{"title":"Preoperative surgical planning MRI for fibroids: What the surgeon needs to know and what to report.","authors":"Jade Acton","doi":"10.1111/1754-9485.13816","DOIUrl":"https://doi.org/10.1111/1754-9485.13816","url":null,"abstract":"<p><p>Uterine leiomyomata, commonly known as fibroids, are prevalent benign tumours affecting a significant percentage of women of reproductive age. Although many patients remain asymptomatic, a substantial proportion experience severe symptoms, including abnormal uterine bleeding and adverse reproductive outcomes. Surgical intervention often becomes necessary for patients with symptomatic fibroids, despite advancements in medical therapies. This article explores the critical role of Magnetic Resonance Imaging (MRI) in the preoperative planning and management of fibroid surgeries. MRI has been proven superior to traditional imaging methods, such as transvaginal ultrasound (TVS), offering a more accurate evaluation of fibroid size, location, number, and characteristics. This enhanced imaging aids in surgical planning by providing detailed anatomical insights, helping gynaecologists choose the appropriate surgical techniques and predict potential complications. Moreover, MRI is instrumental in assessing the risk of malignancy, guiding decisions on whether to proceed with myomectomy or hysterectomy. Technological advancements, such as 3D MRI modelling and augmented reality, promise further improvements in surgical outcomes by enhancing anatomical understanding and precision. These innovations, along with artificial intelligence integration, show potential in reducing operation times and improving patient outcomes. This review underscores the essential role of MRI in contemporary fibroid management and highlights future directions in the field.</p>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mark McOwan, Jack Kinnersly, Nirbaanjot Walia, Patrick Dooley, Scott Robson
{"title":"Validation of Risk Prediction Models for Pneumothorax and Intercostal Catheter Insertion Following CT-Guided Lung Biopsy","authors":"Mark McOwan, Jack Kinnersly, Nirbaanjot Walia, Patrick Dooley, Scott Robson","doi":"10.1111/1754-9485.13827","DOIUrl":"10.1111/1754-9485.13827","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>CT-guided percutaneous transthoracic needle biopsy is the primary method for diagnosing lung lesions. Widely accepted validated risk prediction models are yet to be developed. A recently published study conducted at Grampians Health Services (GHS) developed two risk prediction models for predicting pneumothorax and intercostal catheter (ICC) insertion. This study aims to validate these models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a single-centre, retrospective cohort study performed at GHS. Patients with a CT-guided lung biopsy between January 2020 and July 2023 were included, alongside target-lesion characteristics, procedural-related factors and complications. Predicted probabilities for pneumothorax and ICC insertion were generated for each patient, and the diagnostic accuracy of the previous risk prediction models was evaluated the area under the receiver operating characteristic. A Youden Index was used to determine the sensitivity and specificity at the optimal probability thresholds.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The validation found the model published by GHS demonstrated a diagnostic accuracy of 0.695 (95% CI: 0.601–0.695) for predicting pneumothorax following CT-guided percutaneous biopsy. The model for predicting intercostal catheter insertion had a diagnostic accuracy of 0.762 (95% CI: 0.642–0.762). The sensitivity for predicting pneumothorax and ICC insertion was 81.97% and 92.86%, respectively, for their optimum probability thresholds.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings suggest that the previously published models may be useful in predicting pneumothoraces and ICC insertion following CT-guided percutaneous biopsy. We recommend these models as an adjunctive tool to aid in clinical decision-making during the peri-procedural management of these patients pending further validation with an external cohort.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"69 2","pages":"162-168"},"PeriodicalIF":2.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayesha Arora, Clair Shadbolt, Kim Lam, Sarita Bahure, Yu Xuan Kitzing
