Liposomes incorporating cyclodextrins as a promising drug delivery system to augment the bioavailability of poorly soluble drugs.

IF 3.6 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Liposome Research Pub Date : 2025-03-06 DOI:10.1080/08982104.2025.2473335

Manar Adel Abdelbari, Shaimaa Mosallam

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Abstract

Poorly water-soluble drugs are common and challenging in pharmaceutical industry. The poor solubility can reduce the drugs' therapeutic efficiency and bioavailability. Improving the solubility and bioavailability of poorly water-soluble drugs is a challenge and a main issue in the development and application of these drugs in pharmaceutical industry. Liposomes is phospholipid-based vesicular drug delivery system which act as drug carriers for both lipophilic or hydrophilic drugs and have the ability to solubilize the carried drugs. An innovative approach is the incorporation of cyclodextrins (CDs) into the liposomes encapsulating the drug molecules for improving safety and effectiveness of drug molecules by the use of water-soluble CDs properties, which allow the formation of CDs liposomes complexes with lipophilic molecules. CDs liposomes complex increases targeting effect, regulates drug release, improves drug properties and drug encapsulation efficiency. The aim of this review is to summarize the advantages and applications of liposomes incorporating CDs to enhance bioavailability of poorly soluble drugs.

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含环糊精的脂质体是一种很有前途的药物递送系统，可以提高难溶性药物的生物利用度。

低水溶性药物是制药行业中常见且具有挑战性的问题。溶解度差会降低药物的疗效和生物利用度。提高水溶性差药物的溶解度和生物利用度是目前制药工业开发和应用中面临的挑战和主要问题。脂质体是一种以磷脂为基础的囊状给药系统，可作为亲脂或亲水药物的药物载体，并具有溶解所载药物的能力。一种创新的方法是将环糊精（cd）掺入包封药物分子的脂质体中，利用cd的水溶性特性，使cd脂质体与亲脂分子形成复合物，从而提高药物分子的安全性和有效性。CDs脂质体复合物增加靶向作用，调节药物释放，改善药物性质和药物包封效率。本文综述了含CDs脂质体在提高难溶性药物生物利用度方面的优势和应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Liposome Research 生物-生化与分子生物学

CiteScore

10.50

自引率

2.30%

发文量

审稿时长

3 months

期刊介绍： The Journal of Liposome Research aims to publish original, high-quality, peer-reviewed research on the topic of liposomes and related systems, lipid-based delivery systems, lipid biology, and both synthetic and physical lipid chemistry. Reviews and commentaries or editorials are generally solicited and are editorially reviewed. The Journal also publishes abstracts and conference proceedings including those from the International Liposome Society. The scope of the Journal includes: Formulation and characterisation of systems Formulation engineering of systems Synthetic and physical lipid chemistry Lipid Biology Biomembranes Vaccines Emerging technologies and systems related to liposomes and vesicle type systems Developmental methodologies and new analytical techniques pertaining to the general area Pharmacokinetics, pharmacodynamics and biodistribution of systems Clinical applications. The Journal also publishes Special Issues focusing on particular topics and themes within the general scope of the Journal.