Journal of King Saud University - Science最新文献

{"title":"New best proximity point results on orthogonal F-proximal contractions with applications","authors":"Gunaseelan Mani ,&nbsp;Raman Thandavarayan Tirukalathi ,&nbsp;Sabri T.M. Thabet ,&nbsp;Miguel Vivas-Cortez","doi":"10.1016/j.jksus.2024.103562","DOIUrl":"10.1016/j.jksus.2024.103562","url":null,"abstract":"<div><div>In this work, we propose the ideas of orthogonal <span><math><mi>F</mi></math></span>-proximal contraction mappings, generalized orthogonal <span><math><mi>F</mi></math></span>-proximal contraction mappings and establish several best proximity point theorems in an orthogonally complete metric space (<span><math><mi>OCMS</mi></math></span>) through a non-self mapping. Hence, utilizing these recently discovered results, numerous of the existing findings in the literature are generalized or expanded. An illustration is provided to highlight the utility of our findings. Finally, for illustrative applications, we discuss the qualitative properties of the solutions for a fractional boundary value problem in the Caputo sense, and we study the dynamic economic equilibrium problem.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103562"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent role in molecular structure level (TD-DFT), topology, and molecular docking studies on liquid 2′, 4′-dichloroacetophenone","authors":"S. Mallika ,&nbsp;B. Revathi ,&nbsp;V. Balachandran ,&nbsp;Natarajan Elangovan ,&nbsp;Ling Shing Wong ,&nbsp;Saminathan Kayarohanam ,&nbsp;Natarajan Arumugam ,&nbsp;Sinouvassane Djearamane","doi":"10.1016/j.jksus.2024.103574","DOIUrl":"10.1016/j.jksus.2024.103574","url":null,"abstract":"<div><div>The study investigated the structure, spectroscopy, and chemical reactivity of 2′,4′-dichloroacetophenone using DFT and Hartree-Fock (HF) methods. The B3LYP and LC DFT (CAM-B3LYP) methods were applied to a 6–311++G (d, p) basis set combination. The bond angles and bond lengths are appraised in depth to understand the geometrical framework. The FT-IR and FT-Raman spectra of the respective compound<!--> <!-->were analyzed within the regions of 4000–400 cm⁻¹ respectively. The experimental spectra were compared and discussed in connection with the theoretical spectrum. The VEDA program was implemented to accomplish the vibrational assignments of all the fundamentals highlighted using the PED analysis. TD-DFT level was used to explore the essential electronic properties of LUMO and HOMO energies. To forecast reactive sites, the MEP surface was examined. NBO was computed according to the compound’s reactivity and biological requirements. The Multi-Wave Function Analyzer 3.6 was designed to examine and compare topological inquiries, specifically focusing on the LOL and ELF. The detailed investigation specifies the drug likeness and molecular docking that assisted in the prediction of the physicochemical, pharmacokinetic, and biological availability of 2′,4′-dichloroacetophenone.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103574"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic insights into skin cancer: A bioinformatics and network biology approach to biomarker identification","authors":"Majji Rambabu ,&nbsp;M. Navanneth Gowda ,&nbsp;Prasanna Kumar Selvam ,&nbsp;Karthick Vasudevan ,&nbsp;K.R. Dasegowda ,&nbsp;Parameswaran Saravanan ,&nbsp;Karunakaran Rohini","doi":"10.1016/j.jksus.2024.103510","DOIUrl":"10.1016/j.jksus.2024.103510","url":null,"abstract":"<div><div>Skin cancer is a widespread malignancy that primarily affects light-skinned populations globally, categorized into melanoma and non-melanoma skin cancers (NMSCs). Basal cell carcinoma and squamous cell carcinoma are the most common subtypes within NMSCs, with the global incidence of NMSCs projected to reach 2–3 million cases annually across regions like Europe, Canada, the USA, and Australia. Despite this prevalence, the genetic mechanisms behind skin cancer remain poorly understood. This study presents a novel gene discovery approach, leveraging transcriptome data from Next-Generation Sequencing datasets sourced from the European Nucleotide Archive to uncover new genes and pathways linked to skin cancer. The novelty of this research lies in its comprehensive approach that combines differential gene expression analysis with gene network and pathway enrichment analysis to identify actionable therapeutic targets. By utilizing bioinformatics tools such as DESeq2, Gene Set Enrichment Analysis (GSEA), and Cytoscape, we revealed critical gene interactions and pathways that have been underexplored in the context of skin cancer. Following rigorous quality control using FastQC and transcriptome-seq data alignment to the human genome (hg38), we identified 19 differentially expressed genes, including 2 down-regulated and 17 up-regulated. Key genes such as <em>IL6, CCND2, PLAUR,</em> and <em>CD44</em> were found to be involved in important pathways like IL6_JAK_STAT3_SIGNALING, ANGIOGENESIS, and APICAL_SURFACE. These findings provide valuable insights into skin cancer pathogenesis and offer potential therapeutic targets, laying the groundwork for future research aimed at improving treatment outcomes.