Journal of King Saud University - Science最新文献

{"title":"Ameliorating Effect of Grape (Vitis vinifera L.) Seed and Peel Extracts with Selenium on Ochratoxin-A Exposed Renal Dysfunction in Male Wistar Rats","authors":"Mohamed Farouk Elsadek ,&nbsp;Tse-Wei Chen ,&nbsp;Khalid S. Al-Numair ,&nbsp;Tasneem Sobhy Fahmy","doi":"10.1016/j.jksus.2024.103453","DOIUrl":"10.1016/j.jksus.2024.103453","url":null,"abstract":"<div><h3>Background and Aim</h3><div>Drug-induced nephrotoxicity is extensively documented as the initial stage of kidney disease that particularly results in acute renal injury and chronic renal dysfunction. The single and combined effect of grape peel extract (GPE), grape seed extracts (GSE) and selenium (Sel) were investigated in current study for controlling of renal injury induced by Ochratoxin-A (OTA) in male rats<strong>.</strong></div></div><div><h3>Methods</h3><div>Forty nine male Wistar rats weighing 200 ± 10 g were injected with OTA (0.5 mg/kg bw) to induce nephrotoxicity, then treated with singleand combined applications of GSE, GPE and Sel. In addition, the OTA induced nephrotoxicity rats were screened for various biological and physiological parameters like food ingestion, body weight gain, liver weight, serum kidney biomarkers, serum lipid fractions, enzymatic and non-enzymatic lipid peroxidation indicators and histopathological studies.</div></div><div><h3>Results</h3><div>Our findings suggested that the combination of GSE 2 % and Sel (50–50) treatment reduced renal dysfunction in OTA-induced rats by significantly lowering lipid peroxidation indicators, lipid and kidneys profiles and enhancing enzymatic and non-enzymatic antioxidants biomarkers followed by GSE 2 % then Selenium (0.4 mg/kg) in OTA. Histological analysis of the kidney revealed more severe renal tubule degeneration in OTA-induced rats, While GSE and GPE combonation showed only moderate glomerular tuft enlargement and minimal renal tubule deterioration. Furthermore, the combination of GSE 2 %+Sel (50–50) revealed normal histological structure.</div></div><div><h3>Conclusions</h3><div>Grape seed extracts along with selenium mightbe used as dietary supplements to reduce renal toxicity induced by chemicals or compounds that cause nephrotoxicity.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 10","pages":"Article 103453"},"PeriodicalIF":3.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green technology based agricultural product quality and market prices in China","authors":"Zhi Liu","doi":"10.1016/j.jksus.2024.103451","DOIUrl":"10.1016/j.jksus.2024.103451","url":null,"abstract":"<div><div>Agriculture is a substantial contribution to world economies, and its environmental influence cannot be overstated. As a result, agricultural production has changed over time to incorporate more environmentally friendly practices, such as the usage of green technologies. The purpose of this study is to investigate the impact of agri and green technology adoption on agricultural product market prices, with an emphasis on product quality and environmental consciousness. Surveys were used to collect data from 750 agricultural producers and consumers, and statistical analysis was performed to determine the relationship between technology adoption, product quality, environmental consciousness, and market prices. The data show that there is a considerable positive association between green technology adoption and product quality, which has a favorable impact on market prices. Likewise, the impact of agricultural technology adoption on product quality and market pricing was statistically significant. The study also discovered that consumer environmental knowledge has a considerable positive effect on market prices. These findings show that more investment in green technology adoption is required to improve product quality and meet the growing demand for ecologically friendly agricultural products. Likewise, efforts to raise consumer environmental awareness may help drive market prices higher and incentivize producers to adopt more sustainable farming practices. This study emphasizes the necessity of sustainable agriculture practices and the need to promote the adoption of green technologies in order to ensure the agricultural industry’s long-term sustainability.