Journal of Korean Neurosurgical Society最新文献

{"title":"Association between Neutrophil-to-Albumin Ratio and 28-Day All-Cause Mortality in Patients with Traumatic Brain Injury : A Retrospective Analysis of the MIMIC-IV Database.","authors":"Ziming Huang, Hengfa Ge, Ying Sun","doi":"10.3340/jkns.2025.0061","DOIUrl":"https://doi.org/10.3340/jkns.2025.0061","url":null,"abstract":"<p><strong>Objective: </strong>The neutrophil-to-albumin ratio (NAR) has emerged as a novel prognostic biomarker in multiple disease contexts, including infectious and cardiovascular disorders. Its prognostic relevance in traumatic brain injury (TBI), however, remains unexamined. This study investigates the association between NAR and 28-day all-cause mortality in patients with TBI.</p><p><strong>Methods: </strong>This retrospective study analyzed data from the MIMIC-IV database. Neutrophil counts, serum albumin concentrations, and NAR values were recorded within the first 24 hours following TBI admission. Additional clinical and laboratory parameters were collected. The Youden index was employed to determine the optimal NAR threshold. Receiver operating characteristic (ROC) curve analysis was used to assess the discriminative capacity of NAR for all-cause mortality. Subgroup analyses were conducted to evaluate potential heterogeneity in NAR's prognostic utility across distinct patient subsets. An external validation cohort comprising 112 TBI cases from the institutional database was included to confirm predictive performance. Kaplan-Meier survival analyses were used to compare outcomes between high- and low-NAR groups, while ROC analysis was performed across the entire TBI cohort to assess overall prognostic accuracy.</p><p><strong>Results: </strong>A total of 213 TBI patients were included and stratified based on 28-day survival status : 180 survivors and 33 non-survivors, resulting in an overall mortality rate of 15.5%. Multivariate Cox regression identified NAR as an independent predictor of 28-day all-cause mortality (hazard ratio [HR], 3.224; 95% confidence interval [CI], 1.321-4.594; p<0.001). ROC curve analysis determined an optimal NAR cutoff of 1.2839 for discriminating between survivors and non-survivors. Kaplan-Meier survival analysis revealed significantly elevated mortality among patients with NAR ≥1.2839 compared to those with NAR <1.2839 (log-rank p<0.001). The area under the curve (AUC) for NAR reached 82.45% (95% CI, 67.02-87.50%), surpassing the predictive performance of neutrophil count (AUC, 60.27%) and serum albumin level (AUC, 60.91%) when assessed individually. Subgroup analyses showed no significant interaction effects (p for interaction, 0.302-0.908), indicating consistent predictive performance across patient subgroups. External validation reinforced the prognostic value of NAR : patients in the high-NAR group demonstrated significantly worse survival outcomes (HR, 3.611; 95% CI, 1.385-9.419; p<0.01), with comparable discriminatory accuracy (AUC, 82.91%; 95% CI, 65.13-89.59%).</p><p><strong>Conclusion: </strong>NAR functions as an independent and robust prognostic indicator of 28-day all-cause mortality in patients with TBI. Compared to neutrophil count and serum albumin levels alone, NAR demonstrates superior predictive accuracy and may serve as a valuable biomarker for early mortality risk stratification in this popul","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editors' Pick in September 2025.","authors":"Bum-Tae Kim","doi":"10.3340/jkns.2025.0154","DOIUrl":"https://doi.org/10.3340/jkns.2025.0154","url":null,"abstract":"","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Effects of Human Adipose Tissue-Derived Mesenchymal Stromal Cells Against Radiation-Induced Neural Damage : A Comparative In Vitro Study.","authors":"Jang Hun Kim, Chul Young Kim, Jong-Hoon Kim, Dongho Geum, Dong-Hyuk Park","doi":"10.3340/jkns.2024.0173","DOIUrl":"https://doi.org/10.3340/jkns.2024.0173","url":null,"abstract":"<p><strong>Objective: </strong>Radiotherapy is a key treatment for brain tumors and arteriovenous malformations; however, it is associated with adverse effects such as brain edema, demyelination, and delayed necrosis. These adverse effects are driven by inflammation and apoptosis, initiated by cytokines such as tumor necrosis factor-α, transforming growth factor, and interleukin-1β. Adipose tissuederived mesenchymal stromal cells (ADMSCs) offer protection against radiation-induced damage owing to their pluripotency and antiinflammatory properties. In this study, we investigated the neuroprotective effects of ADMSCs on irradiated brain cells.