Journal of Liposome Research最新文献_第6页

Review of recent preclinical and clinical research on ligand-targeted liposomes as delivery systems in triple negative breast cancer therapy. 配体靶向脂质体作为三阴性乳腺癌治疗的给药系统的最新临床前和临床研究综述。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-03-23 DOI: 10.1080/08982104.2024.2325963

Mohammad Hajimolaali, Farid Abedin Dorkoosh, Sophia G Antimisiaris

{"title":"Review of recent preclinical and clinical research on ligand-targeted liposomes as delivery systems in triple negative breast cancer therapy.","authors":"Mohammad Hajimolaali, Farid Abedin Dorkoosh, Sophia G Antimisiaris","doi":"10.1080/08982104.2024.2325963","DOIUrl":"10.1080/08982104.2024.2325963","url":null,"abstract":"Triple-negative breast Cancer (TNBC) is one of the deadliest types, making up about 20% of all breast cancers. Chemotherapy is the traditional manner of progressed TNBC treatment; however, it has a short-term result with a high reversibility pace. The lack of targeted treatment limited and person-dependent treatment options for those suffering from TNBC cautions to be the worst type of cancer among breast cancer patients. Consequently, appropriate treatment for this disease is considered a major clinical challenge. Therefore, various treatment methods have been developed to treat TNBC, among which chemotherapy is the most common and well-known approach recently studied. Although effective methods are chemotherapies, they are often accompanied by critical limitations, especially the lack of specific functionality. These methods lead to systematic toxicity and, ultimately, the expansion of multidrug-resistant (MDR) cancer cells. Therefore, finding novel and efficient techniques to enhance the targeting of TNBC treatment is an essential requirement. Liposomes have demonstrated that they are an effective method for drug delivery; however, among a large number of liposome-based drug delivery systems annually developed, a small number have just received authorization for clinical application. The new approaches to using liposomes target their structure with various ligands to increase therapeutic efficiency and diminish undesired side effects on various body tissues. The current study describes the most recent strategies and research associated with functionalizing the liposomes' structure with different ligands as targeted drug carriers in treating TNBCs in preclinical and clinical stages.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"671-696"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of optimized resveratrol/piperine-loaded phytosomal nanocomplex for isoproterenol-induced myocardial infarction treatment. 开发优化的白藜芦醇/哌啶载体植物纳米复合物，用于异丙肾上腺素诱导的心肌梗死治疗。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-07-12 DOI: 10.1080/08982104.2024.2378130

Thriveni Raunak Salian, Nadira Noushida, Sourav Mohanto, B H Jaswanth Gowda, Manodeep Chakraborty, Arfa Nasrine, Soumya Narayana, Mohammed Gulzar Ahmed

{"title":"Development of optimized resveratrol/piperine-loaded phytosomal nanocomplex for isoproterenol-induced myocardial infarction treatment.","authors":"Thriveni Raunak Salian, Nadira Noushida, Sourav Mohanto, B H Jaswanth Gowda, Manodeep Chakraborty, Arfa Nasrine, Soumya Narayana, Mohammed Gulzar Ahmed","doi":"10.1080/08982104.2024.2378130","DOIUrl":"10.1080/08982104.2024.2378130","url":null,"abstract":"Cardiovascular disease is a significant and ever-growing concern, causing high morbidity and mortality worldwide. Conventional therapy is often very precarious and requires long-term usage. Several phytochemicals, including Resveratrol (RSV) and Piperine (PIP), possess significant cardioprotection and may be restrained in clinical settings due to inadequate pharmacokinetic properties. Therefore, this study strives to develop an optimized RSV phytosomes (RSVP) and RSV phytosomes co-loaded with PIP (RPP) via solvent evaporation method using Box-Behnken design to enhance the pharmacokinetic properties in isoproterenol-induced myocardial infarction (MI). The optimized particle size (20.976 ± 0.39 and 176.53 ± 0.88 nm), zeta potential (-33.33 ± 1.5 and -48.7 ± 1.6 mV), drug content (84.57 ± 0.9 and 87.16 ± 0.6%), and %EE (70.56 ± 0.7 and 67.60 ± 0.57%) of the prepared RSVP and RPP, respectively demonstrated enhanced solubility and control release in diffusion media. The oral administration of optimized RSVP and RPP in myocardial infarction-induced rats exhibited significant (p < 0.001) improvement in heart rate, ECG, biomarker, anti-oxidant levels, and no inflammation than pure RSV. The pharmacokinetic assessment on healthy Wistar rats exhibited prolonged circulation (>24 h) of RSVP and RPP compared to free drug/s. The enhanced ability of RSVP and RPP to penetrate bio-membranes and enter the systemic circulation renders them a more promising strategy for mitigating MI.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"640-657"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141600272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, and in vitro gene transfer efficacy of novel ionizable cholesterol derivatives. 新型可离子化胆固醇衍生物的设计、合成和体外基因转移功效。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-04-02 DOI: 10.1080/08982104.2024.2333755

