Journal of Liposome Research最新文献_第7页

Statement of Retraction: Biotin anchored nanostructured lipid carriers for targeted delivery of doxorubicin in management of mammary gland carcinoma through regulation of apoptotic modulator. 撤回声明：生物素锚定纳米结构脂质载体通过调节凋亡调节剂靶向递送多柔比星治疗乳腺癌

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-06-01 Epub Date: 2024-04-28 DOI: 10.1080/08982104.2024.2348220

引用次数: 0

Enhancing selegiline hydrochloride efficacy: Box Behnken-optimized liposomal delivery via intranasal route for Parkinson’s disease intervention 提高盐酸西格列汀的疗效：通过鼻内途径优化脂质体给药，干预帕金森病

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-04-09 DOI: 10.1080/08982104.2024.2336549

Kartik Bhairu Khot, Sandeep D S, Gopika Gopan, Shridhar Deshpande N, Prajna Shastry, Akshay Bandiwadekar, Jobin Jose

引用次数: 0

Pharmacokinetics and pharmacodynamic evaluation of hyaluronic acid-modified imatinib-loaded PEGylated liposomes in CD44-positive Gist882 tumor-bearing mice. 在 CD44 阳性 Gist882 肿瘤小鼠体内对透明质酸修饰的伊马替尼负载 PEG 脂质体进行药代动力学和药效学评估。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-07-04 DOI: 10.1080/08982104.2023.2228888

Ju Huang, Jian Chen

{"title":"Pharmacokinetics and pharmacodynamic evaluation of hyaluronic acid-modified imatinib-loaded PEGylated liposomes in CD44-positive Gist882 tumor-bearing mice.","authors":"Ju Huang, Jian Chen","doi":"10.1080/08982104.2023.2228888","DOIUrl":"10.1080/08982104.2023.2228888","url":null,"abstract":"To develop a PEGylated and CD44-targeted liposomes, enabled by surface coating with hyaluronic acid (HA) via amide bond to improve the efficacy of imatinib mesylate (IM), for tumor-targeted cytoplasmic drug delivery. HA was covalently grafted on DSPE-PEG2000-NH2 polymer. HA-modified or unmodified PEGylated liposomes were prepared with ethanol injection method, and the stability, drug release, and cytotoxicity of these liposomes were studied. Meanwhile, intracellular drug delivery efficiency, antitumor efficacy, and pharmacokinetics were also investigated. Ex vivo fluorescence biodistribution was also detected by small animal imaging. In addition, endocytosis mechanism was also explored HA-coated PEGylated liposomes (137.5 nm ± 10.24) had a negative zeta potential (-29.3 mV ± 5.44) and high drug loading (27.8%, w/w). The liposomes were stable with cumulative drug leakage (<60%) under physiological conditions. Blank liposomes were nontoxic to Gist882 cells, and IM-loaded liposomes had higher cytotoxicity to Gist882 cells. HA-modified PEGylated liposomes were internalized more effectively than non-HA coating via CD44-mediated endocytosis. Besides, the cellular uptake of HA-modified liposomes also partly depends on caveolin-medicated endocytosis and micropinocytosis. In rats, both liposomes produced a prolonged half-life of IM (HA/Lp/IM: 14.97h; Lp/IM: 11.15h) by 3- to 4.5-folds compared with the IM solution (3.61h). HA-decorated PEGylated liposomes encapsulated IM exhibited strong inhibitory effect on tumor growth in Gist882 cell-bearing nude mice and formation of 2D/3D tumor spheroids. The Ki67 immunohistochemistry result was consistent with the above results. IM-loaded PEGylated liposomes modified with HA exerted the excellent anti-tumor effect on tumor-bearing mice and more drugs accumulated into the tumor site.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"97-112"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9749651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of GHK peptide-heparin interactions in multifunctional liposomal covering. 评估多功能脂质体中 GHK 肽与肝素的相互作用。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-05-05 DOI: 10.1080/08982104.2023.2206894

Viktoriia Nikolaeva, Marat Kamalov, Timur I Abdullin, Diana Salakhieva, Vitaly Chasov, Alexey Rogov, Mohamed Zoughaib

