Journal of Medical Imaging and Radiation Oncology最新文献_第2页

Evaluation of plan quality, safety, and toxicity of brachytherapy for locally advanced cervical cancer in an Australian setting following changes in prescription and applicator design. 在处方和涂抹器设计改变后，澳大利亚近距离治疗局部晚期宫颈癌的计划质量、安全性和毒性评估

IF 2.2 4区医学

Journal of Medical Imaging and Radiation Oncology Pub Date : 2024-12-12 DOI: 10.1111/1754-9485.13811

Emily Flower, Gemma Busuttil, Eireann Cosgriff, Niluja Thiruthaneeswaran, Salman Zanjani, Emma Sullivan, Alison Salkeld, Jonathan Sykes, David Thwaites, Jennifer Chard

{"title":"Evaluation of plan quality, safety, and toxicity of brachytherapy for locally advanced cervical cancer in an Australian setting following changes in prescription and applicator design.","authors":"Emily Flower, Gemma Busuttil, Eireann Cosgriff, Niluja Thiruthaneeswaran, Salman Zanjani, Emma Sullivan, Alison Salkeld, Jonathan Sykes, David Thwaites, Jennifer Chard","doi":"10.1111/1754-9485.13811","DOIUrl":"https://doi.org/10.1111/1754-9485.13811","url":null,"abstract":"Introduction: Chemoradiotherapy with MRI-guided brachytherapy boosts is the standard of care for locally advanced cervical cancer. Data from the RetroEMBRACE and EMBRACE I trials provide dose-response curves for target volumes and OAR. This study evaluated plan quality, safety and toxicity following escalation of the CTV_HR D90 prescription from 80-90 Gy to 85-95 Gy for two different applicator designs.Methods: A retrospective dosimetric plan quality review was undertaken for consecutively treated locally advanced cervical cancer brachytherapy boosts between 2017 and 2022, and the relationships between implant total reference air kerma (TRAK), CTV_HR volume and vaginal dose were investigated. Safety and ≤grade 3 toxicity results were evaluated.Results: Seventy patients were identified. All patients received a CTV_HR D90 dose >85 Gy and rectum D2cm3 of <75 Gy, while 88.6% of patients received a bladder D2cm3 <90 Gy. Needles were used in 48.6% of patients, and the mean percentage needle TRAK was 38.2%. Increasing the percentage of needle TRAK decreased vaginal TRAK. Sixty-three patients had more than 12 months of follow-up (median 27 months). From this cohort, grade 3 or higher toxicity for vaginal, genitourinary, gastrointestinal and fistula events were seen in 3.2%, 1.6%, 0% and 3.2% of patients, respectively.Conclusion: Increased dose prescriptions and a change of applicator design were successfully adopted into an Australian practice. Applicator design and interstitial needle use affect the plan quality and ability to meet OAR dose constraints following target dose escalation. No safety concerns with needle use or dose escalation were identified.","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterising high-risk plaque on cardiac CT. 心脏CT高危斑块的特征分析。

IF 2.2 4区医学

Journal of Medical Imaging and Radiation Oncology Pub Date : 2024-12-12 DOI: 10.1111/1754-9485.13817

Abdul Rahman Ihdayhid, Amro Sehly, Nick S R Lan, Nadia Denston, Benjamin J W Chow, David E Newby, Michelle C Williams, Girish Dwivedi

{"title":"Characterising high-risk plaque on cardiac CT.","authors":"Abdul Rahman Ihdayhid, Amro Sehly, Nick S R Lan, Nadia Denston, Benjamin J W Chow, David E Newby, Michelle C Williams, Girish Dwivedi","doi":"10.1111/1754-9485.13817","DOIUrl":"https://doi.org/10.1111/1754-9485.13817","url":null,"abstract":"Coronary computed tomography angiography (CCTA) is a well-established and reliable non-invasive imaging modality that provides a comprehensive assessment of coronary artery anatomy and luminal stenosis due to atherosclerosis. Owing to advances in CCTA software and technology, the composition and morphology of coronary plaque can be accurately evaluated. Adverse features which identify plaque as being high-risk or 'vulnerable' can provide a personalised cardiovascular risk assessment over and above stenosis severity. High-risk plaque features on CCTA include spotty calcification, low attenuation plaque, positive remodelling and the napkin ring sign. However, it can be challenging to characterise high-risk plaque accurately on CCTA, and as such, education and experience are required. In this pictorial essay, a comprehensive visual guide to high-risk plaque features on CCTA is provided, with clear examples and challenging cases that highlight common pitfalls. It is important for expert readers to properly identify these features given their association with adverse outcomes and potential future implications on intensive goal-directed medical therapy.","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary veno-occlusive disease: A systematic review of risk factors, clinical presentation, diagnostic investigations, treatment outcomes and prognostic factors. 肺静脉闭塞性疾病：危险因素、临床表现、诊断调查、治疗结果和预后因素的系统综述。

