Journal of Medical Imaging and Radiation Oncology最新文献

{"title":"Dynamic SPECT Assessment of Hepatic Function in Patients With Liver Disease: A Systematic Review and Meta-Analysis","authors":"Bader Aloufi,&nbsp;Roger Fulton,&nbsp;Kathy Willowson,&nbsp;Peter L. Kench","doi":"10.1111/1754-9485.70166","DOIUrl":"10.1111/1754-9485.70166","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Dynamic Single Photon Emission Computed Tomography (dynSPECT) is an advanced functional imaging modality that enables estimation of temporal changes in radiopharmaceutical distribution and physiological function. While dynSPECT has been employed in several clinical applications, it has not been widely applied to liver imaging. This review aims to investigate the role and effectiveness of dynSPECT in assessing hepatic function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following PRISMA guidelines, literature searches were conducted in MEDLINE, PubMed, Scopus, Embase, IEEE, and Web of Science, including all publications available up to December 2025 that assessed liver function using dynSPECT imaging, standard laboratory function tests and clinical scoring systems. Search results were screened by two authors. Included studies were assessed for bias using the QUADAS-2 quality assessment test tool.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixteen eligible studies were incorporated in this review, involving 715 participants, of whom 87% (624) had hepatic diseases. Meta-analysis revealed correlations between dynSPECT measures of liver function and the laboratory tests, including Hepaplastin (<i>r</i> = 0.5471; 95% CI: 0.4523 to 0.6418), Indocyanine Green (ICG) (<i>r</i> = −0.461; 95% CI: −0.831 to −0.081), and Bilirubin (<i>r</i> = −0.425; 95% CI: −0.714 to −0.14). Furthermore, the comparison between the two dynSPECT parameters and clinical scoring systems, including the Child-Pugh score, MELD, and the histologic activity index (HAI), has a significant effect on liver disease assessment, with a combined <i>p</i>-value &lt; 0.001.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>DynSPECT is a useful tool for the assessment of liver function in patients with hepatic dysfunction, providing results comparable to clinical laboratory function tests and scoring systems.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"70 6","pages":"510-529"},"PeriodicalIF":1.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1754-9485.70166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skull Base Metastases: A Pictorial Review","authors":"Ashley Heyworth,&nbsp;Louise van Camp","doi":"10.1111/1754-9485.70150","DOIUrl":"10.1111/1754-9485.70150","url":null,"abstract":"<div>\u0000 \u0000 <p>Compared to other sites of skeletal metastases, skull base metastases are relatively rare with varying incidence reported in the literature. The most frequently implicated cancers are breast, prostate and lung carcinomas and lymphoma. While some lesions are asymptomatic, the clinical presentation may be with pain or cranial neuropathy. Adequate imaging techniques and knowledge of skull base anatomy are essential. Imaging features of metastases at various locations at the skull base will be described, highlighting important anatomical landmarks and clinical implications.</p>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"70 6","pages":"548-553"},"PeriodicalIF":1.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1754-9485.70150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Music Therapy on Physiological Indicators and Subjective Comfort in Patients Undergoing Large Medical Imaging Examinations: A Systematic Review and Meta-Analysis","authors":"Zefang Li,&nbsp;Tiexiong Wu,&nbsp;Haina Fu","doi":"10.1111/1754-9485.70168","DOIUrl":"10.1111/1754-9485.70168","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To systematically evaluate the effects of music therapy on physiological indicators and psychological states in patients undergoing large medical imaging examinations, providing evidence-based support for clinical auxiliary interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature search was conducted across English and Chinese databases, including PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang Database, and VIP Database, from inception to May 2026. RCTs investigating music therapy interventions in patients undergoing medical imaging examinations were collected. Two independent reviewers performed literature screening, data extraction, and quality assessment. A meta-analysis was conducted on outcome indicators including heart rate, anxiety scores, depression scores, and examination cooperation rate. Heterogeneity among studies was evaluated using the I² statistic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 9 RCTs were included. The meta-analysis results demonstrated that music therapy significantly reduced patients' heart rates, with a pooled mean difference (MD) of −2.14 (95% CI: −2.21, −2.08; <i>p</i> &lt; 0.05). It also significantly alleviated anxiety levels, with a pooled SMD of −1.43 (95% CI: −1.49, −1.38; <i>p</i> &lt; 0.05). The analysis of depression scores indicated no statistically significant difference between the two groups (SMD = 0.11, 