Journal of Laryngology and Otology最新文献_第8页

Pathways to the diagnosis of hypopharyngeal cancer in the West of Scotland. 苏格兰西部下咽癌的诊断途径。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-07-20 DOI: 10.1017/S002221512610560X

Olha Zahranychna, Volodymyr Vlasiuk, Jan Horackiewicz, Rhona Hurley, Malcolm A Buchanan, Panagiotis Asimakopoulos, Catriona M Douglas

{"title":"Pathways to the diagnosis of hypopharyngeal cancer in the West of Scotland.","authors":"Olha Zahranychna, Volodymyr Vlasiuk, Jan Horackiewicz, Rhona Hurley, Malcolm A Buchanan, Panagiotis Asimakopoulos, Catriona M Douglas","doi":"10.1017/S002221512610560X","DOIUrl":"10.1017/S002221512610560X","url":null,"abstract":"Objective: Hypopharyngeal cancer is characterised by low survival rates because of the prevalence of the advanced stage. This study aims to analyse the pathways to the diagnosis of hypopharyngeal cancer.Method: A retrospective observational cohort study of 434 patients diagnosed with hypopharyngeal cancer extracted from the Head and Neck cancer multidisciplinary team database in the West of Scotland over 14 years.Results: There were 434 patients with a mean age 67.3 years. The Urgent Suspicion of Cancer referral pathway had 237 patients (54.6 per cent), while 87 patients (20 per cent) had urgent or routine general practitioner referral, 101 (23.3 per cent) were referred by secondary care specialities and 55 (12.7 per cent) presented as emergencies. The majority of patients, 288 (66.3 per cent), experienced symptoms for 3 months before referral and 180 of patients (41.5 per cent) had an ENT clinic appointment within 2 weeks after referral.Conclusion: Diagnostic pathways to hypopharyngeal cancer are efficient despite a variety of clinical presentations. However, most patients present with short symptom duration and advanced disease, highlighting its aggressive nature.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-5"},"PeriodicalIF":1.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomical and Imaging-Based Measurement of the Human Semicircular Canals: From Manual Morphometry to AI-Driven Analysis. 人体半规管的解剖和成像测量：从手工形态测量到人工智能驱动的分析。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-07-20 DOI: 10.1017/S0022215126105593

Jie Zhang, Zhong Bai

引用次数: 0

The impact of an Advanced Nurse Practitioner-led tonsillectomy assessment pathway on patient access to care: a retrospective service evaluation. 高级执业护士主导的扁桃体切除术评估途径对患者获得护理的影响：一项回顾性服务评估。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-07-20 DOI: 10.1017/S0022215126105556

Carmel Connolly, Patrick Cotter

{"title":"The impact of an Advanced Nurse Practitioner-led tonsillectomy assessment pathway on patient access to care: a retrospective service evaluation.","authors":"Carmel Connolly, Patrick Cotter","doi":"10.1017/S0022215126105556","DOIUrl":"10.1017/S0022215126105556","url":null,"abstract":"Objective: To evaluate the impact of a consultant-governed Advanced Nurse Practitioner-led tonsillectomy assessment pathway on patient access to care and service delivery.Methods: A retrospective service evaluation was conducted using routinely collected data for patients referred for tonsillectomy assessment to one consultant service in 2018, prior to implementation, and during the subsequent four years, from 2019 to 2022.Results: Prior to implementation, 34 per cent of patients waited more than 36 months for assessment. By 2022, all patients were assessed within 18 months, with 89 per cent assessed within 12 months. Assessment activity increased substantially, overall referral-to-surgical procedure waiting times reduced and many patients were managed within the Advanced Nurse Practitioner-led pathway without onward consultant review.Conclusion: This consultant-governed Advanced Nurse Practitioner-led pathway was associated with improved access to specialist assessment, increased out-patient capacity and more efficient patient flow within a regional tertiary ear, nose and throat service.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-5"},"PeriodicalIF":1.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating biologic treatments in chronic rhinosinusitis with nasal polyps: a comprehensive review of patient selection. 引导慢性鼻窦炎伴鼻息肉的生物治疗：对患者选择的全面回顾。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-07-17 DOI: 10.1017/S0022215126105544