</p><p><strong>Methods: </strong>Rat cortical neurons, human glioblastoma cells (U87 cell line), and ADMSCs were exposed to radiation doses ranging from 3 Gy to 40 Gy. Co-cultures of irradiated neurons with ADMSCs or their secretomes were assessed for apoptotic and inflammatory markers. Cell viability was measured using lactate dehydrogenase (LDH) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Apoptosis was determined by using Hoechst staining and western blot analysis of proteins such as Bax, caspase-3, and Bcl-2.</p><p><strong>Results: </strong>Higher radiation doses (30-40 Gy) significantly increased apoptosis and decreased the viability of cortical neurons and U87 cells. Co-culture with ADMSCs reduced the levels of apoptosis markers, particularly Bax and cleaved caspase-3, and promoted cell survival. Direct co-culture provided more pronounced protection than did ADMSC secretome treatment, suggesting that cell-to-cell interactions are crucial for neuroprotection.</p><p><strong>Conclusion: </strong>ADMSCs have a significant potential for mitigating radiation-induced brain damage by reducing apoptosis and inflammation. Direct ADMSC co-culture outperformed secretome treatment, thereby emphasizing the importance of physical cell interactions. ADMSC therapy may be a promising approach to protect against radiotherapy-induced neural damage. Further studies are required to optimize the delivery and timing of stem cell therapy.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and Diagnostic Yield of the New AW stereotactic Frame and Its Comparison with The CRW Frame for Brain Biopsy.","authors":"Kugan Vijian, Lau Bik Liang, Donald Ngian San Liew, Zamzuri Idris, Abdul Rahman Izaini Ghani, Jafri Malin Abdullah, Albert Wong Sii Hieng","doi":"10.3340/jkns.2025.0090","DOIUrl":"https://doi.org/10.3340/jkns.2025.0090","url":null,"abstract":"<p><strong>Objective: </strong>The Albert-Wong (AW) stereotactic frame for brain biopsy was created by a Malaysian neurosurgeon in 2015. A phantom-based accuracy study demonstrated that its accuracy was non-inferior to well-established stereotactic frames. The objective of our study is to compare the diagnostic yield and accuracy between two stereotactic frame systems: the CRW and AW frame.</p><p><strong>Methods: </strong>This was a retrospective cross-sectional study. All patients who had undergone frame-based biopsy for intracranial lesions using the CRW or AW frame from the year 2014 to 2022 were included in this study. Sociodemographic details, biopsy characteristics, and histopathological reports were collected, tabulated, and analyzed. A p-value of < 0.05 was regarded as statistically significant.</p><p><strong>Results: </strong>A total of 38 patients underwent frame-based stereotactic biopsy from January 2014 to January 2022. The CRW frame was used for 19 (50%) of the patients, and the remaining utilized the AW frame. Deep lesions were biopsied in 27 (71%) of the patients, and the overall diagnostic yield was 89.5%. When comparing sociodemography and lesion characteristics between the CRW and AW frame groups, no statistically significant differences were found. The diagnostic yield and accuracy of these frames were 100% vs 84% and 100% vs 90% (AW vs CRW), respectively, with no statistical difference between them (p > 0.05).</p><p><strong>Conclusion: </strong>This study found that biopsies with the AW frame demonstrated diagnostic yield and accuracy which were non-inferior to the older more established frame (CRW).</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Practice Guidelines for the Pre-hospital Stage of Acute Stroke in Korea II : Transport Decisions for Patients with Acute Ischemic Stroke.","authors":"Jae Sang Oh, Yuna Jo, Jong Min Lee, Hong Suk Ahn, Jung-Jae Kim, Kyoung Min Jang, Gi-Yong Yun, Jang Hun Kim, Dongwook Seo, Hyeong Jin Lee, Jinwoo Jeong, Kyoung-Chul Cha, Yong Soo Cho, Su Jin Kim, Jongkyu Park, Won-Sang Cho, Hoon Kim, Young Woo Kim, Seung Hun Sheen, Sang Weon Lee, Jae Whan Lee, Tae Gon Kim, Sung-Kon Ha, Sukh Que Park, Soon Chan Kwon","doi":"10.3340/jkns.2025.0103","DOIUrl":"https://doi.org/10.3340/jkns.2025.0103","url":null,"abstract":"<p><p>The