Journal of Liposome Research最新文献

Design, optimization, characterization, and in vitro evaluation of metformin-loaded liposomes for triple negative breast cancer treatment. 用于治疗三阴性乳腺癌的二甲双胍脂质体的设计、优化、表征和体外评估。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-03-08 DOI: 10.1080/08982104.2024.2321528

Daiva Vozgirdaite, Katel Hervé-Aubert, Rustem Uzbekov, Igor Chourpa, Emilie Allard-Vannier

{"title":"Design, optimization, characterization, and in vitro evaluation of metformin-loaded liposomes for triple negative breast cancer treatment.","authors":"Daiva Vozgirdaite, Katel Hervé-Aubert, Rustem Uzbekov, Igor Chourpa, Emilie Allard-Vannier","doi":"10.1080/08982104.2024.2321528","DOIUrl":"10.1080/08982104.2024.2321528","url":null,"abstract":"Recently, metformin (Met) has shown to have antineoplastic properties in cancer treatment by improving hypoxic tumor conditions, and causing reduction in the synthesis of biomolecules, which are vital for cancer growth. However, as an orally administered drug, Met has low bioavailability and rapid renal clearance. Thus, the goal of this study was to vectorize Met inside liposomes in the context of triple negative breast cancer (TNBC), which currently lacks treatment options when compared to other types of breast cancer. Vectorization of Met inside liposomes was done using Bangham method by implementing double design of experiment methodology to increase Met drug loading (minimum-run resolution V characterization design and Box-Behnken design), as it is generally extremely low for hydrophilic molecules. Optimization of Met-loaded liposome synthesis was successfully achieved with drug loading of 190 mg/g (19% w/w). The optimal Met-liposomes were 170 nm in diameter with low PdI (< 0.1) and negative surface charge (-20 mV), exhibiting sustained Met release at pH 7.4. The liposomal Met delivery system was stable over several months, and successfully reduced TNBC cell proliferation due to the encapsulated drug. This study is one the first reports addressing liposome formulation through thin-film hydration using two design of experiment methods aiming to increase drug loading of Met.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"547-561"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liposomal propranolol for treatment of infantile hemangioma at compounding pharmacies. 复方药房用于治疗婴儿血管瘤的普萘洛尔脂质体。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-02-09 DOI: 10.1080/08982104.2024.2313452

Antigone Nifli, Aggeliki Liakopoulou, Elena Mourelatou, Konstantinos Avgoustakis, Sophia Hatziantoniou

{"title":"Liposomal propranolol for treatment of infantile hemangioma at compounding pharmacies.","authors":"Antigone Nifli, Aggeliki Liakopoulou, Elena Mourelatou, Konstantinos Avgoustakis, Sophia Hatziantoniou","doi":"10.1080/08982104.2024.2313452","DOIUrl":"10.1080/08982104.2024.2313452","url":null,"abstract":"Infantile hemangiomas (IH) are common benign soft tissue tumors, frequently affecting infants. While Propranolol Hydrochloride (Pro HCl) has emerged as a promising treatment for IH, its topical application remains challenging due to the need for stable and efficacious carriers. This study investigates the potential of preformulated liposomes as carriers for topical delivery of Pro HCl for the treatment of IH in compounding pharmacies. Liposomes loaded with Pro HCl were prepared using active pharmaceutical ingredient or commercially available propranolol tablets and various dilution media, including Water for Injection (WFI), Dextrose 5%, and NaCl 0.9%. The physicochemical properties of the liposomal formulations (Pro HCl content, encapsulation efficiency, loading capacity, and colloidal stability) were assessed over a 90-day storage at 4 °C. In vitro release kinetics and transdermal permeation of Pro HCl from liposomes were also evaluated. Liposome properties were influenced by the dilution medium. Pro HCl content remained stable in liposomes encapsulating API (Lipo-Pro), regardless of the dilution medium. Lipo-Pro showed sustained drug release over time, suggesting its potential for maintaining therapeutic levels. Pro HCl exhibited enhanced transdermal permeability from Lipo-Pro compared to aqueous solution, indicating its potential for topical IH treatment. Preformulated liposomes offer a stable and effective carrier for Pro HCl, potentially suitable for extemporaneous preparations in compounding pharmacies. Their enhanced transdermal permeability presents a promising alternative for topical IH treatment. This study provides valuable insights into the development of innovative and effective drug delivery strategies for managing IH, with future research focusing on in vivo applications and therapeutic potential.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"523-534"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139712412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethosomes as a carrier for transdermal drug delivery system: methodology and recent developments. 乙硫体作为透皮给药系统的载体：方法和最新进展。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-04-27 DOI: 10.1080/08982104.2024.2339896

