Journal of Investigative Surgery最新文献

{"title":"Low Energy Ultrapulse CO₂ Fractional Laser Combined with Autologous Platelet-Rich Plasma in Periorbital Rejuvenation Treatment.","authors":"Yanwen Qi, Cheng Sun, Yang Zhou, Lizhou Luo, Chengyuan Wang","doi":"10.1080/08941939.2025.2484543","DOIUrl":"https://doi.org/10.1080/08941939.2025.2484543","url":null,"abstract":"<p><strong>Objective: </strong>This paper focuses on the efficacy of low energy ultrapulsed CO₂ fractional laser (LEUCO₂FL) combined with autologous platelet-rich plasma (PRP) in periorbital rejuvenation treatment.</p><p><strong>Methods: </strong>Eighty patients with periorbital wrinkles and eyelid laxity were randomly assigned to a laser group (<i>n</i> = 40) receiving LEUCO₂FL or a combination group (<i>n</i> = 40) receiving additional autologous PRP. Both groups received treatment once per month for a total of three sessions. Cosmetic outcomes were assessed at three months post-treatment using the Global Esthetic Improvement Scale (GAIS). VISIA (wrinkles, texture), SOFT (skin elasticity, moisture), upper eyelid depression, and infraorbital hollowing were evaluated before and at 1, 3, and 6 months post-treatment. Adverse reactions and patient satisfaction were recorded.</p><p><strong>Results: </strong>The combination group exhibited higher overall effective rate of GAIS, greater improvements in wrinkles, texture, skin elasticity, and moisture at all time points, and lower upper eyelid depression and infraorbital hollowing scores than the laser group. While both treatments were well tolerated, patient satisfaction was higher in the combined group than the laser group.</p><p><strong>Conclusion: </strong>LEUCO₂FL combined with autologous PRP demonstrates favorable cosmetic effects in periorbital rejuvenation, significantly improving periorbital wrinkles and texture, enhancing skin elasticity and hydration, and reducing periorbital hollowness.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2484543"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and Validation of Diagnostic Model of Microvascular Invasion in Solitary Hepatocellular Carcinoma.","authors":"Xiu-Qin Wang, Ying-Qi Fan, Dong-Xing Hou, Cui-Cui Pan, Ni Zheng, Yuan-Quan Si","doi":"10.1080/08941939.2025.2484539","DOIUrl":"https://doi.org/10.1080/08941939.2025.2484539","url":null,"abstract":"<p><strong>Background: </strong>The microvascular invasion (MVI) score evaluates the presence of MVI in patients with hepatocellular carcinoma (HCC) by integrating multiple factors associated with MVI. We aimed to establish a MVI scoring system for HCC based on the clinical characteristics and serum biomarkers of patients with HCC.</p><p><strong>Methods: </strong>A total of 1027 patients with HCC hospitalized at Shandong Provincial Hospital from January 2016 to August 2021 were included and randomly divided into the development group and validation group at a ratio of 3:1. Univariable and multivariable logistic regression analyses were conducted to identify independent risk factors for MVI in HCC patients. Based on these independent risk factors, the preoperative MVI scoring system (diagnostic model) for HCC was established and verified. The receiver operating characteristic (ROC) curves, calibration curves and decision curve analyses (DCA) were employed to evaluate the discrimination and clinical application of the diagnostic model.</p><p><strong>Results: </strong>Independent risk factors for MVI of HCC involved Hepatitis B virus infection (HBV), large tumor diameter, higher logarithm of Alpha-fetoprotein (Log AFP), higher logarithm of AFP-L3% (Log AFP-L3%), higher logarithm of protein induced by vitamin K absence or antagonist-II (Log PIVKA-II) and higher logarithm of Carbohydrate antigen 125 (Log CA125). The diagnostic model incorporating these six independent risk factors was finally established. The areas under the ROC curve (AUC) assessed by the nomogram in the development cohort and validation cohort were 0.806 (95% CI, 0.773-0.839) and 0.818 (95% CI, 0.763-0.874) respectively. The calibration curve revealed that the results predicted by our diagnostic model for MVI in HCC were highly consistent with the postoperative pathological outcomes. The DCA further indicated promising clinical application of the diagnostic model.