Journal of Liposome Research最新文献_第2页

Liposomal nano-carriers mediated targeting of liver disorders: mechanisms and applications. 纳米脂质体载体介导的肝脏疾病靶向治疗：机制与应用。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-07-10 DOI: 10.1080/08982104.2024.2377085

Mona M AbouSamra

引用次数: 0

Targeting of M2 macrophages with IL-13-functionalized liposomal prednisolone inhibits melanoma angiogenesis in vivo. 用 IL-13 功能化脂质体泼尼松龙靶向 M2 巨噬细胞可抑制体内黑色素瘤血管生成。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/08982104.2024.2315452

Alina Sesarman, Lavinia Luput, Valentin-Florian Rauca, Laura Patras, Emilia Licarete, Marta-Szilvia Meszaros, Bogdan Razvan Dume, Giorgiana Negrea, Vlad-Alexandru Toma, Dana Muntean, Alina Porfire, Manuela Banciu

{"title":"Targeting of M2 macrophages with IL-13-functionalized liposomal prednisolone inhibits melanoma angiogenesis in vivo.","authors":"Alina Sesarman, Lavinia Luput, Valentin-Florian Rauca, Laura Patras, Emilia Licarete, Marta-Szilvia Meszaros, Bogdan Razvan Dume, Giorgiana Negrea, Vlad-Alexandru Toma, Dana Muntean, Alina Porfire, Manuela Banciu","doi":"10.1080/08982104.2024.2315452","DOIUrl":"10.1080/08982104.2024.2315452","url":null,"abstract":"The intricate cooperation between cancer cells and nontumor stromal cells within melanoma microenvironment (MME) enables tumor progression and metastasis. We previously demonstrated that the interplay between tumor-associated macrophages (TAMs) and melanoma cells can be disrupted by using long-circulating liposomes (LCLs) encapsulating prednisolone phosphate (PLP) (LCL-PLP) that inhibited tumor angiogenesis coordinated by TAMs. In this study, our goal was to improve LCL specificity for protumor macrophages (M2-like (i.e., TAMs) macrophages) and to induce a more precise accumulation at tumor site by loading PLP into IL-13-conjugated liposomes (IL-13-LCL-PLP), since IL-13 receptor is overexpressed in this type of macrophages. The IL-13-LCL-PLP liposomal formulation was obtained by covalent attachment of thiolated IL-13 to maleimide-functionalized LCL-PLP. C57BL/6 mice bearing B16.F10 s.c melanoma tumors were used to investigate the antitumor action of LCL-PLP and IL-13-LCL-PLP. Our results showed that IL-13-LCL-PLP formulation remained stable in biological fluids after 24h and it was preferentially taken up by M2 polarized macrophages. IL-13-LCL-PLP induced strong tumor growth inhibition compared to nonfunctionalized LCL-PLP at the same dose, by altering TAMs-mediated angiogenesis and oxidative stress, limiting resistance to apoptosis and invasive features in MME. These findings suggest IL-13-LCL-PLP might become a promising delivery platform for chemotherapeutic agents in melanoma.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"535-546"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotection effects of kynurenic acid-loaded micelles for the Parkinson's disease models. 犬尿酸胶束对帕金森病模型的神经保护作用。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-05-23 DOI: 10.1080/08982104.2024.2346986

Chiung-Mei Chen, Ching-Yun Huang, Chin-Hui Lai, Yu-Chieh Chen, Yi-Ting Hwang, Chung-Yin Lin