Karishma Mahajan, Poonam Sharma, Vikrant Abbot, Kalpana Chauhan

{"title":"Ethosomes as a carrier for transdermal drug delivery system: methodology and recent developments.","authors":"Karishma Mahajan, Poonam Sharma, Vikrant Abbot, Kalpana Chauhan","doi":"10.1080/08982104.2024.2339896","DOIUrl":"10.1080/08982104.2024.2339896","url":null,"abstract":"Transdermal drug delivery systems (TDDS) have received significant attention in recent years. TDDS are flexible systems that transport active components to the skin for either localized or systemic delivery of drugs through the skin. Among the three main layers of skin, the outermost layer, called the stratum corneum (SC), prevents the entry of water-loving bacteria and drugs with a high molecular weight. The challenge lies in successfully delivering drugs through the skin, which crosses the stratum corneum. The popularity of lipid-based vesicular delivery systems has increased in recent years due to their ability to deliver both hydrophilic and hydrophobic drugs. Ethosomes are specialized vesicles made of phospholipids that can store large amounts of ethanol. Ethosome structure and substance promote skin permeability and bioavailability. This article covers ethosome compositions, types, medication delivery techniques, stability, and safety. In addition to this, an in-depth analysis of the employment of ethosomes in drug delivery applications for a wide range of diseases has also been discussed. This review article highlights different aspects of ethosomes, such as their synthesis, characterization, marketed formulation, recent advancements in TDDS, and applications.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"697-714"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyaluronic acid-coated liposomes for enhanced in vivo efficacy of neogambogic acid via active tumor cell targeting and prolonged systemic exposure. 透明质酸包裹的脂质体可通过肿瘤细胞靶向和延长全身暴露时间来增强新甘草酸的体内疗效。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-05-11 DOI: 10.1080/08982104.2024.2348643

Hongzhen Lv, Miao Miao, Zhichao Wu, Cheng Huang, Xiaozhu Tang, Rugen Yan

{"title":"Hyaluronic acid-coated liposomes for enhanced in vivo efficacy of neogambogic acid via active tumor cell targeting and prolonged systemic exposure.","authors":"Hongzhen Lv, Miao Miao, Zhichao Wu, Cheng Huang, Xiaozhu Tang, Rugen Yan","doi":"10.1080/08982104.2024.2348643","DOIUrl":"10.1080/08982104.2024.2348643","url":null,"abstract":"Neogambogic acid (NGA), which possesses a variety of anticancer activities, is visualized as an anticancer bioactive ingredient. However, the huge vascular stimulation, poor aqueous solubility, and short half-life restricted its clinical use. In this work, an effective nanocarrier was explored to reduce toxicity and enhance the tumor-targeted delivery. Two liposomal formulations, neogambogic acid liposomes (NGA-L), and hyaluronic acid-coated neogambogic acid liposomes (HA-NGA-L) were prepared and characterized with high encapsulation efficiency, slow pattern of drug release, narrow size distribution and higher stability. The cytotoxicity and cellular uptake of HA-NGA-L were higher than those of NGA-L in MDA-MB-231 cells (high CD44 expression), while no obvious differences in MCF-7 cells with (low CD44 expression), suggesting the CD44-mediated cellular internalization of hyaluronic acid-modified liposomes enhanced the cytotoxicity. Mechanistically, elevation of Bax and caspase-3 as well as downregulation of Bcl-2 led to cell apoptosis. Besides, the vascular stimulation and the hemolysis test indicated good safety of HA-NGA-L. In addition, HA-NGA-L was the effective nanocarrier to repress tumor proliferation in MDA-MB-231 tumor xenograft mouse through CD44 mediated active targeting without any obvious histopathological abnormities on major organs. Immunohistochemistry analysis revealed the enhanced elevation of Bax and caspase-3, and reduced expression of Bcl-2 contribute to apoptosis in tumors. Meanwhile, HA-NGA-L increased the AUC and t1/2 by 5.34-fold and 3.94-fold, respectively. In summary, the present study shows that HA-NGA-L may be safe and effective for the tumor-targeted delivery of neogambogic acid.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"605-616"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140908984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric liposomes of emtricitabine employing modified pullulan-an attempt to reduce associated hepatotoxicity. 采用改性拉普兰的恩曲他滨聚合脂质体--减少相关肝毒性的尝试。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-07-01 DOI: 10.1080/08982104.2024.2362352