</p><p><strong>Conclusion: </strong>An effective preoperative diagnostic model for MVI of HCC based on readily available tumor markers and clinical characteristics has been established, which is both clinically significant and easy to implement for diagnosing MVI.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2484539"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect and Safety of Dexmedetomidine Administration on Mother and Foetus/Neonates During General Anaesthesia in Caesarean Section: A Randomised Controlled Trial.","authors":"Zhiqiang Yu, Yan Liu, Fangqi Duan, Qian Li, Dong Yan, Li Zhang, Zhuangzhuang Wang, Minyu Zhang, Qi Zhao","doi":"10.1080/08941939.2025.2495089","DOIUrl":"10.1080/08941939.2025.2495089","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the safety of dexmedetomidine administration to mothers, fetuses, and neonates during general anesthesia in cesarean section (CS).</p><p><strong>Patients and methods: </strong>A total of 60 parturients scheduled for elective CS under general anesthesia were randomly divided into anesthesia in groups (DEX1 and DEX2) and control (C) groups. Groups DEX1 and DEX2 were induced with dexmedetomidine (induction, 0.4 µg/kg; maintenance, 0.4 µg/kg·h) and dexmedetomidine (induction, 0.6 µg/kg; maintenance, 0.6 µg/kg·h), respectively, until birth. Equivalent volumes of normal saline were administered in group C. Anesthesia was induced with propofol and rocuronium in all groups. The mean arterial blood pressure (MAP) and heart rate (HR) of parturients were monitored and recorded; fetal HR was monitored using color doppler ultrasound. The blood gas analysis from the umbilical artery (UA) and umbilical vein (UV), along with the HR, Apgar score and Neurologic Adaptive Capacity Scores (NACS) of neonates, were recorded.</p><p><strong>Results: </strong>Maternal MAP at intubation/skin incision, maternal HR at intubation/skin incision and delivery were significantly lower in groups DEX1 and DEX2 than in group C, no significant differences were observed between groups DEX1 and DEX2. No significant differences were observed in fetal HR, UA and UV blood gas analyses, Apgar score and NACS of neonates in the three groups.</p><p><strong>Conclusion: </strong>Intravenous 0.4 or 0.6 µg/kg doses of dexmedetomidine with propofol for general anesthesia in CS is beneficial for inhibiting the maternal stress response induced by intubation/skin incision and delivery without significant adverse effects on fetuses or neonates. Our findings suggest that dexmedetomidine is safe for mothers, fetuses, and neonates in obstetric general anesthesia.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2495089"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Cyclosporine A Plus Zishen Yutai Pill in the Treatment of Patients with Recurrent Pregnancy Loss.","authors":"Mingzhe Zhang, Min Xu, Li Li, Min Dong, Haiyan Wang, Keyan Luo","doi":"10.1080/08941939.2025.2510310","DOIUrl":"https://doi.org/10.1080/08941939.2025.2510310","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzed the therapeutic effects of cyclosporine A (CsA) plus Zishen Yutai Pill (ZYP) in the treatment of patients with recurrent pregnancy loss (RPL).</p><p><strong>Methods: </strong>This study prospectively included 150 RPL patients who were randomized into CsA and CsA + ZYP groups (<i>n</i> = 75 patients/group). The serum levels of hormones estradiol (E2), human chorionic gonadotropin (HCG), progesterone (P), Th1-type cytokines, and Th2-type cytokines were detected by ELISA. Additionally, we compared the proportions of immune cell subsets (T lymphocytes, Th1, Th2), the incidence of adverse reactions, and live birth rates between the two groups. Furthermore, patients treated with CsA plus ZYP were categorized into appropriate age and elderly age groups based on their age to ascertain the therapeutic effects of CsA plus ZYP on RPL patients of different ages.</p><p><strong>Results: </strong>CsA plus ZYP resulted in markedly higher E2, HCG, and P levels and live birth rates than CsA alone. After treatment with either CsA or CsA plus ZYP, the Th1 cell subset, Th1-type cytokines, and Th1/Th2 ratio significantly decreased but Th2 cell subset and Th2-type cytokines were greatly elevated in both groups, with more pronounced changes induced by CsA plus ZYP. There was no significant difference in the incidence of adverse reactions between the two groups. Furthermore, the therapeutic effect of CsA plus ZYP was better in RPL patients of appropriate age.