IF 2.2 4区医学

Journal of Medical Imaging and Radiation Oncology Pub Date : 2024-12-11 DOI: 10.1111/1754-9485.13814

Louisa P Thong, Benyamin Hakak-Zargar, Andrew T Burns, George N Harisis, Samantha J Ellis, Francis J Ha

{"title":"Pulmonary veno-occlusive disease: A systematic review of risk factors, clinical presentation, diagnostic investigations, treatment outcomes and prognostic factors.","authors":"Louisa P Thong, Benyamin Hakak-Zargar, Andrew T Burns, George N Harisis, Samantha J Ellis, Francis J Ha","doi":"10.1111/1754-9485.13814","DOIUrl":"https://doi.org/10.1111/1754-9485.13814","url":null,"abstract":"Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension. We aimed to systematically evaluate published cases of PVOD to provide an overview of their clinical presentation, management and prognosis to assist early identification and treatment. We conducted a literature search of PubMed and Embase databases for adult cases of 'pulmonary veno-occlusive disease' and 'pulmonary capillary haemangiomatosis'. Data collected included baseline demographics, medical history, clinical presentation, investigations performed, treatment and outcome. Kaplan-Meier survival analysis was used for overall survival with Cox-hazards-regression model used to evaluate treatment outcomes and prognostic factors. A total of 257 cases of PVOD from 113 articles were included in our analysis (mean age 45 ± 17 years, 54% females). Most frequent associations were smoking (28%), systemic sclerosis (10%) and mitomycin exposure (9%). Cardinal CT chest findings included ground glass opacities (75%), interlobular septal thickening (74%) and lymphadenopathy (51%); however, all three features were only seen in 23% (35/151). Median overall survival was 12 months (interquartile range, 3-48 months). Lung transplantation was the only treatment associated with improved survival (P = 0.006). Right ventricular dilatation (P = 0.005), increased mean pulmonary artery pressure (P = 0.01) and reduced 6-minute walk distance (P = 0.04) were associated with poorer overall survival. This systematic review provides a clinically relevant overview of a rare and often fatal condition. There is need for early diagnosis and referral for consideration of lung transplantation, while recognising right ventricular dilatation and elevated pulmonary pressures portend poorer prognosis. PROSPERO international register CRD42024553829.","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imperative for a health-centred focus on climate change in radiology. 放射学必须以健康为中心，关注气候变化。

IF 2.2 4区医学

Journal of Medical Imaging and Radiation Oncology Pub Date : 2024-12-11 DOI: 10.1111/1754-9485.13813

Omar Taboun, Chloe DesRoche, Kate Hanneman

引用次数: 0

A roadmap for modelling radiation-induced cardiac disease. 辐射诱发心脏病建模路线图。

IF 2.2 4区医学

Journal of Medical Imaging and Radiation Oncology Pub Date : 2024-12-01 Epub Date: 2024-07-10 DOI: 10.1111/1754-9485.13716

Samuel C Zhang, Andriana P Nikolova, Mitchell Kamrava, Raymond H Mak, Katelyn M Atkins

{"title":"A roadmap for modelling radiation-induced cardiac disease.","authors":"Samuel C Zhang, Andriana P Nikolova, Mitchell Kamrava, Raymond H Mak, Katelyn M Atkins","doi":"10.1111/1754-9485.13716","DOIUrl":"10.1111/1754-9485.13716","url":null,"abstract":"Cardiac risk mitigation is a major priority in improving outcomes for cancer survivors as advances in cancer screening and treatments continue to decrease cancer mortality. More than half of adult cancer patients will be treated with radiotherapy (RT); therefore it is crucial to develop a framework for how to assess and predict radiation-induced cardiac disease (RICD). Historically, RICD was modelled solely using whole heart metrics such as mean heart dose. However, data over the past decade has identified cardiac substructures which outperform whole heart metrics in predicting for significant cardiac events. Additionally, non-RT factors such as pre-existing cardiovascular risk factors and toxicity from other therapies contribute to risk of future cardiac events. In this review, we aim to discuss the current evidence and knowledge gaps in predicting RICD and provide a roadmap for the development of comprehensive models based on three interrelated components, (1) baseline CV risk assessment, (2) cardiac substructure radiation dosimetry linked with cardiac-specific outcomes and (3) novel biomarker development.","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":" ","pages":"950-961"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Getting to the heart of the matter. 切中要害。

IF 2.2 4区医学

Journal of Medical Imaging and Radiation Oncology Pub Date : 2024-12-01 Epub Date: 2024-08-29 DOI: 10.1111/1754-9485.13749

Shalini K Vinod

引用次数: 0

Cardiac substructure delineation in radiation therapy - A state-of-the-art review. 放射治疗中的心脏亚结构划分--最新进展回顾。

