Journal of Liposome Research最新文献_第6页

Elastic cationic liposomal nanogels: a novel platform for topical nicotinamide mononucleotide delivery. 弹性阳离子脂质体纳米凝胶：局部烟酰胺单核苷酸递送的新平台。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-03-01 Epub Date: 2025-12-11 DOI: 10.1080/08982104.2025.2584982

Hongyu Ye, Yanyan Zhen, Shuyu Chen, Yuxian Lin, Xiaomin Xu, Yingcong Yu, Xianfeng Huang, Yajing Wang, Jing Xie

{"title":"Elastic cationic liposomal nanogels: a novel platform for topical nicotinamide mononucleotide delivery.","authors":"Hongyu Ye, Yanyan Zhen, Shuyu Chen, Yuxian Lin, Xiaomin Xu, Yingcong Yu, Xianfeng Huang, Yajing Wang, Jing Xie","doi":"10.1080/08982104.2025.2584982","DOIUrl":"10.1080/08982104.2025.2584982","url":null,"abstract":"Nicotinamide mononucleotide (NMN), a potent nicotinamide adenine dinucleotide (NAD+) precursor, has demonstrated significant potential in mitigating mitochondrial oxidative stress, alleviating degenerative diseases, and reducing reactive oxygen species (ROS) generation. However, its topical application is hindered by inherent challenges, including high hydrophilicity, poor skin permeability, and limited stability. To address these limitations, we developed elastic cationic liposomal nanogels (EC-Lip-nanogels), a novel delivery system composed of Nap-FF-GHK nanogels and elastic cationic liposomes (EC-Lips). Nap-FF-GHK peptide was synthesized by coupling the self-assembled scaffold Nap-FF with the anti-aging module GHK, which would be self-assembled into cationic nanogels. EC-Lips was constructed by incorporating edge activators (EAs) into cationic liposomes (C-Lips). The NMN-loaded EC-Lip-nanogels were systematically characterized, demonstrating favorable physicochemical properties with an average particle size of 53.2 nm, a zeta potential of +14.0 mV, and a high encapsulation efficiency of 90.2%. Notably, the penetration enhancement achieved by EC-Lips and EC-Lip-nanogels was 22.7% and 16.0%, respectively, compared to free NMN. This study might establish EC-Lip-nanogels as a promising platform for improving the skin permeability of NMN and other hydrophilic bioactive molecules, offering a transformative approach for topical applications.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"13-24"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demonstration of discriminatory power and prediction of in vivo behaviour of complex liposomal injectable formulation using physiologically based pharmacokinetic modeling. 利用基于生理的药代动力学模型证明了复杂脂质体注射制剂的鉴别能力和体内行为预测。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-03-01 Epub Date: 2025-10-29 DOI: 10.1080/08982104.2025.2577200

Rajkumar Boddu, Maddukuri Harika, Vaneet Munjal, Sivacharan Kollipara

{"title":"Demonstration of discriminatory power and prediction of in vivo behaviour of complex liposomal injectable formulation using physiologically based pharmacokinetic modeling.","authors":"Rajkumar Boddu, Maddukuri Harika, Vaneet Munjal, Sivacharan Kollipara","doi":"10.1080/08982104.2025.2577200","DOIUrl":"10.1080/08982104.2025.2577200","url":null,"abstract":"In this current work, a generic complex liposomal injectable formulation was developed. During dossier review, a regulatory agency requested to evaluate the in vivo in vitro relationship (IVIVR) and the discriminative power of dissolution media from in vivo perspective. Establishment of a bio predictive method and IVIVR for liposomes are challenging as in vivo both free and encapsulated drug are measured, while in vitro only free is measured. However, justification of the discriminative power of a dissolution method was made using physiologically based pharmacokinetic (PBPK) modeling. Physicochemical, biopharmaceutical, dissolution profiles and pivotal plasma profiles were integrated for model development. The dissolution profile fitted into first order kinetics and the in vitro Kin vitro rel was used to link liposomal and free drug concentrations in the blood. Model validation was proved by predicting bioequivalence (BE) ratios that are in line with the observed BE outcome. The model was applied to demonstrate discriminatory power of dissolution method by integrating Kin vitro rel derived from various batches. The simulated BE ratios are inline to dissolution difference and thus discriminatory power from in vivo perspective was demonstrated. This justification was accepted by agency and led to acceptance and product approval. This approach opened new avenues for describing in vivo behavior of complex intravenous liposomal formulations.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"1-12"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145401078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Process optimization and synergistic anti-tumor effect of MET and CUR codelivery liposomes with improved drug encapsulation efficiency and stability. MET和CUR共递送脂质体的工艺优化及协同抗肿瘤作用，提高药物包封效率和稳定性。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-03-01 Epub Date: 2025-12-05 DOI: 10.1080/08982104.2025.2596189

