Journal of lasers in medical sciences最新文献_第7页

Low-Level Laser Therapy for Improvement of In Vitro Fertilization Outcomes in Patients with Recurrent Implantation Failure: A Randomized Clinical Trial. 低水平激光疗法改善反复植入失败患者的体外受精结果：随机临床试验

IF 1.4

Journal of lasers in medical sciences Pub Date : 2024-06-05 eCollection Date: 2024-01-01 DOI: 10.34172/jlms.2024.15

Mina Jafarabadi, Yasaman Farbod, Mamak Shariat

{"title":"Low-Level Laser Therapy for Improvement of In Vitro Fertilization Outcomes in Patients with Recurrent Implantation Failure: A Randomized Clinical Trial.","authors":"Mina Jafarabadi, Yasaman Farbod, Mamak Shariat","doi":"10.34172/jlms.2024.15","DOIUrl":"https://doi.org/10.34172/jlms.2024.15","url":null,"abstract":"Introduction: Numerous strategies have been investigated for addressing recurrent implantation failure (RIF) and enhancing endometrial receptivity, yet agreement on the optimal intervention remains elusive. Our investigation endeavors to assess the effect of low-level laser therapy (LLLT) on pregnancy outcomes in individuals who have undergone a minimum of three unsuccessful embryo transfer cycles (ET). Methods: In our randomized single-blinded clinical trial, we enrolled thirty females with a medical history of RIF who were eligible for frozen-thawed embryo transfer (FET). Through a random allocation sequence, the participants were divided into two groups. The LLLT was performed one cycle before blastocyst transfer in 15 cases using a New Age BIOLASER device (New Age Co., Italy) with a 900-milliwatt power output and an 850-nm wavelength. The irradiation sessions were conducted transabdominal on the hypogastric area. The considered outcomes were biochemical pregnancy, identified by a positive blood pregnancy test, and clinical pregnancy, confirmed through visualization of the gestational sac using ultrasonography. Results: The mean age of the subjects was 34.17 years, and they had undergone three to seven previous embryo transfers. There was no significant difference in basic characteristics between the group undergoing laser treatment and the control group. However, the laser-treated group exhibited elevated rates of both biochemical and clinical pregnancies compared to the control group (46.7% vs. 33.3%; P==0.710 and 33.3% vs. 20.0%; P=0.682 respectively). Conclusion: To our knowledge, this study represents the first single-blinded randomized clinical trial to assess the effectiveness of LLLT pretreatment in individuals with RIF. The findings propose that LLLT may potentially enhance biochemical and clinical pregnancy rates among RIF patients.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e15"},"PeriodicalIF":1.4,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Near-Infrared Laser Effects on 143B Cells: A System Biology Approach. 评估近红外激光对 143B 细胞的影响：系统生物学方法

IF 1.4

Journal of lasers in medical sciences Pub Date : 2024-06-02 eCollection Date: 2024-01-01 DOI: 10.34172/jlms.2024.14

Mohammad Rostami Nejad, Masoumeh Farahani, Zahra Razzaghi, Babak Arjmand, Fatemeh Montazer, Fatemeh Bandarian, Farideh Razi, Mostafa Rezaei Tavirani

