonia A. Soto-Rodríguez ,&nbsp;José Luis Balcázar ,&nbsp;Eduardo Quiroz-Guzmán","doi":"10.1016/j.jip.2025.108504","DOIUrl":"10.1016/j.jip.2025.108504","url":null,"abstract":"<div><div>Despite notable advances in shrimp aquaculture over recent decades, infectious diseases remain a major limiting factor for further intensification. Among these, vibriosis has caused substantial economic losses worldwide. This study, therefore, aimed to identify and characterize virulence- and antibiotic resistance-associated genes in <em>Vibrio</em> species isolated from Mexican shrimp farms affected by disease outbreaks. Six <em>Vibrio</em> strains were isolated and identified through whole-genome sequencing. One strain was identified as <em>Vibrio parahaemolyticus</em>, which carries several antibiotic resistance genes on its chromosome and harbors a plasmid containing the <em>pirA</em> and <em>pirB</em> toxin genes responsible for acute hepatopancreatic necrosis disease (AHPND). The remaining five strains were identified as <em>Vibrio diabolicus</em>, which also carry several antibiotic resistance genes but lack the <em>pirA</em>- and <em>pirB</em> toxin genes. Moreover, multilocus sequence typing (MLST) analysis revealed that the <em>V. parahaemolyticus</em> strain identified in this study is genetically more closely related to strains previously isolated in China. In contrast, the <em>V. diabolicus</em> strains show greater similarity to a strain from Colombia, although genetic differences among them remain evident. Taken together, these findings highlight the complexity of genetic relationships among these isolates and suggest possible routes of global dissemination.</div></div>","PeriodicalId":16296,"journal":{"name":"Journal of invertebrate pathology","volume":"215 ","pages":"Article 108504"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral response of the tick Rhipicephalus linnaei to the entomopathogenic fungus Metarhizium anisopliae","authors":"Lucas Prado Barreto ,&nbsp;Ariel de Souza Oliveira ,&nbsp;Dhiogo Neres Carreira ,&nbsp;Jaires Gomes de Oliveira Filho ,&nbsp;Lorena Lopes Ferreira ,&nbsp;Viviane Zeringóta ,&nbsp;Lígia Miranda Ferreira Borges ,&nbsp;Éverton Kort Kamp Fernandes","doi":"10.1016/j.jip.2025.108516","DOIUrl":"10.1016/j.jip.2025.108516","url":null,"abstract":"<div><div>The tick <em>Rhipicephalus linnaei</em> (Acari: Ixodidae), formerly recognized as the tropical lineage of <em>Rhipicephalus sanguineus</em> sensu lato (s.l.), is a globally distributed species. Entomopathogenic fungi offer a promising alternative to synthetic acaricides for tick control, yet little is known about the olfactory behavioral response of <em>R. linnaei</em> to fungal exposure. This study used a Y-tube olfactometer to investigate adult ticks’ attraction or repellency to <em>Metarhizium anisopliae</em> conidia and fungal-colonized tick carcasses. Results showed that most adult <em>R. linnaei</em> moved toward the olfactometer arm containing the lowest conidial concentration (1 × 10⁵ conidia mL⁻¹ in mineral oil), indicating attraction. Similarly, most ticks preferred the arm with five fungal-colonized tick carcasses, which resulted from engorged females previously treated with oil conidial suspension. However, higher conidial concentrations or exposure to one or two fungal-colonized carcasses did not elicit attraction or repellency in ticks. This study is the first to report tick behavioral responses to <em>M. anisopliae</em> conidial suspensions and colonized tick carcasses. The observed attraction, although considered reasonably weak, indicates that volatile organic compounds from <em>M. anisopliae</em> IP 119 may affect tick behavior. In addition, oil formulation seems to stimulate the ticks’ behavioral responses to the fungal conidia, potentially by enhancing or suppressing the production of volatile compounds. These findings provide new insights into tick-fungus interactions, supporting the potential use of <em>M. anisopliae</em> in tick management strategies.