Ju Liang, Xuening Li, Wenlan Wu, Hao Liao

{"title":"Process optimization and synergistic anti-tumor effect of MET and CUR codelivery liposomes with improved drug encapsulation efficiency and stability.","authors":"Ju Liang, Xuening Li, Wenlan Wu, Hao Liao","doi":"10.1080/08982104.2025.2596189","DOIUrl":"10.1080/08982104.2025.2596189","url":null,"abstract":"Based on improved thin-film dispersion method with an optimized preparation process, elevated encapsulation efficiency and excellent stability of the single-chamber liposome, lip@MET/CUR, were achieved for co-delivery of metformin (MET) and curcumin (CUR). To increase the volume of the hydration chamber and the specific surface area during lipid membrane formation, Tween-80 and glass microspheres were introduced in the preparation process. On this basis, the optimal process parameters for high encapsulation efficiency were screened and determined by combining the analytic hierarchy process (AHP), entropy weight method (EWM), and Box-Behnken response surface optimization. Eventually, the optimal encapsulation efficiencies for MET and CUR were determined to be 46.4% ± 1.3% and 94.1% ± 1.5%, respectively. The lip@MET/CUR exhibited an average particle size of 150 ± 2.5 nm with uniform particle size and good storage stability. In vitro drug release experiments revealed a significant sustained-release characteristic of lip@MET/CUR. Specifically, the cumulative release rate of MET decreased from 96.8% to 57.4% within the initial 2 h. Results from MTT assays and experiments conducted in tumor-bearing mice further demonstrated that lip@MET/CUR was more effective in inhibiting the growth of HepG2 cells and tumors compared to free CUR or lip@CUR. In summary, our findings suggest that the optimized lip@MET/CUR formulation holds great potential as a candidate for investigating the synergistic effects of CUR and MET in tumor treatment.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"51-62"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct morphological and internal state of irinotecan in liposomal structures: implications on irinotecan liposomal drug delivery. 伊立替康在脂质体结构中的独特形态和内部状态：对伊立替康脂质体给药的影响。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-03-01 Epub Date: 2025-12-01 DOI: 10.1080/08982104.2025.2593842

Sivakumar Ramachandran, Tathagata Dutta, Jyoti Loomba, Ravikishore Saiempu, Rajasekhara Reddy Challa, Somasekhar Aviligonda, Naveen Kumar Sureddy

{"title":"Distinct morphological and internal state of irinotecan in liposomal structures: implications on irinotecan liposomal drug delivery.","authors":"Sivakumar Ramachandran, Tathagata Dutta, Jyoti Loomba, Ravikishore Saiempu, Rajasekhara Reddy Challa, Somasekhar Aviligonda, Naveen Kumar Sureddy","doi":"10.1080/08982104.2025.2593842","DOIUrl":"10.1080/08982104.2025.2593842","url":null,"abstract":"Liposomes with unique internal states and morphology have profound implications for controlled drug delivery. This article demonstrates that the final morphology (oblong vs. spherical) and internal state of irinotecan as irinotecan-SucroseOctaSulfate(SOS) complex (gelled vs. precipitated) are impacted by the physical state (solid powder vs. liquid solution) of the used drug-entrapping agent, TEA-8-SOS (Triethylamine-octa-sucroseoctasulfate), which additionally defines the corresponding in-vitro drug release profile (sustained vs. rapid release). TEA-8-SOS is available as a semicrystalline, highly hygroscopic powder from Toronto Research Chemical (TRC). Nanoliposomes prepared from these semi-crystalline TEA-8-SOS have mostly gelled internal structure and based on the drug loading concentration or stability ratio (SR), produce either spherical or oblong morphology with implications on sustained in vitro irinotecan release profile. Alternatively, Na-SOS synthesized from sucrose, can be desalted using ion-exchange resins into the free acid form of SOS. However, when Sucroseoctasulfate (free acid form; that does not crystallize), when adjusted to desired pH with TEA (4.2 or 5.5), was used as a drug entrapping agent in the liquid form, the resultant nanoliposome has a precipitated internal structure of irinotecan-SOS complex as revealed in the high-resolution Cryo-TEM images Additionally, the lack of long-range interactions in their internal structure causes irinotecan to be rapidly released from these liposomes. Further, these liposomes have a spherical morphology as opposed to the oblong or prolate morphology seen in irinotecan liposomes prepared with semi-crystalline TEA-8-SOS (similar to Onivyde®). SAXS power-law analysis also confirms low fractal dimension internal structures in liposomes prepared with liquid TEA-8-SOS compared to TRC's semi-crystalline, powder TEA-8-SOS.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"25-33"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in microfluidic and artificial intelligence-assisted design of liposomes for drug delivery applications. 微流体和人工智能辅助药物递送脂质体设计的研究进展。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-03-01 Epub Date: 2025-12-25 DOI: 10.1080/08982104.2025.2602591

