Journal of Laryngology and Otology最新文献

The role of human papillomavirus in the pathogenesis of oropharyngeal squamous cell carcinoma and the impact of vaccination on disease prevention: a narrative review. 人乳头瘤病毒在口咽鳞状细胞癌发病机制中的作用以及疫苗接种对疾病预防的影响：一篇叙述性综述。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-11-05 DOI: 10.1017/S0022215126106124

Muonga Chiyokoma Kabaso, Mahati Iyyappan, Rahma Islam, Deethya Balamurali, Shogo Tajima, Ellie McDougall, Zunair Rahman

{"title":"The role of human papillomavirus in the pathogenesis of oropharyngeal squamous cell carcinoma and the impact of vaccination on disease prevention: a narrative review.","authors":"Muonga Chiyokoma Kabaso, Mahati Iyyappan, Rahma Islam, Deethya Balamurali, Shogo Tajima, Ellie McDougall, Zunair Rahman","doi":"10.1017/S0022215126106124","DOIUrl":"https://doi.org/10.1017/S0022215126106124","url":null,"abstract":"Objective: Oropharyngeal squamous cell carcinoma accounts for over a third of head and neck cancers, with the cost of treatment in the UK reaching £14.3 billion over 15 years. Human papillomavirus (HPV) has surpassed smoking and alcohol as the leading aetiological driver. This review examines HPV pathogenesis and the impact of vaccination on disease prevention.Methods: PubMed, Embase and Medline were searched for articles published to December 2025, combining terms including oropharyngeal, squamous cell carcinoma, HPV, vaccines, pathogenesis and phosphoinositide 3 kinase. Gynaecological HPV malignancies were excluded, and reference lists were hand-searched.Results: Human papillomavirus 16 E6 and E7 oncoproteins degrade p53 and retinoblastoma protein, dysregulate phosphoinositide 3 kinase, protein kinase B and mechanistic target of rapamycin signalling and drive genomic instability. p16 is a useful but imperfect surrogate biomarker. Vaccination reduces oral HPV prevalence and is projected to lower incidence, although uptake remains suboptimal among males and in deprived areas.Conclusion: Gender-neutral vaccination, improved uptake and the development of therapeutic vaccines and phosphoinositide 3 kinase-targeted therapies offer realistic strategies to reduce disease burden.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-7"},"PeriodicalIF":1.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149334220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trans-septal suturing versus intranasal splinting following septoplasty: a systematic review and meta-analysis. 中隔成形术后经鼻中隔缝合与鼻内夹板：一项系统回顾和荟萃分析。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-11-05 DOI: 10.1017/S0022215126106185

Do Hyun Kim, David W Jang, Sehwan Hwang

{"title":"Trans-septal suturing versus intranasal splinting following septoplasty: a systematic review and meta-analysis.","authors":"Do Hyun Kim, David W Jang, Sehwan Hwang","doi":"10.1017/S0022215126106185","DOIUrl":"https://doi.org/10.1017/S0022215126106185","url":null,"abstract":"Objectives: To compare the efficacy and safety of trans-septal suturing versus intranasal splinting after septoplasty through a systematic review and meta-analysis, focusing on post-operative complications and patient-centred outcomes.Methods: Comparative studies directly evaluating both techniques were included. Pooled odds ratios and standardised mean differences with 95 per cent confidence intervals were calculated.Results: Seventeen studies involving 1502 patients were included. No significant differences were found in adhesion, crust formation, septal haematoma, septal perforation or post-operative bleeding. Trans-septal suturing significantly reduced post-operative pain (standardised mean differences, -1.09; 95 per cent confidence intervals, -1.68 to -0.49) and sleep disturbance (standardised mean differences, -0.32; 95 per cent confidence intervals, -0.60 to -0.05) but increased operative time (standardised mean differences, 0.65; 95 per cent confidence intervals, 0.19-1.10). Infection and epiphora tended to be less frequent with trans-septal suturing.Conclusion: Both techniques provide comparable protection against major post-operative complications, but trans-septal suturing improves post-operative comfort at the cost of a modest increase in operative time.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-12"},"PeriodicalIF":1.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149334222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring referring practitioners' preferences for otolaryngology-head and neck surgery clinical letters. 探讨转诊医师对耳鼻喉头颈外科临床信函的偏好。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-11-05 DOI: 10.1017/S0022215126104897

Jennifer Eva Payandeh, Richard Gall

{"title":"Exploring referring practitioners' preferences for otolaryngology-head and neck surgery clinical letters.","authors":"Jennifer Eva Payandeh, Richard Gall","doi":"10.1017/S0022215126104897","DOIUrl":"https://doi.org/10.1017/S0022215126104897","url":null,"abstract":"Objectives: Effective communication between specialists and primary care providers is important for optimal care. This cross-sectional study explored primary care providers' preferences for concise versus detailed clinical letters in otolaryngology-head and neck surgery.Methods: A survey was sent to primary care providers in Manitoba, Canada, to reflect on their past experiences and review sample concise and detailed letters. Quantitative data were analysed using Wilcoxon matched-pairs signed-rank tests and chi-squared tests. Qualitative responses were thematically analysed.Results: Seventy-five percent of respondents (57 incomplete responses, 39 complete) preferred concise letters, citing the readability, inclusion of key information and clear treatment plans. Some participants requested the inclusion of interim recommendations and more comprehensive details. Preferences did not differ by profession (p < 0.05).Conclusion: Most primary care providers prefer concise clinical letters. Detailed rationale and interim plans can be integrated into concise formats to enhance usability without sacrificing essential information. Optimising clinical letters for conciseness may enhance interprofessional communication and care coordination.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149334218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Tranexamic Acid in Septorhinoplasty: An Umbrella Review of Systematic Reviews and Meta-Analyses. 氨甲环酸在鼻中隔成形术中的疗效和安全性：系统评价和荟萃分析综述。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-11-05 DOI: 10.1017/S0022215126106604

