Journal of Interferon and Cytokine Research最新文献_第9页

Activation of the Interleukin-18 Signaling Pathway via Direct Receptor Dimerization in the Absence of Interleukin-18. 在不存在白细胞介素-18的情况下通过直接受体二聚激活白细胞介蛋白-18信号通路。

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2024-01-01 Epub Date: 2023-11-06 DOI: 10.1089/jir.2023.0129

Yasaman Mortazavi, Robert Herrera, Matthieu Masureel, Timurs Maculins, Isabelle Lehoux, Jonathan Sockolosky, Nathan West, Beyza Bulutoglu, Yue Zhao

引用次数: 0

Acknowledgment of Reviewers 2023. 鸣谢 2023 年审稿人。

IF 2.3 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2023-12-21 DOI: 10.1089/jir.2023.29059.ack

引用次数: 0

BioHabana 2022: Preventive and Immunotherapeutic Strategies Against COVID-19 and Cancer in Cuba. 生物哈瓦那2022:古巴针对COVID-19和癌症的预防和免疫治疗战略。

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2023-12-01 Epub Date: 2023-12-04 DOI: 10.1089/jir.2023.0141

Iraldo Bello-Rivero, Tania Crombet-Ramos, Circe Mesa-Pardillo, Yanelys Morera-Díaz, Zaima Mazorra-Herrera, Dagmar Garcia-Rivera, Hugo Nodarse-Cuní, Francisco Hernández-Bernal, Verena Muzio-Gonzalez, Ana Aguilera-Barreto, Dania Vazquez-Blomquist, Maria Del Carmen Domínguez-Horta, Gerardo Guillen-Nieto

{"title":"BioHabana 2022: Preventive and Immunotherapeutic Strategies Against COVID-19 and Cancer in Cuba.","authors":"Iraldo Bello-Rivero, Tania Crombet-Ramos, Circe Mesa-Pardillo, Yanelys Morera-Díaz, Zaima Mazorra-Herrera, Dagmar Garcia-Rivera, Hugo Nodarse-Cuní, Francisco Hernández-Bernal, Verena Muzio-Gonzalez, Ana Aguilera-Barreto, Dania Vazquez-Blomquist, Maria Del Carmen Domínguez-Horta, Gerardo Guillen-Nieto","doi":"10.1089/jir.2023.0141","DOIUrl":"10.1089/jir.2023.0141","url":null,"abstract":"The convergence of life sciences with neurosciences, nanotechnology, data management, and engineering has caused a technological diversification of the biotechnology, pharmaceutical, and medical technology industries, including the phenomenon of digital transformation, which has given rise to the so-called Fourth Industrial Revolution (Industry 4.0). Confronting the COVID-19 pandemic revealed the outstanding response capacity of the scientific community and the biopharmaceutical industry, based on a multidisciplinary and interinstitutional approach that has achieved an unprecedented integration in the history of biomedical science. Cuba, a small country, with scarce material resources, has had remarkable success in controlling the disease, which also highlights the impact of social factors. This report presents a summary of the most relevant presentations of selected topics during the scientific meeting, \"BioHabana 2022: Cancer Immunotherapy and the COVID-19 Pandemic,\" which was held in Havana Cuba in April 2022.","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"571-580"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138482471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conversation with Dr. Daniela Novick. 与Daniela Novick博士的对话。

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2023-12-01 Epub Date: 2023-10-25 DOI: 10.1089/jir.2023.29057.int

Daniela Novick

引用次数: 0

The Association of Serum Midkine Level with Invasion in Placenta Previa: A Case-Control Study from a Tertiary Reference Center. 血清 Midkine 水平与前置胎盘侵犯的关系：一项来自三级参考中心的病例对照研究

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2023-12-01 DOI: 10.1089/jir.2023.0106

Nihat Farisoğullari, Atakan Tanaçan, Bedri Sakcak, Ramazan Denizli, Osman Onur Özkavak, Ezgi Turgut, Özgür Kara, Nuray Yazihan, Dilek Şahin

