Journal of lasers in medical sciences最新文献_第8页

Unveiling Therapeutic Potential: A Systematic Review of Photobiomodulation Therapy and Biological Dressings for Diabetic Foot Ulcers 揭示治疗潜力:糖尿病足溃疡的光生物调节疗法和生物敷料的系统综述

Journal of lasers in medical sciences Pub Date : 2023-10-28 DOI: 10.34172/jlms.2023.49

Sina Karimpour, Mohammad Hussein Amirmotamed, Fariborz Rashno, Foozhan Tahmasebinia, Aliasghar Keramatinia, Fatemeh Fadaee Fathabadi, Hojjat Allah Abbaszadeh, Shahram Darabi

{"title":"Unveiling Therapeutic Potential: A Systematic Review of Photobiomodulation Therapy and Biological Dressings for Diabetic Foot Ulcers","authors":"Sina Karimpour, Mohammad Hussein Amirmotamed, Fariborz Rashno, Foozhan Tahmasebinia, Aliasghar Keramatinia, Fatemeh Fadaee Fathabadi, Hojjat Allah Abbaszadeh, Shahram Darabi","doi":"10.34172/jlms.2023.49","DOIUrl":"https://doi.org/10.34172/jlms.2023.49","url":null,"abstract":"Introduction: Diabetes poses a global health challenge, giving rise to various complications, including diabetic foot ulcers (DFUs). DFUs, marked by ischemic ulcers susceptible to infection and amputation, underscore the urgency for innovative treatments. This study investigated the impact of photobiomodulation therapy (PBT) and autologous platelet gel (APG) on DFUs recovery. Methods: We systematically searched Web of Science, EMBASE, MEDLINE, Cochrane Library, Scopus, and Google Scholar (2015-2023) by using pertinent terms like \"photobiomodulation therapy,\" \"low level light therapy,\" and \"platelet gel.\" After meticulous data extraction and review, 57 articles were chosen and categorized. Among these, three randomized controlled trials involving 186 participants were selected for APG analysis. Results: Findings demonstrate that APG application carries minimal risk and offers promising improvements in healing time, grade, pain reduction, and granulation tissue formation. Similarly, diverse PBT modalities involving distinct probes and wavelengths exhibit the potential to enhance tissue perfusion, expedite healing, and impede wound progression, reducing the need for invasive interventions. Conclusion: PBT and APG emerge as valuable tools to augment wound healing, mitigate inflammation, and avert amputation, representing compelling therapeutic options for DFUs.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collagen Synthesis as a Prominent Process During the Interval between Two Laser Sessions 胶原蛋白合成在两次激光治疗间隔期间是一个突出的过程

Journal of lasers in medical sciences Pub Date : 2023-10-28 DOI: 10.34172/jlms.2023.50

Vahid Mansouri, Babak Arjmand, Maryam Hamzeloo-Moghadam, Mostafa Rezaei Tavirani, Zahra Razzaghi, Alireza Ahmadzadeh, Mitra Rezaei, Reza M Robati

{"title":"Collagen Synthesis as a Prominent Process During the Interval between Two Laser Sessions","authors":"Vahid Mansouri, Babak Arjmand, Maryam Hamzeloo-Moghadam, Mostafa Rezaei Tavirani, Zahra Razzaghi, Alireza Ahmadzadeh, Mitra Rezaei, Reza M Robati","doi":"10.34172/jlms.2023.50","DOIUrl":"https://doi.org/10.34172/jlms.2023.50","url":null,"abstract":"Introduction: Many people suffer from skin photodamage, especially photoaging. The application of a laser to repair damages is a common therapeutic method that is used widely. In the present study, the effectiveness and molecular mechanism of an Er:Glass non-ablative fractional laser on the human skin was assessed via bioinformatics and network analysis. Methods: The gene expression profiles of 17 white female forearm skins which received an Er:Glass non-ablative fractional laser before and after laser treatment in two sessions were extracted from Gene Expression Omnibus (GEO). Data were evaluated via GEO2R and the significant differentially expressed genes (DEGs) were assessed via protein-protein interaction (PPI) network analysis. The central nodes were identified and discussed for the compared set of samples. Results: Five classes of samples were clustered in two categories: first, baseline, 7 and 14 days after the first session of laser treatment, and second, one day after the first laser session, 29 days after the first laser session, and 1 day after the second laser session. The gross cell functions such as cell division and cell cycle and immune response were highlighted as the early affected targets of the laser. Collagen synthesis was resulted after the first laser session. Conclusion: In conclusion, the time interval between laser sessions plays a critical role in the effectiveness of laser therapy. Findings indicate that the gross effect of laser application appears in a short time, and important processes such as collagen synthesis happen later.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Histological Study of Gingival Depigmentation by 808 and 445 nm Diode Lasers 808和445 nm二极管激光对牙龈色素脱色的组织学比较研究