IF 2.2 4区医学

Journal of Medical Imaging and Radiation Oncology Pub Date : 2024-12-01 Epub Date: 2024-05-17 DOI: 10.1111/1754-9485.13668

Robert N Finnegan, Alexandra Quinn, Jeremy Booth, Gregg Belous, Nicholas Hardcastle, Maegan Stewart, Brooke Griffiths, Susan Carroll, David I Thwaites

{"title":"Cardiac substructure delineation in radiation therapy - A state-of-the-art review.","authors":"Robert N Finnegan, Alexandra Quinn, Jeremy Booth, Gregg Belous, Nicholas Hardcastle, Maegan Stewart, Brooke Griffiths, Susan Carroll, David I Thwaites","doi":"10.1111/1754-9485.13668","DOIUrl":"10.1111/1754-9485.13668","url":null,"abstract":"Delineation of cardiac substructures is crucial for a better understanding of radiation-related cardiotoxicities and to facilitate accurate and precise cardiac dose calculation for developing and applying risk models. This review examines recent advancements in cardiac substructure delineation in the radiation therapy (RT) context, aiming to provide a comprehensive overview of the current level of knowledge, challenges and future directions in this evolving field. Imaging used for RT planning presents challenges in reliably visualising cardiac anatomy. Although cardiac atlases and contouring guidelines aid in standardisation and reduction of variability, significant uncertainties remain in defining cardiac anatomy. Coupled with the inherent complexity of the heart, this necessitates auto-contouring for consistent large-scale data analysis and improved efficiency in prospective applications. Auto-contouring models, developed primarily for breast and lung cancer RT, have demonstrated performance comparable to manual contouring, marking a significant milestone in the evolution of cardiac delineation practices. Nevertheless, several key concerns require further investigation. There is an unmet need for expanding cardiac auto-contouring models to encompass a broader range of cancer sites. A shift in focus is needed from ensuring accuracy to enhancing the robustness and accessibility of auto-contouring models. Addressing these challenges is paramount for the integration of cardiac substructure delineation and associated risk models into routine clinical practice, thereby improving the safety of RT for future cancer patients.","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":" ","pages":"914-949"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IRSA ASM 2024 Abstract. 摘要。

IF 2.2 4区医学

Journal of Medical Imaging and Radiation Oncology Pub Date : 2024-12-01 Epub Date: 2024-12-19 DOI: 10.1111/1754-9485.13763

引用次数: 0

IRSA ASM 2024 Abstract. 摘要。

IF 2.2 4区医学

Journal of Medical Imaging and Radiation Oncology Pub Date : 2024-12-01 Epub Date: 2024-12-19 DOI: 10.1111/1754-9485.13764

引用次数: 0

Moving beyond mean heart dose: The importance of cardiac substructures in radiation therapy toxicity. 超越平均心脏剂量：心脏亚结构在放射治疗毒性中的重要性。

IF 2.2 4区医学

Journal of Medical Imaging and Radiation Oncology Pub Date : 2024-12-01 Epub Date: 2024-09-03 DOI: 10.1111/1754-9485.13737

Sarah Bowen Jones, Tom Marchant, Chris Saunderson, Alan McWilliam, Kathryn Banfill

{"title":"Moving beyond mean heart dose: The importance of cardiac substructures in radiation therapy toxicity.","authors":"Sarah Bowen Jones, Tom Marchant, Chris Saunderson, Alan McWilliam, Kathryn Banfill","doi":"10.1111/1754-9485.13737","DOIUrl":"10.1111/1754-9485.13737","url":null,"abstract":"Normal tissue tolerance dose limits to the heart have been established to reduce the risk of radiation-induced cardiac disease (RICD). Dose constraints have been developed based on either the mean dose delivered to the whole heart (MHD) or the dose delivered to a specific volume, for example, volume of heart receiving equal to or greater than 30 Gy (V30). There is increasing evidence that the impact of thoracic radiation on cardiac morbidity and mortality has been underestimated. Consequently, there is a need to reduce the dose delivered to the heart in radical radiotherapy treatment planning. The pathophysiology of RICD may relate to dose to specific cardiac substructures (CS) rather than the traditionally observed MHD for common toxicities. The MHD or V30 Gy threshold dose rarely represents the true dose delivered to individual CS. Studies have shown the dose to specific areas may be more strongly correlated with overall survival (OS). With advances in modern radiotherapy techniques, it is vital that we develop robust, evidence-based dose limits for CS, to fully understand and reduce the risk of RICD, particularly in high-risk populations with cardiac risk factors. The following review will summarise the existing evidence of dose limits to CS, explain how dose limits may vary according to different disease sites or radiation techniques and propose how radiotherapy plans can be optimised to reduce the dose to these CS in clinical practice.","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":" ","pages":"974-986"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0