Sayani Bhattacharyya, Lahari R, Ranganath Mk

{"title":"Polymeric liposomes of emtricitabine employing modified pullulan-an attempt to reduce associated hepatotoxicity.","authors":"Sayani Bhattacharyya, Lahari R, Ranganath Mk","doi":"10.1080/08982104.2024.2362352","DOIUrl":"10.1080/08982104.2024.2362352","url":null,"abstract":"Emtricitabine (FTC) a BCS class I drug, is used for HIV prevention. The high solubility of the drug is the leading cause of severe hepatotoxicity and lactic acidosis. This research focuses on the use of modified pullulan for the preparation of polymeric liposomes of FTC. Modified pullulan was synthesized using cholesterol, and succinic anhydride in a controlled chemical environment. The formation of the polymer was established through analysis of spectra. Varying the drug-polymer ratio (1:1, 1:2, and 1:3), the drug-polymer composite was loaded in the vesicular system of soya phosphatidylcholine and cholesterol. Formulations were evaluated for drug entrapment, particle size, surface morphology, and in vitro and ex vivo drug release. An in vivo study of the pure drug and the best formulation on mice was conducted for 28 days following daily oral administration to evaluate the effect on liver and hematological parameters. The best formulation was further subjected to cytotoxicity study on hepatic cell lines. Spectral analysis confirmed the formation of modified pullulan. All formulations showed high drug entrapment in the nanovesicles. The in vitro and ex vivo drug release profiles depicted a controlled release of the drug. Hematological parameters were found to be under control in the animals throughout the experimentation. A comparative histopathology study on the livers and cytotoxicity study on hepatic cell lines revealed the safety of the best formulation over the pure drug. Hence it can be concluded that polymeric liposomes of FTC can be a promising mode of delivery to overcome its limitations.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"630-639"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liposomal nano-carriers mediated targeting of liver disorders: mechanisms and applications. 纳米脂质体载体介导的肝脏疾病靶向治疗：机制与应用。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-07-10 DOI: 10.1080/08982104.2024.2377085

Mona M AbouSamra

引用次数: 0

Targeting of M2 macrophages with IL-13-functionalized liposomal prednisolone inhibits melanoma angiogenesis in vivo. 用 IL-13 功能化脂质体泼尼松龙靶向 M2 巨噬细胞可抑制体内黑色素瘤血管生成。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/08982104.2024.2315452

Alina Sesarman, Lavinia Luput, Valentin-Florian Rauca, Laura Patras, Emilia Licarete, Marta-Szilvia Meszaros, Bogdan Razvan Dume, Giorgiana Negrea, Vlad-Alexandru Toma, Dana Muntean, Alina Porfire, Manuela Banciu