Nuray Bayar Muluk

{"title":"Navigating biologic treatments in chronic rhinosinusitis with nasal polyps: a comprehensive review of patient selection.","authors":"Nuray Bayar Muluk","doi":"10.1017/S0022215126105544","DOIUrl":"10.1017/S0022215126105544","url":null,"abstract":"Objectives: This review evaluates evidence-based criteria for selecting ideal candidates for biologic therapies in chronic rhinosinusitis with nasal polyps.Methods: A narrative literature search of PubMed, Scopus, Embase and Web of Science (2016-2026) was performed, synthesising data from clinical trials, observational studies and European Position paper on Rhinosinusitis and Nasal Polyps/European Forum for Research and Education in Allergy and Airway Diseasesguidelines.Results: Three United States Food and Drug Administration-approved biologics (dupilumab, mepolizumab and omalizumab) effectively target severe type 2 inflammation. Ideal candidates have prior sinus surgery and greater than or equal to three criteria: elevated T2 biomarkers, systemic corticosteroid dependence, severe anosmia, impaired quality of life or comorbid asthma. Drug selection must be endotype-driven: dupilumab for broad efficacy/non-steroidal anti-inflammatory drug exacerbated respiratory disease, mepolizumab for high eosinophilia/eosinophilic granulomatosis with polyangiitis and omalizumab for severe allergic asthma. Therapeutic efficacy requires mandatory reassessment at six- and 12-month intervals using objective clinical thresholds.Conclusion: Biologics act as a targeted, complementary strategy for refractory disease. Selecting patients demands a precision medicine approach based on accurate phenotyping within a collaborative multidisciplinary framework.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-5"},"PeriodicalIF":1.1,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients' experience of active transcutaneous bone conduction implants: a qualitative study highlighting gaps in clinician awareness. 主动经皮骨传导植入物的患者体验：一项强调临床医生意识差距的定性研究。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-07-17 DOI: 10.1017/S0022215126105611

Annabel Armour, Penny Hill-Feltham, Rachel Andrew, Rebecca Gladdis, Kevin Green, Emma Stapleton

{"title":"Patients' experience of active transcutaneous bone conduction implants: a qualitative study highlighting gaps in clinician awareness.","authors":"Annabel Armour, Penny Hill-Feltham, Rachel Andrew, Rebecca Gladdis, Kevin Green, Emma Stapleton","doi":"10.1017/S0022215126105611","DOIUrl":"10.1017/S0022215126105611","url":null,"abstract":"Objective: This study aimed to explore patients' experience of active transcutaneous hearing implants and identify factors influencing outcomes and access to care.Methods: A qualitative study was conducted at a tertiary referral centre. Adult recipients of active transcutaneous hearing implants were invited to complete open-ended questionnaires. Responses were analysed thematically using NVivo® software until saturation was achieved.Results: Thirty-one responses were analysed (69 percent response rate). Six themes were identified: impact of hearing loss; pre-operative experience; positive impact of the hearing implant; associated drawbacks; variation in audiology support; and limited awareness of hearing implants. Most patients reported significant improvements in hearing, confidence and quality of life. However, experiences were influenced by prior device use, expectations and individual circumstances. Limited clinician awareness was repeatedly identified as a barrier to timely access.Conclusion: Active transcutaneous hearing implants provide substantial patient-reported benefit. Improving clinician awareness and managing expectations may enhance patient experience and access to care.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148470993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin A and retinoids in the treatment of olfactory dysfunction: a systematic review. 维生素A和类维生素A治疗嗅觉功能障碍：系统综述。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-07-15 DOI: 10.1017/S0022215126105507

Kiran Joshi, Dilen Parmar, Heide Mills

{"title":"Vitamin A and retinoids in the treatment of olfactory dysfunction: a systematic review.","authors":"Kiran Joshi, Dilen Parmar, Heide Mills","doi":"10.1017/S0022215126105507","DOIUrl":"10.1017/S0022215126105507","url":null,"abstract":"Objective: To assess the efficacy and safety of vitamin A and retinoid analogues for adult olfactory dysfunction.Methods: A review conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines searched PubMed, Embase, Web of Science and the Cochrane Library from inception to September 2025 for clinical studies evaluating vitamin A or retinoids. Eligible designs included randomised trials, controlled trials, prospective cohorts and large case series.Results: Eight studies including 589 participants were identified. Findings were inconsistent: observational studies and pilot trials suggested possible benefit, particularly in post-infectious disease and with olfactory training, whereas two randomised trials found no significant added benefit. Safety reporting was limited.Conclusions: Current evidence does not support routine vitamin A treatment for olfactory dysfunction. Any benefit is uncertain and may be phenotype-, route- or dose-specific; adequately powered trials using standardised endpoints and adverse-event reporting are required.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Care Diagnosis of Nasal Polyps: A Retrospective Study of Diagnostic Accuracy and Oral Corticosteroid Prescribing Practices. 鼻息肉的初级保健诊断：诊断准确性和口服皮质类固醇处方实践的回顾性研究。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-07-15 DOI: 10.1017/S0022215126105386

