Journal of lasers in medical sciences最新文献

{"title":"Efficacy of 532-nm Nd: YAG Fractional Picosecond Laser with 9 mm High Coverage Handpiece Micro Lens Array in the Treatment of Facial Partial Unilateral Lentiginosis: A Case Report.","authors":"Suparuj Lueangarun, Therdpong Tempark","doi":"10.34172/jlms.2024.24","DOIUrl":"10.34172/jlms.2024.24","url":null,"abstract":"<p><p><b>Introduction:</b> Facial partial unilateral lentiginosis (PUL) is an infrequent skin pigmentation disorder characterized by multiple lentigines. Despite the availability of various treatment modalities, there is no standard treatment for PUL. This study reports a successful treatment of facial PUL in a female patient using a novel 532-nm Nd:YAG fractional picosecond laser (FPL). <b>Case Report:</b> The patient underwent four treatment sessions at four-week intervals. The treatments were administered using a 9 mm high coverage handpiece micro lens array (MLA), with a fluence of 0.2-0.4 J/cm², a frequency of 2 Hz for 2-3 passes, and approximately 10% overlap. The treatment was well-tolerated by the patient, with significant improvement in pigmentation and no significant side effects observed. The outcomes confirmed the efficacy of the 532-nm Nd:YAG FPL in treating facial PUL. <b>Conclusion:</b> The 532-nm Nd:YAG FPL appears to be an effective and well-tolerated treatment for facial PUL, offering significant improvement in pigmentation without notable side effects.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e24"},"PeriodicalIF":1.4,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy Evaluation of Treatment of Psoriasis Via Narrow Band-Ultraviolet Radiation.","authors":"Mohammad Rostami Nejad, Reza M Robati, Zahra Razzaghi, Babak Arjmand, Fatemeh Montazer, Fatemeh Bandarian, Farideh Razi, Mostafa Rezaei Tavirani","doi":"10.34172/jlms.2024.26","DOIUrl":"10.34172/jlms.2024.26","url":null,"abstract":"<p><p><b>Introduction:</b> Psoriasis is a common autoimmune skin disease associated with genetically influenced chronic inflammation accompanied by remitting and deteriorating scaly skin. T-cell targeted biologics, IL-17 inhibitors, IL-12/IL-23 inhibitors, TNF-α inhibitors, PDE4 inhibitors, and ultraviolet (UV) radiation are applied to treat psoriasis. Efficacy evaluation of narrow band UVB (NB-UVB) radiation was the aim of this study. <b>Methods:</b> Data were extracted from Gene Expression Omnibus (GEO) and were pre-evaluated via the GEO2R program. The significant differentially expressed genes (DEGs) were included in the protein-protein interaction (PPI) network analysis. The hubs, bottlenecks, and hub-bottleneck DEGs were introduced as central genes. Activation, inhibition, and expression relationship between central genes were assessed to explore the critical individuals. <b>Results:</b> Among 513 analyzed significant DEGs, 22 hub-bottleneck genes were identified. Further analysis revealed that FN1, STAT3, HIF1A, IL1B, P4HB, SOD2, MMP2, and STAT1 were the crucial genes in psoriasis samples targeted by NB-UVB radiation. <b>Conclusion:</b> In conclusion, NB-UVB radiation as a treatment targets critical genes in peri-lesion skin tissue biopsy of psoriasis patients via a complicated mechanism. This therapeutic method downregulates STAT3, HIF1A, IL1B, and P4HB to treat psoriasis but downregulates STAT1 and SOD2 and upregulates MMP2 and FN1 to develop disease.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e26"},"PeriodicalIF":1.4,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Laser and Microwave in Treatment of Endocrine Disorders: A Systematic Review.","authors":"Giti Noghabaei, Alireza Ahmadzadeh, Fatemeh Pouran, Amirmohsen Mahdavian, Mitra Rezaei, Mohammadreza Razzaghi, Vahid Mansouri, Farajolah Maleki","doi":"10.34172/jlms.2024.23","DOIUrl":"10.34172/jlms.2024.23","url":null,"abstract":"<p><p><b>Introduction:</b> The treatment of endocrine problems like thyroid disease, diabetes mellitus (DM), and polycystic ovary syndrome (PCOS) faces significant challenges so that medical professionals worldwide try to find a new therapeutic approach. However, along with common treatments which include medications, hormone replacement therapy, and