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103510"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on: Effects on magnetic field in squeezing flow of a Casson fluid between parallel plates","authors":"Joshua Liam Lam,&nbsp;Christopher C. Tisdell","doi":"10.1016/j.jksus.2024.103561","DOIUrl":"10.1016/j.jksus.2024.103561","url":null,"abstract":"<div><div>Ahmed et al. (2017) examined the dynamics of a Casson fluid squeezed between two parallel plates where the fluid was also subjected to a constant magnetic field. Therein they claimed to derive a fourth-order boundary value problem from the general governing equations whose solution could be used to form the fluid’s velocity components. The purpose of the present note is to place the ideas in Ahmed et al. (2017) under scrutiny. In doing so we raise some doubts regarding some of the forms therein.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103561"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemicals of Withania coagulans (Stocks) Dunal against androgen receptor: An in silico insight","authors":"Ram Lal Swagat Shrestha ,&nbsp;Jhashanath Adhikari Subin","doi":"10.1016/j.jksus.2024.103558","DOIUrl":"10.1016/j.jksus.2024.103558","url":null,"abstract":"<div><h3>Objectives</h3><div>The androgen receptor is considered a magic target due to its involvement in multiple pathways leading to several maladies and its accessibility for small molecules to bind to it and modulate its normal functioning. The phytochemicals from the plant, Withania coagulans (Stocks) Dunal (common name: Rishyagandha) with traditional practice in healing different diseases were investigated in this regard. The higher safety profile and cost-effective features of plant-based resources in the design and development of drug like candidates seems to be worthy of exploration in the realm of alternate therapeutic options.</div></div><div><h3>Methods</h3><div>Several computational methods involving flexible receptor molecular docking calculations and molecular dynamics simulations were carried out. Spatially and thermodynamically stable adducts with best docking scores were identified using various parameters extracted from the molecular dynamics trajectory to find the hit candidates capable of inhibiting or disrupting the normal functioning of the target protein leading to the cure of the disease. The server based ADMET prediction was performed to comprehend the druglikeness, bioavailability, and toxicity profile of different phytochemicals.</div></div><div><h3>Results</h3><div>The molecule, 24-Methyl-9,19-cyclolanost-25-en-3-ol (PubChem CID: 185036) showed the binding score of −10.726 kcal/mol against androgen receptor (PDB ID: 1E3G) better than that of the native ligand, 17-β-hydroxy-17-methylestra-4,9,11-trien-3-one (PubChem CID: 261000) with −10.268 kcal/mol and selected anticancer drugs (best value of -10.080 kcal/mol for darolutamide). Withacoagulin I (PubChem CID: 71720665) displayed the binding score of −10.108 kcal/mol and was considered the second top molecule. The stability of the protein-phytochemical adducts as calculated from 200 ns long molecular dynamics simulations revealed good geometrical intactness from multiple spatial descriptors (root mean square deviation, radial pair distribution function, and hydrogen bond distribution) and sustained thermodynamical spontaneity from binding free energy changes of the protein-ligand complexes. The pharmacokinetics and pharmacodynamics showed acceptable druglike properties, good bioavailability and safety comparable with that of the reference drugs.</div></div><div><h3>Conclusions</h3><div>The hit molecules could be considered as possibly capable of inhibiting the target protein that would perform as anticancer agents and are recommended for further experimental trials for the verification of theoretical inferences.