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 10","pages":"Article 103451"},"PeriodicalIF":3.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the influence of saline-alkaline stress on germination and seedling growth traits of Arta (Calligonum comosum L. Herit) as influenced by saline-alkaline stresses","authors":"Amnah S. Alshahwan ,&nbsp;Mohammed N. Alyemeni ,&nbsp;Mona S. Alwahibi ,&nbsp;Nadi Awad Al-Harbi ,&nbsp;Salem Mesfir Al-Qahtani ,&nbsp;Abdullah Alaklabi","doi":"10.1016/j.jksus.2024.103444","DOIUrl":"10.1016/j.jksus.2024.103444","url":null,"abstract":"<div><div>This research was conducted to study the effects of saline stress (9:1 M ratio of NaCl: Na₂SO₄, pH 6.27–6.49), alkaline stress (9:1 M ratio of NaHCO₃: Na₂CO₃, pH 9.11–9.25) and saline/alkaline combined stress (NaCl: Na₂SO₄:NaHCO₃: Na₂CO₃ 9:1:9:1, pH 8.94–9.17) using concentrations 25, 50, 75 and 100 mmol/L on seed germination and seedling growth traits of <em>Calligonum comosum</em> L’Her. The experiments were carried out in the laboratories of the Botany and Microbiology Department in the female university dormitory of the Science College, King Saud University. The results of seed germination included the percentage of seed germination, the lengths of both radicle and plumule, and both fresh and dry weights of the seedlings after 14 days of growth under stress treatments. Germination results indicated a significant gradual decrease in seed germination rates with an increase in the concentration of stress treatments, and seed germination was inhibited at concentrations higher than 100 mmol/L in all stress treatments. Also, there was a differential decrease in the parameters of seedling growth represented by the radicle and plumule lengths and both fresh and dry seedling weights with the increase in the concentrations and the greatest effect was the alkaline stress.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 10","pages":"Article 103444"},"PeriodicalIF":3.7,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of anticoagulant potential of Halocnemum strobilaceum (Pall.) against black rat (Rattus rattus Lin.) from Algeria","authors":"Randa Mlik ,&nbsp;Salim Meddour ,&nbsp;Nour Elhouda Mekhadmi ,&nbsp;Abdellah Henni ,&nbsp;Walid Boussebaa ,&nbsp;Asma Abid ,&nbsp;Amar Eddoud ,&nbsp;Makhlouf Sekour","doi":"10.1016/j.jksus.2024.103449","DOIUrl":"10.1016/j.jksus.2024.103449","url":null,"abstract":"<div><h3>Background</h3><p>Black rats (<em>Rattus rattus;</em> Rodentia: Muridae) cause significant damage to agricultural and human health, and they are considered a reservoir for a variety of diseases.</p></div><div><h3>Objectives</h3><p>The current study aimed to evaluate the toxicity of oral anticoagulants derived from <em>Halocnemum strobilaceum</em> (Pall.) M. Bieb. to these dangerous animals.</p></div><div><h3>Method</h3><p>Four selected doses (100, 150, 200 and 300 mg/day/kg of individual weight) and one control were utilized, with 10 repetitions of each dose (5 ♂ and 5 ♀). The extract was powdered on dates as bait.</p></div><div><h3>Results</h3><p>UPLC-ESI/MS-MS chromatography identified three distinct coumarins (coumaric acid, <em>p</em>-coumaric acid and 4-hydroxycoumarin). The results showed that the fourth dose used caused the highest number of deaths (100 % after three days of treatment). In contrast, after 48 h of therapy, all rats examined showed lethargy, anorexia and unconsciousness, followed by rapid death at 72 h in the treated individuals. The LD₅₀ was recorded at 146.4 mg.kg⁻¹ with a LT₅₀ of 59.37 h. At the end of the experiment, the autopsies of all deceased individuals allowed us to observe the bleeding of their internal organs. The analysis of PT and aPTT demonstrated that the halophyte under investigation possesses anticoagulant activity that increased with the concentration. Histological sections of the liver revealed cellular alteration and significant necrosis. As well, the kidneys had vascular occlusion with an inflammatory filtrate.</p></div><div><h3>Conclusions</h3><p>To reduce food losses and wastes caused by these pests, <em>H. strobilaceum</em> will be an important plant for use in protecting against invasive rodents, especially in environmental and stored product programs focused at eradicating rodent pests.