{"title":"The Association of Serum Midkine Level with Invasion in Placenta Previa: A Case-Control Study from a Tertiary Reference Center.","authors":"Nihat Farisoğullari, Atakan Tanaçan, Bedri Sakcak, Ramazan Denizli, Osman Onur Özkavak, Ezgi Turgut, Özgür Kara, Nuray Yazihan, Dilek Şahin","doi":"10.1089/jir.2023.0106","DOIUrl":"10.1089/jir.2023.0106","url":null,"abstract":"We aimed to examine the relationship between serum midkine levels and placental invasion in pregnant women with placenta previa. The study group consisted of 43 pregnant women diagnosed with placenta previa, whereas the control group consisted of 60 healthy pregnant women. Serum midkine levels were compared between pregnant women with placenta previa and the control group in this study's first part. Thereafter, the utility of midkine in the prediction of the abnormally invasive placenta (AIP) was investigated and optimal cutoff values were calculated. Significantly higher serum midkine level was observed in placenta previa cases than in the controls (1.16 ng/mL vs. 0.18 ng/mL, P < 0.001). Serum midkine level was also significantly higher in the AIP group among the placenta previa cases (P = 0.004). In the receiver operating characteristic analysis, the cutoff value of the midkine level in predicting AIP was 1.19 ng/mL. This study revealed that the serum midkine level is higher in pregnant women with AIP. Maternal serum midkine level may be used as a complementary biomarker to the radiological and clinical findings for the prediction of the AIP in placenta previa cases.","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":"43 12","pages":"557-564"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biology of Interleukin-17 and Novel Therapies for Hidradenitis Suppurativa. 白细胞介素-17的生物学特性及对化脓性痢疾的新疗法。

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2023-12-01 Epub Date: 2023-10-12 DOI: 10.1089/jir.2023.0105

Robert Sabat, Johann Eli Gudjonsson, Nicolo Costantino Brembilla, Kelsey R van Straalen, Kerstin Wolk

{"title":"Biology of Interleukin-17 and Novel Therapies for Hidradenitis Suppurativa.","authors":"Robert Sabat, Johann Eli Gudjonsson, Nicolo Costantino Brembilla, Kelsey R van Straalen, Kerstin Wolk","doi":"10.1089/jir.2023.0105","DOIUrl":"10.1089/jir.2023.0105","url":null,"abstract":"Skin disorders affect ∼40% of the human population. One of the most debilitating cutaneous disorders is Hidradenitis suppurativa (HS), a noncommunicable chronic inflammatory disease with an estimated global prevalence of 0.4% to 2.5%. In January 2011, high levels of IL-17 were discovered in skin lesions of HS patients. In the following years, translational and clinical research led to a better understanding of the pathogenesis of HS. In June 2023, more than 12 years after the initial note, secukinumab, an anti-IL-17A monoclonal antibody, was approved for the treatment of moderate to severe HS. This is the next milestone in improving the treatment of these patients after the approval of the anti-TNF-α monoclonal antibody adalimumab in 2015. In this review article, we present the IL-17 pathway in HS and discuss the use of secukinumab as a therapeutic option for this disease. Our review starts with a description of the epidemiology, clinical features, etiology, and pathogenesis of HS. An overview of the IL-17/IL-17 receptor system in general and a detailed description of the known facts about the expression and action of IL-17 in HS follow. Afterward, we consider the results of clinical trials evaluating the safety and efficacy of IL-17 inhibitors in HS. Finally, a comparison is made between secukinumab and adalimumab and the characteristics of the patients that may be particularly suitable for each of these biologics are described.","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"544-556"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41203391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Anti-Interferon-Alpha Autoantibody Levels in Severe/Critical COVID-19 Patients from Peru. 秘鲁重症/危重新冠肺炎患者的高抗干扰素-α自身抗体水平。

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2023-12-01 Epub Date: 2023-10-31 DOI: 10.1089/jir.2023.0087

Maria J Pons, Ana Mayanga-Herrera, Luciano A Palomino-Kobayashi, Antonio M Quispe, Manuel F Ugarte-Gil