Chandra Has, Sanjay Kumar Kureel

{"title":"Advances in microfluidic and artificial intelligence-assisted design of liposomes for drug delivery applications.","authors":"Chandra Has, Sanjay Kumar Kureel","doi":"10.1080/08982104.2025.2602591","DOIUrl":"10.1080/08982104.2025.2602591","url":null,"abstract":"Liposomes are used as a vehicle in targeted drug delivery due to inherent biocompatibility and encapsulative potential for diverse bioactive agents. However, consistent production remains challenging. With the help of microfluidic systems, liposome synthesis can be precisely controlled, conferring consistency and scalability. This review focuses on the integration of innovative microfluidic-based liposome synthesis and artificial intelligence (AI), specifically machine learning (ML), for the design of optimal critical quality attributes (CQAs), such as vesicle size, size distribution and encapsulation efficiency. ML models such as artificial neural networks (ANN), support vector machines (SVM), and random forest (RF) can predict liposome quality with limited input data. Together with design-of-experiment (DoE), these paradigms provide data-driven optimization. However, the interpretability of the model is enhanced by explainable AI (XAI) tools such as SHAP, which identify determinants for every prediction. The integration of these methods makes an advance toward robust and scalable liposome design. We have also summarized the challenges and future perspectives of scaling AI-guided microfluidic platforms into mainstream pharmaceutical development.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"111-128"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyrophosphate-modified liposomes for bone-targeted delivery. 焦磷酸盐修饰脂质体用于骨靶向递送。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-03-01 Epub Date: 2025-12-28 DOI: 10.1080/08982104.2025.2599839

Alberto Dal Corso, Riccardo Becchetti, Cristina Matteo, Sara Turchetti, Paola Fabbrizio, Marta Cancelliere, Gaia Ghiselli, Marina Meroni, Giovanni Nardo, Massimo Zucchetti, Roberta Frapolli, Claudia Nastasi

引用次数: 0

Formulation optimization and biodistribution of epigallocatechin gallate phospholipid complex-loaded NLCs for rheumatoid arthritis treatment. 表没食子儿茶素没食子酸酯磷脂复合物负载NLCs治疗类风湿关节炎的配方优化和生物分布。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-03-01 Epub Date: 2025-12-04 DOI: 10.1080/08982104.2025.2594689

Bharti Mangla, Shanu Yadav, Pankaj Kumar, Geeta Aggarwal

{"title":"Formulation optimization and biodistribution of epigallocatechin gallate phospholipid complex-loaded NLCs for rheumatoid arthritis treatment.","authors":"Bharti Mangla, Shanu Yadav, Pankaj Kumar, Geeta Aggarwal","doi":"10.1080/08982104.2025.2594689","DOIUrl":"10.1080/08982104.2025.2594689","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic autoimmune disorder that undergoes joint pain inflammation and stiffness. Current treatments associated with severe side effects and high costs. Alternative treatment, that is, Epigallocatechin gallate (EGCG) a green tea polyphenol that directly targeted RA inflammatory pathways. But it has bitter taste, poor bioavailability, and toxicity issues. This research aimed to address these limitations through complexation of EGCG with phospholipids (EGCG-PC) and loading it into nanostructured lipid carriers (NLCs). The complexation with phospholipid technique has been shown to be a more successful approach. The solvent evaporation approach has been utilized to manufacture drug complex, which increases the stability and effectiveness of the products. EGCG-PC-NLCs improve solubility, sustained release, and increased bioavailability. The particle size, zeta potential, and PDI of EGCG-PC-NLCs were 159.65 ± 1.34 nm, -21.5 ± 0.99 mV, and 0.148 ± 0.045. It showed sustained drug release in 24 hours where pure EGCG degraded within 4 hours. Anti-rheumatic efficacy was done through in vitro cell viability assays. Toxicity, ex vivo, and in vivo biodistribution studies improved intestinal permeability, exhibited lower toxicity, undergoes lymphatic pathway and avoided rapid clearance. The dual formulation of EGCG phospholipid complex and NLCs showed a safer therapeutic option for RA treatment.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"34-50"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular hydrophilicity dictates the membrane-disruptive efficacy of bile acid-modified lipids in secretory phospholipase A₂-responsive liposomes. 分子亲水性决定了胆汁酸修饰的脂质在分泌磷脂酶a2响应脂质体中的膜破坏功效。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-03-01 Epub Date: 2025-12-21 DOI: 10.1080/08982104.2025.2603592

