Picrotoxin for vertigo control in Ménière's disease and other peripheral vestibular disorders: a systematic review.

IF 0.8 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of Laryngology and Otology Pub Date : 2025-07-14 DOI:10.1017/S0022215125102727

Stefan Lyutenski, Paul James, Marc Bloching

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引用次数: 0

Abstract

Objectives: The aim of this study is to systematically review and analyse the literature regarding clinical application of picrotoxin for vertigo caused by peripheral vestibular disorders.

Methods: We conducted a search in PubMed/MEDLINE and Google Scholar in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses recommendations. The primary selection included all studies exploring the effect of this phytopharmacological substance on the vestibular system and vertigo. The secondary selection included only reports on its clinical use for treatment of Ménière's disease and other peripheral vestibular disorders.

Results: From the 398 identified studies, 18 were included from the primary selection and 6 from the secondary selection. In total, 203 patients received picrotoxin; 85 of them were treated for vertigo with 1-mg picrotoxin suppositories. In this subgroup vertigo was reduced in 74.9 per cent.

Conclusion: Picrotoxin is a non-invasive treatment option worth considering, especially in cochlear-implanted patients with recurring disabling vertigo.

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肉毒杆菌毒素用于控制梅尼埃病和其他外周前庭疾病的眩晕：系统综述。

目的：本研究的目的是系统地回顾和分析有关微旋毒素治疗周围前庭疾病引起的眩晕的临床应用的文献。方法：根据系统评价和荟萃分析推荐的首选报告项目，我们在PubMed/MEDLINE和谷歌Scholar中进行了检索。初步选择包括所有探索这种植物药理学物质对前庭系统和眩晕的影响的研究。二次选择仅包括有关其用于治疗membrolizine病和其他周围前庭疾病的临床应用的报告。结果：在确定的398项研究中，18项来自初级选择，6项来自次级选择。203例患者接受了微毒素治疗；其中85例用微毒素栓剂1 mg治疗眩晕。结论：Picrotoxin是一种值得考虑的非侵入性治疗选择，特别是对于耳蜗植入患者反复致残性眩晕。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.