Cytokine Plasma Levels in Breast Cancer Patients, Before and After Surgery.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Interferon and Cytokine Research Pub Date : 2024-03-01 Epub Date: 2024-02-20 DOI:10.1089/jir.2023.0157
Emmanuel Kontomanolis, Christina Tsigalou, Achilleas Mitrakas, Anastasia G Gkegka, Eleni Efraimidou, Dimitrios Karamanidis, Konstantinos Nikoletos, Tsikouras Panagiotis, Nikolaos Nikoletos, Alexandra Giatromanolaki, Michael I Koukourakis
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引用次数: 0

Abstract

Studying the levels of cytokines in the plasma of patients could be valuable in guiding immunotherapy policies. We assessed the plasma levels of 4 major cytokines [interferon (IFN)-β, interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β)] collected from 19 patients with ductal breast cancer (BCa), before surgery (BS) and 5 days after surgery (AS). The ratio AS/BS was also calculated and correlated with histopathological variables and tumor-infiltrating lymphocyte (TIL) density. The IFN-β and TNF-α levels were significantly higher in BCa patients, BS and AS, than healthy controls (P < 0.02). High IL-2 levels BS were linked with node involvement (P = 0.02), and marginally with HER2 expression (P = 0.08), while high TNF-α levels were linked with high PgR expression (P = 0.02). Increasing IFN-β, IL-2, and TNF-α levels were noted AS, which was more evident in patients with larger tumors. The TGF-β levels were significantly lower in BCa patients (P < 0.007). Linear regression analysis showed a direct association of IFN-β levels AS (P = 0.02, r = 0.52) and of TNF-α AS/BS-ratio (P = 0.001, r = 0.72) with TIL-density. It is suggested that although effector immune response is evident in the majority of early stage BCa patients, removal of the primary tumor further unblocks such responses.

乳腺癌患者手术前后的细胞因子血浆水平
研究患者血浆中的细胞因子水平对指导免疫疗法政策很有价值。我们评估了 19 位导管型乳腺癌(BCa)患者手术前(BS)和手术后 5 天(AS)血浆中 4 种主要细胞因子[干扰素 (IFN)-β、白细胞介素-2 (IL-2)、肿瘤坏死因子α (TNF-α)、转化生长因子β (TGF-β)]的水平。此外,还计算了 AS/BS 比率,并将其与组织病理学变量和肿瘤浸润淋巴细胞(TIL)密度相关联。BCa患者(BS和AS)的IFN-β和TNF-α水平明显高于健康对照组(P = 0.02),与HER2表达略有关联(P = 0.08),而高TNF-α水平与高PgR表达有关(P = 0.02)。AS患者的IFN-β、IL-2和TNF-α水平不断升高,这在肿瘤较大的患者中更为明显。TGF-β水平在BCa患者中明显较低(P P = 0.02,r = 0.52),TNF-α的AS/BS比值(P = 0.001,r = 0.72)与TIL密度相关。这表明,虽然大多数早期 BCa 患者的效应免疫反应是明显的,但切除原发肿瘤会进一步解除这种反应。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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