</p><p><strong>Conclusion: </strong>CsA plus ZYP significantly improved Th1/Th2 balance and increased live birth rates in RPL patients and was more effective in RPL patients of appropriate age.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2510310"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Prognostic Factors Related to Endovascular Treatment of Acute Basilar Artery Occlusion Within 24 Hours of Onset.","authors":"Changchun Jiang, Yu Fan, Yuechun Li, Wei Ma","doi":"10.1080/08941939.2024.2442382","DOIUrl":"https://doi.org/10.1080/08941939.2024.2442382","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the prognostic effect of endovascular treatment (EVT) in patients with acute base artery occlusion (ABAO) within 24 h of onset, and analyze the factors related to prognosis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on all ABAO patients who received EVT within 24 h of onset in the neurology department of Baotou Central Hospital in Inner Mongolia from May 2016 to October 2022. Good prognosis was defined as a Modified Rankin Scale (mRS) score of 0-3 and poor prognosis mRS score of 4-6 at 90 day follow-up, and factors related to prognosis were analyzed.</p><p><strong>Results: </strong>Among the 77 patients included in the analysis, 68 patients (88.3%) achieved recanalization (modified thrombolysis in cerebral infarction, mTICI 2b/3 grade). Thirty eight patients (49.4%) achieved an overall good prognosis. In univariate analysis, age, baseline Glasgow Coma Scale (GCS), baseline National Institutes of Health Stroke Scale (NIHSS), posterior circulation Acute Stroke Prognostic Early CT score (pc ASPECTS), preoperative intravenous thrombolysis, and mTICI2b-3 were factors affecting good prognosis. Multivariate analysis showed that shorter onset to puncture time (OR 0.069; 95% CI, 0.009-0.519; <i>p</i> = 0.009), lower NIHSS (OR 1.179; 95% CI, 1.019-1.364; <i>p</i> = 0.027), and higher pc ASPECTS (OR 0.489, 95% CI, 0.250-0.959, <i>p</i> = 0.037) were factors influencing good prognosis in this study.</p><p><strong>Conclusions: </strong>In summary, endovascular treatment for patients with acute basilar artery occlusion is safe and effective, but EVT may achieve better prognosis within 6 h of onset. The shorter time from onset to puncture at admission, lower baseline NIHSS score, and higher baseline pc-ASPECTS are factors affecting the good prognosis of patients at 90 days.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2442382"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Significance and Prognostic Value of GPR27 in Ovarian Cancer.","authors":"Xiulan Peng, Yahong Cai, Bing Tang, Mingtao Zhang, Xia Wang","doi":"10.1080/08941939.2025.2491781","DOIUrl":"https://doi.org/10.1080/08941939.2025.2491781","url":null,"abstract":"<p><strong>Background: </strong>This study explored the prognostic role of GPR27 and its predictive value to platinum-based therapy in ovarian cancer.</p><p><strong>Material and methods: </strong>A survival analysis of GPR27, and the therapeutic response to platinum in ovarian cancer was investigated using data from the cancer genome atlas (TCGA) and Gene Expression Omnibus (GEO) databases. GPR27 expression was assessed using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry.</p><p><strong>Results: </strong>Database analysis and RT-PCR revealed over-expression of GPR27 mRNA in ovarian cancer tissues compared to normal ovarian tissues. Ovarian cancer patients with up-regulated GPR27 transcription were associated with better overall survival and disease-free survival compared to those with downregulated GPR27 mRNA in the TCGA dataset and Kaplan-Meier plot database (<i>N</i> = 1656). GPR27 demonstrated good predictive value for pathological response in patients with ovarian cancer receiving platinum-based therapy. The predictive performance for 6-month relapse-free survival was higher in endometrioid ovarian cancer (AUC:0.804) than that in serous ovarian cancer. GPR27 protein levels were significantly up-regulated in ovarian cancer tissues compared with normal ovarian tissue, and high GPR27 protein expression correlated with early-stage TNM. ROC analysis revealed that the GPR27 protein, quantified by the immunohistochemistry score, effectively predicted the response to platinum-based therapy response with an AUC of 0.7479 in our cohort.