Haider Merchant, Neil Tan

引用次数: 0

Necessity of calcium and calcitriol supplementation after total thyroidectomy for thyroid carcinoma. 甲状腺癌全甲状腺切除术后补钙和骨化三醇的必要性。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-07-15 DOI: 10.1017/S0022215126105477

Ryota Kiwaki, Takemasa Terao, Yorihisa Orita

{"title":"Necessity of calcium and calcitriol supplementation after total thyroidectomy for thyroid carcinoma.","authors":"Ryota Kiwaki, Takemasa Terao, Yorihisa Orita","doi":"10.1017/S0022215126105477","DOIUrl":"10.1017/S0022215126105477","url":null,"abstract":"Objectives: This retrospective observational study aimed to identify factors and predictors associated with the need for lifelong medication after total thyroidectomy for thyroid carcinoma.Methods: A total of 96 patients who underwent total thyroidectomy for thyroid carcinoma from July 2017 to July 2023 at a tertiary hospital were retrospectively reviewed.Results: Among the participants, 39 (40.6 per cent) of 96 required long-term calcium and calcitriol supplementation. A smaller number of preserved parathyroid glands during surgery was significantly correlated with the necessity to continue calcium supplementation. Poorly corrected calcium levels on the first post-operative day were significantly associated with the need to continue calcitriol and/or calcium supplementation.Conclusion: In patients undergoing total thyroidectomy for thyroid carcinoma, careful preservation of the parathyroid glands may reduce the risk of permanent calcium supplementation, whereas an early post-operative decline in serum calcium levels may help identify patients at a higher risk of requiring prolonged medication.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined olfactory training and pharmacotherapy for post-traumatic olfactory dysfunction: a retrospective comparative study. 嗅觉训练与药物治疗联合治疗创伤后嗅觉功能障碍的回顾性比较研究。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-07-15 DOI: 10.1017/S0022215126105519

Kento Takeichi, Masayoshi Kobayashi, Kohei Nishida, Hiroyuki Morishita, Eisuke Ishigami, Misato Suzumura

引用次数: 0

Racial differences in bone density variation in head and neck cancer patients with osteoradionecrosis: A pilot study. 头颈癌伴骨放射性坏死患者骨密度变化的种族差异-一项初步研究。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-07-14 DOI: 10.1017/S0022215126105532

Srivatsa Surya Vasudevan, Abhijit Gundale, Eleni Mijalis, Amol Takalkar, Kent Burton, Tara Moore-Medlin, Jerry McLarty, Cherie-Ann O Nathan

{"title":"Racial differences in bone density variation in head and neck cancer patients with osteoradionecrosis: A pilot study.","authors":"Srivatsa Surya Vasudevan, Abhijit Gundale, Eleni Mijalis, Amol Takalkar, Kent Burton, Tara Moore-Medlin, Jerry McLarty, Cherie-Ann O Nathan","doi":"10.1017/S0022215126105532","DOIUrl":"10.1017/S0022215126105532","url":null,"abstract":"Objectives: This study aimed to assess pre- and post-radiation therapy mandibular bone densities in head and neck cancer patients with osteoradionecrosis and factors associated with decreased bone densities.Methods: Retrospective pilot study (2007-2017) of osteoradionecrosis patients after 66- to 70-gray radiation therapy. Cortical and cancellous mandibular bone densities ipsilateral/contralateral to tumour were measured on pre-radiation therapy and at three-month and one-year post-radiation therapy positron emission tomography/computed tomography. Two-way analysis of variance and linear regression were used as exploratory analyses, given the pilot nature of the study.Results: Sixteen of 67 head and neck cancer patients had osteoradionecrosis (41-67 years of age; nine African Americans, seven Caucasians). Bone density did not significantly change from baseline within either racial group. African Americans had higher bone densities than Caucasians (pre-radiation therapy ipsilateral cortical: 1044 ± 229.8 vs. 965.6± 278.7 Hounsfield units). At one year, African Americans had higher contralateral cortical (+35.5 per cent; p = 0.008) and cancellous (+109.4 per cent; p = 0.028) bone densities. Multivariable models showed lower contralateral cortical (p = 0.039) and cancellous (p = 0.005) bone densities in Caucasians.Conclusion: In this small pilot study, mandibular bone densities appeared higher in African Americans, with a greater post-radiation therapy reduction observed in Caucasians; these findings are exploratory and require validation in larger cohorts.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-9"},"PeriodicalIF":1.1,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0