mothership (MS) model, where patients are directly transferred to a thrombectomy-capable center, and the drip-and-ship (DS) model, where thrombolysis is initiated at the nearest primary stroke center before transfer for thrombectomy, are the primary transport modes for patients with stroke. We aimed to establish guidelines for selecting the appropriate transfer strategy based on emergent large vessel occlusion (LVO). We developed this guideline based on evidence from systematic reviews and meta-analyses via a de novo process. A systematic literature review was conducted across four databases (MEDLINE, Embase, Cochrane, and KoreaMed) to answer three Population, Intervention, Comparison, and Outcome questions comparing MS and DS models. The risk of bias was assessed using the Newcastle-Ottawa Scale. Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagrams and meta-analyses were generated for functional outcomes, mortality, and successful recanalization. Twenty-six non-randomized controlled studies showed that the MS model improved good functional outcomes by approximately 14% compared with the DS model (odds ratio [OR], 1.14; 95% confidence interval [CI], 1.00-1.30). Fifteen studies reported that mortality in the MS and DS models showed no significant differences (OR, 0.97; 95% CI, 0.84-1.11). Twenty-four studies revealed no significant difference in successful recanalization between the MS and DS models (OR, 0.87; 95% CI, 0.68-1.10). The MS model should be considered first to improve the functional outcome of patients with LVO. However, if thrombectomy cannot be performed immediately after thrombolysis, or if a thrombectomy-enabled hospital is not nearby, the DS model should be considered by stroke specialists depending on transportation time and regional factors. We suggest a mixed approach with the DS model based on specific circumstances or regions to ensure the optimum treatment of patients with acute ischemic stroke (AIS). Appropriate transport for patients with LVO improves the prognosis of AIS.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of T1 Slope as a Predictor of Loss of Cervical Lordosis and Health-Related Quality of Life After Laminoplasty in Patients with Ossification of the Posterior Longitudinal Ligament : A Retrospective Cohort Study.","authors":"Ji-Ho Jung, Jong-Hoon Jeong, Jong-Hwan Hong, Moon-Soo Han, Jung-Kil Lee","doi":"10.3340/jkns.2025.0077","DOIUrl":"https://doi.org/10.3340/jkns.2025.0077","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify risk factors predicting the loss of cervical lordosis (LCL) in patients with multilevel ossification of the posterior longitudinal ligament (OPLL) after laminoplasty. Additionally, we evaluated the impact of these factors on health-related quality of life (HRQOL).</p><p><strong>Methods: </strong>We retrospectively analyzed data from patients who underwent laminoplasty at XX University Hospital between January 2013 and December 2022. A range of radiological parameters and clinical outcome measures were collected perioperatively. Patients were divided into 2 groups based on the severity of LCL. We then evaluated preoperative radiological parameters associated with LCL and clinical outcomes, including HRQOL.</p><p><strong>Results: </strong>A total of 110 patients (93 men and 17 women; mean age, 61.31 ± 10.80 years) were included in the analysis. A higher T1 slope (T1S) (β = -0.412, p=0.004) and a lower extension ratio (β = 0.107, p=0.006) were associated with an increased risk of LCL. T1S proved to be an excellent predictor of LCL, with a cutoff value of 28° (p < 0.001, area under the curve = 0.918). Furthermore, T1S was the only factor significantly correlated with HRQOL after laminoplasty (r = -0.330, p<0.001).</p><p><strong>Conclusion: </strong>T1S was significantly associated not only with LCL but also with HRQOL among patients with multilevel OPLL after laminoplasty. With a T1S cutoff of 28°, a T1S exceeding this threshold can be considered an important prognostic factor when planning laminoplasty in these patients.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Clinical and Radiologic Outcomes of Biportal Endoscopic Posterior Cervical Inclinatory Foraminotomy : A Retrospective Cohort Study.","authors":"Kwan-Su Song, Pius Kim","doi":"10.3340/jkns.2024.0197","DOIUrl":"10.3340/jkns.2024.0197","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate clinical and radiological outcomes of biportal endoscopic posterior cervical inclinatory foraminotomy (BE-PCIF) to treat cervical spondylotic radiculopathy (CSR).