{"title":"Targeting of M2 macrophages with IL-13-functionalized liposomal prednisolone inhibits melanoma angiogenesis in vivo.","authors":"Alina Sesarman, Lavinia Luput, Valentin-Florian Rauca, Laura Patras, Emilia Licarete, Marta-Szilvia Meszaros, Bogdan Razvan Dume, Giorgiana Negrea, Vlad-Alexandru Toma, Dana Muntean, Alina Porfire, Manuela Banciu","doi":"10.1080/08982104.2024.2315452","DOIUrl":"10.1080/08982104.2024.2315452","url":null,"abstract":"The intricate cooperation between cancer cells and nontumor stromal cells within melanoma microenvironment (MME) enables tumor progression and metastasis. We previously demonstrated that the interplay between tumor-associated macrophages (TAMs) and melanoma cells can be disrupted by using long-circulating liposomes (LCLs) encapsulating prednisolone phosphate (PLP) (LCL-PLP) that inhibited tumor angiogenesis coordinated by TAMs. In this study, our goal was to improve LCL specificity for protumor macrophages (M2-like (i.e., TAMs) macrophages) and to induce a more precise accumulation at tumor site by loading PLP into IL-13-conjugated liposomes (IL-13-LCL-PLP), since IL-13 receptor is overexpressed in this type of macrophages. The IL-13-LCL-PLP liposomal formulation was obtained by covalent attachment of thiolated IL-13 to maleimide-functionalized LCL-PLP. C57BL/6 mice bearing B16.F10 s.c melanoma tumors were used to investigate the antitumor action of LCL-PLP and IL-13-LCL-PLP. Our results showed that IL-13-LCL-PLP formulation remained stable in biological fluids after 24h and it was preferentially taken up by M2 polarized macrophages. IL-13-LCL-PLP induced strong tumor growth inhibition compared to nonfunctionalized LCL-PLP at the same dose, by altering TAMs-mediated angiogenesis and oxidative stress, limiting resistance to apoptosis and invasive features in MME. These findings suggest IL-13-LCL-PLP might become a promising delivery platform for chemotherapeutic agents in melanoma.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"535-546"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotection effects of kynurenic acid-loaded micelles for the Parkinson's disease models. 犬尿酸胶束对帕金森病模型的神经保护作用。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-05-23 DOI: 10.1080/08982104.2024.2346986

Chiung-Mei Chen, Ching-Yun Huang, Chin-Hui Lai, Yu-Chieh Chen, Yi-Ting Hwang, Chung-Yin Lin

{"title":"Neuroprotection effects of kynurenic acid-loaded micelles for the Parkinson's disease models.","authors":"Chiung-Mei Chen, Ching-Yun Huang, Chin-Hui Lai, Yu-Chieh Chen, Yi-Ting Hwang, Chung-Yin Lin","doi":"10.1080/08982104.2024.2346986","DOIUrl":"10.1080/08982104.2024.2346986","url":null,"abstract":"Anti-glutamatergic agents may have neuroprotective effects against excitotoxicity that is known to be involved in the pathogenesis of Parkinson's disease (PD). One of these agents is kynurenic acid (KYNA), a tryptophan metabolite, which is an endogenous N-methyl-D-aspartic acid (NMDA) receptor antagonist. However, its pharmacological properties of poor water solubility and limited blood-brain barrier (BBB) permeability rules out its systemic administration in disorders affecting the central nervous system. Our aim in the present study was to investigate the neuroprotective effects of KYNA-loaded micelles (KYNA-MICs) against PD in vitro and in vivo. Lipid-based micelles (MICs) in conjunction with KYNA drug delivery have the potential to enhance the penetration of therapeutic drugs into a diseased brain without BBB obstacles. KYNA-MICs were characterized by particle size (105.8 ± 12.1 nm), loading efficiency (78.3 ± 4.23%), and in vitro drug release (approximately 30% at 24 h). The in vitro experiments showed that KYNA-MICs effectively reduced 2-fold protein aggregation. The in vivo studies revealed that KYNA was successfully delivered by 5-fold increase in neurotoxin-induced PD brains. The results showed significant enhancement of KYNA delivery into brain. We also found that the KYNA-MICs exhibited several therapeutic effects. The KYNA-MICs reduced protein aggregation of an in vitro PD model, ameliorated motor functions, and prevented loss of the striatal neurons in a PD animal model. The beneficial effects of KYNA-MICs are probably explained by the anti-excitotoxic activity of the treatment's complex. As the KYNA-MICs did not induce any appreciable side-effects at the protective dose applied to a chronic PD mouse model, our results demonstrate that KYNA provides neuroprotection and attenuates PD pathology.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"593-604"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liposomes in the cosmetics: present and outlook. 化妆品中的脂质体：现状与展望。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-05-07 DOI: 10.1080/08982104.2024.2341139