{"title":"Evaluation of Near-Infrared Laser Effects on 143B Cells: A System Biology Approach.","authors":"Mohammad Rostami Nejad, Masoumeh Farahani, Zahra Razzaghi, Babak Arjmand, Fatemeh Montazer, Fatemeh Bandarian, Farideh Razi, Mostafa Rezaei Tavirani","doi":"10.34172/jlms.2024.14","DOIUrl":"https://doi.org/10.34172/jlms.2024.14","url":null,"abstract":"Introduction: Photothermal therapy (PTT) by using a near-infrared (NIR) laser, as a successful treatment of cancer, has attracted extensive attention of researchers. Its advantages as a noninvasive and suitable method have been confirmed. Discovery of the NIR laser molecular mechanism at the cellular level via system biology assessment to identify the crucial targeted genes is the aim of this study. Methods: RNA-seq series of six samples were retrieved from Gene Expression Omnibus (GEO) and pre-evaluated by the GEO2R program for more analysis. The significant differentially expressed genes (DEGs) were determined and studied via gene expression analysis, protein-protein interaction (PPI) network assessment, action map evaluation, and gene ontology enrichment. Results: HSPA5, DDIT3, TRIB3, PTGS2, HMOX1, ASNS, GDF15, SLC7A11, and SQSTM1 were identified as central genes. Comparing the central genes and the determined crucial genes via gene expression analysis, actin map results, and gene ontology enrichment led to the introduction of HSPA5, DDIT3, PTGS2, HMOX1, and GDF15 as critical genes in response to the NIR laser. Conclusion: The results indicated that the principle biological process \"Endoplasmic reticulum unfolded protein response\" and HSPA5, DDIT3, PTGS2, HMOX1, and GDF15 are the crucial targets of the NIR laser. The results also showed that the NIR laser induces stress conditions in the irradiated cells.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e14"},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Effectiveness of TENS and Low-Level Laser Therapy Applied to the Sciatic Nerve Region in Chronic Lumbar Radiculopathy. 应用于慢性腰椎病坐骨神经区域的 TENS 和低强度激光疗法的疗效比较。

IF 1.4

Journal of lasers in medical sciences Pub Date : 2024-05-26 eCollection Date: 2024-01-01 DOI: 10.34172/jlms.2024.13

Sevil Karagül, Sibel Kibar, Saime Ay, Deniz Evcik, Süreyya Ergin

{"title":"Comparison of the Effectiveness of TENS and Low-Level Laser Therapy Applied to the Sciatic Nerve Region in Chronic Lumbar Radiculopathy.","authors":"Sevil Karagül, Sibel Kibar, Saime Ay, Deniz Evcik, Süreyya Ergin","doi":"10.34172/jlms.2024.13","DOIUrl":"https://doi.org/10.34172/jlms.2024.13","url":null,"abstract":"Introduction: This study was carried out to assess and compare the efficacies of transcutaneous electrical nerve stimulation (TENS) and low-level laser therapy (LLLT) applied to sciatic Valleix points to reduce sciatica in patients with chronic lumbar radiculopathy. Methods: The study population consisted of 164 patients with chronic radicular pain caused by LDH. The remaining 75 patients were studied in three groups. TENS and hotpack were applied to the lower back region of all patients. In addition, group 1 (n=24), group 2 (n=25), and group 3 (n=26) received LLLT (4 J/cm2 for each point), TENS, and sham LLLT, respectively, on sciatic Valleix points five days a week, for three weeks (15 sessions). Outcomes were assessed at the beginning of the treatment, after completion of 3 weeks of treatment, and after three months (follow-up). Results: Post-treatment assessments indicated that all parameters investigated within the scope of the study improved in all three groups, except for the VAS leg pain (VASLP) score in group 3. Post-treatment VASLP and DN4 scores of group 1 were significantly superior to those of group 2 (P˂0.001). Follow-up assessments revealed an improvement only in the VASLP score and in group 1. The VASLP, DN-4, and ODI scores of groups 1 and 2 were significantly superior to those of group 3. There was no significant difference between the groups in the PSQI score and lumbar ROM value. Conclusion: Both LLLT and TENS were found to be effective in treating the sciatic nerve associated with lumbar disk herniation with radiculopathy. LLLT was found to be more effective than TENS in reducing leg and neuropathic pains. Follow-up assessments revealed that the only lasting effect of the treatments, which continued into the third month, was the improvement in leg pain.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e13"},"PeriodicalIF":1.4,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Visible and Infrared Photobiomodulation on Diabetic Foot Ulcers. 可见光和红外光生物调节对糖尿病足溃疡的影响

IF 1.4

Journal of lasers in medical sciences Pub Date : 2024-05-15 eCollection Date: 2024-01-01 DOI: 10.34172/jlms.2024.12

