Bhargavi Chandrasekar, Alexandra Bell, Andrew Kinshuck
{"title":"Prevalence and risk factors for dysplasia and malignancy in a large cohort of patients with recurrent respiratory papillomatosis.","authors":"Bhargavi Chandrasekar, Alexandra Bell, Andrew Kinshuck","doi":"10.1017/S0022215124002172","DOIUrl":"10.1017/S0022215124002172","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to evaluate the rate of dysplasia and carcinoma-ex-papillomatosis in patients with recurrent respiratory papillomatosis and assess for any risk factors.</p><p><strong>Methods: </strong>A 15-year retrospective observational cohort study was performed from a single centre. Data on patient demographics, treatment history and pathology results were extracted from clinical records.</p><p><strong>Results: </strong>Of the 123 patients identified, nine had juvenile-onset recurrent respiratory papillomatosis and 114 had adult-onset recurrent respiratory papillomatosis. Thirteen (11 per cent) of patients with adult-onset recurrent respiratory papillomatosis had dysplasia, and one patient progressed to carcinoma-ex-papillomatosis. Patients with evidence of dysplasia had an average older age of disease onset compared to those without dysplasia (49 years <i>vs</i> 39 years, <i>p</i> = 0.03).</p><p><strong>Conclusion: </strong>An older age of recurrent respiratory papillomatosis onset was the only risk factor for dysplasia. Gender, tobacco use, subglottic or tracheal involvement, number of surgeries and cidofovir were not prognostic factors in this series.</p>","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"507-511"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ménière's 'drop attacks' and a changing of the guard at <i>The Journal of Laryngology & Otology</i>.","authors":"Edward Fisher","doi":"10.1017/S0022215125102685","DOIUrl":"https://doi.org/10.1017/S0022215125102685","url":null,"abstract":"","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":"139 6","pages":"433"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"To evaluate the results of mastoid obliteration and reconstruction of posterior meatal wall after canal wall down mastoidectomy using ready-to-use, self-setting hydroxyapatite bone cement.","authors":"Salman Hashmi, Syed Zohaib Maroof Hussain, Owais Matto, Samuel Dewhurst, Asad Qayyum","doi":"10.1017/S0022215124001737","DOIUrl":"10.1017/S0022215124001737","url":null,"abstract":"<p><strong>Objectives: </strong>Despite a lot of scientific advancements in otology, canal wall-down mastoidectomy is still considered to be the standard of care in the management of extensive cholesteatoma. To avoid large cavity related problems, mastoid obliteration has been described in the literature for many decades. Controversy prevails among otologists regarding the materials used for obliteration. This study aimed to evaluate the results of mastoid obliteration and reconstruction of posterior meatal wall after mastoidectomy using ready-to-use, self-setting hydroxyapatite bone cement.</p><p><strong>Methods: </strong>Retrospective analysis was performed of all consecutive patients who underwent canal wall down mastoidectomies and primary mastoid obliteration with ready-to-use, self-setting hydroxyapatite bone cement. Minimum follow-up was 1 year. Primary Outcome measures include need for explantation and post-operative complications.</p><p><strong>Results: </strong>Total of 26 patients were included in the study. Only one patient required complete explantation. All patients acquired dry cavities in the final follow-up. Few minor complications including external auditory canal granulations and post-aural wound dehiscence. There was no cholesteatoma recidivism.</p><p><strong>Conclusion: </strong>Ready-to-use, self-setting hydroxyapatite bone cement serves the purpose of mastoid obliteration. In addition, it is time efficient and requires less expertise. It has excellent outcomes in terms of cholesteatoma recidivism. We recommend further research in this area with a large cohort.</p>","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"458-463"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kieran Chalmers, Phillip Staibano, Michael K Gupta, Michael Au
