{"title":"Comparative Efficacy of Postoperative Compression Methods After EVLT for Great Saphenous Vein Insufficiency.","authors":"Niki Tadayon, Mostafa Mousavizadeh, Fateme Yousefimoghaddam, Faezeh Jadidian, Mohammadmoein Mirhosseini, Naser Hadavand","doi":"10.34172/jlms.2024.02","DOIUrl":"https://doi.org/10.34172/jlms.2024.02","url":null,"abstract":"<p><p><b>Introduction:</b> The preference for endovascular techniques in treating varicose veins, particularly in the great saphenous vein (GSV), has increased due to their minimally invasive nature and reduced complications. Post-operative care, especially involving compression therapy, remains crucial to improve outcomes, prevent varicose vein recurrence, and enhance overall recovery. This study aimed to evaluate the efficacy of eccentric compression therapy compared to alternative post-operative care methods following endovenous laser treatment (EVLT) for GSV insufficiency. <b>Methods:</b> This prospective randomized clinical trial encompassed 88 EVLT procedures for GSV insufficiency. The participants were divided into two groups, each receiving different postoperative compression methods, and were evaluated over a specified period. The primary outcome was the pain scale after EVLT; meanwhile, the secondary outcome measured in the present study was the rate of GSV occlusion after EVLT. <b>Results:</b> Both groups underwent all EVLT procedures successfully without any complications. At the one-month duplex ultrasound (DUS) follow-up, the sapheno-femoral junction occlusion rates were 97% (43 out of 44) for group A (eccentric compression plus gradual compression stocking) and 95% (42 out of 44) for group B (only gradual compression stocking). Ecchymosis was observed in only 12 patients across both groups, accounting for an overall occurrence of 13.6%. Group A patients reported significantly lower analgesic usage (10%) compared to group B (18%), although this difference did not reach statistical significance. Analysis of postoperative pain data utilizing the visual analog scale (VAS) showed a median value of 5.5 in group B patients, which decreased to 3.1 with the application of eccentric compression. Moreover, there was less ecchymosis in group A observed by one week. <b>Conclusion:</b> This study contributes to the ongoing discourse on the efficacy of postoperative compression in varicose vein treatment. It underscores the necessity for more comprehensive, well-designed studies to yield clearer conclusions and provide better guidance for post-procedure care.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e2"},"PeriodicalIF":1.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11033854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehdi Gheisari, Reza M Robati, Zahra Hassanzadeh Tabatabaei, Tara Barat
{"title":"The Efficacy of Long-Pulsed, 1064-nm Nd:YAG Laser Versus Aluminum Chloride 20% Solution in the Treatment of Axillary Hyperhidrosis.","authors":"Mehdi Gheisari, Reza M Robati, Zahra Hassanzadeh Tabatabaei, Tara Barat","doi":"10.34172/jlms.2023.71","DOIUrl":"10.34172/jlms.2023.71","url":null,"abstract":"<p><p><b>Introduction:</b> Hyperhidrosis (HH) refers to uncontrollable excessive sweating that has a significant negative impact on the quality of life. The aim of this study was to compare the efficacy and safety of the long-pulsed, 1064-nm Nd:YAG laser and aluminum chloride (ALCL<sub>3</sub> ) 20% solution in axillary HH treatment. <b>Methods:</b> In this single-center, within-patient comparison clinical trial, 12 patients with axillary HH were treated monthly for 3 to 4 consecutive sessions with the long-pulsed, 1064-nm Nd:YAG laser system on one axilla, while the contralateral axilla was treated with ALCL<sub>3</sub> 20 % by the patient. Treatment response was evaluated by comparing the area of sweating at the end of each session and 6 months after treatment termination using the iodine starch test. <b>Results:</b> Both treatments led to the reduction of HH from baseline with the mean area of sweating reduced from 109.3±36.6 to 38.3±19.8 and from 92.5±31.6 to 35.6±17.1 in laser- and ALCL<sub>3</sub>-treated axilla respectively (Both <i>P</i><0.001). In the 6-month follow-up, the area of sweating was 60.6±29.2 in the laser-treated armpit and 78.3±23.6 in the ALCL<sub>3</sub>-treated side, which were 45% and 14.4% lower compared to the baseline respectively. Adverse events were temporary, and none caused each of the treatments to be discontinued. <b>Conclusion:</b> The long-pulsed, 1064-nm Nd:YAG laser with hair reduction setting can stand as a potential therapeutic option for axillary HH since it is as effective as ALCL<sub>3</sub>. The therapeutic effect is superior in the long term for the laser; nevertheless, the beneficial effect of both treatments may lessen the following treatment cessation.