{"title":"Pathology and risk stratification-based evaluation of ovarian masses on MRI.","authors":"Ayesha Arora, Clair Shadbolt, Kim Lam, Sarita Bahure, Yu Xuan Kitzing","doi":"10.1111/1754-9485.13819","DOIUrl":"https://doi.org/10.1111/1754-9485.13819","url":null,"abstract":"<p><p>Characterisation of an indeterminate ovarian mass is important as it guides management and clinical outcomes. Ultrasound is the first-line modality in the assessment of ovarian tumours. When ovarian masses are indeterminate on ultrasound, MRI provides excellent resolution in tissue characterisation and enhancement patterns. Ovarian masses can be categorised based on risk-scoring systems such as the American College of Radiology (ACR) MRI Ovarian-Adnexal Reporting and Data System (O-RADS). The imaging features of non-neoplastic, benign, borderline and malignant neoplastic ovarian lesions are discussed in this review with a focus on the pathology process accounting for the MRI appearance. Characteristic findings and clues in differentiating a benign lesion from a malignancy are presented in this review.</p>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IRSA ASM 2024 Abstract","authors":"","doi":"10.1111/1754-9485.13764","DOIUrl":"10.1111/1754-9485.13764","url":null,"abstract":"<p><b>Aim:</b> Interventionalist experience high-lifetime radiation dosages due to the use of pulsed fluoroscopy. They also experience orthopaedic problems due to the necessity of wearing lead gowns to protect from this radiation. To alleviate both the radiation and orthopaedic issues, we trialled an innovative shielding system, Rampart (tm) which surrounds the patient's torso with lead equivalent acrylic shielding. Our trial period coincided with the initial COVID-19 outbreak and lockdowns which provided an additional use of the shielding as a protection from spread of COVID-19 infection from patients.</p><p><b>Method:</b> Using Ray safe (tm) i3 Dosimeters, we measured primary operator radiation dosimetry. This was measured at the head (H), upper torso (T) and waist height (W). Both with the Rampart (tm) shield and without it. The measurements were conducted over a usual week's case load.</p><p><b>Results:</b> 20 cases were performed, 10 with the Rampart (tm) system in place and 10 without. At the primary operator position we found an effective radiation attenuation of H: 70.3%, T: 98.3%, W: 99.5% with lead gowns. Compared to an effective radiation attenuation just using the Rampart(tm) external shielding of H: 89.3%, T: 92.4%, W: 89.0%. Using both lead gowns and the Rampart (tm) gave over 99.9 %. Airflow test also showed a laminar air flow away from the operator from the patient's head.</p><p><b>Conclusion:</b> Whilst not as effective alone as lead gowns in radiation attenuation, the Rampart (tm) system was demonstrated to be an effective radiation safety device with the possibility of no lead or lighter lead use. Additional benefits that were observed from its use included significant radiation protection to the operator, protection to body areas not protected by lead, (head arms) as well shielding from direct aerosol contact with the patient which has proven to be an important consideration in the current COVID-19 pandemic.</p>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"68 8","pages":"e4"},"PeriodicalIF":2.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1754-9485.13764","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IRSA ASM 2024 Abstract","authors":"","doi":"10.1111/1754-9485.13763","DOIUrl":"10.1111/1754-9485.13763","url":null,"abstract":"<p><b>Aim:</b> Radiological interventions are increasingly complex and also increasingly performed on high body mass index (BMI) patients. As such we sought to quantify the radiation dose to the eyes of the operator, the dose area product and skin dose to the patient, as well as variations in cardiac angiographic image quality. Over the range of normal to high BMI's.</p><p><b>Methods:</b> Five thickness of Acrylic 15, 20, 25, 30 and 35 cm were used to simulate increasing patient BMI. The patient dose area product and skin dose were measured from the built-in metering systems of the angiographic system. The simulated operator eye dose was measured using (Rando) tm Phantom and a (Unfors)tm radiation detector at 150–170 cm in 5 cm gradients at the primary operator position. For image quality measurement, a Westmead testing object was used to test high and low contrast range and line pairs per 0.5 mm.</p><p><b>Results:</b> Our study shows that whilst a low-grade linear decrease in image quality and corresponding rise in radiation dose is seen over the standard patient BMI ranges. There is a very large nonlinear drop in image quality and corresponding large rise in radiation dose in the high BMI patient range (over 25) using standard settings. Our secondary aim was proven in the results showing the high effectiveness (over 90%) of the standard lead equivalent acrylic shielding in protecting the operators' eyes. Especially for the very high levels found in the extreme patient size cohort.</p><p><b>Conclusion:</b> These results indicate the important need of the radiographers' role in radiation safety. Selecting the most efficient frame rate/Ma settings possible, positioning of the detector, monitoring of ongoing case dose and that operators are using radiation protection equipment, especially the ceiling acrylic (Pb) shield for the higher BMI patients.</p>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"68 8","pages":"e3"},"PeriodicalIF":2.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1754-9485.13763","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Krishna Pranathi Settipalli, Sophie Dunkerton, John Hilton, Grace Aw, Gregory Lock, Kenneth Mitchell, Alan Coulthard