{"title":"Mucoepidermoid carcinoma of unknown primary in the head and neck: a case report and review of the literature.","authors":"Kieran Chalmers, Phillip Staibano, Michael K Gupta, Michael Au","doi":"10.1017/S0022215124002147","DOIUrl":"10.1017/S0022215124002147","url":null,"abstract":"<p><strong>Objective: </strong>Mucoepidermoid carcinoma of unknown primary (MEC-UP) in the head and neck is a rare presentation of the most common salivary gland cancer. Cancers of unknown primary sites often have poorer prognoses than similar cancers with known primary. Few cases of MEC-UP have been reported; therefore, the objective of this report is an overview of the diagnosis and management of MEC-UP.</p><p><strong>Methods: </strong>We present two patients with low-grade MEC-UP at a high-volume tertiary care institution in Ontario, and a database search returning 1560 citations of which five studies with seven MEC-UP cases were identified.</p><p><strong>Results: </strong>Review of the limited cases suggest many clinicians use positron emission tomography-computed tomography (PET-CT) in addition to panendoscopy and targeted biopsies with consideration for diagnostic tonsillectomy in diagnostic work-up.</p><p><strong>Conclusion: </strong>Like other salivary gland cancers, primary therapeutic surgical resection is recommended with low threshold for adjuvant radiotherapy to regions at high risk for harbouring the primary malignancy, especially in cases of high-grade histopathology.</p>","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"521-525"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predicting fall risk in elderly ındividuals: a comparative analysis of machine learning models using patient characteristics, functional balance tests and computerized dynamic posturography.","authors":"Emre Soylemez, Suna Tokgoz-Yilmaz","doi":"10.1017/S0022215124002160","DOIUrl":"10.1017/S0022215124002160","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to predict the risk of falling using patient characteristics, computerized dynamic posturography and functional balance tests in machine learning.</p><p><strong>Methods: </strong>One hundred twenty elderly individuals were included in this study. The fall status, physical characteristics and medical history of individuals were investigated. Pure tone audiometry test, simple functional balance tests and sensory organization test were applied to the individuals.</p><p><strong>Results: </strong>The machine learning model that incorporated co-morbidities, physical characteristics and functional balance tests achieved a 100 per cent accuracy in predicting fall risk. Models using only co-morbidities and physical characteristics, functional balance tests or the sensory organization test had accuracies of 87.5 per cent, 83.34 per cent and 91.66 per cent, respectively.</p><p><strong>Conclusion: </strong>Advanced balance systems are not always necessary to assess fall risk. Instead, fall risk can be effectively determined using simple balance tests, co-morbidities, and patient characteristics in machine learning.</p>","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"464-472"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dean G Kennedy, Amos M Mwaura, Nicholas R Wilson, Jonathan M Carnino, Jessica R Levi
{"title":"Understanding paediatric laryngomalacia: a study of social determinants and associated diseases.","authors":"Dean G Kennedy, Amos M Mwaura, Nicholas R Wilson, Jonathan M Carnino, Jessica R Levi","doi":"10.1017/S0022215124001567","DOIUrl":"10.1017/S0022215124001567","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the influence of socioeconomic factors on the incidence of laryngomalacia in paediatric in-patients.</p><p><strong>Methods: </strong>Data from the 2016 Healthcare Cost and Utilization Project Kid Inpatient Database were analysed. Variables included zip code median income, race and/or ethnicity, primary expected payer and associated International Statistical Classification of Diseases and Related Health Problems 10th Revision codes in admission.</p><p><strong>Results: </strong>Lower median income zip codes showed a 6.4 per cent increase in laryngomalacia admissions, while higher-income zip codes had an 8.0 per cent decrease. Black patients exhibited a 24.5 per cent increase and Asian or Pacific Islander patients showed a 42.5 per cent decrease in laryngomalacia admissions. Medicaid and other government programme payers had a 22.1 per cent increase, while Medicare, private insurance and self-pay patients had decreases of 35.5, 20.9 and 55.7 per cent, respectively. Laryngomalacia was associated with a number of disease processes from a multitude of organ systems in a statistically significant manor.</p><p><strong>Conclusion: </strong>Socioeconomic status, race, primary expected payer and co-morbid disease process significantly impact laryngomalacia admissions.</p>","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"501-506"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shadia Hashim Kurichiyil, Joshua D Whittaker, C Lucy Dalton