</p><p><strong>Conclusion: </strong>GPR27 was up-regulated in ovarian cancer, compared with that of normal ovarian tissue, and was strongly correlated with survival outcomes and response to platinum-based therapy. GPR27 may serve as a reliable biomarker for platinum -based therapy in ovarian cancer patients.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2491781"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Porcine Model of Laparoscopic Intersphincteric Resection for Ultra-Low Rectal Cancer.","authors":"Min-Wei Zhou, Ji-Xin Ma, Zheng-Qing Yan, Zheng-Dong Qiao, Zhen-Yang Li, Xiao-Dong Gu, Sen Yan, Yi-Wen Zang, Zong-You Chen, Yi-Ming Zhou, Jian-Hua Ding, Jian-Bin Xiang","doi":"10.1080/08941939.2025.2497327","DOIUrl":"https://doi.org/10.1080/08941939.2025.2497327","url":null,"abstract":"<p><strong>Objective: </strong>To develop a porcine model for laparoscopic intersphincteric resection (ISR) targeting ultra-low rectal cancer.</p><p><strong>Methods: </strong>Six Bama mini-pigs underwent a standard laparoscopic ISR procedure: (1) Ligation and transection of the inferior mesenteric vessels; (2) Exposure and sparing of the pelvic autonomic nerves; (3) Dissection of the rectum; (4) Dissection and transection of hiatal ligament and rectourethralis muscle; (5) Transanal dissection of the anal canal; (6) Dissection of the intersphincteric space (ISS); (7) End-to-end handsewn coloanal anastomosis (CAA). Pathological evaluations were conducted to ascertain the precision of the ISR. Furthermore, postoperative fecal incontinence scores were systematically assessed on a weekly basis throughout a 12-week post-surgery follow-up period.</p><p><strong>Results: </strong>All six pigs survived surgery without conversion to an open approach. There were no occurrences of incisional infection or any surgical complications, including anastomotic leakage, anastomotic bleeding, or ileus. Postoperatively, one pig manifested constipation and three exhibited anal redness, both conditions ameliorating within a week. No erosive ulcers were detected. Notably, all animals exhibited fecal staining on their tails within the first two weeks post-surgery, transitioning to formed feces by the third week. Improvement in defecation frequency was observed after 6 weeks, with a noticeable reduction in defecation areas after one month. Incontinence scores, evaluated three months post ISR surgery, revealed no significant abnormalities in anal function compared to preoperative assessments.</p><p><strong>Conclusions: </strong>This study established a replicable porcine model for laparoscopic ISR, demonstrating its potential utility in clinical and fundamental research related to ultra-low rectal cancer treatment.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2497327"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between NLR and PLR Ratios and the Occurrence and Prognosis of Progressive Hemorrhagic Injury in Patients with Traumatic Brain Injury.","authors":"Tingting Wang, Zheng Yang, Bin Zhou, Yanfei Chen","doi":"10.1080/08941939.2025.2470453","DOIUrl":"10.1080/08941939.2025.2470453","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the relationship between neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) ratios and the occurrence and prognosis of progressive hemorrhagic injury (PHI) in patients with traumatic brain injury (TBI).</p><p><strong>Methods: </strong>This retrospective study included 166 TBI patients. Clinical data were collected and NLR and PLR were assessed. Receiver operating characteristic (ROC) curve analysis was conducted to assess the predictive value of NLR and PLR for PHI occurrence in TBI patients. Logistic regression analysis was performed to identify risk factors influencing PHI development and poor neurological prognosis.</p><p><strong>Results: </strong>The PHI group (<i>n</i> = 77) exhibited significantly higher NLR and PLR ratios than the non-PHI group (<i>n</i> = 89). Independent risk factors for PHI occurrence included higher Abbreviated Injury Scale scores, absent pupillary reflexes, lower Glasgow Coma Scale (GCS) scores, and elevated NLR and PLR ratios. The combined use of NLR and PLR ratios demonstrated superior predictive performance for PHI occurrence, with a higher area under the curve (AUC: 0.843) and sensitivity (77.9%, cutoff values: 17.19 for NLR and 196.33 for PLR) compared to NLR alone (AUC: 0.794, sensitivity: 53.2%, cutoff value: 21.78) or PLR alone (AUC: 0.665, sensitivity: 53.2%, cutoff value: 235.48). For poor neurological prognosis, higher AIS scores, lower GCS scores, and elevated NLR ratios were identified as independent risk factors.