Yajing Wang, Jiahui Jiang, Ziwei Ding, Tao Zhang, Yingying Shi, Xianfeng Huang, Xiaozhong Shen

{"title":"Design, synthesis, and in vitro gene transfer efficacy of novel ionizable cholesterol derivatives.","authors":"Yajing Wang, Jiahui Jiang, Ziwei Ding, Tao Zhang, Yingying Shi, Xianfeng Huang, Xiaozhong Shen","doi":"10.1080/08982104.2024.2333755","DOIUrl":"10.1080/08982104.2024.2333755","url":null,"abstract":"ABSTACTThe medicinal properties of genetic drugs are highly dependent on the design of delivery systems. Ionizable cationic lipids are considered core materials in delivery systems. However, there has not yet been a widespread consensus on the relationship between the wide diversity of lipid structure design and gene delivery efficiency. The aims of the research work were to synthesize ionizable cholesterol derivatives (iChol-lipids) and to evaluate their potential applications as gene delivery vector. A series of iChol-lipids with different head groups were synthesized with carbamate bond spacer. The chemical structures were characterized by 1H NMR, MS, melting range, and pKa. The interactions between iChol-lipids and MALAT1-siRNA were studied by molecular dynamics simulations and compared with market available DC-Chol, which revealed that hydrogen bonds, salt-bridge, and electrostatic interaction were probably involved. The self-assemble behaviors of these lipids were intensively investigated and evaluated by dynamic laser scattering in the presence of different helper lipids and PEGylated lipids. Their plasmid binding ability, transfection efficiency, hemolytic toxicity, and cytotoxicity were fully studied. IZ-Chol-LNPs was proved to be highly potential to effectively complex with DNA, and endosome escape mechanisms mediated by proton sponge effect was verified by pH-sensitive fluorescence probe BCFL.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"562-574"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remote loading in liposome: a review of current strategies and recent developments. 脂质体中的远程装载：当前策略和最新发展综述。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-02-11 DOI: 10.1080/08982104.2024.2315449

Navami Rajan Nambiar, Shreya Gaur, Gayathri Ramachandran, Ravi Shankar Pandey, Sabitha M, Lekshmi R Nath, Tathagata Dutta, M S Sudheesh

{"title":"Remote loading in liposome: a review of current strategies and recent developments.","authors":"Navami Rajan Nambiar, Shreya Gaur, Gayathri Ramachandran, Ravi Shankar Pandey, Sabitha M, Lekshmi R Nath, Tathagata Dutta, M S Sudheesh","doi":"10.1080/08982104.2024.2315449","DOIUrl":"10.1080/08982104.2024.2315449","url":null,"abstract":"Liposomes have gained prominence as nanocarriers in drug delivery, and the number of products in the market is increasing steadily, particularly in cancer therapeutics. Remote loading of drugs in liposomes is a significant step in the translation and commercialization of the first liposomal product. Low drug loading and drug leakage from liposomes is a translational hurdle that was effectively circumvented by the remote loading process. Remote loading or active loading could load nearly 100% of the drug, which was not possible with the passive loading procedure. A major drawback of conventional remote loading is that only a very small percentage of the drugs are amenable to this method. Therefore, methods for drug loading are still a problem for several drugs. The loading of multiple drugs in liposomes to improve the efficacy and safety of nanomedicine has gained prominence recently with the introduction of a marketed formulation (Vyxeos) that improves overall survival in acute myeloid leukemia. Different strategies for modifying the remote loading process to overcome the drawbacks of the conventional method are discussed here. The review aims to discuss the latest developments in remote loading technology and its implications in liposomal drug delivery.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"658-670"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcein release from DPPC liposomes by phospholipase A2 activity: Effect of cholesterol and amphipathic copolymers. 磷脂酶 A2 活性从 DPPC 脂质体中释放钙黄绿素：胆固醇和两性共聚物的影响。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-12-01 Epub Date: 2024-06-07 DOI: 10.1080/08982104.2024.2361610