Ebraheem Albazee, Husain Alsaffar, Abdullah Shakhs Alghamdi, Ahmad Saad Alharthi, Bayan Khalid Sabb Gul

引用次数: 0

Paediatric Eustachian tube balloon dilatation: the first UK experience. 小儿咽鼓管球囊扩张：英国首例经验。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-11-05 DOI: 10.1017/S0022215126106069

Emma Hogg, Grace Khong, Sunil Dutt Sharma

{"title":"Paediatric Eustachian tube balloon dilatation: the first UK experience.","authors":"Emma Hogg, Grace Khong, Sunil Dutt Sharma","doi":"10.1017/S0022215126106069","DOIUrl":"https://doi.org/10.1017/S0022215126106069","url":null,"abstract":"Background: Eustachian tube balloon dilatation is a minimally invasive procedure to treat Eustachian tube dysfunction. Although widely adopted in adults, there are no published UK paediatric series. This project evaluated outcomes of balloon dilatation for Eustachian tube dysfunction in children treated at our tertiary ENT paediatric unit.Methods: A retrospective review was conducted of paediatric patients undergoing balloon dilatation for Eustachian tube dysfunction over a three-year period. Eustachian Tube Dysfunction Questionnaire-7 scores were recorded pre-operatively and at six weeks and three months post-operatively.Results: Sixteen patients underwent balloon dilatation and 46 per cent of patients had concurrent procedures. The mean pre-operative Eustachian Tube Dysfunction Questionnaire-7 score was 27.1, improving significantly to 12.4 at 6 weeks and 11.25 at 3 months (p < 0.0001). All patients demonstrated symptomatic improvement, including those with repaired cleft palate who had undergone repeated ventilation tube insertion previously.Conclusion: Balloon dilatation significantly improved patient-reported outcomes in paediatric Eustachian tube dysfunction and this study represents the first reported UK paediatric series.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-3"},"PeriodicalIF":1.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149334219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Clinical Benefit And Treatment Tolerability Of Fluticasone Versus Fluticasone-Azelastine Therapy In Moderate-To-Severe Allergic Rhinitis. 氟替卡松治疗中重度变应性鼻炎的早期临床获益和治疗耐受性比较

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-11-05 DOI: 10.1017/S0022215126106690

Uğur Alptürk, Bülent Topuz, Erdem Mengi, Cüneyt Orhan Kara

引用次数: 0

Time-dependent predictors of bone-anchored hearing implant extrusion after primary implantation: a longitudinal study. 初次植入术后骨锚定助听器挤压的时间依赖预测因素：一项纵向研究。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-11-05 DOI: 10.1017/S0022215126105982

Ali Esseili, Tyler J Gathman, Julio Roque, Lulia Kana, Joseph Norman, Izza Ali, Masanari Kato, Hyunseo Jung, Rachel Goffeney, Sandra Porps, Seilesh Babu

引用次数: 0

Management and outcomes of small U3-U4 thyroid nodules: do sub-centimetre U3 nodules require biopsy? 小U3- u4甲状腺结节的治疗和结果：亚厘米U3结节需要活检吗？

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-11-04 DOI: 10.1017/S0022215126105301

Noon Nassr, Kala Kumaresan, Sinnappa Gunasekaran, Nalinda Panditaratne

{"title":"Management and outcomes of small U3-U4 thyroid nodules: do sub-centimetre U3 nodules require biopsy?","authors":"Noon Nassr, Kala Kumaresan, Sinnappa Gunasekaran, Nalinda Panditaratne","doi":"10.1017/S0022215126105301","DOIUrl":"https://doi.org/10.1017/S0022215126105301","url":null,"abstract":"Objective: To evaluate management and outcomes of small (≤20 mm) U3-U4 thyroid nodules in UK practice and assess whether selected sub-centimetre U3 nodules require biopsy.Methods: Retrospective cohort study at a UK district general hospital, including U3-U4 thyroid nodules ≤20 mm identified in 2022, with a follow-up to June 2025. The primary outcome was histologically confirmed thyroid malignancy. Secondary outcomes included fine-needle aspiration, cytology and surgical intervention.Results: Eight-one nodules (73 patients) were included. Sixty-one nodules (75.3 per cent) underwent fine-needle aspiration and 31 nodules (38.3 per cent) underwent surgical procedure. The investigation was driven by ultrasound grade rather than size. Sub-centimetre nodules were less likely to be resolved by fine-needle aspiration or surgical procedure. Among the resected nodules, 26 out of 31 (83.9 per cent) were malignant, with no difference across size bands.Conclusion: Management of small U3-U4 nodules is determined by ultrasound grade and cytology rather than size. These findings support the consideration of a surveillance-first approach for selected sub-centimetre U3 nodules, provided the appropriate follow-up pathways are in place.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149322122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regarding 'Does dorsal preservation rhinoplasty preserve nasal airway function? A systematic review'. 关于“背侧保留鼻成形术是否保留鼻气道功能？”系统评价”。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-11-04 DOI: 10.1017/S0022215126106215

Andre Sousa Machado

引用次数: 0

Recurrent Respiratory Papillomatosis: Current Evidence, Knowledge Gaps and Future Directions. 复发性呼吸道乳头状瘤病：目前的证据，知识差距和未来的方向。

IF 1.1 4区医学

Journal of Laryngology and Otology Pub Date : 2026-11-03 DOI: 10.1017/S0022215126106677

Emke Van den Broek, Soumaya Asaggau

引用次数: 0