{"title":"Evaluation of GHK peptide-heparin interactions in multifunctional liposomal covering.","authors":"Viktoriia Nikolaeva, Marat Kamalov, Timur I Abdullin, Diana Salakhieva, Vitaly Chasov, Alexey Rogov, Mohamed Zoughaib","doi":"10.1080/08982104.2023.2206894","DOIUrl":"10.1080/08982104.2023.2206894","url":null,"abstract":"Small biospecific peptides with defined chemical structure and cellular responses are promising alternatives to full-length therapeutic proteins. Identification of these peptides solely or in combination with other bioactive factors and determination of their targets are of substantial interest in current drug delivery research. This study is aimed at the development of new liposomal formulations of ECM-derived GHK peptide known for its multiple regeneration-related activities but poorly recognized cellular targets. In situ association of membranotropic GHK derivative with unilamellar liposomes was performed to prepare GHK-modified liposomes with defined properties. According to DLS, the GHK component on the liposomal surface interacted with heparin in a specific manner compared to other polysaccharides and RGD counterpart, whereas ITC analysis of such interactions was complicated. The results provide a useful tool for screening of bio-interactions of synthetic peptide-presenting liposomes by the DLS technique. They were also employed to produce a multi-functional nanosized GHK-heparin covering for liposomes. The resulting composite liposomes possessed low size dispersity, increased anionic charge, and mechanical rigidity. The heparin component significantly promoted the accumulation of GHK-modified liposomes in 3T3 fibroblasts so that the composite liposomes exhibited the highest cell-penetrating activity. Furthermore, the latter formulation stimulated cell proliferation and strongly inhibited ROS production and GSH depletion under oxidative stress conditions. Together, the results support that cell-surface glycosaminoglycans can be involved in GHK-mediated liposomal delivery, which can be further greatly enhanced by association with heparin. The composite liposomes with GHK-heparin covering can be considered as an advanced GHK-based formulation for therapeutic and cosmeceutical applications.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"18-30"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9403168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the role of lipid composition on liposome-protein interactions. 揭示脂质成分对脂质体-蛋白质相互作用的作用

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-06-20 DOI: 10.1080/08982104.2023.2224449

Valeria Nele, Federica D'Aria, Virginia Campani, Teresa Silvestri, Marco Biondi, Concetta Giancola, Giuseppe De Rosa

{"title":"Unravelling the role of lipid composition on liposome-protein interactions.","authors":"Valeria Nele, Federica D'Aria, Virginia Campani, Teresa Silvestri, Marco Biondi, Concetta Giancola, Giuseppe De Rosa","doi":"10.1080/08982104.2023.2224449","DOIUrl":"10.1080/08982104.2023.2224449","url":null,"abstract":"Upon in vivo administration of nanoparticles, a protein corona forms on their surface and affects their half-life in circulation, biodistribution properties, and stability; in turn, the composition of the protein corona depends on the physico-chemical properties of the nanoparticles. We have previously observed lipid composition-dependent in vitro and in vivo microRNA delivery from lipid nanoparticles. Here, we carried out an extensive physico-chemical characterisation to understand the role of the lipid composition on the in vivo fate of lipid-based nanoparticles. We used a combination of differential scanning calorimetry (DSC), membrane deformability measurements, isothermal titration calorimetry (ITC), and dynamic light scattering (DLS) to probe the interactions between the nanoparticle surface and bovine serum albumin (BSA) as a model protein. The lipid composition influenced membrane deformability, improved lipid intermixing, and affected the formation of lipid domains while BSA binding to the liposome surface was affected by the PEGylated lipid content and the presence of cholesterol. These findings highlight the importance of the lipid composition on the protein-liposome interaction and provide important insights for the design of lipid-based nanoparticles for drug delivery applications.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"88-96"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9667830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review on transethosomes as a novel vesicular approach for drug delivery through transdermal route. 全面综述透硫体作为一种通过透皮途径给药的新型囊泡方法。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-06-20 DOI: 10.1080/08982104.2023.2221354

