Journal of Liposome Research最新文献_第5页

Ultra-small lipid nanoparticles for controlled release of coenzyme Q10: physicochemical characterization, antioxidant activity analysis, and hemolysis study. 用于辅酶Q10控制释放的超小脂质纳米颗粒：物理化学表征，抗氧化活性分析和溶血研究。

IF 4.7 4区医学

Journal of Liposome Research Pub Date : 2026-06-01 Epub Date: 2026-03-01 DOI: 10.1080/08982104.2026.2634669

Gokce Dicle Kalaycioglu, Burcu Okmen Altas, Nihal Aydogan

{"title":"Ultra-small lipid nanoparticles for controlled release of coenzyme Q10: physicochemical characterization, antioxidant activity analysis, and hemolysis study.","authors":"Gokce Dicle Kalaycioglu, Burcu Okmen Altas, Nihal Aydogan","doi":"10.1080/08982104.2026.2634669","DOIUrl":"10.1080/08982104.2026.2634669","url":null,"abstract":"Coenzyme Q10 (CoQ10) is a potent antioxidant, anticancer and anti-inflammatory agent. However, the number of therapeutic applications of CoQ10 are limited because of its poor water solubility. In the present study, CoQ10-loaded ultra-small lipid nanoparticles (LPs) were prepared by melt-emulsification method. In order to examine the effect of the usage of liquid lipid in the structure of LPs, besides solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs) were also prepared by the use of olive oil in two of five different formulations. The effects of different formulations on the physicochemical properties of the carriers including size, zeta-potential, crystallinity and storage stability. These LPs were subjected to in vitro release studies, antioxidant activity analysis and ex vivo hemocompatibility tests. The kinetic model of the release rate of CoQ10 showed that the release profile can be controlled by adjusting the composition of the LPs in terms of lipid and emulsifier type. Antioxidant activity analysis showed that, nanoencapsulation of CoQ10 improved the hydroxyl scavenging activity of CoQ10 and decreases its EC50 value. The best performance was obtained from NLC2 in which 30% olive oil present with respect to total lipid. Furthermore, compared to CoQ10 solution, SLN1 and SLN3 exhibited an excellent sustained release profile. In conclusion, it is proved that the ultra-small LPs can improve the stability, bioavailability and antioxidant ability of CoQ10 whereas offered personalized and customizable biocompatible drug delivery systems with adjustable release kinetics.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"208-220"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoliposomal juglone/β-cyclodextrin complex as a biocontrol strategy against plant pathogenic bacteria. 纳米脂质体核桃酮/β-环糊精复合物对植物病原菌的生物防治策略。

IF 4.7 4区医学

Journal of Liposome Research Pub Date : 2026-06-01 Epub Date: 2026-01-22 DOI: 10.1080/08982104.2026.2618757

Kubra Bezir, Sumer Horuz, Serap Acar, Munevver Muge Cagal

{"title":"Nanoliposomal juglone/β-cyclodextrin complex as a biocontrol strategy against plant pathogenic bacteria.","authors":"Kubra Bezir, Sumer Horuz, Serap Acar, Munevver Muge Cagal","doi":"10.1080/08982104.2026.2618757","DOIUrl":"10.1080/08982104.2026.2618757","url":null,"abstract":"Tomatoes are susceptible to a variety of pathogens, including bacteria, which can significantly impact plant yield and quality. The application of natural antibacterial agents, such as juglone, has shown promise in the biocontrol of these pathogens. The main objective of this study was to investigate the effects of liposomal encapsulation on enhancing the bioavailability of juglone as a biocontrol agent. The entrapment of juglone in nanoliposomes as water-soluble cyclodextrin complexes represents a novel strategy that merges the distinct advantages of these two systems into one. In this study, the juglone/β-cyclodextrin inclusion complex was successfully encapsulated in nanoliposomes (J/β-CD/L). Physicochemical and morphological characterizations of the formulations were conducted. The release of juglone from liposomes exhibited a cumulative release of 46.73% at 72 hours. The MIC values of the J/β-CD/L molecule against plant pathogenic bacteria Pseudomonas syringae pv. tomato strain SH-1 (Pst), Xanthomonas euvesicatoria strain SH-2 (Xeu), and Clavibacter michiganensis subsp. michiganensis strain SH-3 (Cmm) were 68.93 µg/mL, 34.47 µg/mL, and 68.93 µg/mL, respectively. These MIC values were found to be lower than free juglone. Based on the seed germination results, the prepared formulation did not show any phytotoxic effect on tomato seeds at the applied concentrations. Thus, the nanoliposomal encapsulation technique appears to be a promising method for enhancing the antibacterial effectiveness of juglone as a biocontrol agent.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"156-167"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of ganciclovir/resveratrol coloaded bilosomes for improvement of ophthalmic delivery and therapeutic efficacy. 更昔洛韦/白藜芦醇包载胆小体改善眼部输送和治疗效果的研究进展。