</p><p><strong>Methods: </strong>This retrospective study included patients with CSR who underwent BE-PCIF between April 2020 and April 2023. Patient demographic data were collected and clinical outcomes were assessed using the Visual analog scale (VAS) and MacNab criteria. Various radiological parameters, including inclinatory angles, were collected and correlations with demographic or radiological factors were evaluated.</p><p><strong>Results: </strong>We included 101 patients (46 men and 55 women) with a mean age of 56.99 years, encompassing 162 surgical levels primarily affecting the C5-6 and C6-7 vertebrae. The postoperative VAS scores decreased to less than 1, with 90.1% of patients reporting excellence according to the MacNab criteria. None of the patients experienced any major postoperative complications, including instability. The isthmic distance (ID) expansion ratio, representing the degree of distal decompression, was 2.4, with a minor facet resection rate of 0.4. Right-sided surgeries or surgeries at lower cervical levels correlated with higher inclinatory angles, with a p-value of 0.003 each. Significant correlations were noted between the inclinatory angle and both the facet resection rate and ID expansion ratio, with coefficients of 0.45 and 0.3, respectively, both having a p-value of <0.001, indicating strong statistical significance.</p><p><strong>Conclusion: </strong>BE-PCIF effectively relieves pain and enhances clinical outcomes in CSR patients. The use of the inclinatory angle approach facilitates cervical foraminal expansion and sufficient neural decompression, with higher angles required for adequate decompression at lower cervical levels.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"446-455"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Clazosentan and Nimodipine on Vasospasm and Vasospasm-Related Outcomes after Aneurysmal Subarachnoid Hemorrhage : A Post-hoc Propensity Score-Matched Analysis of Six Randomized Clinical Trials.","authors":"Sung Ho Lee, Kyu-Sun Choi, Osamu Togo, Ik Seong Park","doi":"10.3340/jkns.2024.0195","DOIUrl":"10.3340/jkns.2024.0195","url":null,"abstract":"<p><strong>Objective: </strong>Clazosentan is a recently approved endothelin receptor antagonist indicated for the prevention of vasospasm and related complications following aneurysmal subarachnoid hemorrhage (aSAH). To date, no direct, head-to-head comparison between clazosentan and nimodipine has been conducted. In this study, we indirectly assessed the efficacy and safety of these two drugs in preventing vasospasm and its associated outcomes after aSAH.</p><p><strong>Methods: </strong>Participants from six randomized clinical trials of clazosentan were reclassified into three subgroups based on their concomitant use of oral nimodipine : 1) a clazosentan subgroup (without nimodipine), 2) a nimodipine subgroup (without clazosentan), and 3) a placebo subgroup (receiving neither clazosentan nor nimodipine). Data from participants who received the approved dose of clazosentan 10 mg/h was analyzed. To account for heterogeneities among the analyzed studies, we performed within-study comparisons of subgroups and pooled data from the same subgroup. To further balance the three groups, we conducted a propensity score-matching and compared the outcomes among subgroups. The outcomes measured were angiographic vasospasm within 14 days after aSAH and vasospasm-related morbidity and all-cause mortality (MM) within 6 weeks, defined as death, vasospasm-related new cerebral infarcts, delayed ischemic neurological deficits, or initiation of rescue therapy. Incidence and relative risk reduction (RRR) were analyzed across subgroups, and overall safety was reviewed.</p><p><strong>Results: </strong>The pooled data from within-study comparisons demonstrated that clazosentan significantly reduced the risk of vasospasm (RRR, 0.48; 95% confidence interval [CI], 0.35 to 0.58) and MM (RRR, 0.47; 95% CI, 0.30 to 0.60) compared to placebo, whereas nimodipine did not. In the propensity score-matched analysis, clazosentan demonstrated a significant risk reduction in outcomes when compared to nimodipine (RRR, 0.63; 95% CI, 0.46 to 0.75 for vasospasm; RRR, 0.29; 95% CI, 0.04 to 0.48 for MM) and placebo (RRR, 0.59; 95% CI, 0.40 to 0.72 for vasospasm; RRR, 0.41; 95% CI, 0.21 to 0.56 for MM).The overall safety results were comparable across the three subgroups and consistent with the expected range for endothelin receptor antagonists.