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"14 ","pages":"e71"},"PeriodicalIF":1.5,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saeede Zadsirjan, Mohammad Asnaashari, Tina Estarami, Soolmaz Heidari, Babak Shokri, Atoosa Yazdani
{"title":"Effect of Non-thermal Plasma Therapy on Pushout Bond Strength of Epoxy Resin and Tricalcium Silicate-Based Endodontic Sealers.","authors":"Saeede Zadsirjan, Mohammad Asnaashari, Tina Estarami, Soolmaz Heidari, Babak Shokri, Atoosa Yazdani","doi":"10.34172/jlms.2023.70","DOIUrl":"10.34172/jlms.2023.70","url":null,"abstract":"<p><p><b>Introduction:</b> The current study aimed to assess the effect of non-thermal plasma (NTP) on the pushout bond strength (PBS) of epoxy resin and tricalcium silicate-based endodontic sealers. <b>Methods:</b> Forty single-canal extracted teeth were decoronated at the coronal region, underwent root canal preparation, and were assigned to four groups (n=10) for the application of AH26 sealer, NTP+AH26 (P-AH26), Endoseal TCS sealer, and NTP+Endoseal TCS sealer (P-TCS). The root canals were sectioned into 1 mm slices, and the PBS value was measured in a universal testing machine. Data were analyzed by the Friedman, Kruskal-Wallis, and Dunn tests (<i>P</i><0.05). <b>Results:</b> The PBS of TCS and P-TCS groups was not significantly different (<i>P</i>>0.05). The PBS of the P-AH26 group was significantly lower than that of the AH26 group in the middle third (<i>P</i><0.05). The PBS of the AH26 group was higher than the other groups in all sections. The PBS in the apical third was lower than other sections in all groups (<i>P</i><0.05). <b>Conclusion:</b> NTP had no significant effect on the PBS of Endoseal TCS. NTP significantly decreased the PBS of AH26 sealer in the middle third but had no significant effect on its bond strength in other sections.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"14 ","pages":"e70"},"PeriodicalIF":1.5,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Blue Laser-Activated Silver Nanoparticles from Grape Seed Extract for Photodynamic Antimicrobial Therapy Against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>.","authors":"Ahmad Khalil Yaqubi, Suryani Dyah Astuti, Andi Hamim Zaidan, Dezy Zahrotul Istiqomah Nurdin","doi":"10.34172/jlms.2023.69","DOIUrl":"10.34172/jlms.2023.69","url":null,"abstract":"<p><p><b>Introduction:</b> Living organisms, particularly humans, frequently encounter microorganisms like bacteria, fungi, and viruses in their surroundings. Silver nanoparticles are widely used in biomedical devices due to their antibacterial, antifungal, and antiviral properties. The study evaluates the efficacy of blue laser and silver nanoparticles from grape seed extract (AgNPs-GSE) in reducing gram-negative <i>Escherichia coli</i> and gram-positive <i>Staphylococcus aureus</i> bacteria causing infections. <b>Methods:</b> The sample consisted of four groups: a control without laser irradiation (T0), <i>E. coli</i> samples (A1 and A2) irradiated with a 405 nm diode laser at different times and concentrations of silver nanoparticles, and <i>S. aureus</i> samples (A3 and A4) irradiated with a 405 nm diode laser at different times and concentrations. Bacteria in groups A2 and A4 were treated with a photosensitizer (PS) made from grape seed extracts, incubated for 10 minutes, and then irradiated for 90, 120, 150, and 180 seconds. The samples were cultured on Tryptic Soy Agar (TSA) media, incubated at 37 °C, counted by using a Quebec colony counter, and analyzed using ANOVA and Tukey tests with a significance level of <i>P</i><0.05. <b>Results:</b> The study found that 10 µl of AgNPs-GSE, when combined with exposure to a blue laser at 405 nm and a dose of 3.44 J/cm<sup>2</sup>, can effectively photoinactivate <i>E. coli</i> and <i>S. aureus</i> bacteria. The addition of AgNPs-GSE to <i>E. coli</i> bacteria led to a significant reduction in their viability, with a reduction of 73.93%, 80.96%, and 83.80%, respectively. Similarly, when <i>S. aureus</i> bacteria were irradiated for 180 seconds by adding 1 mM, 1.5 mM, and 2 mM AgNPs-GSE, bacterial viability was reduced by 70.87%, 78.04%, and 87.01%, respectively. <b>Conclusion:</b> The findings from the present study indicate that at an energy density of 3.44 J/cm<sup>2</sup>, it was possible to inactivate <i>E. coli</i> by 83.80% and <i>S. aureus</i> by 87.01%.