95% CI: −0.62, 0.84; <i>p</i> = 0.77). The analysis of examination cooperation rates showed that music therapy improved the examination cooperation rate, with a pooled risk ratio (RR) of 1.34 (95% CI: 1.28, 1.40; <i>p</i> &lt; 0.05). High heterogeneity was observed in certain outcome indicators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Music therapy can, to a certain extent, improve the physiological and psychological states of patients undergoing medical imaging examinations, as manifested by reduced heart rates, alleviated anxiety, and an increased examination cooperation rate. However, its efficacy in improving depressive states remains unclear. Given the high heterogeneity in some analytical results, further large-sample, high-quality RCTs are required for verification.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"70 6","pages":"530-538"},"PeriodicalIF":1.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Student/JMO","authors":"","doi":"10.1111/1754-9485.70160","DOIUrl":"https://doi.org/10.1111/1754-9485.70160","url":null,"abstract":"","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"70 S1","pages":"S13-S19"},"PeriodicalIF":1.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148974890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SpyGlass-Assisted Percutaneous Transhepatic Cholangioscopy in Patients With Biliary Duct Calculi: A Retrospective Cohort Study From an Australasian Centre","authors":"Tae Gon Yoo,&nbsp;Yi Sing Wee,&nbsp;Snehal Patel,&nbsp;Sanket Srinivasa,&nbsp;Jonathan Koea,&nbsp;Rahul Bera","doi":"10.1111/1754-9485.70113","DOIUrl":"10.1111/1754-9485.70113","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Percutaneous transhepatic cholangioscopy has emerged as a viable alternative to endoscopic retrograde cholangiopancreatography for the management of biliary duct calculi. This study aimed to evaluate the outcomes of treating biliary duct calculi using SpyGlass-assisted percutaneous transhepatic cholangioscopy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective review was conducted of all patients who underwent SpyGlass-assisted percutaneous transhepatic cholangioscopy at a single-centre between May 2021 and December 2024. Demographic, clinical, imaging, procedural, and adverse event data were collected from electronic medical records. The primary outcome was clinical success, defined as complete resolution of presenting symptoms with associated improvement in biochemical markers. The secondary outcome was technical success, defined as complete clearance of biliary duct calculi on direct visualisation using SpyGlass cholangioscopy and fluoroscopic imaging. Adverse events were recorded and classified according to severity using the Clavien-Dindo classification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between May 2021 and December 2024, 27 patients underwent 42 SpyGlass-assisted percutaneous transhepatic cholangioscopy procedures for 32 distinct clinical presentations. Clinical success was achieved in all presentations, and technical success was recorded at 83% of procedures. Adverse events occurred in 36% of procedures, the majority of which were minor (Clavien-Dindo classification Grade 1 or 2). There was a single case of procedure-related mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SpyGlass-assisted percutaneous transhepatic cholangioscopy appears to be a safe and effective alternative for the management of biliary duct calculi, particularly in cases where endoscopic retrograde cholangiopancreatography is unsuccessful or contraindicated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"70 6","pages":"554-560"},"PeriodicalIF":1.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faculty of Radiation Oncology 2022 New Zealand Workforce Census","authors":"Jack Mitchell,&nbsp;Melissa James,&nbsp;Nathan Stevens,&nbsp;Hon Trinh,&nbsp;Gerard Adams,&nbsp;Tuan Ha,&nbsp;Marcel Knesl,&nbsp;Edward Sia,&nbsp;Daniel Xing,&nbsp;Ramesh Pandey,&nbsp;Nicole Buddle,&nbsp;Yvonne Zissiadis,&nbsp;Raphael Chee,&nbsp;the RANZCR Economics and Workforce Committee","doi":"10.1111/1754-9485.70094","DOIUrl":"10.1111/1754-9485.70094","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>This study reports the findings of the 2022 Royal Australian and New Zealand College of Radiologists (RANZCR) workforce census, providing an updated overview of the New Zealand (NZ) radiation oncology workforce. The purpose was to assess workforce demographics, distribution, training, and service capacity, and highlight challenges that have persisted since the 2018 census.