Interleukin-6 Family of Cytokines in Cancers.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Interferon and Cytokine Research Pub Date : 2024-02-01 Epub Date: 2024-01-17 DOI:10.1089/jir.2023.0103
Iwona Zaporowska-Stachowiak, Michał Springer, Katarzyna Stachowiak, Mary Oduah, Maciej Sopata, Katarzyna Wieczorowska-Tobis, Wiesław Bryl
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引用次数: 0

Abstract

Nine soluble ligands [interleukin-6 (IL-6), interleukin-11 (IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, interleukin-27 (IL-27), and interleukin-31] share the ubiquitously expressed transmembrane protein-glycoprotein-130 beta-subunit (gp130) and thus form IL-6 family cytokines. Proteins that may be important for cancerogenesis, CT-1, IL-11, IL-27, LIF, OSM, and CNTF, belong to the superfamily of IL-6. Cytokines such as IL-6, IL-11, and IL-27 are better investigated in comparison with other members of the same family of cytokines, eg, CT-1. Gp130 is one of the main receptors through which these cytokines exert their effects. The clinical implication of understanding the pathways of these cytokines in oncology is that targeted therapy to inhibit or potentiate cytokine activity may lead to remission in some cases.

癌症中的白细胞介素-6 家族细胞因子
九种可溶性配体[白细胞介素-6 (IL-6)、白细胞介素-11 (IL-11)、白血病抑制因子 (LIF)、鹅肌肽 M (OSM)、睫状肌神经营养因子 (CNTF)、心脏营养素-1 (CT-1)、白细胞介素-27(IL-27)和白细胞介素-31]共享普遍表达的跨膜蛋白-糖蛋白-130 beta-亚基(gp130),因此形成 IL-6 家族细胞因子。可能对癌症发生有重要影响的蛋白质 CT-1、IL-11、IL-27、LIF、OSM 和 CNTF 都属于 IL-6 的超家族。IL-6、IL-11 和 IL-27 等细胞因子与 CT-1 等同属一个细胞因子家族的其他成员相比,得到了更好的研究。Gp130 是这些细胞因子发挥作用的主要受体之一。了解这些细胞因子在肿瘤学中的作用途径的临床意义在于,抑制或增强细胞因子活性的靶向治疗可能会使某些病例的病情得到缓解。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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