surgery; there is a growing interest in alternative therapies like laser therapy, which offers a non-invasive and unique technique for treating endocrine disorders alone or in combination with traditional methods. The main goal of this review was to do a systematic review on the role of the laser and Microwave in the treatment endocrine disorders. <b>Methods:</b> In the present systematic review, the most important databases, including PubMed, Scopus and Google Scholar, were searched for the studies examining the effect of lasers on the treatment of endocrine problems by using appropriate keywords and specific strategies from 1995 to 2023. All the studies that were not about lasers and endocrine were excluded. <b>Results:</b> Based on 51 reviewed studies, lasers and radiofrequency ablation such as RFA are effective in the treatment of thyroid diseases, hyperparathyroidism, pancreatic disorders, and sexual dysfunctions. Laser-induced interstitial thermal therapy (LITT) and microwave ablation (MWA) are genuine minimally invasive methods for the treatment of benign nodules, adenomas, and tumor ablation including pancreatic carcinomas and adrenal tumors. Intravenous laser blood irradiation (ILBI) which uses red, UV, and blue light could be effective in treating various metabolic disorders, such as DM. <b>Conclusion:</b> Laser as a cutting-edge and minimally invasive approach could treat various endocrine disorders. It has a great potential to treat and regulate hormonal imbalances, decrease inflammation, and relieve symptoms of various ailments, such as endocrine disorders.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e23"},"PeriodicalIF":1.4,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Photobiomodulation on the Conditioned Media of 3T3-L1 Cells in the Treatment of Breast Cancer.","authors":"Maryam Sinaei, Saba Sekhavat, Jaber Zafari, Atousa Moradzadegan","doi":"10.34172/jlms.2024.22","DOIUrl":"10.34172/jlms.2024.22","url":null,"abstract":"<p><p><b>Introduction:</b> Breast cancer ranks among the most prevalent malignancies, and its prompt diagnosis significantly amplifies the prospects of successful treatment. Approximately one in seven women will experience a breast cancer diagnosis in their lifetime. Stromal cells and their secreted factors exert various effects on tumor growth, impacting proliferation, invasion, and metastasis. Research has emphasized the significant impact of proteins secreted by adipose tissue on breast cancer proliferation, surpassing the influence of factors released by other cell types. Yet, the specific transcription factors and cofactors involved in adipokine expression in the tumor microenvironment remain enigmatic. <b>Methods:</b> In this study, adipocyte cells were cultured and exposed to 980 nm and 650 nm Photobiomodulation. The MDA-MD-231 cells (triple negative cancer cell line) were cultured with a conditioned medium from laser-treated cells. The real-time assay was employed to analyze the gene expression level changes involved in apoptosis. <b>Results:</b> Results showed that the irradiated conditioned medium at 980 nm and 650 nm caused a reduction in cell viability of cancer cells. Conversely, the conditioned medium from the irradiated cells triggered an increase in the expression of <i>Caspase 3</i>, <i>Caspase 9</i>, and <i>BAX2</i> genes, alongside a decrease in <i>BCL2</i> gene expression. <b>Conclusion:</b> The findings highlighted the potential of the laser-treated conditioned medium to induce apoptosis pathways in cancer cells, demonstrating a promising avenue for further research in utilizing low-level laser therapy in breast cancer treatment.