Marco Soto-Arriaza, Eduardo Cena Ahumada, Sebastián Bonardd, Jaime Melendez

{"title":"Calcein release from DPPC liposomes by phospholipase A2 activity: Effect of cholesterol and amphipathic copolymers.","authors":"Marco Soto-Arriaza, Eduardo Cena Ahumada, Sebastián Bonardd, Jaime Melendez","doi":"10.1080/08982104.2024.2361610","DOIUrl":"10.1080/08982104.2024.2361610","url":null,"abstract":"In this study, we evaluated the impact of incorporating diblock and triblock amphiphilic copolymers, as well as cholesterol into DPPC liposomes on the release of a model molecule, calcein, mediated by exogenous phospholipase A2 activity. Our findings show that calcein release slows down in the presence of copolymers at low concentration, while at high concentration, the calcein release profile resembles that of the DPPC control. Additionally, calcein release mediated by exogenous PLA2 decreases as the amount of solubilized cholesterol increases, with a maximum between 18 mol% and 20 mol%. At concentrations higher than 24 mol%, no calcein release was observed. Studies conducted on HEK-293 and HeLa cells revealed that DPPC liposomes reduced viability by only 5% and 12%, respectively, after 3 hours of incubation, while DPPC liposome in presence of 33 mol% of Cholesterol reduced viability by approximately 11% and 23%, respectively, during the same incubation period. For formulations containing copolymers at low and high concentrations, cell viability decreased by approximately 20% and 40%, respectively, after 3 hours of incubation. Based on these preliminary results, we can conclude that the presence of amphiphilic copolymers at low concentration can be used in the design of new DPPC liposomes, and together with cholesterol, they can modulate liposome stabilization. The new formulations showed low cytotoxicity in HEK-293 cells, and it was observed that calcein release depended entirely on PLA2 activity and the presence of calcium ions.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"617-629"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of free vs. liposomal naringenin in white adipose tissue browning in C57BL/6j mice 游离与脂质体柚皮苷对 C57BL/6j 小鼠白色脂肪组织褐变的影响比较

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-09-19 DOI: 10.1080/08982104.2024.2405131

Kübra Uçar Baş, Aslıhan Ağaçdiken, Elif Didem Örs Demet, Dilem Tuğal Aslan, Tuba Reçber, Süleyman Can Öztürk, Tugba Gulsun, Mustafa Çelebier, Zeynep Göktaş

引用次数: 0

A comparative study of sensitizers and liposome composition in radiation-induced controlled drug release for cancer therapy. 辐射诱导癌症治疗药物控释中敏化剂和脂质体成分的比较研究。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-09-11 DOI: 10.1080/08982104.2024.2401800

E Loscertales,J Mateo,S España

{"title":"A comparative study of sensitizers and liposome composition in radiation-induced controlled drug release for cancer therapy.","authors":"E Loscertales,J Mateo,S España","doi":"10.1080/08982104.2024.2401800","DOIUrl":"https://doi.org/10.1080/08982104.2024.2401800","url":null,"abstract":"This study investigates drug-loaded liposomes designed for controlled release under ionizing radiation to refine cancer treatment precision. Liposomes as carriers enable targeted chemotherapy delivery, reducing healthy tissue damage risk. Liposomes containing poly- or mono-unsaturated fatty acids and various sensitizing agents were assessed for responsiveness to UV light and γ photon irradiation including rose bengal (RB), protoporphyrin IX (PPIX), verteporfin (VP), cercosporin (CERC) and hypericin (HYP). Carboxyfluorescein (CF) was used as a surrogate for drug release measurements. VP and PPIX induced rapid drug release and lipid peroxidation under UV light, while RB prompted quick drug release under UV light and a modest immediate release under γ irradiation, eventually reaching full release a few hours after irradiation, demonstrating dose-dependent effects. Smaller liposomes displayed accelerated release, emphasizing size-dependent kinetics. In vitro analyses evaluated radiosensitizing effects of RB-loaded liposomes. Clonogenic assays indicated that RB-filled liposomes had minimal direct radiobiological effects but increased indirect radiation damage, as shown by the curvature of the cell survival curve. Our study sheds light on factors influencing liposomal drug release under ionizing radiation, spotlighting RB as a promising radiosensitizer requiring further investigation for cancer therapy potential.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":"29 1","pages":"1-12"},"PeriodicalIF":4.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142180938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and preparation of pH-sensitive cytotoxic liposomal formulations containing antitumor colchicine analogues for target release. 含有抗肿瘤秋水仙碱类似物的pH敏感细胞毒性脂质体制剂的设计和制备。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-09-01 Epub Date: 2023-11-01 DOI: 10.1080/08982104.2023.2274428