</p></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 10","pages":"Article 103449"},"PeriodicalIF":3.7,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1018364724003616/pdfft?md5=30a9a1b82513bced1dba307c69385846&pid=1-s2.0-S1018364724003616-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trapezoidal breakwater on reducing resonant wave amplitude on a rectangular basin","authors":"Ikha Magdalena ,&nbsp;Yovan Aurelius Darmawan Phang ,&nbsp;Hany Qoshirotur Rif’atin ,&nbsp;Cherdvong Saengsupavanich ,&nbsp;Sarinya Sanitwong-Na-Ayutthaya","doi":"10.1016/j.jksus.2024.103425","DOIUrl":"10.1016/j.jksus.2024.103425","url":null,"abstract":"<div><div>In this study, we delve into the effectiveness of trapezoidal breakwaters in mitigating resonance phenomena. The challenge at hand is to identify the optimal configuration capable of halting resonance. Employing Shallow Water Equations with a friction term to encapsulate the breakwater’s roughness, we analytically solve the model to determine the natural wave period. This period serves as the instigator of an unstoppable harmonic oscillation. Numerically, we use the Finite Volume Method on a Staggered Grid to simulate the model for several cases to pinpoint the infimum value of the natural wave period required to impede resonance phenomena. This research holds significance for those involved in coastal protection design, particularly in the context of trapezoidal breakwaters. The findings contribute to the effective reduction, rather than amplification, of wave height, thereby enhancing the reliability of such coastal protection structures.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 10","pages":"Article 103425"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermodynamic and buoyancy force effects of Cu and TiO2 nanoparticles in engine oil flow over an inclined permeable surface","authors":"Raghunath Kodi ,&nbsp;Ramachandra Reddy Vaddemani ,&nbsp;Haribabu Kommaddi ,&nbsp;Samad Noeiaghdam ,&nbsp;Unai Fernandez-Gamiz","doi":"10.1016/j.jksus.2024.103434","DOIUrl":"10.1016/j.jksus.2024.103434","url":null,"abstract":"<div><p>This study investigates the heat and mass transmission behavior in an unsteady magnetohydrodynamic (MHD) movement of nanofluids over an inclined permeable surface, with applications in enhancing thermal management systems such as automotive cooling and industrial heat exchangers. The model specifically examines the consequence of thermal diffusion (Soret effect) and buoyant forces on Cu and TiO2 nanoparticles dispersed in engine oil. The governing equations, comprising velocity, energy, and concentration equations, are recast into nonlinear ODEs manipulating similitude adaptations. These ODEs are then solved through a standard perturbation method under appropriate boundary conditions. The key findings indicate that enhancing thermal radiation diminishes the velocity and temperature profiles, while raising chemical reaction rates decrease concentration levels. Additionally, higher Soret parameter values are associated with increased velocity and concentration. Quantitatively, TiO2-engine oil nanofluids exhibit a 15% higher velocity compared to Cu-engine oil nanofluids, highlighting the superior performance of TiO2 in dynamic thermal systems. Furthermore, numerical outcomes for the local skin contention, Nusselt numeral, and Sherwood digit are tabulated to illustrate the consequence of material properties. The outcomes of this study are particularly beneficial in optimizing the design of heat exchangers, improving fuel efficiency in automotive engines, and enhancing industrial processes where precise thermal control is critical.</p></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 10","pages":"Article 103434"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S101836472400346X/pdfft?md5=0277e8ba617e4cb14c8d980b8d9496b7&pid=1-s2.0-S101836472400346X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Correlation between platelet metrics and cardiovascular risk in prediabetes with coronary artery disease: A two-year cross-sectional study” [J. King Saud Univ.