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e22"},"PeriodicalIF":1.4,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Photobiomodulation and <i>Akkermansia muciniphila</i> on THP-1 Derived Macrophage Polarization Treated with Gliadin Peptide.","authors":"Somayeh Jahani-Sherafat, Sara Mollaghaei, Nastaran Asri, Mostafa Rezaei Tavirani, Kaveh Baghaei, Mohammad Rostami-Nejad","doi":"10.34172/jlms.2024.21","DOIUrl":"10.34172/jlms.2024.21","url":null,"abstract":"<p><p><b>Introduction:</b> Photobiomodulation (PBM) and <i>Akkermansia muciniphila</i> have been shown to be effective in improving inflammatory conditions with positive effects on increasing the population of anti-inflammatory M2 macrophages (MQs). In this study, gliadin-stimulated THP-1 derived MQs were treated with <i>A. muciniphila</i> and PBM to evaluate their effects on promoting the polarization of M2 MQs. <b>Methods:</b> The human monocyte cell line (THP-1) was differentiated to MQs. MQs were stimulated with 200 μg/mL gliadin for 24 hours and then treated with PBM 810 nm alone and in combination with <i>A. muciniphila</i> for the following 24 hours to evaluate their effects on MQs polarization. THP-1 derived MQs were also treated with PBM and <i>A. muciniphila</i> to evaluate their effects on non-stimulated MQs. CD11b, CD80, and CD206 levels were evaluated by using the flow cytometry technique. Moreover, the expression of some M1 and M2-related cytokines was determined. <b>Results:</b> PBM therapy of gliadin-stimulated MQs decreased IL-6 and increased TGF-β, IL-10 and TNF-α expression compared with gliadin exposed MQs. PBM along with <i>A. muciniphila</i> treatment induced IL-6, TNF-α, and IL-10 expression in MQs in comparison to the untreated group. It also elevated TGF-β, IL-10 and TNF-α levels in gliadin-triggered MQs in comparison to gliadin-stimulated MQ cells. <b>Conclusion:</b> The result of this study showed the potential of PBMT and <i>A. muciniphila</i> for modulating inflammatory responses and MQs polarization. This may open new perspectives to find possible therapeutic targets for celiac diseases.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e21"},"PeriodicalIF":1.4,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Recovery Time Effects on Human Primary Neonatal Dermal Fibroblasts After Exposure to Solar-Simulated Ultraviolet Radiation.","authors":"Fatemeh Bandarian, Farideh Razi, Mostafa Rezaei-Tavirani, Babak Arjmand, Somayeh Jahani Sherafat, Mohammad Rostami Nejad","doi":"10.34172/jlms.2024.20","DOIUrl":"https://doi.org/10.34172/jlms.2024.20","url":null,"abstract":"<p><p><b>Introduction:</b> Photoaging that is accompanied by gene expression alteration is known as early aging of the skin due to overexposure to natural and/or artificial ultraviolet radiation (UVR). The assessment of gene expression alteration in human primary neonatal dermal fibroblasts depending on recovery time after exposure to solar simulated ultraviolet radiation (ssUVR) is the main aim of this bioinformatic study. <b>Methods:</b> Data are extracted from Gene Expression Omnibus (GEO). The pre-evaluation is done via the GEO2R program. The Significant differentially expressed genes (DEGs) were assessed via protein-protein interaction (PPI) network analysis, and the central genes were identified. The central genes were enriched via gene ontology assessment. <b>Results:</b> Among 224 significant DEGs, 20 central genes including TOP2A, MKI67, BRCA1, HELLS, MAD2L1, ANLN, KIF11, MSH2, KRAS, NCAPG, RFC3, PLK4, WDHD1, BLM, CDKN3, KIF15, SMARCA5, and ATAD2 as hub genes and TOP2A, MKI67, BRCA1, ANLN, KRAS, PLK4, SMARCA5, MMP2, and TLR4 as bottleneck genes were determined. Eight central genes were associated with 16 biological terms. <b>Conclusion:</b> In conclusion, significant differences appeared between gene expression conditions of the cells after 1-day and 5-day recovery. Molecular events include the repair and continuation of photodamages. It is possible to introduce drug targets to prevent the progress of induced damages.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e20"},"PeriodicalIF":1.4,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Low-Level Laser Therapy on the Osseointegration of Immediately Loaded Implants with a Connective Tissue Graft: A Randomized Clinical Trial.","authors":"Mohadese Momeni, Malihe Safari, Arash Sarrafzadeh, Ehsan Momeni","doi":"10.34172/jlms.2024.19","DOIUrl":"https://doi.org/10.34172/jlms.2024.19","url":null,"abstract":"<p><p><b>Introduction:</b> This study assessed the effect of low-level laser therapy (LLLT) on the osseointegration of immediately loaded implants with a connective tissue graft (CTG). <b>Methods:</b> This clinical trial was