Ekaterina S Shchegravina, Daria S Tretiakova, Alsu R Sitdikova, Sofia D Usova, Ivan A Boldyrev, Anna S Alekseeva, Elena V Svirshchevskaya, Elena L Vodovozova, Alexey Yu Fedorov

引用次数: 0

Antibacterial effect of protease-responsive cationic eugenol liposomes modified by gamma-polyglutamic acid against Staphylococcus aureus. γ -聚谷氨酸修饰蛋白酶反应性阳离子丁香酚脂质体对金黄色葡萄球菌的抑菌作用。

IF 3.6 4区医学

Journal of Liposome Research Pub Date : 2024-09-01 Epub Date: 2023-11-15 DOI: 10.1080/08982104.2023.2280829

Xiaochen Chen, Yiwei Wang, Changzhu Li, Zichun Hua, Haiying Cui, Lin Lin

{"title":"Antibacterial effect of protease-responsive cationic eugenol liposomes modified by gamma-polyglutamic acid against Staphylococcus aureus.","authors":"Xiaochen Chen, Yiwei Wang, Changzhu Li, Zichun Hua, Haiying Cui, Lin Lin","doi":"10.1080/08982104.2023.2280829","DOIUrl":"10.1080/08982104.2023.2280829","url":null,"abstract":"Eugenol, as a natural antibacterial agent, has been widely studied for its inhibitory effect on the common food-borne pathogen Staphylococcus aureus (S. aureus). However, the widespread application of eugenol is still limited by its instability and volatility. Herein, γ-polyglutamic acid coated eugenol cationic liposomes (pGA-ECLPs) were successfully constructed by self-assembly with an average particle size of 170.7 nm and an encapsulation efficiency of 36.2%. The formation of pGA shell significantly improved the stability of liposomes, and the encapsulation efficiency of eugenol only decreased by 20.7% after 30 days of storage at 4 °C. On the other hand, the pGA layer can be hydrolyzed by S. aureus, achieving effective control of release through response to bacterial stimuli. The application experiments further confirmed that pGA-ECLPs effectively prolonged the antibacterial effect of eugenol in fresh chicken without causing obvious sensory effects on the food. The above results of this study provide an important reference for extending the action time of natural antibacterial substances and developing new stimuli-responsive antibacterial systems.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"411-420"},"PeriodicalIF":3.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107591491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium phosphates enhanced with liposomes - the future of bone regeneration and drug delivery. 脂质体增强磷酸钙-骨再生和药物输送的未来。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-09-01 Epub Date: 2023-12-07 DOI: 10.1080/08982104.2023.2285973

Marite Skrinda-Melne, Janis Locs, Andra Grava, Arita Dubnika

{"title":"Calcium phosphates enhanced with liposomes - the future of bone regeneration and drug delivery.","authors":"Marite Skrinda-Melne, Janis Locs, Andra Grava, Arita Dubnika","doi":"10.1080/08982104.2023.2285973","DOIUrl":"10.1080/08982104.2023.2285973","url":null,"abstract":"Effective healing and regeneration of various bone defects is still a major challenge and concern in modern medicine. Calcium phosphates have emerged as extensively studied bone substitute materials due to their structural and chemical resemblance to the mineral phase of bone, along with their versatile properties. Calcium phosphates present promising biological characteristics that make them suitable for bone substitution, but a critical limitation lies in their low osteoinductivity. To supplement these materials with properties that promote bone regeneration, prevent infections, and cure bone diseases locally, calcium phosphates can be biologically and therapeutically modified. A promising approach involves combining calcium phosphates with drug-containing liposomes, renowned for their high biocompatibility and ability to provide controlled and sustained drug delivery. Surprisingly, there is a lack of research focused on liposome-calcium phosphate composites, where liposomes are dispersed within a calcium phosphate matrix. This raises the question of why such studies are limited. In order to provide a comprehensive overview of existing liposome and calcium phosphate composites as bioactive substance delivery systems, the authors review the literature exploring the interactions between calcium phosphates and liposomes. Additionally, it seeks to identify potential interactions between calcium ions and liposomes, which may impact the feasibility of developing liposome-containing calcium phosphate composite materials. Liposome capacity to protect bioactive compounds and facilitate localized treatment can be particularly valuable in scenarios involving bone regeneration, infection prevention, and the management of bone diseases. This review explores the implications of liposomes and calcium phosphate material containing liposomes on drug delivery, bioavailability, and stability, offering insights into their advantages.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"507-522"},"PeriodicalIF":4.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138176386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0