Cheng Wen, Yanjiao Liu, Dan Li, Guodong Zhu

{"title":"Molecular hydrophilicity dictates the membrane-disruptive efficacy of bile acid-modified lipids in secretory phospholipase A2-responsive liposomes.","authors":"Cheng Wen, Yanjiao Liu, Dan Li, Guodong Zhu","doi":"10.1080/08982104.2025.2603592","DOIUrl":"10.1080/08982104.2025.2603592","url":null,"abstract":"The enzymatic degradation of bile acid-modified phospholipids by secretory phospholipase A2 (sPLA2) can induce membrane disruption in liposomes. However, the influence of bile acid hydrophilicity on this disruptive effect remains unclear. In this study, we synthesized four lipids by conjugating lithocholic acid (LCA: 3α-OH), chenodeoxycholic acid (CDCA: 3α-OH, 7α-OH) or its derivatives (7k-CDCA: 3α-OH, 7 = O; bk-CDCA: 3 = O, 7 = O) to a phosphocholine backbone. We found that sPLA2-mediated release of 6-carboxyfluorescein (6-CF) from liposomes was significantly faster with LCA-PC (100% release) than with the more hydrophilic CDCA-, 7k-CDCA-, or bk-CDCA-PC (14-30% release) in 2 hours. Assays of enzymatic degradation rates indicated that the low efficacy of CDCA-PC and 7k-CDCA-PC correlated with their slow hydrolysis by sPLA2. Although bk-CDCA-PC was degraded at a rate (13.01%) similar to LCA-PC (15.07%) in 2 hours, dialysis experiments revealed that its metabolite (bk-CDCA) readily diffused into the aqueous phase, unlike LCA, which remained anchored to the membrane. This demonstrates that the firm interfacial settlement of the bile acid metabolite is crucial for the membrane-disruptive effect. Our findings establish that increased hydrophilicity of the bile acid moiety attenuates the sPLA2-induced pore-forming effect, providing a critical guideline for the future design of sPLA2-responsive liposomal systems.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"103-110"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astragaloside IV and ceramide IIIB co-modified ferulic acid ethosomes: a promising novel approach for skin anti-aging. 黄芪甲苷和神经酰胺IIIB共修饰阿魏酸小体：一种有前景的皮肤抗衰老新方法。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-03-01 Epub Date: 2025-12-08 DOI: 10.1080/08982104.2025.2596935

Zhongrong Qin, Zhixin Wen, Hang Lu, Haoquan Yu, Yiyuan Liu, Jingmin Feng, Xiangyu Sun, Wei Lei, Ping Zhao

引用次数: 0

Development of icariin-loaded bone-targeting liposomes and its anti-osteoporosis effects and mechanism. 淫羊藿载骨靶向脂质体的研制及其抗骨质疏松作用和机制。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-03-01 Epub Date: 2025-12-21 DOI: 10.1080/08982104.2025.2602599

Liangju Sheng, Xishen Zhou, Jing Wang, Cuiling Dai, Xiaoting Zhao, Qin Yang, Bin Zong

{"title":"Development of icariin-loaded bone-targeting liposomes and its anti-osteoporosis effects and mechanism.","authors":"Liangju Sheng, Xishen Zhou, Jing Wang, Cuiling Dai, Xiaoting Zhao, Qin Yang, Bin Zong","doi":"10.1080/08982104.2025.2602599","DOIUrl":"10.1080/08982104.2025.2602599","url":null,"abstract":"Osteoporosis increases fracture risk, necessitating safe therapies. Icariin has anti-osteoporosis effects but exhibits poor solubility, short circulation, and lack of bone targeting. We developed tetracycline (TC)/1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) (DSPE-PEG) co-modified liposomes (Icariin-TC-DSPE-PEG-L) to deliver icariin. Formulation variables (phospholipid/cholesterol, phospholipid/icariin, and phospholipid/TC-DSPE-PEG ratios) were optimized using an orthogonal experimental design with particle size and encapsulation efficiency as responses. Optimized liposomes showed small size (157.5 ± 0.27 nm), zeta potential (-24.14 ± 0.25 mV), low PDI (0.149 ± 0.002), high encapsulation efficiency (92.85 ± 0.06%), and drug loading (10.48 ± 0.17%). Hydroxyapatite binding and in vivo fluorescence imaging confirmed enhanced bone affinity and accumulation. Quantitative pharmacokinetic analysis demonstrated prolonged systemic exposure of Icariin-TC-DSPE-PEG-L compared with free icariin and non-targeted liposomes, indicating improved circulation and bioavailability. In osteoporotic rats, the formulation significantly improved bone microstructure, increased bone mass, and regulated bone homeostasis. The TC/PEG co-modified liposomes effectively overcame limitations of icariin's delivery, thus offering a novel therapeutic strategy for osteoporosis. Notwithstanding, long-term toxicity of TC/PEG co-modified liposomes and mechanisms underlying its therapeutic efficacy will be explored in the not-too-distant future.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"87-102"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0