Zhaohe Huang, Hong Meng, Li Xu, Xiaojing Pei, Jie Xiong, Yanan Wang, Xin Zhan, Shujing Li, Yifan He

{"title":"Liposomes in the cosmetics: present and outlook.","authors":"Zhaohe Huang, Hong Meng, Li Xu, Xiaojing Pei, Jie Xiong, Yanan Wang, Xin Zhan, Shujing Li, Yifan He","doi":"10.1080/08982104.2024.2341139","DOIUrl":"10.1080/08982104.2024.2341139","url":null,"abstract":"Liposomes are small spherical vesicles composed of phospholipid bilayers capable of encapsulating a variety of ingredients, including water- and oil-soluble compound, which are one of the most commonly used piggybacking and delivery techniques for many active ingredients and different compounds in biology, medicine and cosmetics. With the increasing number of active cosmetic ingredients, the concomitant challenge is to effectively protect, transport, and utilize these substances in a judicious manner. Many cosmetic ingredients are ineffective both topically and systemically when applied to the skin, thus changing the method of delivery and interaction with the skin of the active ingredients is a crucial step toward improving their effectiveness. Liposomes can improve the delivery of active ingredients to the skin, enhance their stability, and ultimately, improve the efficacy of cosmetics and and pharmaceuticals. In this review, we summarized the basic properties of liposomes and their recent advances of functionalities in cosmetics and and pharmaceuticals. Also, the current state of the art in the field is discussed and the prospects for future research areas are highlighted. We hope that this review will provide ideas and inspiration on the application and development of cosmetics and pharmaceuticals.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"715-727"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of optimized resveratrol/piperine-loaded phytosomal nanocomplex for isoproterenol-induced myocardial infarction treatment. 开发优化的白藜芦醇/哌啶载体植物纳米复合物，用于异丙肾上腺素诱导的心肌梗死治疗。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-07-12 DOI: 10.1080/08982104.2024.2378130

Thriveni Raunak Salian, Nadira Noushida, Sourav Mohanto, B H Jaswanth Gowda, Manodeep Chakraborty, Arfa Nasrine, Soumya Narayana, Mohammed Gulzar Ahmed

{"title":"Development of optimized resveratrol/piperine-loaded phytosomal nanocomplex for isoproterenol-induced myocardial infarction treatment.","authors":"Thriveni Raunak Salian, Nadira Noushida, Sourav Mohanto, B H Jaswanth Gowda, Manodeep Chakraborty, Arfa Nasrine, Soumya Narayana, Mohammed Gulzar Ahmed","doi":"10.1080/08982104.2024.2378130","DOIUrl":"10.1080/08982104.2024.2378130","url":null,"abstract":"Cardiovascular disease is a significant and ever-growing concern, causing high morbidity and mortality worldwide. Conventional therapy is often very precarious and requires long-term usage. Several phytochemicals, including Resveratrol (RSV) and Piperine (PIP), possess significant cardioprotection and may be restrained in clinical settings due to inadequate pharmacokinetic properties. Therefore, this study strives to develop an optimized RSV phytosomes (RSVP) and RSV phytosomes co-loaded with PIP (RPP) via solvent evaporation method using Box-Behnken design to enhance the pharmacokinetic properties in isoproterenol-induced myocardial infarction (MI). The optimized particle size (20.976 ± 0.39 and 176.53 ± 0.88 nm), zeta potential (-33.33 ± 1.5 and -48.7 ± 1.6 mV), drug content (84.57 ± 0.9 and 87.16 ± 0.6%), and %EE (70.56 ± 0.7 and 67.60 ± 0.57%) of the prepared RSVP and RPP, respectively demonstrated enhanced solubility and control release in diffusion media. The oral administration of optimized RSVP and RPP in myocardial infarction-induced rats exhibited significant (p < 0.001) improvement in heart rate, ECG, biomarker, anti-oxidant levels, and no inflammation than pure RSV. The pharmacokinetic assessment on healthy Wistar rats exhibited prolonged circulation (>24 h) of RSVP and RPP compared to free drug/s. The enhanced ability of RSVP and RPP to penetrate bio-membranes and enter the systemic circulation renders them a more promising strategy for mitigating MI.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"640-657"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141600272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0