IF 4.7 4区医学

Journal of Liposome Research Pub Date : 2026-06-01 Epub Date: 2026-01-12 DOI: 10.1080/08982104.2026.2614785

Khaled Shalaby, Mohammed Elmowafy, Hazim M Ali, Raghad Ayed Alenazi, Diaa Massoud, Ayman Salama, Ghareb M Soliman, A A A Darwish, Mohamed A Safwat

{"title":"Development of ganciclovir/resveratrol coloaded bilosomes for improvement of ophthalmic delivery and therapeutic efficacy.","authors":"Khaled Shalaby, Mohammed Elmowafy, Hazim M Ali, Raghad Ayed Alenazi, Diaa Massoud, Ayman Salama, Ghareb M Soliman, A A A Darwish, Mohamed A Safwat","doi":"10.1080/08982104.2026.2614785","DOIUrl":"10.1080/08982104.2026.2614785","url":null,"abstract":"Bilosomes have been investigated as potential carrier for ocular delivery. Ocular viral infection may lead to direct or autoimmune damages, uveoretinitis, and disturbed vision. In this work, we fabricated ganciclovir (antiviral agent) and resveratrol (natural antioxidant and anti-inflammatory) coloaded bilosomes. The influence of bile salt concentration and chitosan coating was investigated. Formulations were subjected to physicochemical characterizations and the selected formulations were assessed for structural analyses, in vitro release, ex vivo corneal permeation, and in vivo appraisal. Increasing bile salt concentration resulted in an increase in particle diameter and zeta-potential negativity, while chitosan coating increased vesicular size and shifted the zeta potential to positive values. F3 (containing 10 mg/mL sodium taurocholate) and F4 (chitosan coated F3) showed satisfying results of physicochemical characteristics. Structural analyses proved that lipophilic resveratrol was located in lipid bilayer while hydrophilic ganciclovir was located in aqueous core of the vesicles and both of them were in an amorphous state. F4 provided excellent ocular delivery of resveratrol and ganciclovir presented by higher transcorneal flux (3.27 ± 0.28 and 2.31 ± 0.17 μg/cm2/h, respectively) and permeability coefficient (1.64 ± 0.09 and 1.15 ± 0.08 cm2/h, respectively) when compared to F3 and drugs' suspension. Histological evaluation demonstrated that F4 surpassed F3, showing non-irritant properties and marked anti-inflammatory activity. Conclusively, these findings suggested that F4 coloaded with ganciclovir and resveratrol might be a promising strategy for the feasible treatment of ocular viral infection and its accompanying inflammatory symptoms.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"129-141"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of archaeal lipids from A. pernix K1 on the in vitro stability and active loading efficiency of liposomes composed of sphingomyelin and cholesterol. 冬青K1古细菌脂质对鞘磷脂和胆固醇组成脂质体体外稳定性和活性负载效率的影响。

IF 4.7 4区医学

Journal of Liposome Research Pub Date : 2026-06-01 Epub Date: 2026-02-01 DOI: 10.1080/08982104.2026.2619597