Minahal Munir, Muhammad Zaman, Muhammad Ahsan Waqar, Huma Hameed, Tehseen Riaz

{"title":"A comprehensive review on transethosomes as a novel vesicular approach for drug delivery through transdermal route.","authors":"Minahal Munir, Muhammad Zaman, Muhammad Ahsan Waqar, Huma Hameed, Tehseen Riaz","doi":"10.1080/08982104.2023.2221354","DOIUrl":"10.1080/08982104.2023.2221354","url":null,"abstract":"Drug delivery through transdermal route is one of the effective methods for the application of drugs. It overcomes many drawbacks which are encountered with the oral route. Moreover, many drugs are not able to pass through the stratum corneum, which is the main barrier for the transdermal drug delivery. Formation of ultra-deformable vesicles (UDVs) is a novel technique for the transdermal applications of the drugs. Transethosomes (TEs), ethosomes, and transferosomes are all part of the UDV. Because of the presence of increased concentrations of ethanol, phospholipids, and edge activators, TEs provide improved drug permeation through the stratum corneum. Because of the elasticity of TEs, drug penetration into the deeper layer of skin also increases. TEs can be prepared using a variety of techniques, including the cold method, hot method, thin film hydration method, and the ethanol injection method. It increases patient adherence and compliance because it is a non-invasive procedure of administering drugs. Characterization of the TEs includes pH determination, size and shape, zeta potential, particle size determination, transition temperature, drug content, vesicle stability, and skin permeation studies. These vesicular systems can be utilized to deliver a variety of medications transdermally, including analgesics, antibiotics, antivirals, and anticancer and arthritis medications. This review aims to describe vesicular approaches that had been used to overcome the barrier for the transdermal delivery of drug and also describes brief composition, method of preparation, characterization tests, mechanism of penetration of TEs, as well as highlighted various applications of TEs in medicine.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"203-218"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9655598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The presence of uncoated gold nanoparticle aggregates may alter the phase of phosphatidylcholine lipid as evidenced by vibrational spectroscopies. 振动光谱证明，未涂层金纳米粒子聚集体的存在可能会改变磷脂酰胆碱脂质的相位。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-07-26 DOI: 10.1080/08982104.2023.2239905

Lea Pašalić, Qiqian Liu, Petra Vukosav, Tea Mišić Radić, Aicha Azziz, Marjan Majdinasab, Mathieu Edely, Marc Lamy de la Chapelle, Danijela Bakarić

{"title":"The presence of uncoated gold nanoparticle aggregates may alter the phase of phosphatidylcholine lipid as evidenced by vibrational spectroscopies.","authors":"Lea Pašalić, Qiqian Liu, Petra Vukosav, Tea Mišić Radić, Aicha Azziz, Marjan Majdinasab, Mathieu Edely, Marc Lamy de la Chapelle, Danijela Bakarić","doi":"10.1080/08982104.2023.2239905","DOIUrl":"10.1080/08982104.2023.2239905","url":null,"abstract":"Spherical structures built from uni- and multilamellar lipid bilayers (LUV and MLV) are nowadays considered not just as nanocarriers of various kinds of therapeutics, but also as the vehicles that, when coupled with gold (Au) nanoparticles (NPs), can also serve as a tool for imaging and discriminating healthy and diseased tissues. Since the presence of Au NPs or their aggregates may affect the properties of the drug delivery vehicle, we investigated how the shape and position of Au NP aggregates adsorbed on the surface of MLV affect the arrangement and conformation of lipid molecules. By preparing MLVs constituted from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of uncoated Au NP aggregates found i) both within liposome core and on the surface of the outer lipid bilayer, or ii) adsorbed on the outer lipid bilayer surface only, we demonstrated the maintenance of lipid bilayer integrity by microscopic techniques (cryo-TEM, and AFM). The employment of SERS and FTIR-ATR techniques enabled us not only to elucidate the lipid interaction pattern and their orientation in regards to Au NP aggregates but also unequivocally confirmed the impact of Au NP aggregates on the persistence/breaking of van der Waals interactions between hydrocarbon chains of DPPC.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"113-123"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liposome bilayer stability: emphasis on cholesterol and its alternatives. 脂质体双分子层的稳定性：重点是胆固醇及其替代物。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-06-28 DOI: 10.1080/08982104.2023.2226216

Hamdi Nsairat, Abed Alqader Ibrahim, Areej M Jaber, Sharif Abdelghany, Randa Atwan, Naeem Shalan, Hiba Abdelnabi, Fadwa Odeh, Mohamed El-Tanani, Walhan Alshaer