</p><p><strong>Conclusion: </strong>Clazosentan at 10 mg/h significantly reduced the incidence of cerebral vasospasm and MM following aSAH, compared to both placebo and nimodipine. Further clinical studies are warranted to compare the efficacy of clazosentan and nimodipine to optimize treatment strategies for aSAH.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"392-404"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing the Ascending Pharyngeal Artery for Onyx Embolization in Cranial Dural Arteriovenous Fistulas : A Retrospective Analysis.","authors":"Hye Won Choi, Tae Keun Jee, Young Woon Lee, Je Young Yeon, Pyoung Jeon, Jong-Soo Kim, Keon Ha Kim","doi":"10.3340/jkns.2024.0168","DOIUrl":"10.3340/jkns.2024.0168","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study evaluates our experience with transarterial embolization (TAE) of dural arteriovenous fistulas (dAVFs) using the ascending pharyngeal artery (APA), considering its selective application as a route for the treatment.</p><p><strong>Methods: </strong>We performed a retrospective analysis of medical records and radiologic data of all patients who underwent TAE through the APA at our institution from January 2009 to April 2021.</p><p><strong>Results: </strong>We identified 305 patients with cranial dAVFs treated endovascularly at our center, focusing on 11 cases (3.6%) where the APA was used for Onyx embolization. Of the 11 dAVFs, five (45%) were completely occluded, three (27%) showed residual shunt but cortical venous reflux disappeared, and three (27%) showed decreased shunt flow but persistent cortical venous reflux. Cranial nerve palsy occurred in two of the cases in which TAE was performed with the jugular branch and hypoglossal branch of the neuromeningeal trunk, which partially improved over 4 to 6 months. No new instances of infarction or hemorrhage were noted on subsequent magnetic resonance angiography.</p><p><strong>Conclusion: </strong>Transarterial Onyx embolization through the APA could be a limited option reserved for cases where embolization using other branches is challenging or carries a high risk of incomplete treatment. While embolizing through the jugular and hypoglossal branches of the APA neuromeningeal trunk requires greater caution, selecting the posterior meningeal artery or pharyngeal trunk appears to be associated with a lower risk. A comprehensive understanding of angiography is crucial for identifying cases suitable for this approach and those with a higher risk of complications.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"415-424"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Anterior Cingulotomy for Intractable Pain Caused Thalamic Glioma.","authors":"Kostiantyn Kostiuk, Davyd Tevzadze","doi":"10.3340/jkns.2024.0148","DOIUrl":"10.3340/jkns.2024.0148","url":null,"abstract":"<p><p>Stereotactic bilateral anterior cingulotomy, including lesions in the anterior and midcingulate cortex, is one of the methods used for treating thalamic pain syndrome. In cases of non-ischemic thalamic lesions, simultaneous stereotactic biopsy of the lesion can be performed in combination with cingulotomy. In this paper we present a case of a 45-year-old male with a lesion in the right thalamus, causing a severe contralateral hemi-pain syndrome. Bilateral radiofrequency anterior cingulotomy and stereotactic biopsy were performed during a single surgery. Pain completely subsided within a few days following the anterior cingulotomy. Histological examination identified a diffuse astrocytoma (World Health Organization grade II, ICD-O 9400/3), and the patient was subsequently referred for LINAC-based radiosurgery. The pain syndrome was controlled for 4 years, after which the pain syndrome returned with an increase in tumor size. Simultaneous anterior cingulotomy and stereotactic biopsy of the thalamic lesion represent a safe intervention for thalamic pain syndrome, enabling the alleviation of pain, verification of the lesion's etiology, and the application of appropriate treatment.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"488-493"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}