-Sci. 36(8) (2024) 103337]","authors":"Sunil Kumar ,&nbsp;Harshitha Reddy ,&nbsp;Sourya Acharya ,&nbsp;Avinash Parepalli ,&nbsp;Dhruv Tawar ,&nbsp;Samyank Jain kumar ,&nbsp;Meraj Khan ,&nbsp;Mohammad Athar ,&nbsp;Esam Ibraheem Azhar ,&nbsp;Sayed Sartaj Sohrab","doi":"10.1016/j.jksus.2024.103429","DOIUrl":"10.1016/j.jksus.2024.103429","url":null,"abstract":"","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 10","pages":"Article 103429"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1018364724003410/pdfft?md5=d63cb3ab94946722422328b138c18367&pid=1-s2.0-S1018364724003410-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salt stress effects on growth, physiology, and ionic concentrations in hydroponically grown barley genotypes","authors":"Qurat-Ul-Ain Sadiq ,&nbsp;Muhammad Nazim ,&nbsp;Tanveer ul haq ,&nbsp;Mehak Fatima ,&nbsp;Abida Hussain ,&nbsp;Muqarrab Ali ,&nbsp;Bhupendra Mathpal ,&nbsp;Mona S. Alwahibi","doi":"10.1016/j.jksus.2024.103448","DOIUrl":"10.1016/j.jksus.2024.103448","url":null,"abstract":"<div><p>Soil salinity is a major abiotic stress that severely affects crop production in different regions of the globe. Barley is an essential cereal crop and there is a significant genetic variation among barley varieties for tolerance towards salt stress. Understanding of salinity tolerance mechanisms assists in developing salt tolerant barley varieties in a hydroponics experiment. There were twelve barley varieties and two NaCl stress levels (Control, 100 and 200 mM) in this study. The nursery of barley was seeded in sand and at two-leaf stage; plants were transplanted into hydroponic tubs. The plants were grown under salt stress for 65 days and data regarding several morpho-physiological parameters were collected. The statistical analysis of the collected data was implemented by using completely randomized design (CRD) with factorial arrangement. Exposure to NaCl stress significantly reduced shoot and root growth and relative leaf water contents (RLWC), while increasing Na⁺ concentration, with B-9006 showing the highest root dry weight (0.39 g) and YSM1 recorded the lowest root dry weight (0.10 g) under 100 mM NaCl. The maximum (232 ppm) Na⁺ concentration in leaf sap was observed in variety B-15011 (70 % from control) and minimum was observed in B-15018. Maximum K⁺ mM concentration in leaf sap was found as 72 % in Aia-03 and minimum was observed as 50 % in B-15035. At stress level of 200 mM, highest shoot dry weight (2.52 g) was observed in ZP2 (73 % decreased from control) while minimum shoot dry weight (0.19 g) (96 % decrease from control) was recorded in Franklin genotype. Maximum root dry weight (0.24 g) was observed in B-9006 genotype while minimum root dry weight (0.04 g) was recorded in Gairdner. Maximum K⁺/Na⁺ ratio (1.20) was recorded in B-15018 and minimum (0.14) was seen in B-15035. Therefore, based on our results, barley genotypes can be classified into salt-tolerant (B-9006, B-15018, Yerong, Aia-03), salt-sensitive (Gairdner, Franklin, B-15035, B-05011), and moderately tolerant groups at both 100 and 200 mM NaCl levels.</p></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 10","pages":"Article 103448"},"PeriodicalIF":3.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1018364724003604/pdfft?md5=7d71e40f0b219b94b6c8e49fca2f1795&pid=1-s2.0-S1018364724003604-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the impact of phyto-hormones on the morpho-biochemical traits of soybean through seed treatment and foliar application","authors":"Muhammad Shehzad ,&nbsp;Muhammad Sajid Munir ,&nbsp;Muhammad Nazim ,&nbsp;Majid Mahmood Tahir ,&nbsp;Mehdi Maqbool ,&nbsp;Muhammad Amjad Nawaz ,&nbsp;Hafiz Muhammad Rashad Javeed ,&nbsp;Abdullah Ahmed Al-Ghamdi","doi":"10.1016/j.jksus.2024.103446","DOIUrl":"10.1016/j.jksus.2024.103446","url":null,"abstract":"<div><p>Global climate variations, mainly extreme temperatures reduce crop production and contributed to global food insecurity. Plant growth regulators (PGRs) improve physiological efficiency, photosynthetic capacity, and assimilate partitioning in field crops. However, their influence on soybean (Glycine max L.) yield and seed quality is under-researched. This study investigates