Faraj Tabeie, Sara Tabakhha, Soheila Sadeghi, Alireza Ebadi

{"title":"Effect of Visible and Infrared Photobiomodulation on Diabetic Foot Ulcers.","authors":"Faraj Tabeie, Sara Tabakhha, Soheila Sadeghi, Alireza Ebadi","doi":"10.34172/jlms.2024.12","DOIUrl":"https://doi.org/10.34172/jlms.2024.12","url":null,"abstract":"Introduction: Diabetes is a highly prevalent disease worldwide. Despite routine treatments, there is no effective treatment approach for patients with diabetic foot ulcers (DFUs). A new approach to reduce complications and control DFU is low-level laser therapy (LLLT). In the present study, we evaluated the therapeutic effects of LLLT on the symptoms of DFU patients. Methods: Sixty diabetic patients with DFU were included in this randomized clinical trial and were randomly allocated into two groups of laser (n=30) and control (n=30) with signed written consent. The LLLT group underwent visible and infra-red laser therapy and conventional medical treatment, while the control group received only conventional medical treatment. The total laser irradiation sessions of the patients were 20 sessions, (three sessions a week) and each session lasted for 30 minutes over the entire surface of the wound. The power density per session for each laser was calculated to be 35.65 mW/cm2 with an energy density of 64.17 J/cm2. Results: The mean area of ulcers in the LLLT group reduced significantly (P<0.001) from 441.7±365.5 mm2 before LLLT to 163.9±213.9 mm2 from the baseline up to the last session of LLLT, indicating a 62.99% reduction in mean ulcer area. In the control group, the mean ulcer area did not change significantly. Wagner's classification of the patients in the LLLT group reduced to lower grades significantly (P<0.01), while the classification moved towards higher grades in the control group (P<0.08). Conclusion: In this study, we showed the effectiveness of LLLT in the reduction of the surface and depth of DFUs. The results documented that patients experienced significant improvements in the healing of their foot ulcers after laser therapy. It is recommended that the LLLT be considered as a non-invasive method for the treatment of DFU patients.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e12"},"PeriodicalIF":1.4,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Effect of Low-level Laser Therapy on Candida albicans Colonies Isolated From Patients Undergoing Radiotherapy for Head and Neck Cancer. 体外低强度激光疗法对头颈癌放疗患者分离出的白色念珠菌菌落的影响

IF 1.4

Journal of lasers in medical sciences Pub Date : 2024-05-08 eCollection Date: 2024-01-01 DOI: 10.34172/jlms.2024.11

Novia Tri Hasanah, Irna Sufiawati, Adji Kusumadjati, Mas Adi Sunardi

{"title":"In Vitro Effect of Low-level Laser Therapy on Candida albicans Colonies Isolated From Patients Undergoing Radiotherapy for Head and Neck Cancer.","authors":"Novia Tri Hasanah, Irna Sufiawati, Adji Kusumadjati, Mas Adi Sunardi","doi":"10.34172/jlms.2024.11","DOIUrl":"https://doi.org/10.34172/jlms.2024.11","url":null,"abstract":"Introduction: Studies on head and neck cancer (HNC) patients undergoing radiotherapy have revealed increased numbers of Candida spp., leading to oral candidiasis and oral mucositis. The effects of laser therapy on Candida spp. have been studied with varied results. This study aimed to investigate the effect of low-level laser therapy (LLLT) on C. albicans colonies isolated from HNC patients undergoing radiotherapy. Methods: This study included a treated group, wherein 11 C. albicans isolates were obtained from the saliva of HNC patients undergoing radiotherapy at a dose exceeding 30 Gy. The control groups consisted of an untreated negative control and a positive control treated with nystatin. The treatment groups were subjected to LLLT in continuous mode for 50 seconds at a wavelength of 976 nm, 0.1 W at a dose of 5 J/cm2 for Laser 1 (L1) group and 0.2 W at a dose of 10 J/cm2 for Laser 2 (L2) group. The tests were conducted using C. albicans inoculum equivalent to a 0.5-McFarland suspension on 96-well plates. All test group inoculums were then cultured on Sabouraud dextrose agar (SDA), and the colony count was assessed at 104 CFU/mL. Results: LLLT at 5 and 10 J/ cm2 reduced C. albicans colonies by 7.01% and 10.94%, respectively, but the reductions were not statistically significant (P>0.05). Nystatin eliminated all the colonies. Conclusion: LLLT shows potential for reducing C. albicans colonies in HNC patients undergoing radiotherapy. However, further studies with varied parameters and methods are necessary.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e11"},"PeriodicalIF":1.4,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome Therapy and Photobiomodulation Therapy Regulate mi-RNA 21, 155 Expressions, Nucleus Acetylation and Glutathione in a Polycystic Ovary Oocyte: An In Vitro Study. 外泌体疗法和光生物调节疗法可调控多囊卵巢卵母细胞中的 mi-RNA 21、155 表达、核乙酰化和谷胱甘肽：体外研究。