Jan Kejžar, Mihaela Skrt, Tamara Polajžer, Nataša Poklar Ulrih

{"title":"Effect of archaeal lipids from A. pernix K1 on the in vitro stability and active loading efficiency of liposomes composed of sphingomyelin and cholesterol.","authors":"Jan Kejžar, Mihaela Skrt, Tamara Polajžer, Nataša Poklar Ulrih","doi":"10.1080/08982104.2026.2619597","DOIUrl":"10.1080/08982104.2026.2619597","url":null,"abstract":"Archaeal lipids offer a useful strategy for improving liposomal systems because of their inherent stability under extreme conditions. Incorporating lipids from Aeropyrum pernix K1 allowed us to optimize sphingomyelin-cholesterol formulation. These archaeal lipids enabled complete recovery of liposome morphology after destabilization with 4 mM Ca2+ followed by EDTA, indicating that membrane integrity is maintained in the presence of calcium. This is noteworthy given the anionic nature of the archaeal lipids, which in this case provide colloidal stability without increasing sensitivity to Ca2+. The addition of 2 mol% archaeal lipids also supported high encapsulation efficiency of 95% for active vincristine loading and performed better than the binary mixture when vesicles were prepared by extrusion without cosolvents. Furthermore, reducing the archaeal lipid fraction preserved biological stability provided by sphingomyelin-cholesterol, as confirmed by flow cytometry and fluorescence microscopy, whereas pure archaeosomes composed entirely of archaeal lipids have been reported to show poor stability in biological systems.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"168-182"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Force sharing between the liposome biomembrane and viscous core: an experimental study. 脂质体生物膜与黏性核之间的力共享：实验研究。

IF 4.7 4区医学

Journal of Liposome Research Pub Date : 2026-06-01 Epub Date: 2026-02-17 DOI: 10.1080/08982104.2026.2625933

Matej Daniel, Katarína Mendová, Martin Otáhal

{"title":"Force sharing between the liposome biomembrane and viscous core: an experimental study.","authors":"Matej Daniel, Katarína Mendová, Martin Otáhal","doi":"10.1080/08982104.2026.2625933","DOIUrl":"10.1080/08982104.2026.2625933","url":null,"abstract":"The mechanical properties of liposomes are critical for their efficacy as drug delivery vehicles. A liposome's stiffness is a composite property of its membrane and encapsulated core, but deconvolving these contributions is a significant challenge, as current methods rely on model-dependent assumptions. This study introduces a novel, experimental method to isolate the core's mechanical contribution. We fabricated giant unilamellar vesicles (GUVs) with either a simple buffer or a viscoelastic hyaluronic acid (HA) core and characterized them using atomic force microscopy (AFM). The core's contribution was isolated by subtracting the force response of buffer-filled liposomes from that of HA-filled ones. The contact point was identified from the change in data fluctuations. Our results demonstrate that the HA core dramatically increases the liposome's resistance to deformation. While the membrane stiffness is dominant in small deformations (up to 25 nm), the viscous core becomes dominant at larger deformations, bearing over 80% of the total load for deformations larger than 150 nm. This direct, model-independent approach provides a tool for understanding the biomechanics of filled liposomes and enables the rational engineering of liposomal drug carriers with mechanical properties precisely tuned for enhanced therapeutic performance.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"252-259"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liposomes as versatile drug delivery vehicles: emerging trends, technological innovations and future perspectives. 作为多功能药物传递载体的脂质体：新兴趋势、技术创新和未来展望。

IF 4.7 4区医学

Journal of Liposome Research Pub Date : 2026-06-01 Epub Date: 2026-02-06 DOI: 10.1080/08982104.2026.2619919

Anishiya Michael, Disha Bhattacharya, Vigneshwaran Gopal, Dhanushya Suresh, Jana Arun, G N K Ganesh

{"title":"Liposomes as versatile drug delivery vehicles: emerging trends, technological innovations and future perspectives.","authors":"Anishiya Michael, Disha Bhattacharya, Vigneshwaran Gopal, Dhanushya Suresh, Jana Arun, G N K Ganesh","doi":"10.1080/08982104.2026.2619919","DOIUrl":"10.1080/08982104.2026.2619919","url":null,"abstract":"Liposomes are vesicular carriers and highly engineered multifunctional platforms that can address the broadest range of therapeutic needs. So far, their capacity to encapsulate the hydrophobic and hydrophilic components, as well as their ability to vary their surface chemistry and biocompatibility, has enabled their use on a large scale in oncology, infectious diseases, vaccine delivery, and gene therapy. New developments focus on surface engineering to enhance targeting, stimuli-responsive and intelligent liposome engineering to achieve site-specific drug delivery, and incorporation into hybrid nanocarrier systems that build on and leverage the advantages of multiple delivery platforms. A further expansion in clinical application has been the use of co-delivery and combination therapy approaches, which permit synergistic treatment regimens. Innovations in route-specific delivery, such as inhalable, transdermal, and intranasal liposomal delivery systems or expanded therapeutic delivery and patient adherence. The introduction of individualized and precision liposomal therapy through molecular characterization is a step in the right direction toward individualized treatment regimens. Liposomal medicines have been widely and commercially successful, and liposomal drugs have been approved by the FDA many times (and large-scale production, maximization of stability, regulatory uniformity, and uniform clinical translation are also now no longer problematic). The review provides a combined consideration of the current trend, new technology development, and market awareness with a prospective opportunity description of integrating liposomal delivery with new diagnostic and adaptive therapeutic approaches. Therefore, liposomes will keep leading the pack of forthcoming drug delivery methods as they silence a broader nanotechnology breakthrough through adopting patient-centric approaches.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"234-251"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan-coated taxifolin liposomes preserve renal structure and function in mice. 壳聚糖包被的taxifolin脂质体保护小鼠肾脏结构和功能。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-05-29 DOI: 10.1080/08982104.2026.2669122