Journal of lasers in medical sciences Pub Date : 2023-10-25 DOI: 10.34172/jlms.2023.48

Seyed Masoud Mojahedi Nasab, Matthias Frentzen, Somayeh Rahmani, Fahimeh Anbari, Saranaz Azari-Marhabi, Jörg Meister, Deniz Mojahedi Nasab

引用次数: 0

Evaluation of the Cellular Resistance Process in Treated Cells Via Extracorporeal Photopheresis 体外光再生技术评价处理细胞的细胞抗性过程

Journal of lasers in medical sciences Pub Date : 2023-10-18 DOI: 10.34172/jlms.2023.46

Babak Arjmand, Mostafa Rezaei Tavirani, Somayeh Jahani Sherafat, Mitra Rezaei, Masoumeh Farahani, Majid Rezaei Tavirani

{"title":"Evaluation of the Cellular Resistance Process in Treated Cells Via Extracorporeal Photopheresis","authors":"Babak Arjmand, Mostafa Rezaei Tavirani, Somayeh Jahani Sherafat, Mitra Rezaei, Masoumeh Farahani, Majid Rezaei Tavirani","doi":"10.34172/jlms.2023.46","DOIUrl":"https://doi.org/10.34172/jlms.2023.46","url":null,"abstract":"Introduction: Extracorporeal photopheresis (ECP) is a therapeutic method applied against some diseases such as cancers. Using 8-methoxypsoralen (8-MOP) and UVA radiation in ECP is associated with achievement in the treatment of patients with leukemic cutaneous T-cell lymphoma (CTCL). Evaluation of cellular resistance versus ECP is the aim of this study. Methods: Data were downloaded from the Gene Expression Omnibus (GEO) database and were analyzed via the GEO2R program. The significant DEGs were assessed via protein-protein interaction (PPI) network analysis by using the STRING database and Cytoscape software. The critical genes were evaluated via gene ontology by using the ClueGO application of Cytoscape software. The identified biological processes were determined and analyzed. Results: Fifty-seven significant DEGs were determined. The main connected component of the PPI network including 32 queried significant DEGs plus 50 first neighbors was constructed. Nineteen histones as critical nodes were assessed via gene ontology, and \"nucleosome organization\" was pointed out as the crucial biological process. Finally, 15 histones from H2A, H2B, and H3 histone families were identified as the key genes that are involved in the resistance property of the treated cells. Conclusion: In conclusion, 15 members of H2A, H2B, and H3 families (especially H2A family) were considered as the origin of resistance versus ECP treatment. It is concluded that sensitivity to ECP treatment depends on gross molecular events which are involved in the functions of histones.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135943833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Low-Level Laser Therapy on Differentiation and Proliferation of Human Dental Pulp Stem Cells: A Systematic Review 低水平激光治疗对人牙髓干细胞分化和增殖的影响:系统综述

Journal of lasers in medical sciences Pub Date : 2023-10-17 DOI: 10.34172/jlms.2023.47

Hamed Karkehabadi, Jaber Zafari, Elham Khoshbin, Roshanak Abbasi, Sogand Esmailnasab, Amin Doosti-Irani