{"title":"Neuroprotection effects of kynurenic acid-loaded micelles for the Parkinson's disease models.","authors":"Chiung-Mei Chen, Ching-Yun Huang, Chin-Hui Lai, Yu-Chieh Chen, Yi-Ting Hwang, Chung-Yin Lin","doi":"10.1080/08982104.2024.2346986","DOIUrl":"10.1080/08982104.2024.2346986","url":null,"abstract":"Anti-glutamatergic agents may have neuroprotective effects against excitotoxicity that is known to be involved in the pathogenesis of Parkinson's disease (PD). One of these agents is kynurenic acid (KYNA), a tryptophan metabolite, which is an endogenous N-methyl-D-aspartic acid (NMDA) receptor antagonist. However, its pharmacological properties of poor water solubility and limited blood-brain barrier (BBB) permeability rules out its systemic administration in disorders affecting the central nervous system. Our aim in the present study was to investigate the neuroprotective effects of KYNA-loaded micelles (KYNA-MICs) against PD in vitro and in vivo. Lipid-based micelles (MICs) in conjunction with KYNA drug delivery have the potential to enhance the penetration of therapeutic drugs into a diseased brain without BBB obstacles. KYNA-MICs were characterized by particle size (105.8 ± 12.1 nm), loading efficiency (78.3 ± 4.23%), and in vitro drug release (approximately 30% at 24 h). The in vitro experiments showed that KYNA-MICs effectively reduced 2-fold protein aggregation. The in vivo studies revealed that KYNA was successfully delivered by 5-fold increase in neurotoxin-induced PD brains. The results showed significant enhancement of KYNA delivery into brain. We also found that the KYNA-MICs exhibited several therapeutic effects. The KYNA-MICs reduced protein aggregation of an in vitro PD model, ameliorated motor functions, and prevented loss of the striatal neurons in a PD animal model. The beneficial effects of KYNA-MICs are probably explained by the anti-excitotoxic activity of the treatment's complex. As the KYNA-MICs did not induce any appreciable side-effects at the protective dose applied to a chronic PD mouse model, our results demonstrate that KYNA provides neuroprotection and attenuates PD pathology.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"593-604"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liposomes in the cosmetics: present and outlook. 化妆品中的脂质体：现状与展望。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-05-07 DOI: 10.1080/08982104.2024.2341139

Zhaohe Huang, Hong Meng, Li Xu, Xiaojing Pei, Jie Xiong, Yanan Wang, Xin Zhan, Shujing Li, Yifan He

{"title":"Liposomes in the cosmetics: present and outlook.","authors":"Zhaohe Huang, Hong Meng, Li Xu, Xiaojing Pei, Jie Xiong, Yanan Wang, Xin Zhan, Shujing Li, Yifan He","doi":"10.1080/08982104.2024.2341139","DOIUrl":"10.1080/08982104.2024.2341139","url":null,"abstract":"Liposomes are small spherical vesicles composed of phospholipid bilayers capable of encapsulating a variety of ingredients, including water- and oil-soluble compound, which are one of the most commonly used piggybacking and delivery techniques for many active ingredients and different compounds in biology, medicine and cosmetics. With the increasing number of active cosmetic ingredients, the concomitant challenge is to effectively protect, transport, and utilize these substances in a judicious manner. Many cosmetic ingredients are ineffective both topically and systemically when applied to the skin, thus changing the method of delivery and interaction with the skin of the active ingredients is a crucial step toward improving their effectiveness. Liposomes can improve the delivery of active ingredients to the skin, enhance their stability, and ultimately, improve the efficacy of cosmetics and and pharmaceuticals. In this review, we summarized the basic properties of liposomes and their recent advances of functionalities in cosmetics and and pharmaceuticals. Also, the current state of the art in the field is discussed and the prospects for future research areas are highlighted. We hope that this review will provide ideas and inspiration on the application and development of cosmetics and pharmaceuticals.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"715-727"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of optimized resveratrol/piperine-loaded phytosomal nanocomplex for isoproterenol-induced myocardial infarction treatment. 开发优化的白藜芦醇/哌啶载体植物纳米复合物，用于异丙肾上腺素诱导的心肌梗死治疗。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-07-12 DOI: 10.1080/08982104.2024.2378130

Thriveni Raunak Salian, Nadira Noushida, Sourav Mohanto, B H Jaswanth Gowda, Manodeep Chakraborty, Arfa Nasrine, Soumya Narayana, Mohammed Gulzar Ahmed

