Novel drug delivery to the brain for neurodegenerative disorder treatment using carbon nanotubes

IF 3.7 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of King Saud University - Science Pub Date : 2024-11-01 DOI:10.1016/j.jksus.2024.103513

Mohammed Al-zharani , Md Saquib Hasnain , Mohammed S. Al-Eissa , Reem A. Alqahtani

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Abstract

Neurodegenerative disorders pose a significant challenge in drug delivery because of the substantial obstacle presented by the blood–brain barrier (BBB). Conventional therapeutic agents frequently encounter constraints in efficiently penetrating the brain, thus requiring inventive delivery strategies. This review explores the potential aspects of the carbon nanotubes (CNTs) as an advanced drug delivery system for treating neurodegenerative disorders. CNTs, with their distinctive structural and physicochemical characteristics, present an intriguing framework for addressing challenges related to drug delivery across the BBB. The review emphasizes the functionalization of CNTs, utilizing diverse chemical modification techniques to improve their biocompatibility and effectiveness as drug carriers. The variations have a significant effect on crucial factors related to the growth of neurons.

Moreover, the review emphasizes the therapeutic ability of CNTs in treating neurodegenerative disorders. By introducing purified CNT substrates, an increase in the growth of dendrites and improved adhesion of hippocampal neurons was reported. This has led to significant progress in the processing of neuronal signals and the development of neural circuits. Finally, this review offers in-depth understanding of the innovative and enhanced nano-scaffolds provided by CNTs for transporting therapeutic substances to the brain. This offers potential for more efficient treatments for neurodegenerative disorders.

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利用碳纳米管向大脑输送新型药物，治疗神经退行性疾病

由于血脑屏障（BBB）带来的巨大障碍，神经退行性疾病给药物输送带来了巨大挑战。传统的治疗药物在有效穿透大脑方面经常遇到限制，因此需要创新的给药策略。本综述探讨了碳纳米管（CNTs）作为一种先进的给药系统在治疗神经退行性疾病方面的潜力。碳纳米管具有独特的结构和理化特性，为应对跨 BBB 给药的挑战提供了一个有趣的框架。综述强调了利用各种化学修饰技术对碳纳米管进行功能化处理，以提高其生物相容性和作为药物载体的有效性。此外，综述还强调了 CNT 在治疗神经退行性疾病方面的治疗能力。据报道，通过引入纯化的碳纳米管基底，海马神经元的树突生长和粘附性得到了改善。这在神经元信号处理和神经回路开发方面取得了重大进展。最后，本综述深入介绍了由 CNT 提供的创新和增强型纳米支架，用于向大脑输送治疗物质。这为更有效地治疗神经退行性疾病提供了潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of King Saud University - Science Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

2.60%

发文量

642

审稿时长

49 days

期刊介绍： Journal of King Saud University – Science is an official refereed publication of King Saud University and the publishing services is provided by Elsevier. It publishes peer-reviewed research articles in the fields of physics, astronomy, mathematics, statistics, chemistry, biochemistry, earth sciences, life and environmental sciences on the basis of scientific originality and interdisciplinary interest. It is devoted primarily to research papers but short communications, reviews and book reviews are also included. The editorial board and associated editors, composed of prominent scientists from around the world, are representative of the disciplines covered by the journal.