{"title":"Effect of Low-Level Laser Therapy on Differentiation and Proliferation of Human Dental Pulp Stem Cells: A Systematic Review","authors":"Hamed Karkehabadi, Jaber Zafari, Elham Khoshbin, Roshanak Abbasi, Sogand Esmailnasab, Amin Doosti-Irani","doi":"10.34172/jlms.2023.47","DOIUrl":"https://doi.org/10.34172/jlms.2023.47","url":null,"abstract":"Introduction: Considering the positive impact of laser treatment on the proliferation of certain cell types, we opted to perform a systematic review aimed at evaluating the effects of laser therapy and photobiomodulation on the proliferation and differentiation of human dental pulp stem cells (hDPSCs). Methods: We included all research studies examining the impact of laser therapy on hDPSCs, without limitations on publication dates or article languages. The major international databases, including PubMed, ISI Web of Science, and Scopus, were searched from inception to April 2022 by the relevant keywords. Results: In total, 1886 studies were identified in the initial search from the mentioned databases and other sources. Finally, 17 relevant studies were included in the present systematic review after removing duplicates and non-relevant articles. The results indicated the useful effect of low-level laser therapy (LLLT) on the hDPSCs. Conclusion: The findings of this systematic review indicate the useful role of LLLT in cell therapy, proliferation, and differentiation associated with hDPSCs.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136078472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory, Antioxidant, and Wound-Healing Effects of Photobiomodulation on Type-2 Diabetic Rats 光生物调节对2型糖尿病大鼠的抗炎、抗氧化和伤口愈合作用

Journal of lasers in medical sciences Pub Date : 2023-10-16 DOI: 10.34172/jlms.2023.45

Atefeh Moheghi, Seyyed Mohammad Hossein Noori Mougehi, Abdollah Amini, Atarodalsadat Mostafavinia, Fatemehalsadat Rezaei, Fatemeh Bagheri Tadi, Sufan Chien, Mohammad Bayat

{"title":"Anti-inflammatory, Antioxidant, and Wound-Healing Effects of Photobiomodulation on Type-2 Diabetic Rats","authors":"Atefeh Moheghi, Seyyed Mohammad Hossein Noori Mougehi, Abdollah Amini, Atarodalsadat Mostafavinia, Fatemehalsadat Rezaei, Fatemeh Bagheri Tadi, Sufan Chien, Mohammad Bayat","doi":"10.34172/jlms.2023.45","DOIUrl":"https://doi.org/10.34172/jlms.2023.45","url":null,"abstract":"Introduction: In the current study, the effects of photobiomodulation (PBM) treatments were examined based on biomechanical and histological criteria and mRNA levels of catalase (CAT), superoxide dismutase (SOD), and NADPH oxidase (NOX) 1 and 4 in a postponed, ischemic, and infected wound repair model (DIIWHM) in rats with type 2 diabetes (DM2) during the inflammation (day 4) and proliferation (day 8) stages. Methods: To study ischemic wound repair in a diabetic rat model (DIIWHM), 24 rats with type-2 diabetes were randomly divided into four groups and infected with methicillin-resistant Staphylococcus aureus (MRSA). The control groups consisted of CG4 (control group on day 4) and CG8 (control group on day 8), while the PBM groups comprised PBM4 (PBM treatment group on day 4) and PBM8 (PBM treatment group on day 8). These group assignments allowed for comparisons between the control groups and the PBM-treated groups at their respective time points during the study. Results: On days 4 and 8 of wound restoration, the PBM4 and PBM8 groups showed substantially modulated inflammatory responses and improved formation of fibroblast tissue compared with the CG groups (P<0.05). Concurrently, the effects of PBM8 were significantly superior to those of PBM4 (P<0.05). The antioxidant results on days 4 and 8 revealed substantial increases in CAT and SOD in the PBM groups compared with the CGs (P<0.05). Substantial decreases were observed in the antioxidant agents NOX1 and NOX4 of the PBM4 and PBM8 groups compared with both CGgroups (P<0.05). Conclusion: PBM treatments significantly sped up the inflammatory and proliferating processes in a DHIIWM in DM2 animals by modifying the inflammatory reaction and boosting fibroblast proliferation. Overall, the current findings indicated substantially better results in the PBM groups than in the CG groups.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136183573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Effectiveness of the Carbon Dioxide (CO2) Laser in Minor Oral Surgery: A Systematic Review 二氧化碳(CO2)激光在口腔小手术中的有效性评价:系统综述

Journal of lasers in medical sciences Pub Date : 2023-10-15 DOI: 10.34172/jlms.2023.44