{"title":"The ELVIS study: Medium and long-term Efficacy of LVIS EVO stent-assisted coil embolisation for unruptured saccular intracranial aneurysms—A tertiary single-centre experience","authors":"Krishna Pranathi Settipalli, Sophie Dunkerton, John Hilton, Grace Aw, Gregory Lock, Kenneth Mitchell, Alan Coulthard","doi":"10.1111/1754-9485.13820","DOIUrl":"10.1111/1754-9485.13820","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The LVIS EVO (MicroVention<sup>®</sup>) is a braided stent designed to assist coil embolisation of intracranial aneurysms. It offers several structural innovations over previous and currently available braided, and laser-cut, stents that are theorised to improve procedural success. This retrospective audit aims to determine the success and complication rates of LVIS EVO-assisted coil embolisation in unruptured saccular aneurysms at a tertiary neurovascular referral centre in Queensland, Australia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The medical records of all patients who underwent elective LVIS EVO-assisted coil embolisation at our institution between 2020 and 2024 were reviewed. Clinical and radiologic outcomes, including occlusion rate, occlusion grade (modified Raymond Roy classification—MRRC), complications, recurrence rate, and change in modified Rankin scale (mRS) were recorded, alongside aneurysm characteristics and technical procedural details.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 29 cases, 2 were excluded due to complex aneurysms requiring off-label LVIS EVO use. Twenty-seven (27) saccular aneurysms in 26 patients (18 female; 8 male) were included. Most (22/27) involved the anterior cerebral artery (ACA), primarily the anterior communicating artery (18/27). Complete occlusion was seen in 55.6% (15/27) of cases immediately post-procedure, in 85.2% (23/27) at 3 months, and in 84.2% (16/19) at a median of 12-months post-procedure. A recurrence was seen in 7.4% (2/27) of patients. No procedural or long-term complications, and no significant changes in 90-day mRS, were noted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results show 100% technical success reflecting existing literature and contribute further by providing data on medium to long-term success rates with LVIS EVO-assisted coil embolisation for unruptured saccular aneurysms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"69 2","pages":"212-220"},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lung cancer screening in Australia: The time approaches","authors":"Miranda Siemienowicz","doi":"10.1111/1754-9485.13818","DOIUrl":"10.1111/1754-9485.13818","url":null,"abstract":"","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"69 2","pages":"211"},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily Flower, Gemma Busuttil, Eireann Cosgriff, Niluja Thiruthaneeswaran, Salman Zanjani, Emma Sullivan, Alison Salkeld, Jonathan Sykes, David Thwaites, Jennifer Chard
{"title":"Evaluation of plan quality, safety, and toxicity of brachytherapy for locally advanced cervical cancer in an Australian setting following changes in prescription and applicator design","authors":"Emily Flower, Gemma Busuttil, Eireann Cosgriff, Niluja Thiruthaneeswaran, Salman Zanjani, Emma Sullivan, Alison Salkeld, Jonathan Sykes, David Thwaites, Jennifer Chard","doi":"10.1111/1754-9485.13811","DOIUrl":"10.1111/1754-9485.13811","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Chemoradiotherapy with MRI-guided brachytherapy boosts is the standard of care for locally advanced cervical cancer. Data from the RetroEMBRACE and EMBRACE I trials provide dose-response curves for target volumes and OAR. This study evaluated plan quality, safety and toxicity following escalation of the CTV_HR D90 prescription from 80–90 Gy to 85–95 Gy for two different applicator designs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective dosimetric plan quality review was undertaken for consecutively treated locally advanced cervical cancer brachytherapy boosts between 2017 and 2022, and the relationships between implant total reference air kerma (TRAK), CTV_HR volume and vaginal dose were investigated. Safety and ≤grade 3 toxicity results were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventy patients were identified. All patients received a CTV_HR D90 dose >85 Gy and rectum D2cm<sup>3</sup> of <75 Gy, while 88.6% of patients received a bladder D2cm<sup>3</sup> <90 Gy. Needles were used in 48.6% of patients, and the mean percentage needle TRAK was 38.2%. Increasing the percentage of needle TRAK decreased vaginal TRAK. Sixty-three patients had more than 12 months of follow-up (median 27 months). From this cohort, grade 3 or higher toxicity for vaginal, genitourinary, gastrointestinal and fistula events were seen in 3.2%, 1.6%, 0% and 3.2% of patients, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Increased dose prescriptions and a change of applicator design were successfully adopted into an Australian practice. Applicator design and interstitial needle use affect the plan quality and ability to meet OAR dose constraints following target dose escalation. No safety concerns with needle use or dose escalation were identified.