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"14 ","pages":"e69"},"PeriodicalIF":1.5,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luiz Felipe Palma, Thales Dos Santos Porfírio, Rafael Verardi Serrano, Luana Campos, Luís Otávio Carvalho de Moraes
{"title":"Photobiomodulation Therapy for Managing Motor and Sensory Dysfunctions Following Temporomandibular Joint Surgery: A Case Report.","authors":"Luiz Felipe Palma, Thales Dos Santos Porfírio, Rafael Verardi Serrano, Luana Campos, Luís Otávio Carvalho de Moraes","doi":"10.34172/jlms.2023.67","DOIUrl":"10.34172/jlms.2023.67","url":null,"abstract":"<p><p><b>Introduction:</b> Surgical procedures involving the temporomandibular joint (TMJ) are frequently associated with nerve injuries and subsequent dysfunctions. Considering that traumatic peripheral nerve injuries may resolve slowly and their prognosis is generally unpredictable, the current study aimed to report a clinical case in which both motor (affecting the temporal and zygomatic branches of the facial nerve) and sensory dysfunctions (affecting the auriculotemporal nerve of the trigeminal nerve) following TMJ surgery were effectively treated by using photobiomodulation therapy (PBMT). <b>Case Report:</b> PBMT sessions, involving a total of 30 facial points, were administered twice a week for 10 weeks. The following parameters were utilized: wavelength of 808 nm, energy density of 75 J/cm<sup>2</sup>, power output of 100 mW, total energy of 3 J, and duration of 30 seconds per point. A considerable improvement in both facial asymmetry and muscle function was achieved within 5 weeks, along with a total restoration of cutaneous sensitivity. By the 10th week of PBMT, the facial movement dysfunction was completely resolved. <b>Conclusion:</b> According to the current case, PMBT seems to be an effective intervention to manage motor and sensory nerve dysfunctions following TMJ surgery.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"14 ","pages":"e67"},"PeriodicalIF":1.5,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Topographical Analysis of Human Enamel after Phosphoric Acid Etching and Er,Cr:YSGG Laser Irradiation.","authors":"Saja Qasim Salman, Basima Mohammed Ali Hussein","doi":"10.34172/jlms.2023.68","DOIUrl":"10.34172/jlms.2023.68","url":null,"abstract":"<p><p><b>Introduction:</b> Dental hard and soft tissues have been successfully removed by using the Er,Cr:YSGG laser, but there is a controversy about using lasers over conventional tooth surface preparation for bonding aesthetic restoration. Surface roughness and wettability in response to Er,Cr:YSGG laser irradiation are essential properties for restoration longevity. <b>Methods:</b> Fifty-one intact human premolars removed in orthodontic treatment were included in this study and divided into three groups (n=17). The first group (G1) was the control without surface treatment, (G2) was treated with 37% phosphoric acid for 15 seconds, and (G3) was treated with the Er,Cr:YSGG laser using the following parameters: 2 W or 3 W at 20 Hz, 10% air and water ratio using the MZ6 laser tip. The standardization of laser irradiation was accomplished by a computerized numerical control unit. The surface of the samples was evaluated by using a light microscope, profilometer, atomic force microscopy (AFM), SEM, and wettability tests. <b>Results:</b> The SEM examination revealed that the lased enamel surface was clean, irregular, and devoid of a smear layer, while the acid etch surface was relatively smooth and covered with a smear layer. The surface roughness of the lased enamel surface was significantly higher than that of other groups, according to the results of the profilometer as well as the AFM tests. The wettability test showed that the lased enamel surface recorded a significant reduction in the contact angle in comparison to the other groups. <b>Conclusion:</b> It can be concluded that the Er,Cr:YSGG laser can be used as an alternative and safe method to the acid-etching technique for surface treatment.