{"title":"Development of optimized resveratrol/piperine-loaded phytosomal nanocomplex for isoproterenol-induced myocardial infarction treatment.","authors":"Thriveni Raunak Salian, Nadira Noushida, Sourav Mohanto, B H Jaswanth Gowda, Manodeep Chakraborty, Arfa Nasrine, Soumya Narayana, Mohammed Gulzar Ahmed","doi":"10.1080/08982104.2024.2378130","DOIUrl":"10.1080/08982104.2024.2378130","url":null,"abstract":"Cardiovascular disease is a significant and ever-growing concern, causing high morbidity and mortality worldwide. Conventional therapy is often very precarious and requires long-term usage. Several phytochemicals, including Resveratrol (RSV) and Piperine (PIP), possess significant cardioprotection and may be restrained in clinical settings due to inadequate pharmacokinetic properties. Therefore, this study strives to develop an optimized RSV phytosomes (RSVP) and RSV phytosomes co-loaded with PIP (RPP) via solvent evaporation method using Box-Behnken design to enhance the pharmacokinetic properties in isoproterenol-induced myocardial infarction (MI). The optimized particle size (20.976 ± 0.39 and 176.53 ± 0.88 nm), zeta potential (-33.33 ± 1.5 and -48.7 ± 1.6 mV), drug content (84.57 ± 0.9 and 87.16 ± 0.6%), and %EE (70.56 ± 0.7 and 67.60 ± 0.57%) of the prepared RSVP and RPP, respectively demonstrated enhanced solubility and control release in diffusion media. The oral administration of optimized RSVP and RPP in myocardial infarction-induced rats exhibited significant (p < 0.001) improvement in heart rate, ECG, biomarker, anti-oxidant levels, and no inflammation than pure RSV. The pharmacokinetic assessment on healthy Wistar rats exhibited prolonged circulation (>24 h) of RSVP and RPP compared to free drug/s. The enhanced ability of RSVP and RPP to penetrate bio-membranes and enter the systemic circulation renders them a more promising strategy for mitigating MI.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"640-657"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141600272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of recent preclinical and clinical research on ligand-targeted liposomes as delivery systems in triple negative breast cancer therapy. 配体靶向脂质体作为三阴性乳腺癌治疗的给药系统的最新临床前和临床研究综述。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-03-23 DOI: 10.1080/08982104.2024.2325963

Mohammad Hajimolaali, Farid Abedin Dorkoosh, Sophia G Antimisiaris

{"title":"Review of recent preclinical and clinical research on ligand-targeted liposomes as delivery systems in triple negative breast cancer therapy.","authors":"Mohammad Hajimolaali, Farid Abedin Dorkoosh, Sophia G Antimisiaris","doi":"10.1080/08982104.2024.2325963","DOIUrl":"10.1080/08982104.2024.2325963","url":null,"abstract":"Triple-negative breast Cancer (TNBC) is one of the deadliest types, making up about 20% of all breast cancers. Chemotherapy is the traditional manner of progressed TNBC treatment; however, it has a short-term result with a high reversibility pace. The lack of targeted treatment limited and person-dependent treatment options for those suffering from TNBC cautions to be the worst type of cancer among breast cancer patients. Consequently, appropriate treatment for this disease is considered a major clinical challenge. Therefore, various treatment methods have been developed to treat TNBC, among which chemotherapy is the most common and well-known approach recently studied. Although effective methods are chemotherapies, they are often accompanied by critical limitations, especially the lack of specific functionality. These methods lead to systematic toxicity and, ultimately, the expansion of multidrug-resistant (MDR) cancer cells. Therefore, finding novel and efficient techniques to enhance the targeting of TNBC treatment is an essential requirement. Liposomes have demonstrated that they are an effective method for drug delivery; however, among a large number of liposome-based drug delivery systems annually developed, a small number have just received authorization for clinical application. The new approaches to using liposomes target their structure with various ligands to increase therapeutic efficiency and diminish undesired side effects on various body tissues. The current study describes the most recent strategies and research associated with functionalizing the liposomes' structure with different ligands as targeted drug carriers in treating TNBCs in preclinical and clinical stages.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"671-696"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, and in vitro gene transfer efficacy of novel ionizable cholesterol derivatives. 新型可离子化胆固醇衍生物的设计、合成和体外基因转移功效。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-04-02 DOI: 10.1080/08982104.2024.2333755