引用次数: 0

A cochleate formulation optimized by D-optimal mixture design enhances oral bioavailability of Revaprazan. 通过 D-最佳混合物设计优化的蜗牛配方提高了雷伐普赞的口服生物利用度。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-05-09 DOI: 10.1080/08982104.2023.2209171

Yoon Tae Goo, Min Song Kim, Ji Yeh Choi, Gi Hyeong Sin, Sun Ho Hong, Chang Hyun Kim, Young Wook Choi

{"title":"A cochleate formulation optimized by D-optimal mixture design enhances oral bioavailability of Revaprazan.","authors":"Yoon Tae Goo, Min Song Kim, Ji Yeh Choi, Gi Hyeong Sin, Sun Ho Hong, Chang Hyun Kim, Young Wook Choi","doi":"10.1080/08982104.2023.2209171","DOIUrl":"10.1080/08982104.2023.2209171","url":null,"abstract":"A cochleate formulation was developed to enhance the oral bioavailability of revaprazan (RVP). Dimyristoyl phosphatidylcholine (DMPC) liposome containing dicetyl phosphate (DCP) successfully formed a cochleate after treatment with CaCl2, whereas that containing sodium deoxycholate did not. Cochleate was optimised using a D-optimal mixture design with three independent variables-DMPC (X1, 70.58 mol%), cholesterol (X2, 22.54 mol%), and DCP (X3, 6.88 mol%)-and three response variables: encapsulation efficiency (Y1, 76.92%), released amount of free fatty acid at 2 h (Y2, 39.82%), and released amount of RVP at 6 h (Y3, 73.72%). The desirability function was 0.616, showing an excellent agreement between the predicted and experimental values. The cylindrical morphology of the optimised cochleate was visualised, and laurdan spectroscopy confirmed the dehydrated membrane interface, showing an increased generalised polarisation value (approximately 0.5) over small unilamellar vesicle of RVP (RVP-SUV; approximately 0.1). The optimised cochleate showed greater resistance to pancreatic enzyme than RVP-SUV. RVP was released in a controlled manner, achieving approximately 94% release in 12 h. Following oral administration in rats, the optimised cochleate improved the relative bioavailability of RVP by approximately 274%, 255%, and 172% compared to RVP suspension, a physical mixture of RVP and the cochleate, and RVP-SUV, respectively. Thus, the optimised cochleate formulation might be a good candidate for the practical development of RVP.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"31-43"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9801465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review on lipid nanocarrier systems for cancer treatment: fabrication, future prospects and clinical trials. 全面综述用于癌症治疗的脂质纳米载体系统：制造、未来前景和临床试验。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-05-05 DOI: 10.1080/08982104.2023.2204372

Mohamed Fawzi Kabil, Osama A Badary, Frank Bier, Shaker A Mousa, Ibrahim M El-Sherbiny

{"title":"A comprehensive review on lipid nanocarrier systems for cancer treatment: fabrication, future prospects and clinical trials.","authors":"Mohamed Fawzi Kabil, Osama A Badary, Frank Bier, Shaker A Mousa, Ibrahim M El-Sherbiny","doi":"10.1080/08982104.2023.2204372","DOIUrl":"10.1080/08982104.2023.2204372","url":null,"abstract":"Over the last few decades, cancer has been considered a clinical challenge, being among the leading causes of mortality all over the world. Although many treatment approaches have been developed for cancer, chemotherapy is still the most utilized in the clinical setting. However, the available chemotherapeutics-based treatments have several caveats including their lack of specificity, adverse effects as well as cancer relapse and metastasis which mainly explains the low survival rate of patients. Lipid nanoparticles (LNPs) have been utilized as promising nanocarrier systems for chemotherapeutics to overcome the challenges of the currently applied therapeutic strategies for cancer treatment. Loading chemotherapeutic agent(s) into LNPs improves drug delivery at different aspects including specific targeting of tumours, and enhancing the bioavailability of drugs at the tumour site through selective release of their payload, thus reducing their undesired side effects on healthy cells. This review article delineates an overview of the clinical challenges in many cancer treatments as well as depicts the role of LNPs in achieving optimal therapeutic outcomes. Moreover, the review contains a comprehensive description of the many LNPs categories used as nanocarriers in cancer treatment to date, as well as the potential of LNPs for future applications in other areas of medicine and research.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"135-177"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9403163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0