conducted on patients with buccal bone dehiscence requiring dental implants. A CTG was harvested from the palate and placed in the labial side by considering the 2 mm distance between the implant thread and bone. Autogenous bone was harvested from the tuberosity, mixed with the allograft, and implanted at the site. After sufficient torquing of the implant, a customized abutment was fabricated and placed. The patients were randomly assigned to two groups (n=5) of intervention and control. The patients in the intervention group received LLLT with a 940 nm gallium-aluminum-arsenide laser while those in the control group received placebo irradiation. The primary implant stability was measured before the delivery of customized abutment while the secondary implant stability was measured after 12 weeks by Osstell® and reported as the implant stability quotient (ISQ). <b>Results:</b> No significant difference was found in secondary ISQ between the laser and control groups (<i>P</i>>0.05). In the intervention group, a significant difference was found between the primary and secondary ISQ in the buccolingual dimension (<i>P</i><0.05) but not in the mesiodistal dimension (<i>P</i>>0.05). The two groups had no significant difference in gingival thickness or vertical bone gain (<i>P</i>>0.05). All implants were successful with no complications. <b>Conclusion:</b> LLLT had a significant positive efficacy for the enhancement of secondary stability of implants in the buccolingual dimension. CTG showed optimal efficacy for the treatment of buccal bone dehiscence.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e19"},"PeriodicalIF":1.4,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Photobiomodulation Therapy and Regenerative Medicine for Diabetic Foot Ulcers: Pathogenesis and Multidisciplinary Treatment Approach.","authors":"Elahe Torabi, Samareh Omidvari, Zahra Azimzadeh, Shahram Darabi, Aliasghar Keramatinia, Mohammad Ali Asghari, Hojjat Allah Abbaszadeh, Fariborz Rashnoo","doi":"10.34172/jlms.2024.18","DOIUrl":"https://doi.org/10.34172/jlms.2024.18","url":null,"abstract":"<p><p><b>Introduction:</b> Diabetes is associated with several debilitating complications, including the development of diabetic foot ulcers (DFUs), which can have serious consequences. This study emphasizes a multidisciplinary approach, providing a thorough overview of DFU pathogenesis and available treatments. <b>Methods:</b> An extensive literature review, covering studies published between 2000 and 2023, was conducted to gather data on DFU pathophysiology and treatments, including wound dressings, photobiomodulation, off-loading devices, adjunct medicines, and stem cell therapy. <b>Results:</b> DFUs are complicated due to infection, ischemia, and neuropathy. Sufficient wound dressings maintain a moist environment, promoting autolytic debridement and facilitating the healing process. Through cellular mechanisms, photobiomodulation therapy (PBM) was observed to expedite the healing process. Additionally, off-loading devices were invented to reduce ulcer pressure and promote healing. Adjunct therapies such as negative pressure wound therapy and hyperbaric oxygen therapy were identified as valuable tools for enhancing healing outcomes. Furthermore, autologous and allogeneic stem cell treatments exhibited the potential for promoting tissue regeneration and expediting the healing process. <b>Conclusion:</b> The complex pathophysiology of DFUs necessitates a multimodal treatment approach. Essential components include PBM, wound dressings, off-loading devices, adjunct treatments, and stem cell therapy.