Yajing Wang, Jiahui Jiang, Ziwei Ding, Tao Zhang, Yingying Shi, Xianfeng Huang, Xiaozhong Shen

{"title":"Design, synthesis, and in vitro gene transfer efficacy of novel ionizable cholesterol derivatives.","authors":"Yajing Wang, Jiahui Jiang, Ziwei Ding, Tao Zhang, Yingying Shi, Xianfeng Huang, Xiaozhong Shen","doi":"10.1080/08982104.2024.2333755","DOIUrl":"10.1080/08982104.2024.2333755","url":null,"abstract":"ABSTACTThe medicinal properties of genetic drugs are highly dependent on the design of delivery systems. Ionizable cationic lipids are considered core materials in delivery systems. However, there has not yet been a widespread consensus on the relationship between the wide diversity of lipid structure design and gene delivery efficiency. The aims of the research work were to synthesize ionizable cholesterol derivatives (iChol-lipids) and to evaluate their potential applications as gene delivery vector. A series of iChol-lipids with different head groups were synthesized with carbamate bond spacer. The chemical structures were characterized by 1H NMR, MS, melting range, and pKa. The interactions between iChol-lipids and MALAT1-siRNA were studied by molecular dynamics simulations and compared with market available DC-Chol, which revealed that hydrogen bonds, salt-bridge, and electrostatic interaction were probably involved. The self-assemble behaviors of these lipids were intensively investigated and evaluated by dynamic laser scattering in the presence of different helper lipids and PEGylated lipids. Their plasmid binding ability, transfection efficiency, hemolytic toxicity, and cytotoxicity were fully studied. IZ-Chol-LNPs was proved to be highly potential to effectively complex with DNA, and endosome escape mechanisms mediated by proton sponge effect was verified by pH-sensitive fluorescence probe BCFL.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"562-574"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remote loading in liposome: a review of current strategies and recent developments. 脂质体中的远程装载：当前策略和最新发展综述。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-02-11 DOI: 10.1080/08982104.2024.2315449

Navami Rajan Nambiar, Shreya Gaur, Gayathri Ramachandran, Ravi Shankar Pandey, Sabitha M, Lekshmi R Nath, Tathagata Dutta, M S Sudheesh

{"title":"Remote loading in liposome: a review of current strategies and recent developments.","authors":"Navami Rajan Nambiar, Shreya Gaur, Gayathri Ramachandran, Ravi Shankar Pandey, Sabitha M, Lekshmi R Nath, Tathagata Dutta, M S Sudheesh","doi":"10.1080/08982104.2024.2315449","DOIUrl":"10.1080/08982104.2024.2315449","url":null,"abstract":"Liposomes have gained prominence as nanocarriers in drug delivery, and the number of products in the market is increasing steadily, particularly in cancer therapeutics. Remote loading of drugs in liposomes is a significant step in the translation and commercialization of the first liposomal product. Low drug loading and drug leakage from liposomes is a translational hurdle that was effectively circumvented by the remote loading process. Remote loading or active loading could load nearly 100% of the drug, which was not possible with the passive loading procedure. A major drawback of conventional remote loading is that only a very small percentage of the drugs are amenable to this method. Therefore, methods for drug loading are still a problem for several drugs. The loading of multiple drugs in liposomes to improve the efficacy and safety of nanomedicine has gained prominence recently with the introduction of a marketed formulation (Vyxeos) that improves overall survival in acute myeloid leukemia. Different strategies for modifying the remote loading process to overcome the drawbacks of the conventional method are discussed here. The review aims to discuss the latest developments in remote loading technology and its implications in liposomal drug delivery.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"658-670"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcein release from DPPC liposomes by phospholipase A2 activity: Effect of cholesterol and amphipathic copolymers. 磷脂酶 A2 活性从 DPPC 脂质体中释放钙黄绿素：胆固醇和两性共聚物的影响。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-06-07 DOI: 10.1080/08982104.2024.2361610