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103558"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A parametrized approach to generalized fractional integral inequalities: Hermite–Hadamard and Maclaurin variants","authors":"Abdelghani Lakhdari ,&nbsp;Bandar Bin-Mohsin ,&nbsp;Fahd Jarad ,&nbsp;Hongyan Xu ,&nbsp;Badreddine Meftah","doi":"10.1016/j.jksus.2024.103523","DOIUrl":"10.1016/j.jksus.2024.103523","url":null,"abstract":"<div><div>This paper introduces a novel parametrized integral identity that forms the basis for deriving a comprehensive class of generalized fractional integral inequalities. Building on recent advancements in fractional calculus, particularly in conformable fractional integrals, our approach offers a unified framework for various known inequalities. The novelty of this work lies in its ability to generate new and more general inequalities, including Hermite–Hadamard-, Maclaurin-, and corrected Maclaurin-type inequalities, by selecting specific parameter values. These results extend the scope of fractional integral inequalities and provide new insights into their structure. To demonstrate the practical applicability and accuracy of the theoretical findings, we present a detailed numerical example along with graphical representations.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103523"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulatory effects of glutamic acid on growth, photosynthetic pigments, and stress responses in olive plants subjected to cadmium stress","authors":"Muhammad Hamzah Saleem ,&nbsp;Sadia Zafar ,&nbsp;Sadia Javed ,&nbsp;Muhammad Anas ,&nbsp;Temoor Ahmed ,&nbsp;Shafaqat Ali ,&nbsp;Iman Mirmazloum ,&nbsp;Ajaz Ahmad","doi":"10.1016/j.jksus.2024.103540","DOIUrl":"10.1016/j.jksus.2024.103540","url":null,"abstract":"<div><div>Cadmium (Cd) is a toxic heavy metal that severely impacts plant growth and photosynthesis and induces oxidative stress. This study investigates the modulatory effects of glutamic acid (GA) on <em>Olea europaea</em> (olive) seedlings subjected to cadmium stress. The experiment included control, Cd-stressed, GA-treated, and combined Cd and GA-treated groups. Cd exposure significantly reduced plant growth, as evidenced by decreased root length (3.5 cm) and shoot length (9 cm) compared to control plants (5 cm and 12 cm, respectively). Additionally, Cd stress led to a reduction in chlorophyll content (16.2 mg/g fresh weight) and elevated oxidative markers like H₂O₂ and MDA. The application of GA significantly improved plant growth and physiological parameters, with statistically significant increases in root length (up to 6.5 cm) and shoot length (up to 14 cm) in the combined treatment group (<em>p</em> ≤ 0.05). Furthermore, GA treatment led to a marked elevation in total chlorophyll content (up to 27.5 mg/g fresh weight), compared to 16.2 mg/g in Cd-stressed plants (p ≤ 0.05), reflecting a significant improvement in photosynthetic efficiency. GA also elevated the antioxidant enzyme activity catalase (CAT) and peroxidase (POD), reducing oxidative stress by decreasing hydrogen peroxide and MDA levels. The findings suggest that glutamic acid effectively mitigates Cd-induced phytotoxicity, enhancing stress resistance and promoting plant growth. This research provides valuable insights into using glutamic acid as a possible approach to mitigate heavy metal stress in plants, offering implications for agriculture and environmental management in Cd-contaminated areas. Specific applications may include its use in phytoremediation practices or as a supplement in agricultural management to improve crop resilience in polluted environments. Further research could explore the molecular mechanisms underlying GA’s protective effects and its potential synergy with other biostimulants to enhance heavy metal tolerance in a broader range of crops.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103540"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seed inoculation with Rhizobium japonium bacteria improved fatty acid composition of different soybean (Glycine max L.) genotypes","authors":"Aynur Bilmez Özçınar","doi":"10.1016/j.jksus.2024.103492","DOIUrl":"10.1016/j.jksus.2024.103492","url":null,"abstract":"<div><h3>Background</h3><div>Soybean is an important crop for food security as it fulfills global oil requirements. Seed inoculation with bacteria is frequently used to increase its production; however, it could change the seed composition. Nevertheless, the genotypes respond differently to the bacteria. Therefore, it is necessary to assess the impact of <em>Rhizobium</em> bacteria on the seed composition.</div></div><div><h3>Methods</h3><div>This two-year (2018 and 2019) study investigated the effects of seed inoculation with <em>Rhizobium japonicum</em> on fatty acid composition of different soybean genotypes. Three frequently cultivated soybean genotypes, i.e., ‘Gapsoy16′, ‘Traksoy’, and ‘İlksoy’ were included in the study. The seeds were either inoculated with <em>R. japonicum</em> or sown without inoculation. The fatty acid profile, i.e., saturated fatty acids (palmitic and stearic acid) and unsaturated fatty acids (oleic, linoleic, linolenic, and arachidic acids) was determined, and the collected data were analyzed by single and multivariate analysis.