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e18"},"PeriodicalIF":1.4,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Fibroblast Growth Factor 2 and Low-Level Laser Therapy on the Adhesion and Proliferation of Periodontal Ligament Stem Cells.","authors":"Amirhosein Mahmoudian, Hanieh Nokhbatolfoghahaie, Neda Hakimiha, Fazele Atarbashi-Moghadam, Ali Azadi","doi":"10.34172/jlms.2024.17","DOIUrl":"https://doi.org/10.34172/jlms.2024.17","url":null,"abstract":"<p><p><b>Introduction:</b> The adhesion ability of mesenchymal stem cells can significantly affect their viability and is considered a prerequisite for cell therapy. The current study sought to evaluate the effect of fibroblast growth factor 2 (FGF2) and low-level laser therapy (LLLT), either individually or in conjunction, on the adhesion and proliferation of periodontal ligament stem cells (PDLSCs) when applied on the first day of cell seeding. <b>Methods:</b> The experimental groups of this study comprised a control group and different combinations of adjunctive FGF2 (50 ng/mL) and LLLT with an 808 nm diode laser in one (LLLT-1) or two sessions (LLLT-2) of irradiation. The proliferation and adhesion of cells were evaluated by using the methylthiazolyl tetrazolium (MTT) assay and 4',6-diamidino-2-phenylindole (DAPI) staining. All experiments were done in triplicates on the first, third, and fifth days after cell seeding. Two-way ANOVA and post hoc Tukey tests were used to analyze the data of the MTT assay. <i>P</i><0.05 was considered statistically significant. <b>Results:</b> One-day post-culture, only significant differences were found between the control group and the FGF2 (<i>P</i>=0.04) and FGF2+LLLT-2 application (<i>P</i>=0.04) groups. After three days post-cell culture, only a significantly higher proliferation rate was found in the control group than in the FGF2 group (<i>P</i>=0.01). After five days, the control group and LLLT-2 groups showed significantly higher amounts of proliferation compared to the other groups (<i>P</i><0.05). DAPI staining qualitatively confirmed the results of the MTT assay. <b>Conclusion:</b> The LLLT can be applied to PDLSCs on the day of seeding without causing a notable decrease in their viability and adhesion. Conversely, the administration of FGF2 should be restricted on the seeding day and postponed to subsequent days as it may have adverse effects on their adhesion and proliferation.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e17"},"PeriodicalIF":1.4,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Photodynamic Therapy with Four Light-Sensitive Materials on the Bond Strength of Fiber Posts to Root Dentin.","authors":"Sedighe Sadat Hashemikamangar, Shadi Pourahmadi, Nasim Chiniforush","doi":"10.34172/jlms.2024.16","DOIUrl":"https://doi.org/10.34172/jlms.2024.16","url":null,"abstract":"<p><p><b>Introduction:</b> Fiber-reinforced composite posts (FRCP) have become popular due to their multiple advantages in teeth with extensive crown destruction. Proper disinfection is essential for the successful bonding of these posts. Commonly used solutions for cleaning and disinfecting the root canals adversely affect the bond strength (BS). Photodynamic therapy is an alternative method for irrigating the root canal and disinfecting the post space.This study was designed to evaluate the impact of photodynamic therapy on the BS of fiber posts to root canal dentin. <b>Methods:</b> Human maxillary canines were recruited for this study. The tooth crowns were removed at the cervical line and endodontically treated. After fiber post spaces were prepared, the teeth were assigned to five groups based on the light-sensitive material: deionized water, indocyanine green and 810-nm laser, methylene blue and 660-nm laser, toluidine blue and 635-nm laser, curcumin and LED. The posts were cemented after photodynamic therapy. Cervical, middle, and apical samples were prepared by transverse sectioning. Push-out bond strength (PBS) values were measured in a universal testing machine. Finally, the data underwent statistical analyses with ANOVA and Howell-Games tests. <b>Results:</b> One-way ANOVA revealed no significant differences between the groups (<i>P</i><0.001). The Games-Howell test showed that curcumin (7.23±3.75) and the control group (5.92±4.04) had a similar BS (<i>P</i>>0.005). The BS was lower in the methylene blue (3.34±2.15), indocyanine green (2.59±3.16), and toluidine blue (2.45±1.73) groups than in the control group (<i>P</i><0.005). <b>Conclusion:</b> Unlike other light-sensitive materials, curcumin did not adversely affect the BS.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"15 ","pages":"e16"},"PeriodicalIF":1.4,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}