</div></div>","PeriodicalId":16296,"journal":{"name":"Journal of invertebrate pathology","volume":"215 ","pages":"Article 108516"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ingestion of polystyrene microplastics by Bombyx mori larvae disrupts midgut epithelial barrier integrity and potentially promotes susceptibility to BmNPV infection","authors":"Wenjing Shao ,&nbsp;Yani Kang ,&nbsp;Wenbin Yu ,&nbsp;Yifei Kong ,&nbsp;Yiming Huo ,&nbsp;Zihan He ,&nbsp;Xiaolong Hu ,&nbsp;Xing Zhang","doi":"10.1016/j.jip.2025.108463","DOIUrl":"10.1016/j.jip.2025.108463","url":null,"abstract":"<div><div>Microplastics (MPs) are ubiquitous environmental contaminants with potential implications for host-virus interactions, which has attracted global interest because MPs have been recognized as emerging pollutants. Despite growing concern over MPs, their influence on viral infections, particularly in invertebrate models, remains poorly understood. In this study, we employed the silkworm, <em>Bombyx mori</em>, as a model organism to investigate the impact of microplastic (MP) exposure on viral replication and the gut microbiome. Real-time PCR and Western blotting results showed that exposure to MPs was accompanied by significantly increased BmNPV viral gene expression (<em>ie-1</em>, <em>vp39</em>, <em>gp41</em>) and VP39 production in the midgut, suggesting an increase in BmNPV replication. Exposure to MPs disrupted gut microbiome composition, leading to a decrease in beneficial bacteria (e.g., <em>Vibrionaceae</em>) and an increase in opportunistic pathogens, potentially contributing to increased susceptibility to BmNPV. Notably, the increased permeability of the midgut epithelium in response to MP exposure likely facilitated viral entry and enhanced infection. These findings underscore the potential risks of MPs in facilitating viral replication and systemic infection and emphasize the necessity of further research to explore the complex relationships between MPs, gut microbiota, and viral infections across different ecological settings.</div></div>","PeriodicalId":16296,"journal":{"name":"Journal of invertebrate pathology","volume":"214 ","pages":"Article 108463"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Vairimorpha (Nosema) ceranae and Lotmaria passim on antimicrobial peptide expression in the digestive tract of honey bees (Apis mellifera L.)","authors":"Courtney I. MacInnis ,&nbsp;Lien T. Luong ,&nbsp;Stephen F. Pernal","doi":"10.1016/j.jip.2025.108435","DOIUrl":"10.1016/j.jip.2025.108435","url":null,"abstract":"<div><div><em>Vairimorpha</em> (<em>Nosema</em>) <em>ceranae</em> and <em>Lotmaria passim</em> are two commonly encountered digestive tract parasites of the Western honey bee (<em>Apis mellifera</em> L.). Although these parasites are associated with colony losses, little is known regarding how they affect the bee humoral defense response, particularly at the level of the digestive tract where the parasites are found. Using locally-obtained parasite isolates, the effects of both single and mixed <em>V. ceranae</em> and <em>L. passim</em> infections on the bee humoral defense response were evaluated at the digestive tract level by quantifying the expression of three antimicrobial peptides (apidaecin, defensin-1, hymenoptaecin) at five timepoints post-infection. Parasite density was also monitored in digestive tract tissues at these five timepoints to determine if the parasites, particularly <em>L. passim</em>, have distinct host tissue preferences. In general, it was found that bees do not elicit distinct humoral defense responses within the digestive tract in response to infection with either single or mixed <em>V. ceranae</em> and <em>L. passim</em> infections. Increased <em>L. passim</em> density in hindgut tissues compared to midgut tissues at each of the five timepoints suggests a hindgut preference for the parasite. Interestingly, for bees that received mixed infections, both <em>L. passim</em> and <em>V. ceranae</em> densities were elevated in hindgut tissues, suggesting that there could be an interaction occurring between the two parasites.</div></div>","PeriodicalId":16296,"journal":{"name":"Journal of invertebrate pathology","volume":"214 ","pages":"Article 108435"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral potential and mode of action of Metarhizium pinghaense 15R-derived polysaccharide against baculovirus","authors":"Jiwon Jang ,&nbsp;Gui Hwan Han ,&nbsp;Seong Hun Im ,&nbsp;Jeong Won Kim ,&nbsp;Soo Dong Woo ,&nbsp;Tae Young Shin","doi":"10.1016/j.jip.2025.108474","DOIUrl":"10.1016/j.jip.2025.108474","url":null,"abstract":"<div><div>Polysaccharides have been reported to function as antiviral agents against various viruses. In this study, a polysaccharide extracted from <em>Metarhizium pinghaense</em> 15R demonstrated inhibitory effects against <em>Bombyx mori</em> nucleopolyhedrovirus (BmNPV). When Bm5 cells were co-inoculated with the <em>M. pinghaense</em> 15R −derived polysaccharide and eGFP-cloned BmNPV budded virus (BV), eGFP expression was significantly reduced compared to the