</p><p><strong>Conclusion: </strong>TBI patients with elevated NLR and PLR ratios are at increased risk of developing PHI. In severe TBI cases, patients with high NLR ratios during the early stages tend to experience poor neurological outcomes.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2470453"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Triangular Muscle Flap Esophagogastrostomy After Proximal Gastrectomy.","authors":"Guangyu Chen, Zhenyu Chen, Yaning Song, Baifa Sheng, Xiong Li, Lin Zhang, Yongkuan Cao, Lin Xue, Liye Liu","doi":"10.1080/08941939.2025.2465573","DOIUrl":"10.1080/08941939.2025.2465573","url":null,"abstract":"<p><strong>Background: </strong>Standardized proximal gastrectomy for upper-third gastric cancer (UGC) is lacking due to the current methods' inability to prevent reflux and facilitate postoperative endoscopic monitoring surveillance. In this study, we provide a detailed description of proximal gastrectomy utilizing a new triangular muscle flap for esophagogastrostomy and evaluate the postoperative outcomes of this technique.</p><p><strong>Method: </strong>A total of 17 patients diagnosed with early-stage primary UGC underwent laparoscopic proximal gastrectomy between May 2021 and May 2022. Subsequently, a new triangular muscle flap was used for esophagogastrostomy.</p><p><strong>Results: </strong>No in-hospital deaths occurred during the study period. However, two patients experienced complications early in the study, including one case of pulmonary infection and another of abdominal abscess infection. Importantly, none of the patients exhibited any reflux symptoms. Postoperatively, 15 patients were diagnosed with grade N/M esophagitis, one with grade A, and one with grade B. All patients are currently alive without tumor recurrence.</p><p><strong>Conclusions: </strong>This surgical technique can be safely performed and demonstrates excellent results in preventing gastroesophageal reflux. Further investigation through a multi-center clinical study is warranted to confirm its efficacy.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2465573"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized Minimally Invasive Jejunoileal Bypass Compared to Traditional Minimally Invasive Jejunoileal Bypass in the Treatment of Type 2 Diabetes: A Retrospective Cohort Study.","authors":"Xiaoling Chen, Minghui Ao, Zhengcai Li, Zifang Wang, Xinguo Zhang, Jing Chen","doi":"10.1080/08941939.2025.2525335","DOIUrl":"https://doi.org/10.1080/08941939.2025.2525335","url":null,"abstract":"<p><strong>Objective: </strong>The efficacy and safety of optimized minimally invasive jejunoileal bypass (OM-JIB) compared to traditional minimally invasive jejunoileal bypass (TM-JIB) in the treatment of type 2 diabetes mellitus (T2DM) were evaluated.</p><p><strong>Methods: </strong>The included patients were placed into two groups (TM-JIB group [<i>n</i> = 49] and OM-JIB group [<i>n</i> = 48]) based on the surgical method. The surgical parameters, basic information, the laboratory results, 1-y postoperative outcomes, and postoperative complication rates were compared.</p><p><strong>Results: </strong>The operative time was longer for the OM-JIB group compared to the TM-JIB group (<i>p</i> < 0.05) with no differences in the intraoperative blood loss and length of hospital stay (<i>p</i> > 0.05). Both groups exhibited significant reductions in BMI, fasting plasma glucose, 2-hour plasma glucose, and glycated hemoglobin over time (<i>p</i> < 0.05). The OM-JIB group achieved a similar efficacy rate to the TM-JIB group at the 1-y follow-up evaluation (<i>p</i> > 0.05). However, the postoperative complication rate was significantly lower in the OM-JIB group than the TM-JIB group (2.08% vs. 16.33%, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>OM-JIB treatment of T2DM patients was shown to be as effective as TM-JIB, but with significantly fewer complications than TM-JIB, thus enhancing patient safety.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2525335"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}