Thaer A Altakhaineh, Mohammad H Abukhalil, Walhan Alshaer, Zalina Zahari, Mulham Alfatama

{"title":"Chitosan-coated taxifolin liposomes preserve renal structure and function in mice.","authors":"Thaer A Altakhaineh, Mohammad H Abukhalil, Walhan Alshaer, Zalina Zahari, Mulham Alfatama","doi":"10.1080/08982104.2026.2669122","DOIUrl":"https://doi.org/10.1080/08982104.2026.2669122","url":null,"abstract":"Isoproterenol (ISO), a nonselective β-adrenergic agonist, is widely used to induce myocardial injury and has been reported to cause secondary renal damage known as cardiorenal syndrome, partly driven by oxidative stress and inflammation. Taxifolin (TAX), a flavonoid with potent antioxidant and anti-inflammatory properties, is limited in clinical application due to poor solubility and low bioavailability. This study developed and evaluated chitosan-coated taxifolin liposomes (CS-TL) for the prevention of ISO-induced renal injury in mice. TAX liposomes (TL) were prepared via the ethanol injection method and coated with chitosan to obtain CS-TL. Physicochemical properties, including encapsulation efficiency (EE), particle size, and zeta potential, were characterized. Male mice pretreated with TL or CS-TL received ISO to induce cardiorenal damage. TL exhibited EE of 86.35 ± 3.15%, particle size of 154.8 ± 1.68 nm, and zeta potential of -32.54 ± 3.27 mV, while CS-TL demonstrated EE of 90.70 ± 1.47%, particle size of 289.4 ± 3.27 nm, and zeta potential of +35.26 ± 2.85 mV. ISO induced marked renal tissue damage, increased oxidative stress, inflammatory response, and apoptosis, and suppressed Nrf2/HO-1. Notably, CS-TL pretreatment markedly attenuated ISO-induced alterations in the aforementioned parameters and preserved renal histological architecture. These findings suggest that CS-TL could serve as a promising adjunctive therapeutic strategy for renoprotection in cardiorenal syndromes by ameliorating inflammation, oxidative stress, and apoptosis and restoring the Nrf2/HO-1 cascade.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"1-10"},"PeriodicalIF":4.3,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the editorial 'On the use of high ethanol content dialysis media in in vitro release studies of lipid nanocarriers'. 对社论《关于在脂质纳米载体体外释放研究中使用高乙醇含量透析介质》的回应。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-05-14 DOI: 10.1080/08982104.2026.2672321

Costas Demetzos

引用次数: 0

Biophysical and biological evaluation of free and liposomal doxorubicin and β-carotene reveals enhanced therapeutic selectivity in MCF-7 breast cancer cells. 游离和脂质体阿霉素和β-胡萝卜素的生物物理和生物学评价显示MCF-7乳腺癌细胞的治疗选择性增强。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-05-12 DOI: 10.1080/08982104.2026.2671264

Hany M A Elrahman, Medhat W Shafaa, Michael Masoomi, Moustafa Ibrahim, Mahmoud A Elbaset, Ayman M Ibrahim

