Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer.

IF 1.9 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Interferon and Cytokine Research Pub Date : 2024-04-01 Epub Date: 2024-03-18 DOI:10.1089/jir.2023.0190

Ziwei Zhu, Qian Peng, Xingmei Duan, Jie Li

引用次数: 0

Abstract

Interleukin 12 (IL-12) is a heterodimer consisting of 2 subunits, p35 and p40, with unique associations and interacting functions with its family members. IL-12 is one of the most important cytokines regulating the immune system response and is integral to adaptive immunity. IL-12 has shown marked therapeutic potential in a variety of tumor types. This review therefore summarizes the characteristics of IL-12 and its application in tumor treatment, focusing on its antitumor effects in colorectal cancer (CRC) and potential radiosensitization mechanisms. We aim to provide a current reference for IL-12 and other potential CRC treatment strategies.

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白细胞介素-12：结构、功能及其对结直肠癌的影响。

白细胞介素 12（IL-12）是一种异源二聚体，由 p35 和 p40 两个亚基组成，与其家族成员具有独特的关联和相互作用功能。IL-12 是调节免疫系统反应的最重要细胞因子之一，是适应性免疫不可或缺的成分。IL-12 已在多种肿瘤类型中显示出明显的治疗潜力。因此，本综述总结了 IL-12 的特点及其在肿瘤治疗中的应用，重点关注其在结直肠癌（CRC）中的抗肿瘤作用和潜在的放射增敏机制。我们的目标是为 IL-12 和其他潜在的 CRC 治疗策略提供当前参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Interferon and Cytokine Research 医学-免疫学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

2.2 months

期刊介绍： Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.