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"14 ","pages":"e68"},"PeriodicalIF":1.5,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immune Response in Laser Tattoo Removal: A Systematic Review.","authors":"Arya Tjipta, Hafiz Ramadhan, Rahmi Amelia Lubis","doi":"10.34172/jlms.2023.66","DOIUrl":"10.34172/jlms.2023.66","url":null,"abstract":"<p><p><b>Introduction:</b> The immune response to laser tattoo removal poses a significant challenge in its management, primarily due to its unpredictable nature, which can range from mild hypersensitivity reactions to severe anaphylaxis. Such responses can potentially hinder the effectiveness of laser tattoo removal procedures. Therefore, gaining a comprehensive understanding of the immune response to tattoo removal using laser techniques is of utmost importance to develop more efficient management strategies. This study aims to address this need by analyzing eight carefully selected articles obtained through a thorough literature review. <b>Methods:</b> To explore the immune response associated with laser techniques in tattoo removal, we employed a rigorous research methodology. A thorough literature review was conducted using reputable search engines such as Google Scholar, SagePub, and PubMed to collect relevant articles. Initially, 788 potential articles were identified through this process. Following meticulous scrutiny, only eight articles that met stringent inclusion criteria were selected for our study. This meticulous selection process ensures that the information presented here is derived from high-quality and pertinent research. <b>Results:</b> Based on the analysis of the eight selected articles, our findings illuminate the various immune responses that emerge following tattoo removal using laser techniques. These responses include hypersensitivity reactions, allergic manifestations, and, in certain instances, anaphylaxis. Hypersensitivity reactions typically manifested as erythema, edema, and pruritus, while allergic responses were observed in the form of urticaria. In summary, our study highlights that the immune response to laser tattoo removal primarily elicits hypersensitivity and, in some cases, anaphylaxis reactions. <b>Conclusion:</b> Our study underscores the significance of clinicians being vigilant regarding potential immune responses during laser tattoo removal. It is crucial to closely monitor patients to promptly address any adverse reactions. Further research holds the potential to enhance our understanding, paving the way for improved management strategies that can enhance patient safety and treatment success.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"14 ","pages":"e66"},"PeriodicalIF":1.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring Intercellular Dynamics: Ultra-Weak Biophoton Emission as a Novel Indicator of Altered Cell Functions and Disease in Oligospermia Mice.","authors":"Arefeh Aryan, Fakhroddin Aghajanpour, Masoomeh Dashtdar, Fatemeh Hejazi, Maryam Salimi, Azar Afshar, Reza Soltani, Ahad Hasan Seyed Hasani, Abbas Aliaghaei, Hojjat-Allah Abbaszadeh, Hasan Mahmoodi, Leila Zahedi, Mohammad-Amin Abdollahifar, Fatemeh Fadaei Fathabadi","doi":"10.34172/jlms.2023.65","DOIUrl":"10.34172/jlms.2023.65","url":null,"abstract":"<p><p><b>Introduction:</b> Biophoton emission, the spontaneous release of photons from living cells, has emerged as an attractive field of research in the study of biological systems. Scientists have recently discovered that changes in biophoton emission could serve as potential indicators of pathological conditions. This intriguing phenomenon suggests that cells might communicate and interact with each other through the exchange of these faint but significant light signals. Therefore, the present study introduces intercellular relationships with biophoton release to detect normal and abnormal cell functions to further achieve cellular interactions by focusing on cell and cell arrangement in disease conditions. <b>Methods:</b> Twenty male mice were assigned to control and busulfan groups. Five weeks after the injection of busulfan, the testis was removed, and then the stereological techniques and TUNEL assay were applied to estimate the histopathology of the testis tissue sections. <b>Results:</b> The findings revealed that the ultra-weak biophoton emission in the control group was significantly lower than in the busulfan group. The oligospermia mice model showed that it significantly changed the spatial arrangement of testicular cells and notably decreased the testis volume, length of seminiferous tubules, and the number of testicular cells. The results of the TUNEL assay showed that the percentage of apoptotic cells significantly increased in the busulfan group. <b>Conclusion:</b> The ultra-weak biophoton emission from testis tissue was reduced in oligospermia mice. As a result, the decline of ultra-weak biophoton can indicate a change in cell arrangement, a decrease in intercellular interaction, and eventually disease.