</div></div><div><h3>Results</h3><div>Seed inoculation with <em>R. japonicum</em> significantly altered the fatty acid composition of different genotypes; however, varied effects were recorded for the genotype. Linoleic acid, oleic acid, and palmitic acid made up ∼ 33 % of total fatty acids in seeds. Linoleic acid contents varied between 30.78–34.02 %, whereas oleic acid contents ranged between 27.85–31.04 %. Similarly, palmitic acid contents differed between 15.53–16.93 %. The ‘İlksoy’ and ‘Gapsoy’ had the highest contents of palmitic and oleic acids, respectively. Overall, inoculation of bacteria increased the composition of unsaturated fatty acids and lowered saturated fatty acids.</div></div><div><h3>Conclusion</h3><div>Seed inoculation with <em>R. japonicum</em> increased the essential fatty acid composition in ‘Traksoy’ genotype. However, ‘İlksoy’ genotype recorded a decrease in unsaturated fatty acids. Therefore, ‘Traksoy’ can be inoculated with <em>R. japonicum</em> to improve fatty acid profile.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103492"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142551956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of TRAF1 gene polymorphisms in susceptibility to Acute Lymphoblastic Leukemia in Saudi patients","authors":"Fadwa M. Alkhulaifi ,&nbsp;Jamilah Alshammari ,&nbsp;Hussah M. Alobaid ,&nbsp;Fatimah Basil Al-Mukaynizi ,&nbsp;Safa A. Alqarzae ,&nbsp;Suliman Alomar","doi":"10.1016/j.jksus.2024.103582","DOIUrl":"10.1016/j.jksus.2024.103582","url":null,"abstract":"<div><div>Acute Lymphoblastic Leukemia (ALL) is a genetic malignancy characterized by the uncontrolled proliferation of hematopoietic precursor cells and evasion of immune surveillance. This study investigates the association between TRAF1 gene polymorphisms and the risk of developing ALL. Understanding the role of single nucleotide polymorphisms (SNPs) in the TRAF1 gene, which has been previously implicated in various immune-related disorders, may provide valuable insights into the molecular mechanisms of ALL and help identify potential therapeutic targets. A total of 265 subjects were recruited for this study, comprising 150 ALL patients and 115 healthy controls. Genotyping was performed using TaqMan PCR, focusing on four TRAF1 SNPs: rs2239657G/A, rs2416804G/C, rs7021049G/T, and rs3761847G/A. The minor allele frequencies and genotype distributions were compared between groups, with relative risks and statistical differences evaluated. Additionally, TRAF1 mRNA expression levels were assessed in both ALL patients and healthy individuals using qRT-PCR. The results demonstrated a significant association between the TRAF1 rs2239657G/A polymorphism and an increased risk of ALL, while the rs2416804G/C polymorphism was associated with a significantly reduced risk. Notably, TRAF1 was overexpressed in ALL patients, indicating its potential role in the pathogenesis of ALL. This overexpression suggests that TRAF1 may contribute to the interaction between inflammation and oncogenesis, providing new insights into the disease’s progression and highlighting TRAF1 as a possible biomarker for therapeutic intervention.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103582"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing early detection of autistic spectrum disorder in children using machine learning approaches","authors":"Rashid Ayub ,&nbsp;Syed Immamul Ansarullah ,&nbsp;Faizan Samdani ,&nbsp;Ali Akhtar ,&nbsp;Mohd Afzal ,&nbsp;Shaik Moinuddin Ahmed","doi":"10.1016/j.jksus.2024.103468","DOIUrl":"10.1016/j.jksus.2024.103468","url":null,"abstract":"<div><div>Diagnosing Autism Spectrum Disorder (ASD) presents a multifaceted challenge, demanding accurate and efficient screening methods. Applying machine learning techniques offers a promising avenue for enhancing diagnostic accuracy and efficiency. This research investigates the efficiency of machine learning in distinguishing individuals with ASD from those without, utilizing a comprehensive dataset comprising screening questions, demographic factors, and ASD related diagnostic classifications. We applied chi-square feature selection technique and also tested Random Forest, Logistic Regression, Gradient Boosting Classifier, and Extra Trees Classifier. Each model showed optimal performance and exhibit high precision, recall, and F1-score for both ASD-positive and ASD-negative instances. Additionally, AUROC curves further validated the models’ exceptional discriminatory abilities, with exceptional results. Our findings highlight the potential of machine learning algorithms for enhancing ASD diagnosis accuracy and efficiency in clinical settings. Further research and validation on larger datasets are required to understand the importance of machine learning methods in ASD diagnosis.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 10","pages":"Article 103468"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}