virus-only control group. Additionally, the polysaccharide-treated group showed greater cell viability and proliferation than the ribavirin-treated group. Further investigation into the antiviral mechanism revealed that the polysaccharide inhibited both viral attachment and secondary infection of BmNPV. This antiviral activity is likely due to its high sulfate content (18 %), which is widely associated with enhanced viral inhibition. A silkworm larva bioassay demonstrated that when the occlusion body (OB) and polysaccharide were combined and administered via feeding, survival rates on Day 7 were significantly higher than those observed in the OB-only treatment group. Similarly, when the polysaccharide was injected along with BV, a significant increase in survival was observed on Day 8 when compared to the BV-only treatment group. Furthermore, the co-injection of polysaccharide and BV resulted in the upregulation of immune-related genes associated with antimicrobial peptides (AMPs), such as gloverin 2, lebocin, hemolin, defensin, and beta-glucan recognition protein (βGRP), in <em>B. mori</em> within 48 h. These findings suggest that the polysaccharide enhances the immune response in <em>B. mori</em> and has potential as a natural antiviral agent for insect viruses.</div></div>","PeriodicalId":16296,"journal":{"name":"Journal of invertebrate pathology","volume":"214 ","pages":"Article 108474"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of natural products and synthetic analogs which inhibit microsporidia spores and prevent infection","authors":"Qingyuan Huang ,&nbsp;Lauren E. Brown ,&nbsp;Guoqing Pan ,&nbsp;Junhong Wei ,&nbsp;John A. Porco Jr ,&nbsp;Jie Chen ,&nbsp;Aaron W. Reinke","doi":"10.1016/j.jip.2025.108492","DOIUrl":"10.1016/j.jip.2025.108492","url":null,"abstract":"<div><div>Microsporidiosis, a disease caused by microsporidia, affects many animals, with symptoms ranging from diarrhea to death, especially in immunocompromised individuals. Current treatments, such as the drugs albendazole and fumagillin, are limited in efficacy. To address this problem, we utilized <em>Caenorhabditis elegans</em> infected with its naturally occurring microsporidian parasite <em>Nematocida parisii</em> to evaluate 4,080 structurally diverse compounds from the Boston University Center for Molecular Discovery (BU-CMD) chemical library. From this screen, we identified 34 compounds that restored the reproductive capacity of <em>C. elegans</em>. We chose 17 compounds for additional validation experiments and all of them prevented <em>N. parisii</em> infection in <em>C. elegans</em>, with 10 of these capable of suppressing microsporidia invasion by inactivating mature spores. Additionally, five of the identified compounds were effective against <em>Pancytospora epiphaga</em>, a species related to human<em>-</em>infecting microsporidia. Together this work identifies and characterizes compounds that inhibit microsporidia infection.</div></div>","PeriodicalId":16296,"journal":{"name":"Journal of invertebrate pathology","volume":"214 ","pages":"Article 108492"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wolbachia-Based Biocontrol of Aedes aegypti: Current Progress, Challenges, and Future Prospects","authors":"Ashif Ahamed ,&nbsp;Safdar Ali ,&nbsp;Mehboob Hoque","doi":"10.1016/j.jip.2025.108468","DOIUrl":"10.1016/j.jip.2025.108468","url":null,"abstract":"<div><div><em>Wolbachia</em> is used as a potential biocontrol tool to reduce dengue mosquitoes and also to reduce dengue virus (DENV) load in transinfected <em>Aedes aegypti</em>. Different field trials including the ones by the World Mosquito Program (WMP) have deployed <em>Wolbachia</em> carrying DENV primary vectors at different target sites worldwide. Field trials suggest that through the Population Replacement Strategy (PRS) and Incompatible Insect Technique (IIT), <em>Wolbachia</em> can either introgress into the local <em>Ae. aegypti</em> population or reduce their population size by cytoplasmic incompatibility, leading to subsequent reduction in dengue incidence at target sites. Key challenges for this strategy include establishing and sustaining the transinfected mosquito population, selecting the appropriate bacterial strain, ensuring the long term establishment of transinfected dengue mosquitoes across multiple generations, determining appropriate approach for mosquito field release, addressing operational constraints, and managing potential viral evolution. Moreover, the outcome of <em>Wolbachia</em> mediated biological control of <em>Ae. aegypti</em> in a broad scale is yet to be seen and the long-term stability of <em>Wolbachia</em> in transinfected mosquitoes remains unconfirmed. Significant success has been recorded in a broad scale deployment of <em>w</em>AlbB-carrying <em>Ae. aegypti</em> through the ongoing <em>Wolbachia</em> Malaysia project, resulting in reduction of dengue fever cases. Successful large-deployment of this strategy has also been performed in Colombia and Indonesia (1.7 to 3.3 million people and 135–540 km² area). Similar investigations on broad scale for longer period across different environmental conditions using transinfected mosquito deployment and associated risk analysis are imperative before adopting this biological control approach as a potent dengue control strategy worldwide.</div></div>","PeriodicalId":16296,"journal":{"name":"Journal of invertebrate pathology","volume":"214 ","pages":"Article 108468"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral load differences associated with infection outcomes and resistance to white spot syndrome virus (WSSV) infection in mud crab, Scylla serrata","authors":"Angela Camille Aguila-Toral ,&nbsp;Gardel Xyza L. Silvederio ,&nbsp;Dan Joseph Logronio ,&nbsp;Kelly S. Bateman ,&nbsp;Grant D. Stentiford ,&nbsp;Edgar C. Amar ,&nbsp;Rachel Ravago-Gotanco","doi":"10.1016/j.jip.2025.108450","DOIUrl":"10.1016/j.jip.2025.108450","url":null,"abstract":"<div><div>White spot syndrome virus (WSSV), the causative agent of white spot disease, remains a serious threat to crustacean aquaculture. Infecting a wide range of crustaceans, host species exhibit varying susceptibility and mortality rates. Mud crabs, <em>Scylla serrata,</em> a high-value aquaculture commodity across the Indo-Pacific region, are known to be relatively resistant to WSSV. However, there is limited information on the progression of WSSV infection in the species which can provide insight into mechanisms of resistance. Employing a time course experimental challenge of <em>S. serrata</em> with WSSV, this study characterized viral load dynamics in juveniles over a period of 144 h post infection (hpi) in relation to (1) disease outcomes (survival or mortality); (2) distribution among tissue types (gills, gut, hepatopancreas, and hemolymph); and (3) variability between two different juvenile cohorts. Viral load progression suggests that WSSV resistance in mud crabs may be due to two distinct mechanisms. One mechanism involves the capability of <em>S. serrata</em> for viral clearance following active viral replication. Viral growth in <em>S. serrata</em> demonstrates three phases: early stage or onset characterized by minimal change in viral load (0 to 24-hpi), logarithmic stage of active replication with rapid increase in viral copy number (24 to 72-hpi), with the third phase (96–144 hpi), exhibiting differential patterns with infection outcome. Dead crabs exhibited a plateau phase where viral loads remained similar to peak levels, while crabs that were still alive beyond 96 hpi exhibited a resolution phase, characterized by reduction in viral load, returning to non-infected levels. Another apparent mechanism for WSSV resistance involved overall inhibition of replication, with recalcitrant individuals exhibiting markedly low viral loads at expected logarithmic infection phase timepoints (48–72 hpi). This study also revealed tissue tropism of WSSV in <em>S. serrata.</em> Gills appear to be the primary site of WSSV replication, exhibiting the highest viral load from the early to peak stages of infection compared to other tissue types such as the gut, hepatopancreas, and hemolymph. The establishment of viral load curves to track the progression of WSSV infection, and characterization of viral abundance across different tissues through the course of infection, represents novel information that has key implications on the role of <em>S. serrata</em> as carriers/vectors of WSSV. This may have practical implications for disease mitigation measures for aquaculture facilities, and development of new strategies to prevent and reduce pathogen infection in mud crab to support sustainable aquaculture production.