{"title":"High Anti-Interferon-Alpha Autoantibody Levels in Severe/Critical COVID-19 Patients from Peru.","authors":"Maria J Pons, Ana Mayanga-Herrera, Luciano A Palomino-Kobayashi, Antonio M Quispe, Manuel F Ugarte-Gil","doi":"10.1089/jir.2023.0087","DOIUrl":"10.1089/jir.2023.0087","url":null,"abstract":"Innate immune responses through the production of type I interferon-α (anti-IFN-α) play an essential role in the defense against viruses. The autoantibodies (auto-Abs) anti-IFN-α are implicated in COVID-19 pathogenesis with higher levels among patients with worse prognoses. The study aimed to assess the levels of anti-IFN-α auto-Abs in Peruvian patients with severe/critical hospitalized COVID-19 compared to asymptomatic/mild COVID-19 outpatients and healthy controls. We analyzed 101 serum samples, including 56 (55.5%) severe/critical, 13 (12.3%) asymptomatic/mild COVID-19 patients, and 32 (32.2%) healthy controls, which we tested using a commercial ELISA anti-IFN-α-auto-Abs kit. We observed seropositivity of 48.2% (26/54) to anti-IFN-α auto-Abs among the severe/critical COVID-19 group, but 0% (0/13) and 3.1% (1/32) among the asymptomatic/mild COVID-19 and healthy groups (P = 0.021), respectively. Furthermore, we observed a significant association between the log10 of anti-IFN-α auto-Abs and the COVID-19 status, with the log10 of anti-IFN-α auto-Abs levels being significantly higher among the severe/critical COVID-19 group compared to the healthy controls (β = 1.20; confidence interval [95% CI]: 0.72-1.67; P < 0.001). Such association remains significant either when adjusted by age and gender (adjusted β = 1.16; 95% CI: 0.62-1.70; P < 0.001) and when adjusted by the subjects' age, gender, and obesity (adjusted β = 1.16; 95% CI: 0.62-1.70; P < 0.001). Despite not measuring neutralizing activity, this study highlights the high frequency of these auto-Abs in the Peruvian population with a worse prognosis of COVID-19.","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"565-570"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71412568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Serum Chemokine Ligand 20 Levels and Disease Activity and Th1/Th2/Th17-Related Cytokine Levels in Rheumatoid Arthritis. 类风湿性关节炎患者血清趋化因子配体20水平与疾病活性和Th1/Th2/Th17相关细胞因子水平的相关性。

IF 2.3 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2023-11-01 Epub Date: 2023-10-09 DOI: 10.1089/jir.2023.0057

Liuqing Wang, Xuelian Hong, Hongwei Du

{"title":"Association Between Serum Chemokine Ligand 20 Levels and Disease Activity and Th1/Th2/Th17-Related Cytokine Levels in Rheumatoid Arthritis.","authors":"Liuqing Wang, Xuelian Hong, Hongwei Du","doi":"10.1089/jir.2023.0057","DOIUrl":"10.1089/jir.2023.0057","url":null,"abstract":"Rheumatoid arthritis (RA) is a type of arthritis autoimmune disease characterized by systemic chronic inflammation. C-C Chemokine ligand 20 (CCL20) is the same as most chemokines with immunomodulatory and inflammatory processes. The correlation of CCL20 in RA remains unclear. This study aimed to explore the association among levels of CCL20, T helper cell (TH) subset (Th1/Th2/Th17)-related cytokine levels, and clinical indices of RA disease activity. Serum CCL20 levels were quantified by enzyme-linked immunosorbent assay, and a flow-fluorescence technique was used to assess Th1/Th2/Th17-related cytokine levels. The serum CCL20 levels in patients were significantly higher than those in healthy controls and positively associated with C-reactive protein levels, erythrocyte sedimentation rate, and disease activity score-28 (DAS28). Patients with RA were categorized into 4 major groups, including remission, low, moderate, and high disease activity, with related DAS28 scores for each group. CCL20 levels of the disease moderate/high activity group were moderately positively correlated with IL-6 levels, but not with the other Th1/Th2/Th17-related cytokines. Serum CCL20 levels correlate strongly with RA disease activity and clinical inflammation and were significantly elevated in patients compared to healthy individuals. CCL20 plays a key role in the immune response of patients with RA and is, therefore, a potential biomarker of disease activity.","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"512-517"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41182793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proinflammatory Bone Marrow Mesenchymal Stem Cell-Derived Exosomal miR-150-3p Suppresses Proinflammatory Polarization of Alveolar Macrophages in Sepsis by Targeting Inhibin Subunit Beta A. 炎性骨髓间充质干细胞来源的外泌体miR-150-3p通过靶向抑制素亚单位βA抑制脓毒症中肺泡巨噬细胞的炎性极化。

IF 2.3 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2023-11-01 Epub Date: 2023-10-11 DOI: 10.1089/jir.2023.0068