Marco Soto-Arriaza, Eduardo Cena Ahumada, Sebastián Bonardd, Jaime Melendez

{"title":"Calcein release from DPPC liposomes by phospholipase A2 activity: Effect of cholesterol and amphipathic copolymers.","authors":"Marco Soto-Arriaza, Eduardo Cena Ahumada, Sebastián Bonardd, Jaime Melendez","doi":"10.1080/08982104.2024.2361610","DOIUrl":"10.1080/08982104.2024.2361610","url":null,"abstract":"In this study, we evaluated the impact of incorporating diblock and triblock amphiphilic copolymers, as well as cholesterol into DPPC liposomes on the release of a model molecule, calcein, mediated by exogenous phospholipase A2 activity. Our findings show that calcein release slows down in the presence of copolymers at low concentration, while at high concentration, the calcein release profile resembles that of the DPPC control. Additionally, calcein release mediated by exogenous PLA2 decreases as the amount of solubilized cholesterol increases, with a maximum between 18 mol% and 20 mol%. At concentrations higher than 24 mol%, no calcein release was observed. Studies conducted on HEK-293 and HeLa cells revealed that DPPC liposomes reduced viability by only 5% and 12%, respectively, after 3 hours of incubation, while DPPC liposome in presence of 33 mol% of Cholesterol reduced viability by approximately 11% and 23%, respectively, during the same incubation period. For formulations containing copolymers at low and high concentrations, cell viability decreased by approximately 20% and 40%, respectively, after 3 hours of incubation. Based on these preliminary results, we can conclude that the presence of amphiphilic copolymers at low concentration can be used in the design of new DPPC liposomes, and together with cholesterol, they can modulate liposome stabilization. The new formulations showed low cytotoxicity in HEK-293 cells, and it was observed that calcein release depended entirely on PLA2 activity and the presence of calcium ions.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"617-629"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-modified liposomal in-situ nasal gel enhances brain targeting of berberine hydrochloride for Alzheimer's therapy: optimization and in vivo studies. 表面修饰脂质体鼻腔原位凝胶增强了盐酸小檗碱治疗阿尔茨海默氏症的脑靶向性：优化和体内研究。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-11-25 DOI: 10.1080/08982104.2024.2431908

Sejal Bahndare, Dyandevi Mathure, Hemantkumar Ranpise, Malati Salunke, Rajendra Awasthi

{"title":"Surface-modified liposomal in-situ nasal gel enhances brain targeting of berberine hydrochloride for Alzheimer's therapy: optimization and in vivo studies.","authors":"Sejal Bahndare, Dyandevi Mathure, Hemantkumar Ranpise, Malati Salunke, Rajendra Awasthi","doi":"10.1080/08982104.2024.2431908","DOIUrl":"https://doi.org/10.1080/08982104.2024.2431908","url":null,"abstract":"This work aimed to formulate surface-modified berberine hydrochloride (BER)-loaded liposomes containing in-situ nasal gel for bran targeting. The liposomes were prepared by ethanol-injection method and optimized following a 32 full-factorial design. Size, morphology, zeta potential, ex-vivo permeation, and in-vitro release were estimated. The surface of optimized liposome was modified with ascorbic acid. The size of surface-modified liposomes was bigger (191.4 nm) than the unmodified liposomes (171 nm). Surface-modified liposomes were embedded in in-situ gel using poloxamer and Carbopol 934P. Liposomal in-situ gel showed higher permeation (71.94%) in contrast to the plain gel (46.64%). In-vivo pharmacokinetic examination of payload from liposomal in-situ gel displayed higher concentration in brain (Cmax of 93.50 ng/mL). The liposomal in-situ nasal gel had a higher drug targeting efficiency (138.43%) and a higher drug targeting potential (27.77%) confirming improved brain targeting. In male Wistar rats, the pharmacodynamic parameters (path length and escape latency) were evaluated with trimethyl tin-induced neurodegeneration. Animals treated with BER-loaded in-situ gel significantly decreased escape latency and path length in comparison to the control group. Histopathological assessment showed that the formulated gel was safe for intranasal administration. The developed formulation has the potential to effectively enhance the efficacy of BER in Alzheimer's disease management.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0