IF 1.4

Journal of lasers in medical sciences Pub Date : 2024-04-30 eCollection Date: 2024-01-01 DOI: 10.34172/jlms.2024.10

Samira Sahraeian, Hojjat Allah Abbaszadeh, Robabeh Taheripanah, Mohammad Amin Edalatmanesh, Somayeh Keshavarzi, Alaleh Ghazifard

{"title":"Exosome Therapy and Photobiomodulation Therapy Regulate mi-RNA 21, 155 Expressions, Nucleus Acetylation and Glutathione in a Polycystic Ovary Oocyte: An In Vitro Study.","authors":"Samira Sahraeian, Hojjat Allah Abbaszadeh, Robabeh Taheripanah, Mohammad Amin Edalatmanesh, Somayeh Keshavarzi, Alaleh Ghazifard","doi":"10.34172/jlms.2024.10","DOIUrl":"https://doi.org/10.34172/jlms.2024.10","url":null,"abstract":"Introduction: Polycystic ovary syndrome (PCOS) is a complex condition that can have various symptoms and complications, one of which is infertility. Dysregulation of miRNA has been associated with the pathogenesis of numerous illnesses such as PCOS. In this study, we evaluated the effect of photobiomodulation therapy (PBMT) and exosome therapy (EXO) on the regulation of miRNA and nucleus acetylation in a PCOS oocyte. Methods: In this research, 36 oocytes divided into three groups: control, EXO, and PBM (Wavelength of 640 nm). Subsequently, in-vitro maturation (IVM) was evaluated. Real-time PCR was used to evaluate miRNA-21,16,19,24,30,106,155 and GAPDH. Afterward, oocyte glutathione (GSH) and nucleus acetylation were measured by H4K12. Results: The expression of the miR-16, miRNA-19, miRNA-24, miRNA-106 and miRNA-155 genes in the EXO and PBMT groups was significantly down-regulated in comparison to the control group, but the expression of miRNA-21 and miR-30 significantly increased in the EXO and PBMT groups in comparison to the control group. The EXO and PBMT significantly increased GSH and nucleus acetylation (P<0.0001). Conclusion: The results of this study showed that the use of EXO and PBMT can improve GSH and nucleus acetylation in the PCOS oocyte and also change the expression of miRNAs.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e10"},"PeriodicalIF":1.4,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Light and Thermal Stimulation of Bone Marrow Stem Cells. 光和热联合刺激骨髓干细胞。

IF 1.4

Journal of lasers in medical sciences Pub Date : 2024-04-17 eCollection Date: 2024-01-01 DOI: 10.34172/jlms.2024.08

Ruben Chailakhyan, Alla Grosheva, Nataliya Vorobieva, Vladimir Yusupov, Alexander Sviridov