Mohammad Asnaashari, Mohammadreza Behnam Roudsari, Maryam Sadat Shirmardi

{"title":"Evaluation of the Effectiveness of the Carbon Dioxide (CO2) Laser in Minor Oral Surgery: A Systematic Review","authors":"Mohammad Asnaashari, Mohammadreza Behnam Roudsari, Maryam Sadat Shirmardi","doi":"10.34172/jlms.2023.44","DOIUrl":"https://doi.org/10.34172/jlms.2023.44","url":null,"abstract":"Introduction: Lasers in oral surgery have been extensively studied in recent years. Laser treatment is now a well-known technology that is frequently employed on oral soft tissues. The carbon dioxide (CO2) laser was one of the first soft tissue removal lasers. Because of the strong affinity of the CO2 laser to water, it is best used for removing, vaporizing, and coagulating these tissues. In minor oral surgery, CO2 laser therapy has shown advantages. Therefore, this study examined the CO2 laser use in minor oral soft tissue surgery. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards were followed in this study. A question for research encompassing the inclusion criteria for the participants, intervention, comparison, outcome, and study design (PICOS) was formulated. The search queries were entered into the PubMed/Medline, Scopus, and Embase databases. Consideration was given to publications published between January 1, 2018 and March 15, 2023. Results: The research included 37 studies after narrowing search results, eliminating duplicate titles, and conducting an eligibility review (three animal studies, seven case reports, three case series, and twenty-four clinical studies). CO2 lasers alone or in combination with other therapies successfully treated oral potentially malignant disorders (OPMDs), oral tumors, oral fibrous-epithelial lesions, gingival melanin hyperpigmentation, pyogenic granuloma, socket preservation, mucocele, high labial frenulum attachment, and so on. CO2 lasers reduced intra- and postoperative complications and adverse effects, improved postoperative functional results, ablated tissues with precision, and minimized disease recurrence and malignant transformation. Conclusion: Our study found that the CO2 laser in oral minor surgeries is successful, but further randomized clinical trials and multicenter studies are recommended to compare CO2 laser surgery to other treatments.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135761294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Erbium:YAG Laser Recycling on Mechanical Characteristics of Retrieved Orthodontic Mini-screws 铒YAG激光回收对矫治微型螺钉力学特性的影响

Journal of lasers in medical sciences Pub Date : 2023-10-11 DOI: 10.34172/jlms.2023.42

Soghra Yassaei, Hossien Agha Aghili, Atie Behrouzirad

{"title":"Effect of Erbium:YAG Laser Recycling on Mechanical Characteristics of Retrieved Orthodontic Mini-screws","authors":"Soghra Yassaei, Hossien Agha Aghili, Atie Behrouzirad","doi":"10.34172/jlms.2023.42","DOIUrl":"https://doi.org/10.34172/jlms.2023.42","url":null,"abstract":"Introduction: This study aimed to evaluate the influence of two recycling methods on the mechanical and surface characteristics of orthodontic mini-screws. Methods: Thirty-six retrieved mini-screws were randomly classified into two equal groups. In the first group (laser recycled group (LG)), the Er:YAG laser (2940 nm, 5.5 W, 275 mJ, perpendicular to the mini-screws at a distance of 7-10 mm, 25 s) was used to recycle mini-screws. In the second group (phosphoric acid and sodium hypochlorite recycled group (ASG)), the mini-screws were kept in 37% phosphoric acid gel (10 minutes) and then placed in 5.25% sodium hypochlorite for 30 minutes. Eighteen new mini-screws were selected as the control group (CG). Maximum insertion torque (MIT), maximum removal torque (MRT), and fracture torque (FT) of all mini-screws were measured. A sample from each group was examined for the surface changes of the mini-screw and tissue remnants under a scanning electron microscope (SEM). Results: The mean MIT was significantly higher in both LG and ASG groups than the CG (P<0.001 and P=0.002, respectively). However, no significant difference was shown between the LG and ASG groups. The mean values of MRT and FT showed no significant difference between the groups. The amount of tissue remnants in the ASG group was significantly higher than that in the LG group. The evidence of porosity and corrosion was observed on the ASG mini-screw surface, and there was an increase in roughness on the LG mini-screw surface. Conclusion: The Er:YAG laser recycling of mini-screws is a proper method causing minimum damage to the screw surface.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136252520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Effects of Er:YAG Laser, Sodium Hypochlorite, and QMix on Root Canals Infected With Enterococcus faecalis and Candida albicans Er:YAG激光、次氯酸钠和QMix对粪肠球菌和白色念珠菌根管感染的比较疗效