{"title":"Face and content validation of artificial temporal bone dissection for otolaryngology training.","authors":"Shadia Hashim Kurichiyil, Joshua D Whittaker, C Lucy Dalton","doi":"10.1017/S0022215124001774","DOIUrl":"10.1017/S0022215124001774","url":null,"abstract":"<p><strong>Objective: </strong>To assess the face and content validity of artificial temporal bone dissection in surgical training in the UK.</p><p><strong>Methods: </strong>Expert and non-expert groups participated in artificial temporal bone dissection at the Queen Elizabeth Hospital, Birmingham, UK. Face and content validity were assessed by a validated post-dissection questionnaire.</p><p><strong>Results: </strong>The median content validity score was 34 out of 35 (interquartile range 32.00-35.00). Mean face validity score compared to human was 45.76 out of 65 (95 per cent CI 42.57-48.94). Face validity compared to cadaveric models demonstrated equivalence (95 per cent CI 25.30-30.70, crossing equivalence value 27.00). Experts rated face validity less favourably than non-experts (<i>p</i> = 0.012 and 0.042, respectively). Content validity was equivalent between experts and non-experts (<i>p</i> = 0.052). There were no significant differences in total content (<i>p</i> = 0.606) and face validity (<i>p</i> = 0.133, <i>p</i> = 0.105) scores between different artificial bones.</p><p><strong>Conclusion: </strong>The high content and face validity suggests ENT training programs should consider formally incorporating artificial models into mastoid surgery training pathways.</p>","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"451-457"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TP53 mutation may underlie increasing incidence of external auditory canal carcinoma.","authors":"A Pandya, D Chandrasekharan, K Suchak, J S Virk","doi":"10.1017/S0022215124002159","DOIUrl":"10.1017/S0022215124002159","url":null,"abstract":"<p><strong>Background: </strong>Primary neoplasm of the external auditory canal has historically been documented to have a low incidence rate of between one and six per million internationally, with UK incidence yet to be officially cited.</p><p><strong>Methods: </strong>Here, we report a rise in incidence at a single UK trust with seven carcinomas (six T4 external auditory canal squamous cell and one T4 basal cell) reported within an 18-month period. All tumours underwent next generation sequencing.</p><p><strong>Results: </strong>The cases recorded represented a twofold rise in incidence in reference to international literature from a population-adjusted estimate of 0.5-3 cases for the catchment area to seven cases. All cases were treated with temporal bone resections (n = 7) and with post-operative radiotherapy in six cases. Tumour analysis showed all were <i>TP53</i> mutant and human papilloma virus (HPV)/<i>P16</i> negative.</p><p><strong>Conclusion: </strong>We suggest chronic inflammation and genetic alterations as putative contributory factors in our case series and outline clinical strategies for timely detection of external auditory canal neoplasms.</p>","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"482-487"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jesslyn Clarance Lamtara, Sudanthi Wijewickrema, Jean-Marc Gerard, Stephen O'Leary
{"title":"Face and content validation of additive manufacturing temporal bone specimens.","authors":"Jesslyn Clarance Lamtara, Sudanthi Wijewickrema, Jean-Marc Gerard, Stephen O'Leary","doi":"10.1017/S0022215124002226","DOIUrl":"10.1017/S0022215124002226","url":null,"abstract":"<p><strong>Background: </strong>Otology training solely using cadavers is challenging because of scarcity and high costs. The use of additive manufacturing technology is a promising alternative. This study aimed to qualitatively validate new additive manufacturing temporal bone specimens for their realism and ability to train surgical skills.</p><p><strong>Methods: </strong>Three additive manufacturing models generated using cadaveric temporal bones were evaluated. Three otologists with experience as trainers dissected and evaluated each specimen.</p><p><strong>Results: </strong>The additive manufacturing specimens scored an average of 4.26 ± 0.72 (out of 5) points and received positive feedback. The agreement between the three expert raters was high (intra-class correlation coefficient of 0.745).</p><p><strong>Conclusion: </strong>The results suggested that the additive manufacturing temporal bones were able to faithfully reproduce a training experience similar to that on cadaveric temporal bones. Further studies that investigate the effectiveness of these specimens in training surgical skills are needed before integrating them into surgical training curricula.</p>","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"473-481"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}