{"title":"Combined Light and Thermal Stimulation of Bone Marrow Stem Cells.","authors":"Ruben Chailakhyan, Alla Grosheva, Nataliya Vorobieva, Vladimir Yusupov, Alexander Sviridov","doi":"10.34172/jlms.2024.08","DOIUrl":"https://doi.org/10.34172/jlms.2024.08","url":null,"abstract":"Introduction: The purpose of this study is to achieve a significant increase in the proliferative activity of mesenchymal stem cells (MSCs) of the bone marrow (BM) at early passages after laser exposure to a suspension of these cells and to estimate the effect of light and heat components of laser radiation on the proliferation of BM MSCs. Methods: The studies were performed on rats BM MSCs. MSC suspension was placed into the wells and heated by using laser radiation (980 nm wavelength) or a water bath at 70 °C providing similar temperature dynamics. The studies were carried out in 3 comparison groups: (1) control suspension of MSCs, which was not subjected to heating in a water bath or laser exposure; (2) MSC suspension, which was heated for in a water bath; and (3) suspension of MSCs, which was subjected to laser exposure. The exposure times for the 2nd and 3rd experimental groups were 10- 50 seconds. Results: Under optimal parameters of laser action on the suspension of BM MSCs, a six-fold increase in the number of BM MSCs colonies was registered compared to the control. The role of the light and heat components of laser exposure to MSCs was determined by comparable heating of a suspension of BM MSCs in a water bath, at which only a twofold increase in the number of colonies was maximally obtained. Conclusion: The increase in the MSC proliferation activity occurs due to their Thermo-Photobiomodulation. The result obtained is important for practical use in cell transplantation in the treatment of traumatic injuries of bone, cartilage, and tendon tissues when a rapid and multiple increase in the initial number of autologous BM MSCs is required.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e8"},"PeriodicalIF":1.4,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of CO₂ Laser-Assisted Titanium Tetra-fluoride on Demineralization of Enamel Around Orthodontic Brackets. 二氧化碳激光辅助四氟化钛对正畸托槽周围釉质脱矿的影响

IF 1.4

Journal of lasers in medical sciences Pub Date : 2024-04-17 eCollection Date: 2024-01-01 DOI: 10.34172/jlms.2024.09

Vahid Moshkelgosha, Reza Zandian, Mona Sohrabi, Reza Fekrazad

{"title":"Effect of CO2 Laser-Assisted Titanium Tetra-fluoride on Demineralization of Enamel Around Orthodontic Brackets.","authors":"Vahid Moshkelgosha, Reza Zandian, Mona Sohrabi, Reza Fekrazad","doi":"10.34172/jlms.2024.09","DOIUrl":"https://doi.org/10.34172/jlms.2024.09","url":null,"abstract":"Introduction: One of the clinical problems following orthodontic treatment is white spot lesions around orthodontic brackets due to enamel demineralization. Confronting enamel demineralization during fixed treatments has long been a challenge for orthodontists. The aim of this in vitro study was to evaluate the effect of CO2 laser and Titanium Tetra-fluoride (TiF4) application on the prevention of enamel demineralization around orthodontic brackets. Methods: Eighty permanent premolars were selected and bonded with brackets. They were randomly divided into four groups (n=20): topical titanium tetra-fluoride gel 4% (TiF4), CO2 laser (10.6 μm wavelength for 10 seconds, peak power=291 W), fluoride+laser (F+L) and control (C). All specimens were demineralized for 10 days in a 0.2 M acetate buffer solution. The mean lesion depths were determined by using polarized light microscopy. Results: The mean depth of lesion was the highest in the C group and then decreased in the TiF4, CO2 laser, and F+L groups, respectively. The difference between all groups was significant (P<0.05), except for the CO2 laser and F+L groups. Conclusion: The lowest amount of demineralization around the orthodontic brackets was observed in the L+F group, followed by the CO2 laser, TiF4, and control groups, respectively.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e9"},"PeriodicalIF":1.4,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Lasers on the Healing of Periapical Lesion: A Systematic Review. 激光对根尖周病变愈合的影响：系统回顾

IF 1.5

Journal of lasers in medical sciences Pub Date : 2024-04-16 eCollection Date: 2024-01-01 DOI: 10.34172/jlms.2024.06