{"title":"Biophysical and biological evaluation of free and liposomal doxorubicin and β-carotene reveals enhanced therapeutic selectivity in MCF-7 breast cancer cells.","authors":"Hany M A Elrahman, Medhat W Shafaa, Michael Masoomi, Moustafa Ibrahim, Mahmoud A Elbaset, Ayman M Ibrahim","doi":"10.1080/08982104.2026.2671264","DOIUrl":"10.1080/08982104.2026.2671264","url":null,"abstract":"Breast cancer remains a major health challenge, highlighting the need for more effective and safer therapies. Although doxorubicin is widely used, its clinical utility is limited by oxidative stress-induced toxicity. This study investigated β-carotene and doxorubicin co-delivery in free and liposomal forms using multiple soy lecithin-based formulations. Physicochemical characterization was performed using FTIR spectroscopy, TEM, DLS, zeta potential analysis, and DSC. Biological evaluation was conducted in MCF-7 cells using cytotoxicity assay, apoptosis assay, cell cycle analysis, and comet assay.while cytotoxic selectivity was further assessed by IC50 determination in non-tumorigenic MCF-10A breast epithelial cells. The prepared liposomes showed a uniform spherical morphology, narrow size distribution, and favorable physicochemical stability. Free doxorubicin demonstrated potent anticancer activity against MCF-7 cells (IC50 = 2.46 µg/mL), but was associated with significant apoptosis and DNA damage. liposomal doxorubicin showed moderated cytotoxicity (IC50 = 4.73 µg/mL), consistent with a controlled release profile. Notably, the co-delivery of β-carotene and doxorubicin in liposomes reduced cytotoxic potency (IC50 = 9.98 µg/mL), associated with inducing G2/M cell cycle arrest and apoptosis while reducing genotoxic effects. Liposomal β-carotene and empty liposomes exhibited minimal cytotoxicity. In MCF-10A cells, all liposomal formulations and β-carotene showed negligible toxicity (IC50 > 100 µg/mL), whereas free doxorubicin was highly toxic (IC50 ≈ 5 µg/mL). This toxicity was partially reduced when combined with β-carotene (IC50 ≈ 20 µg/mL). Overall, these findings suggest that liposomal co-delivery of β-carotene and doxorubicin may enhance therapeutic efficacy while potentially reducing off-target toxicity.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"1-16"},"PeriodicalIF":4.3,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoliposomes based drug delivery for the treatment of various types of cancers: current trends and future perspectives. 基于纳米脂质体的药物递送治疗各种类型的癌症：目前的趋势和未来的展望。

IF 4.3 4区医学

Journal of Liposome Research Pub Date : 2026-05-04 DOI: 10.1080/08982104.2026.2664876

Binapani Barik, Tahreen Taj, Rabab Fatima, Sanjay Dey, Syed Mustafizur Rahaman, Radheshyam Pal, Sumel Ashique, Md Sadique Hussain, Sabina Yasmin, Mohammad Khalid, Md Yousuf Ansari

{"title":"Nanoliposomes based drug delivery for the treatment of various types of cancers: current trends and future perspectives.","authors":"Binapani Barik, Tahreen Taj, Rabab Fatima, Sanjay Dey, Syed Mustafizur Rahaman, Radheshyam Pal, Sumel Ashique, Md Sadique Hussain, Sabina Yasmin, Mohammad Khalid, Md Yousuf Ansari","doi":"10.1080/08982104.2026.2664876","DOIUrl":"https://doi.org/10.1080/08982104.2026.2664876","url":null,"abstract":"Multifunctional lipid-based nanoparticles, like nanoliposomes (NLPs), effectively deliver therapeutic and diagnostic functions, with recent modifications to liposomes reducing toxicity to human cells. These NLPs and micelles enhance therapeutic efficacy through surface modifications, creating pH-sensitive, targeted, long-circulating systems. Process selection depends on the nanoparticle components' physicochemical properties, which influence formulations. This article explores engineered NLPs for the treatment of various diseases like fungal infection, breast cancer, and metabolic disorders, compares their properties, breakthroughs in ligand-targeted, stimuli-responsive, scalable NLP production techniques and applications to conventional liposomes, and discusses the preparation process. It reviews generation differences in liposomal preparations, offering insights into current trends in nanoparticle drug delivery, highlighting their translational applicability beyond oncology. Liposomal formulations have shown promise in targeted delivery, yet only a few have proven successful. Several recent studies demonstrated that functionalized NLPs improved therapeutic efficacy through surface modifications, enabling tissue targeting and controlled drug release in various disorders, including cancer therapy. Other multifunctional lipid-based nanoparticles are developed for medicinal and diagnostic purposes. This review covers the design, manufacturing, and application of engineered nanoliposomes, addressing challenges like poor solubility and off-target effects while exploring future directions for clinical applications. The article presents an overview of the potential impact of engineered NLPs on the advancement of precision medicine in the context of metabolic diseases.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"1-19"},"PeriodicalIF":4.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0