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A survey was distributed to all practicing radiation oncologists and trainees in NZ. Data were collected on demographics, qualifications, workload, practice setting, subspecialty involvement, training experiences, and the perceived impact of COVID-19. Responses were collated and descriptive analyses performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The census recorded a workforce with a median age of 51 years (range 33–71), and 43% female representation. Most worked across both public and private sectors, with high reported working hours. Brachytherapy practice participation declined compared with previous censuses. Among trainees, concerns included workload, job availability, and work–life balance, with many indicating a preference for part-time and/or urban practice. COVID-19 was associated with delays in service delivery, though the majority reported no exam or fellowship disruptions. Anticipated increases in hypofractionation use were noted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The 2022 census highlights a workforce under strain from high clinical demand, limited growth, and looming retirements. Key challenges include inequitable representation of Māori and Pasifika clinicians, declining subspecialty capacity, and risks of burnout. Coordinated national workforce planning, with a focus on recruitment, retention, equity, and flexible models of training and employment, will be essential to ensure sustainable radiation oncology services in NZ. This census therefore reinforces the urgent need for coordinated national workforce planning to safeguard the future of radiation oncology services in NZ.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"70 6","pages":"577-586"},"PeriodicalIF":1.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventional Radiology Society of Australasia Quality Care Guidelines for Prostate Artery Embolisation for Men With Symptomatic Benign Prostatic Hyperplasia in Australia and New Zealand.","authors":"William E L Ormiston, Glen Schlaphoff, Andrew Owen, Brendan Buckley, Dinesh Ranatunga, Christopher Rogan, Nicholas I Brown","doi":"10.1111/1754-9485.70179","DOIUrl":"https://doi.org/10.1111/1754-9485.70179","url":null,"abstract":"<p><strong>Objective: </strong>This guideline defines recommendations for the provision of quality care for prostate artery embolisation (PAE) treatment for symptomatic benign prostatic hyperplasia (BPH). It has been developed using the AGREE-II framework and aligns with current evidence, sourced from Randomised Controlled Trials, meta-analyses and expert consensus. Recommendations are graded according to the level of evidence supporting them.</p><p><strong>Target audience: </strong>Men with symptomatic BPH considering their treatment options and referring clinicians including general practitioners, urologists and interventional radiologists.</p><p><strong>Formulation of recommendations: </strong>This guideline was developed using a modified Delphi approach among a panel of expert interventional radiologists, with a structured review of current literature including randomised controlled trials, meta-analyses and high-quality cohort studies.</p><p><strong>Target users: </strong>This guideline is intended for use by medical practitioners involved in the assessment and management of men with symptomatic BPH, including general practitioners, urologists and interventional radiologists. It may also inform policy-makers, hospital administrators and quality assurance bodies regarding the standard of care for PAE.</p><p><strong>Updating procedure: </strong>This guideline will be reviewed 5 years after publication, or earlier if significant new evidence emerges. Updates will follow the AGREE CheckUp process and will be published in relevant peer-reviewed outlets and society guidelines.</p>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is a Reduction of Contralateral Adrenal Volume Assessed by CT Volumetry a Predictor of Autonomous Cortisol Secretion in Patients With Adrenal Incidentalomas?","authors":"Talia Walter,&nbsp;Erika Stark,&nbsp;Steven Soule,&nbsp;Stefan Gabrielson","doi":"10.1111/1754-9485.70090","DOIUrl":"10.1111/1754-9485.70090","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Adrenal incidentalomas are common lesions with potential functional activity such as autonomous cortisol secretion (ACS), which influences management. Current diagnosis relies on biochemical testing, notably the dexamethasone suppression test (DST). This study aimed to evaluate whether CT-derived volumetry of adrenal incidentalomas and contralateral adrenal glands—specifically the ratio of adenoma volume to contralateral volume (AV/CV) could serve as a reliable screening marker for ACS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analysed all adult patients referred with unilateral adrenal adenomas between January 2022 and January 2023. Patients with bilateral lesions, metastatic disease, or interfering medications were excluded. All underwent standard hormonal assessment with 1 mg overnight DST and had volumetric analysis of adrenal glands on CT imaging performed independently by two radiologists, calculating AV, CV and their ratio. The correlation between AV/CV and post-DST cortisol levels was assessed using Pearson's coefficient, and ROC analysis evaluated the predictive accuracy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Inter-observer variability was <i>r</i> = 0.997 for AV and <i>r</i> = 0.791 for CV. There was no significant correlation between AV/CV ratio and cortisol post-DST. An AV/CV ratio ≥ 1 demonstrated low sensitivity (52%) and specificity (48%) for ACS prediction. Although a ratio ≥ 3 was highly specific (&gt; 90%), its sensitivity was limited (17%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study did not show a correlation between AV/CV ratio and the presence of ACS, contrasting earlier promising studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"70 6","pages":"505-509"},"PeriodicalIF":1.