Parham Hazrati, Ali Azadi, Ashkan Tizno, Mohammad Asnaashari

{"title":"The Effect of Lasers on the Healing of Periapical Lesion: A Systematic Review.","authors":"Parham Hazrati, Ali Azadi, Ashkan Tizno, Mohammad Asnaashari","doi":"10.34172/jlms.2024.06","DOIUrl":"https://doi.org/10.34172/jlms.2024.06","url":null,"abstract":"Introduction: Endodontic treatment of teeth with periapical lesions presents more clinical difficulty. Various lasers in several methods are used in endodontics, and most of them are utilized as an adjunctive protocol in order to reduce the bacterial load of the root canal system. Improved disinfection plays a crucial role in enhanced and accelerated healing of periapical lesions. This review aims to summarize studies assessing the effect of lasers on periapical lesion healing. Methods: PubMed/MEDLINE, Scopus, Embase, and Web of Science (ISI) online databases were searched, with no publication year or status restriction, for relevant articles on April 2023. Clinical studies evaluating the effect of laser application on the periapical lesion of patients using radiographic assessment were considered eligible for inclusion. Results: Eight studies were included after carefully screening the obtained articles, first by their title and abstract and then by their full texts. Diode (4), Er, Cr: YSGG (3), and Nd: YAG (1) lasers were used with output powers that varied from 0.75 to 2 watts. Photodynamic therapy was employed in two studies, and in other studies, the root canal system was directly irradiated. Irradiation of the root canal system was adjunctive to standard preparation in all studies. The healing of the teeth treated with lasers was not inferior to those conventionally treated. In all of the included studies, laser application outperformed the standard cleaning and shaping protocol; however, this improved or faster healing was not statistically significant in most studies. Conclusion: Lasers might expedite and improve the healing process of periapical lesions. Since lasers enhance the quality of cleaning of the root canal system, it is hard to point out the exact mechanism of it. Further investigations are needed to realize the effectiveness of this treatment modality and to discover the underlying biological concepts.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e6"},"PeriodicalIF":1.5,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11033856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Effects of Exosome Therapy and Photobiomodulation Therapy on the Spermatogenesis Arrest in Male Mice After Scrotum Hyperthermia. 外泌体疗法和光生物调节疗法对阴囊热疗后雄性小鼠精子发生停滞的治疗作用

IF 1.5

Journal of lasers in medical sciences Pub Date : 2024-03-03 eCollection Date: 2024-01-01 DOI: 10.34172/jlms.2024.03

Fakhrosadat Tabatabaee, Shahram Darabi, Reza Soltani, Fakhroddin Aghajanpour, Azar Afshar, Hojjat Allah Abbaszadeh, Hassan Rajabi-Maham

{"title":"Therapeutic Effects of Exosome Therapy and Photobiomodulation Therapy on the Spermatogenesis Arrest in Male Mice After Scrotum Hyperthermia.","authors":"Fakhrosadat Tabatabaee, Shahram Darabi, Reza Soltani, Fakhroddin Aghajanpour, Azar Afshar, Hojjat Allah Abbaszadeh, Hassan Rajabi-Maham","doi":"10.34172/jlms.2024.03","DOIUrl":"https://doi.org/10.34172/jlms.2024.03","url":null,"abstract":"Introduction: In men, several factors cause infertility, among which we can mention damage to sperm due to high temperature. So far, various treatments have been proposed for it, but they have not been highly effective. The current study aimed to evaluate the effect of exosome therapy (EXO) and photobiomodulation therapy (PBMT) on spermatogenesis arrest in male mice after scrotum hyperthermia. Methods: In this experimental study, the animals were divided into four groups: control, scrotal hyperthermia, scrotal hyperthermia+EXO (100 μL/d) (mice were treated for 30 days), scrotal hyperthermia+PBMT (laser of 0.03 J/cm2 for 30 seconds/for 30 days). Hyperthermia was induced by exposure to the temperature of 43 °C for 20 minute every day for 5 times. After 6 weeks, the animals were sacrificed. Results: The treated groups showed a significant increase in sperm parameters, as compared to the hyperthermic groups. Moreover, these favorable effects were observed in relation to the volume of testicular tissue, the number of germ cells, Leydig cells and Sertoli cells, and the level of testosterone. Research on antioxidants showed a significant reduction in oxidized glutathione (GSSG) and reactive oxygen species (ROS) in the treatment groups in comparison to the hyperthermia group (P<0.001). Also, there has been a significant increase in the amount of hydrogen peroxide enzyme observed in the hyperthermia group as opposed to the treatment group (P<0.001). Conclusion: These findings show that EXO and PBMT can improve spermatogenesis caused by hyperthermia, reduce ROS and GSSG, and increase glutathione (GSH) and sperm quality.","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e3"},"PeriodicalIF":1.5,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11033855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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