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"14 ","pages":"e65"},"PeriodicalIF":1.5,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tahmineh Ezazi Bojnordi, Laleh Eslamian, Vajiheh Marsoosi, Alireza Golbabaei, Mehrdad Sheikh Vatan, Alireza A Shamshirsaz, Nasim Eshraghi, Marjan Ghaemi
{"title":"Doppler Finding, Cardiovascular Function Assessment, and Fetuses' Survival Following the Fetoscopic Laser in Twin-to-Twin Transfusion Syndrome.","authors":"Tahmineh Ezazi Bojnordi, Laleh Eslamian, Vajiheh Marsoosi, Alireza Golbabaei, Mehrdad Sheikh Vatan, Alireza A Shamshirsaz, Nasim Eshraghi, Marjan Ghaemi","doi":"10.34172/jlms.2023.64","DOIUrl":"10.34172/jlms.2023.64","url":null,"abstract":"<p><p><b>Introduction:</b> This study aimed to evaluate the effectiveness of selective laser photocoagulation of communicating vessels (SLPCV) on cardiac function in twins with twin-to-twin transfusion syndrome (TTTS). <b>Methods:</b> This retrospective cohort study evaluated 178 women with twin pregnancies complicated with TTTS and scheduled for SLPCV between 16 and 26 weeks of gestation. The severity of TTTS was determined by Quintero staging and the severity of cardiovascular disorders by the CHOP (Children's Hospital of Philadelphia) score. Patient survival was evaluated through a one-month-after-birth follow-up of fetuses. <b>Results:</b> The study revealed significant improvements in Doppler indices in both donors and recipients after SLPCV. The CHOP score also significantly decreased after the intervention. One-month-after-birth survival rates were 55.1% in donors and 56.7% in recipients. Some Doppler indexes of fetuses before SLPCV could predict survival until one month after birth. <b>Conclusion:</b> The study suggests that SLPCV can improve cardiac function in fetuses with TTTS and that some Doppler indexes can predict survival outcomes. Additionally, the severity of TTTS can be a powerful indicator of the severity of cardiovascular complications.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"14 ","pages":"e64"},"PeriodicalIF":1.5,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Invariant point message passing for protein side chain packing.","authors":"Nicholas Z Randolph, Brian Kuhlman","doi":"10.1101/2023.08.03.551328","DOIUrl":"10.1101/2023.08.03.551328","url":null,"abstract":"<p><p>Protein side chain packing (PSCP) is a fundamental problem in the field of protein engineering, as high-confidence and low-energy conformations of amino acid side chains are crucial for understanding (and designing) protein folding, protein-protein interactions, and protein-ligand interactions. Traditional PSCP methods (such as the Rosetta Packer) often rely on a library of discrete side chain conformations, or rotamers, and a forcefield to guide the structure to low-energy conformations. Recently, deep learning (DL) based methods (such as DLPacker, AttnPacker, and DiffPack) have demonstrated state-of-the-art predictions and speed in the PSCP task. Building off the success of geometric graph neural networks for protein modeling, we present the Protein Invariant Point Packer (PIPPack) which effectively processes local structural and sequence information to produce realistic, idealized side chain coordinates using <i>χ</i>-angle distribution predictions and geometry-aware invariant point message passing (IPMP). On a test set of ~1,400 high-quality protein chains, PIPPack is highly competitive with other state-of-the-art PSCP methods in rotamer recovery and per-residue RMSD but is significantly faster.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"6 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10769188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90050848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}