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-Induced Cutaneous Tissue Reactions in Neurointerventional Procedures: A Systematic Review of Reported Effects and Associated Dose Levels","authors":"Mohamed Khaldoun Badawy,&nbsp;Fatimah Balasim,&nbsp;Caitlan De Hoedt,&nbsp;Mercer Kim,&nbsp;Samuel Montgomery Lilli,&nbsp;Alice Gutowski","doi":"10.1111/1754-9485.70156","DOIUrl":"10.1111/1754-9485.70156","url":null,"abstract":"<p>Neurointerventional procedures can deliver high localised skin doses and may cause radiation-induced cutaneous tissue reactions, yet the doses at which these occur have not been synthesised specifically for this setting. We systematically reviewed reported cutaneous reactions and associated radiation doses after fluoroscopy- or digital subtraction angiography-guided cranial or spinal neurointerventional procedures. Following PRISMA 2020, Ovid MEDLINE, Embase, Scopus and the Cochrane Library were searched in April 2026; case reports, case series and observational studies reporting a cutaneous reaction and/or a relevant skin dose were eligible. Screening and extraction were performed by two independent reviewers, and studies were appraised with the Joanna Briggs Institute checklists; findings were synthesised narratively, with cohort-derived incidence reported separately from case-level data. Twenty-five studies (approximately 686 patients; 11 countries) were included. Alopecia/epilation was the dominant reaction (21 studies); dermatitis/erythema (4) and ulceration/necrosis (2) were less frequent. Among cohorts, incidence ranged from approximately 5% to 56% and rose with skin dose and procedural complexity. Reported onset doses tracked established deterministic thresholds: temporary epilation clustered around the approximately 3 Gy threshold, whereas erythema and ulceration occurred at higher, usually cumulative, doses, and epilation below approximately 2 Gy was reported in radiosensitive patients. Alopecia appeared 2–5 weeks after the procedure and ulceration months to years later. Dose metrics were inconsistent, and 4 of 25 studies reported no dose. Standardised reporting of peak skin dose and dose-triggered, structured follow-up is needed.</p>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"70 6","pages":"561-572"},"PeriodicalIF":1.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1754-9485.70156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Contrast MRI for Hepatocellular Carcinoma Surveillance and Diagnosis: A Systematic Review and Meta-Analysis of Diagnostic Accuracy","authors":"Hua Zhou,&nbsp;Tiansheng Wen,&nbsp;Suyun Xie,&nbsp;Jun Guo","doi":"10.1111/1754-9485.70091","DOIUrl":"10.1111/1754-9485.70091","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, particularly among patients with chronic liver disease and cirrhosis. Non-contrast magnetic resonance imaging (NC-MRI) has emerged as a potential alternative imaging modality for HCC surveillance and diagnosis, avoiding the risks associated with contrast agents; however, its diagnostic performance has not been fully established. This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of NC-MRI for the detection and surveillance of HCC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive systematic search of five electronic databases (PubMed, EMBASE, Scopus, the Cochrane Library, and Web of Science) was conducted. Eligible studies evaluated NC-MRI for HCC diagnosis or surveillance and reported sufficient data to construct diagnostic accuracy measures. Data were extracted on study characteristics, patient populations, NC-MRI protocols, reference standards, and diagnostic outcomes, including sensitivity, specificity, diagnostic odds ratio (DOR), and likelihood ratios. Subgroup analyses were performed according to study design, reference standard, and imaging intent (diagnostic vs. surveillance).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-one studies comprising 7412 participants were included. The pooled sensitivity and specificity of NC-MRI for HCC detection were 84% and 94%, respectively. The pooled DOR was 78 (95% CI: 50–122), with a positive likelihood ratio (LR+) of 13 (95% CI: 9–19) and a negative likelihood ratio (LR−) of 0.17 (95% CI: 0.13–0.22). Subgroup analyses demonstrated higher diagnostic performance in prospective studies and when NC-MRI was applied for surveillance purposes. Studies using histopathology as the reference standard also showed high diagnostic accuracy, with a DOR of 74.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>NC-MRI demonstrates consistently high diagnostic accuracy across diverse study settings and represents a promising contrast-free imaging option in selected high-risk populations. However, its role in population-based surveillance requires cautious interpretation, particularly for early-stage disease and warrants further prospective validation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"70 6","pages":"587-600"},"PeriodicalIF":1.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1754-9485.70091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}