the synergistic effects of auxin (2,4-D) and gibberellin (GA₃) at 60 and 90 mg L⁻¹ concentrations. This study investigates the impact of phytohormones, specifically gibberellic acid (GA3) and 2,4-dichlorophenoxyacetic acid (2,4-D), on the morphological and biochemical traits of soybean (<em>Glycine</em> max L.) through seed treatment and foliar application. These Growth regulators were applied through seed treatment at the time of sowing and foliar application at the time of flowering initiation stage. The experiment was designed using a RCBD arrangement and each block replicated thrice time. Seed treatment with 2,4-D at 90 mg/L showed that maximum plant height (116.80 cm), first node height (8.04 cm), No. of branches per plant (18.67), root length (18.12 cm) stem diameter (0.05 cm), no. of pods per plant (32.60), seed yield (1532.30 kg ha⁻¹), biological yield (4109.30 ha⁻¹), and harvest index (39.36 %). The GA₃ (seed treatment) at conc. of 90 and 60 mg L⁻¹ resulted in a significantly increased no. of nodule fresh weight, nodules per plant, and dry weight respectively. But the no. of seeds per pod did not showed significant results throughout the study. However, the foliar applied of 2,4-D at 90 mg L⁻¹ resulted in significantly increased leaf area index (LAI) compared to the seed treatment. PGRs had a significant influence on quality traits. Thus, the application notably improved the potential of soybean and successful oilseed crop. Therefore, it is showed that using PGRs are extremely helpful for attaining higher growth, yield production, and improved quality of soybean.</p></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 10","pages":"Article 103446"},"PeriodicalIF":3.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1018364724003586/pdfft?md5=e2a6940d653afeb597524dd3a121e72b&pid=1-s2.0-S1018364724003586-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial activities of organic solvent extracts of four seaweeds from Oman","authors":"Abdullah Al-Nassri ,&nbsp;Ahmed Al-Alawi ,&nbsp;Salma Al-Adwani","doi":"10.1016/j.jksus.2024.103431","DOIUrl":"10.1016/j.jksus.2024.103431","url":null,"abstract":"<div><p>Seaweeds are valuable sources of bioactive compounds in biomedicine, cosmetics, food, and pharmacology. The purpose of this investigation was to study the antimicrobial properties of organic solvent extracts from two red seaweed species (<em>Melanothamnus somalensis &amp; Gelidium omanense</em>), and two brown seaweed species (<em>Jolyna furcata &amp; Nizamuddinia zanardinii</em>) compiled from the southern coastline of Oman against several bacterial strains of global health concern <em>(Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa)</em> and one fungal strain <em>(Candida albicans).</em> Five organic solvents were used sequentially to achieve extraction. The solvents were applied in the following order: hexane, dichloromethane, ethyl acetate, acetone, and methanol. Only the methanol extract of <em>Nizamuddinia zanardinii</em> (MeNZ) showed interesting antimicrobial activity; the inhibition zone was 13 ± 1 mm. Furthermore, MeNZ was fractionated, and fraction 1 (MeNZ-F1) was recognized to have antimicrobial activity; the inhibition zone was 14.66 ± 0.57 mm. The stock concentration exhibited higher antimicrobial activity compared to the diluted concentrations after 3 h of incubation. The TEM and SEM results indicated that <em>E. coli</em> treated with the active fraction exhibited irregular shape, rough surface, and leakage of cellular content. Additionally, ribosomes were clustered and directed toward the inner membrane of the bacteria, while the DNA clustered in the center of the cell. In conclusion, the methanol extract of <em>Nizamuddinia zanardinii</em> has shown high efficacy against pathogenic bacteria and fungi. Therefore, it can be a valuable candidate for improving/developing antimicrobial drugs in the pharmaceutical and food industries.</p></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 10","pages":"Article 103431"},"PeriodicalIF":3.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1018364724003434/pdfft?md5=3ddb9a53ba341f45794cf736b988dc17&pid=1-s2.0-S1018364724003434-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}