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"69 2","pages":"295-303"},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdul Rahman Ihdayhid, Amro Sehly, Nick S R Lan, Nadia Denston, Benjamin J W Chow, David E Newby, Michelle C Williams, Girish Dwivedi
{"title":"Characterising high-risk plaque on cardiac CT","authors":"Abdul Rahman Ihdayhid, Amro Sehly, Nick S R Lan, Nadia Denston, Benjamin J W Chow, David E Newby, Michelle C Williams, Girish Dwivedi","doi":"10.1111/1754-9485.13817","DOIUrl":"10.1111/1754-9485.13817","url":null,"abstract":"<div>\u0000 \u0000 <p>Coronary computed tomography angiography (CCTA) is a well-established and reliable non-invasive imaging modality that provides a comprehensive assessment of coronary artery anatomy and luminal stenosis due to atherosclerosis. Owing to advances in CCTA software and technology, the composition and morphology of coronary plaque can be accurately evaluated. Adverse features which identify plaque as being high-risk or ‘vulnerable’ can provide a personalised cardiovascular risk assessment over and above stenosis severity. High-risk plaque features on CCTA include spotty calcification, low attenuation plaque, positive remodelling and the napkin ring sign. However, it can be challenging to characterise high-risk plaque accurately on CCTA, and as such, education and experience are required. In this pictorial essay, a comprehensive visual guide to high-risk plaque features on CCTA is provided, with clear examples and challenging cases that highlight common pitfalls. It is important for expert readers to properly identify these features given their association with adverse outcomes and potential future implications on intensive goal-directed medical therapy.</p>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"69 2","pages":"206-210"},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Louisa P Thong, Benyamin Hakak-Zargar, Andrew T Burns, George N Harisis, Samantha J Ellis, Francis J Ha
{"title":"Pulmonary veno-occlusive disease: A systematic review of risk factors, clinical presentation, diagnostic investigations, treatment outcomes and prognostic factors","authors":"Louisa P Thong, Benyamin Hakak-Zargar, Andrew T Burns, George N Harisis, Samantha J Ellis, Francis J Ha","doi":"10.1111/1754-9485.13814","DOIUrl":"10.1111/1754-9485.13814","url":null,"abstract":"<div>\u0000 \u0000 <p>Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension. We aimed to systematically evaluate published cases of PVOD to provide an overview of their clinical presentation, management and prognosis to assist early identification and treatment. We conducted a literature search of PubMed and Embase databases for adult cases of ‘pulmonary veno-occlusive disease’ and ‘pulmonary capillary haemangiomatosis’. Data collected included baseline demographics, medical history, clinical presentation, investigations performed, treatment and outcome. Kaplan–Meier survival analysis was used for overall survival with Cox-hazards-regression model used to evaluate treatment outcomes and prognostic factors. A total of 257 cases of PVOD from 113 articles were included in our analysis (mean age 45 ± 17 years, 54% females). Most frequent associations were smoking (28%), systemic sclerosis (10%) and mitomycin exposure (9%). Cardinal CT chest findings included ground glass opacities (75%), interlobular septal thickening (74%) and lymphadenopathy (51%); however, all three features were only seen in 23% (35/151). Median overall survival was 12 months (interquartile range, 3–48 months). Lung transplantation was the only treatment associated with improved survival (<i>P</i> = 0.006). Right ventricular dilatation (<i>P</i> = 0.005), increased mean pulmonary artery pressure (<i>P</i> = 0.01) and reduced 6-minute walk distance (<i>P</i> = 0.04) were associated with poorer overall survival. This systematic review provides a clinically relevant overview of a rare and often fatal condition. There is need for early diagnosis and referral for consideration of lung transplantation, while recognising right ventricular dilatation and elevated pulmonary pressures portend poorer prognosis. PROSPERO international register CRD42024553829.</p>\u0000 </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"69 2","pages":"186-197"},"PeriodicalIF":2.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}