</div></div>","PeriodicalId":16296,"journal":{"name":"Journal of invertebrate pathology","volume":"214 ","pages":"Article 108450"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substitutions in the cardiac glycoside binding site of the Na+/K+-ATPase do not explain differences in salinity tolerance between Steinernema entomopathogenic nematodes","authors":"Perla Achi ,&nbsp;Cullen McCarthy ,&nbsp;Lanie Bavier ,&nbsp;Robert Pena ,&nbsp;W. Nate Collison ,&nbsp;Victoria Iglesias ,&nbsp;Preston Christensen ,&nbsp;Ahmed Aljidui ,&nbsp;Anil Baniya ,&nbsp;Connor Goldy ,&nbsp;Rose C. Adrianza ,&nbsp;Suraj Reddy ,&nbsp;Simon C. Groen ,&nbsp;Adler R. Dillman","doi":"10.1016/j.jip.2025.108494","DOIUrl":"10.1016/j.jip.2025.108494","url":null,"abstract":"<div><div>Soil salinity varies widely across geographies both due to natural factors and human activities, including agriculture, road salt application, sea level rise, and desertification. Increases in soil salinity may affect organisms widely and particularly impact soil food webs. As parasites, entomopathogenic nematodes (EPNs) occupy crucial links in soil food webs and are important for agriculture as biological control agents of insect pests. Previous research found that the EPN <em>Steinernema carpocapsae</em> may exhibit higher salt tolerance than several of its congeners. We recently identified that <em>S. carpocapsae</em> uniquely evolved two amino acid substitutions in the first extracellular loop of the sodium pump (Na⁺/K⁺-ATPase). Here, we tested whether these substitutions explain <em>S. carpocapsae</em>’s reported lower sensitivity to salt. Our results confirm that <em>S. carpocapsae</em> exhibits higher salt tolerance and show that it can more effectively locate and infect insect hosts than its congeners <em>S. feltiae</em> and <em>S. hermaphroditum</em> in highly saline environments. We then retraced the evolution of the two amino acid substitutions in <em>S. carpocapsae</em> by introducing them alone and in combination in <em>Caenorhabditis elegans</em> using CRISPR genome engineering. We found that <em>C. elegans</em> mutants with single substitutions showed improved salt tolerance. However, this improvement disappeared in the double mutant, whose sodium pump mimicked that of <em>S. carpocapsae</em>. This pattern of negative epistasis between the amino acid substitutions suggests they are not responsible for variation in salt tolerance between <em>Steinernema</em> species. Sodium pump evolution in <em>S. carpocapsae</em> might instead be driven by encounters with cardiac glycosides, which are released into soil by several clades of plants including milkweeds, sequestered by some of this EPN’s herbivorous insect hosts, and known to target the first extracellular loop of the sodium pump. Our findings provide valuable insights into EPN adaptation to changes in environmental sodium levels and may have implications for their use in biological control.</div></div>","PeriodicalId":16296,"journal":{"name":"Journal of invertebrate pathology","volume":"214 ","pages":"Article 108494"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morrittospora corbiculae n. gen. n. sp., a microsporidian parasite infecting the invasive Asian clam Corbicula fluminea from the River Thames, London","authors":"Rachel Foster ,&nbsp;Kelly S. Bateman ,&nbsp;Paul F. Clark ,&nbsp;Matthew J. Green ,&nbsp;Chantelle Hooper ,&nbsp;Stuart H. Ross ,&nbsp;Paul Stebbing ,&nbsp;Georgia M. Ward ,&nbsp;David Bass","doi":"10.1016/j.jip.2025.108478","DOIUrl":"10.1016/j.jip.2025.108478","url":null,"abstract":"<div><div>Microsporidia are highly diverse parasites of a broad range of eukaryotic hosts in both aquatic and terrestrial ecosystems. Freshwater diversity of microsporidia and their associations with bivalves is understudied, particularly in invasive non-native hosts. In this study we use molecular methods complemented by histopathology and transmission electron microscopy to screen native and invasive bivalve species from the River Thames for the presence of microsporidia. We reveal a novel microsporidian parasite infecting the invasive Asian clam <em>Corbicula fluminea</em> at a high prevalence, described in this manuscript as <em>Morrittospora corbiculae</em> n. gen. n. sp. Histopathology showed this parasite infects epithelial cells of <em>C. fluminea</em> digestive gland. Molecular and histopathology investigation also demonstrated potential spillover of infection to other co-habiting bivalve species in the River Thames. We place the newly described microsporidian lineage in a phylogenetic context and discuss the potential implications of microsporidian parasites in the spread of invasive non-native species.</div></div>","PeriodicalId":16296,"journal":{"name":"Journal of invertebrate pathology","volume":"214 ","pages":"Article 108478"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145390384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}