Multifunctional liposomal gel in regenerative medicine.

Abstract

The synergistic approach of liposome integrated with gel matrix could reshape the current frameworks of drug delivery technology. The liposome-based approaches are limited by inadequate stability and rapid leakage of drug molecules. Undesired and immediate drug release from gel increases the local concentration of drug and causes toxicity. So, the stabilization of liposomes within a gel matrix can be an effective option to provide an ingenious solution to the conventional limitation on short half-life, instability, toxicity, uncontrolled drug release and poor retention of drug molecules on the target site. The capability to incorporate antibacterial as well as anti-oxidant drugs, antimicrobial peptides, ligands, growth hormones, antigens, and imaging agents had contributed to the establishment of multifunctional liposomal gel system has significant advantage in regenerative medicine area. This review will focus the advantage of multifunctional liposomal gels in context of infectious wound healing, skin rejuvenation, musculoskeletal repair and trauma management, spinal cord injury treatment, tumor specific chemotherapy as well as immunotherapy and vaccination. The versatility in executing the multiple functions will be a valuable solution for advancing the therapeutic outcomes in regenerative medicine.