Journal of lasers in medical sciences Pub Date : 2023-10-11 DOI: 10.34172/jlms.2023.43

Agime Dragidella, Ariana Kameri

{"title":"Comparative Effects of Er:YAG Laser, Sodium Hypochlorite, and QMix on Root Canals Infected With <i>Enterococcus faecalis</i> and <i>Candida albicans</i>","authors":"Agime Dragidella, Ariana Kameri","doi":"10.34172/jlms.2023.43","DOIUrl":"https://doi.org/10.34172/jlms.2023.43","url":null,"abstract":"Introduction: During endodontic treatment, the smear layer can reduce disinfectant efficacy. The aim of this study was to evaluate the antimicrobial efficacy of Er:YAG laser radiation and its combination with NaOCl and QMix against Enterococcus faecalis and Candida albicans and their comparison with conventional irrigation with only NaOCl and QMix. Methods: Two hundred extracted single-rooted teeth after root canal preparation were divided into two groups and inoculated with E. faecalis and C. albicans. According to the treatment method, all samples were divided into five treatment groups: (1) Er:YAG laser, (2) NaOCl, (3) QMix, (4) Er:YAG laser plus NaOCl, and (5) Er:YAG laser plus QMix. After 24 hours of agar plate cultivation, cell viability was recorded with a flow cytometer. Results: All treatment modalities showed efficiency in the reduction of microbial cells. For laser treatment alone after exposure for 90 seconds, significantly fewer non-death cells were seen, compared to 30-second treatment. For both timings (30 and 90 seconds), irrigation with NaOCl or QMix after laser application resulted in significantly fewer vital cells of E. faecalis and C. albicans, compared with laser treatment alone (P<0.001). The samples treated with only NaOCl showed a significantly higher percentage of vital E. faecalis and Candida albicans cells, compared to the samples treated with only QMix (P<0.001). Conclusion: Higher Er: YAG laser exposure time (90 seconds) after its combination with QMix and NaOCl improves the efficacy in the reduction of E. faecalis and C. albicans from the root canal, compared to 30-second laser exposure time and conventional irrigation methods with NaOCl and QMix.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136252517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Photobiomodulation on the Treatment of Hereditary Mitochondrial Diseases 光生物调节在遗传性线粒体疾病治疗中的作用

Journal of lasers in medical sciences Pub Date : 2023-10-10 DOI: 10.34172/jlms.2023.41

Richard Baskerville, Nykle Krijgsveld, Patrick Esser, Glen Jeffery, Joanna Poulton

{"title":"The Effect of Photobiomodulation on the Treatment of Hereditary Mitochondrial Diseases","authors":"Richard Baskerville, Nykle Krijgsveld, Patrick Esser, Glen Jeffery, Joanna Poulton","doi":"10.34172/jlms.2023.41","DOIUrl":"https://doi.org/10.34172/jlms.2023.41","url":null,"abstract":"Introduction: Despite a wide variety of clinical presentations in hereditary Mitochondrial Diseases, muscle fatigue is a common theme and impairs a patient’s quality of life and ability to function. Current treatments are only supportive and include nutritional supplementation and physical therapy. Photobiomodulation therapy (PBMT) using low-intensity, narrow spectrum light in the red/near infrared (NIR) range, from a low-level laser or light-emitting diode sources, enhances mitochondrial function in preclinical and clinical studies on a range of conditions. However, little research has been done on the effectiveness of photobiomodulation in hereditary mitochondrial disorders. Methods: We performed a scoping review of the evidence of the beneficial effects of photobiomodulation for treating the muscle-related symptoms of hereditary mitochondrial disease. Results: No studies regarding photobiomodulation in hereditary mitochondrial disease were identified. However, in other clinical conditions featuring acquired mitochondrial impairment, we identified studies that suggested improved function, although sample sizes were small in number and statistical power. Conclusion: There is emerging evidence of efficacy for PBMT for diseases involving acquired mitochondrial insufficiency. We identified no published research on PBMT in hereditary mitochondrial disease, but this review confirms a theoretical rationale for a positive effect and suggests further research.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136360072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0