Guojin Liang, Yueying Feng, Wan Tang, Lifeng Yao, Changshun Huang, Yijun Chen

{"title":"Proinflammatory Bone Marrow Mesenchymal Stem Cell-Derived Exosomal miR-150-3p Suppresses Proinflammatory Polarization of Alveolar Macrophages in Sepsis by Targeting Inhibin Subunit Beta A.","authors":"Guojin Liang, Yueying Feng, Wan Tang, Lifeng Yao, Changshun Huang, Yijun Chen","doi":"10.1089/jir.2023.0068","DOIUrl":"10.1089/jir.2023.0068","url":null,"abstract":"Bone marrow mesenchymal stem cell (BMSC)-derived exosomes can protect lung tissues against sepsis, but its related mechanism remains elusive. BMSCs were primed with or without lipopolysaccharide (LPS) before extracting exosomes. The isolated exosomes were identified by transmission electron microscopy, nanoparticle tracking analysis, and western blot. LPS-stimulated macrophages were cocultured with exosomes for 24 h, followed by enzyme-linked immunosorbent assay, flow cytometry, and molecular experiments. Bioinformatics and luciferase assay were employed to investigate the interaction between miR-150-3p and inhibin subunit beta A (INHBA). MiR-150-3p expression was increased in exosomes in a proinflammatory environment. Exosomes suppressed proinflammatory polarization by downregulating IL-6, IL-1β, iNOS, and CD86, as well as promoted anti-inflammatory polarization by upregulating IL-10, ARG-1, and CD206 in LPS-stimulated macrophages. Such effects were more pronounced by LPS-primed exosomes, which was reversed in the absence of miR-150-3p. MiR-150-3p targeted INHBA. INHBA silencing decreased CD86 expression and increased CD206 expression in macrophages, but these effects were reversed by exosomal miR-150-3p inhibition. Proinflammatory BMSC-derived exosomal miR-150-3p suppressed proinflammatory polarization and promoted anti-inflammatory polarization of alveolar macrophages to attenuate LPS-induced sepsis by targeting INHBA.","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"518-530"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41203392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRPM2-L Participates in the Interleukin-6 Pathway to Enhance Tumor Growth in Prostate Cancer by Hypoxia-Inducible Factor-1α. TRPM2-L参与白细胞介素-6通路通过缺氧诱导因子-1α促进癌症前列腺肿瘤生长。

IF 2.3 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2023-11-01 Epub Date: 2023-10-31 DOI: 10.1089/jir.2023.0088

Kai Cheng, Qingmei Jia, Christopher Batbatan, Zhihua Guo, Fengtao Cheng

{"title":"TRPM2-L Participates in the Interleukin-6 Pathway to Enhance Tumor Growth in Prostate Cancer by Hypoxia-Inducible Factor-1α.","authors":"Kai Cheng, Qingmei Jia, Christopher Batbatan, Zhihua Guo, Fengtao Cheng","doi":"10.1089/jir.2023.0088","DOIUrl":"10.1089/jir.2023.0088","url":null,"abstract":"Interleukin-6 (IL-6) can promote cell proliferation in prostate cancer (PCa). Full-length transient receptor potential melastatin 2 (TRPM2-L) is highly expressed in PCa. However, the association between IL-6 and TRPM2-L in PCa is unclear. Here, human PCa cell lines, PC-3 and DU-145, were treated with 10 μg/mL tocilizumab, an IL-6 receptor (IL-6R) inhibitor, and the TRPM2-L protein expression in cells was significantly decreased. Cells were stably transfected with TRPM2 short-interfering RNA (siRNA) and cell survival clearly declined. Recombinant IL-6 treatment weakened the effects of TRPM2-siRNA on cell survival. TRPM2-L binds directly to IL-6R in PC-3 and DU-145 cells. The protein expression of hypoxia-inducible factor-1α was suppressed by reduction with TRPM2-L in PC-3 and DU-145 cells. Human umbilical vein endothelial cells (HUVECs) were indirectly cocultured with PCa cells, and the invasion and angiogenic activity of HUVECs were enhanced after coculture with PCa cells. However, TRPM2-L reduction in PCa cells significantly decreased the invasion and angiogenic activity of HUVECs compared to the control coculture. In vivo, xenograft tumors were induced using PC-3 cells. Tocilizumab treatment or TRPM2-L reduction clearly suppressed tumor growth. Meanwhile, the injection of mouse recombinant IL-6 weakened the antitumor effects of TRPM2-L reduction. These data demonstrate that the IL-6/TRPM2-L axis in PCa tumor growth is important, and interference of the IL-6/TRPM2-L axis may be a novel approach for PCa therapy.","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"495-511"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71412569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0